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FAKULTAS FARMASI UNIVERSETAS JENDERAL ACHMAD YANI Jl. Terusan Jenderal Sudirman PO BOX 148, Cimahi, Jawa Barat, 40531, Indonesia
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INDONESIA
Kartika : Jurnal Ilmiah Farmasi
Published by Universitas Jenderal Achmad Yani
ISSN : 23546565     EISSN : 25023438     DOI : https://doi.org/10.26874/kjif.v6i1.135
Core Subject : Health, Science, Social,
Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Social Sciences
Kartika: Jurnal Ilmiah Farmasi (KJIF) merupakan media publikasi ilmiah dalam bidang kefarmasian yang diterbitkan oleh Fakultas Farmasi Universitas Jenderal Achmad Yani, bekerjasama dengan Ikatan Apoteker Indonesia (PD IAI Jawa Barat). Ruang lingkup artikel yang diterbitkan adalah: Farmasetika, Kimia Farmasi, Kimia Analisa, Farmasi Fisika, Farmakognosi dan Etnobotani, Natural Produk, Farmakologi dan Toksikologi, Praktik Kefarmasian dan Farmasi Rumah Sakit, Farmakogenomik, Farmakoekonomi, Studi Kasus dan Uji Klinis.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 6 Documents
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Search results for , issue "Vol 9 No 2 (2024)" : 6 Documents clear
STUDI IN SILICO SENYAWA AKTIF PADA DAUN SAMBILOTO (ANDROGRAPHIS PANICULATA) SEBAGAI INHIBITOR ANDROGEN PADA KANKER PROSTAT Davinali, Belva Annora Alfita; Stephanie, Manuela Joy; Hanifa, Hasya Qanita Ali; Aurelia, Khanna Ragita; Prasiska, Rizky; Nurdin, Halwa Aulia; Nuwarda, Rina Fajri
Kartika : Jurnal Ilmiah Farmasi Vol 9 No 2 (2024)
Publisher : Fakultas Farmasi Universitas Jenderal Achmad Yani, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/kjif.v9i2.721

Abstract

Kanker prostat adalah penyakit kanker yang berkembang di sel-sel kelenjar prostat pria, yang dapat menyebar ke bagian tubuh lainnya, terutama tulang dan nodus limfa. Di Indonesia, kanker prostat menjadi kanker kelima yang paling umum terjadi pada pria, dan menempati urutan kedua kanker paling umum terjadi pada pria di dunia. Reseptor Androgen (AR) adalah protein reseptor yang berperan penting dalam pertumbuhan sel kanker prostat dan telah digunakan sebagai sel target untuk pengembangan obat terkait penyembuhan kanker prostat. Penelitian ini bertujuan untuk studi in silico aktivitas senyawa kimia pada daun tanaman sambiloto (Andrographis paniculata) untuk menghambat reseptor Androgen (1E3G) untuk mengobati kanker prostat. Penelitian dilakukan dengan metode molecular docking menggunakan perangkat lunak Chemdraw, Chem3D, AutoDockTools 1.5.6., BIOVIA Discovery Studio 2021, dan Ligandscout. Hasil penelitian menunjukkan bahwa senyawa Andrografolid mempunyai energi ikatan bebas terendah yaitu -10.73 KKal/mol serta interaksi pada beberapa residu asam amino yang sama dengan ligan alami, yaitu Metribolon. Karena itu dapat disimpulkan bahwa dari daun sambiloto senyawa andrografolid merupakan senyawa yang paling berpotensi dalam penghambatan reseptor Andorgen.  Kata kunci : Andrographolide, reseptor androgen, studi in silico   Abstract Prostate cancer is a malignancy in men’s prostate gland cells, which can spread to other parts of the body, most commonly bones and lymph nodes. In Indonesia, prostate cancer is the third most common type of cancer among men, and is the second most commoncancer in men in the world. Androgen receptor (AR) is a receptor protein that plays an important role in the growth of prostate cancer cells and has been used as a target cell for developing drugs for prostate cancer treatment. This research aims to study in silico the activity of chemical compounds in the leaves of the sambiloto plant (Andrographis paniculata) to inhibit the Androgen receptor (1E3G) to treat prostate cancer. Tests were Carried out with molecular docking method using the software Chemdraw 3D, AutoDockTools 1.5.6., BIOVIA Discovery Studio 2021, and Ligandscout. The results showed that Andrographolid compounds had the lowest free bond energy of -10.73 KKal/mol and interactions in several amino acid residues that were the same as natural ligands, namely Metribolon. Therefore, it can be concluded that from sambiloto leaves, andrographolid compounds are the most potential compounds in inhibiting Andorgen receptors. Keywords : Andrographolide, Androgen receptor, in silico study.
PENANGANAN PERMASALAHAN SIFAT HIGROSKOPIS PADA FORMULASI SEDIAAN TABLET Ratih, Hestiary; Gosepa, Oke Setiawan
Kartika : Jurnal Ilmiah Farmasi Vol 9 No 2 (2024)
Publisher : Fakultas Farmasi Universitas Jenderal Achmad Yani, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/kjif.v9i2.728

Abstract

Sebagian besar bahan aktif farmasi (BAF) bersifat sangat higroskopis dalam bentuk padatan. Higroskopisitas yang tinggi dapat menimbulkan beberapa permasalahan antara lain terjadinya perubahan sifat fisikokimia pada bahan aktif.  Perubahan sifat fisiko kimia tersebut dapat berdampak pada usia simpan sediaan tablet sehingga menjadi lebih singkat. Kajian literatur ini bertujuan untuk memberikan informasi mengenai penanganan pada proses produksi sediaan tablet yang memiliki sifat padatan bahan baku higroskopis. Metode penyusunan kajian literatur ini bersumber dari 42 artikel yang berasal dari artikel jurnal nasional maupun internasional yang telah terbit pada sepuluh tahun terakhir (2014-2024), artikel yang terkumpul dilakukan seleksi dan identifikasi berdasarkan kriteria inklusi dan eksklusi. Hasil kajian penelusuran pustaka terkait dengan upaya yang dapat dilakukan dalam penanganan permasalahan sifat higroskopis padatan farmasi pada formulasi sediaan tablet, antara lain yaitu, dengan teknik penyalutan film, teknik enkapsulasi (dengan spray-drying/freeze-drying dan koaservasi kompleks), teknik ko-proses (co-process), dan rekayasa kristal (co-crystal). Berdasarkan kajian literatur yang telah dilakukan dapat disimpulkan bahwa beberapa teknik dalam memodifikasi sifat fisik bahan aktif farmasi pada formulasi sediaan tablet dapat menangani permasalahan sifat higroskopis bahan aktif dengan meningkatkan pengendalian higroskopisitas suatu padatan sehingga dapat meningkatkan stabilitas bahan aktif. Kata kunci:  Formulasi, higroskopis, penanganan, sediaan, tablet.   Abstract The majority of active pharmaceutical ingredients (API) are highly hygroscopic in solid form. High hygroscopicity can cause several problems, including changes in the physicochemical properties of active ingredients which can cause difficulties in formulating a preparation such as tablets, so that this can affect the shelf life of tablet preparations which become shorter. This literature review aims to find out the formulation handling in the production process of tablet preparations that have the characteristics of highly hygroscopic solids. The method of preparing this literature review comes from 42 articles originating from national and international journal articles that have been published in the last ten years (2014 - 2024), the collected articles were selected and identified based on the inclusion and exclusion criteria. The results of the literature search review related to efforts that can be made in handling the problem of hygroscopic properties of pharmaceutical solids in tablet dosage formulations, including film coating techniques, encapsulation techniques (by spray-drying/freeze-drying and complex coacervation), co-process techniques, and crystal engineering (co-crystal). Based on the literature review that has been conducted, it can be concluded that several techniques in modifying the physical properties of active pharmaceutical ingredients in tablet formulations can handle the problem of the hygroscopic nature of active ingredients by increasing the control of hygroscopicity of a solid so as to increase the stability of active ingredients. Keywords: Formulation, hygroscopic, handling, preparation, tablets.  
PENGARUH VARIASI WAKTU EKSTRAKSI TERHADAP KADAR SAPONIN TOTAL EKSTRAK AIR AKAR TEBU HITAM (Saccharum officinarum L.) SECARA SPEKTROFOTOMETRI UV-VIS Sarwendah, Adzkia Salsa; Lindawati, Novena
Kartika : Jurnal Ilmiah Farmasi Vol 9 No 2 (2024)
Publisher : Fakultas Farmasi Universitas Jenderal Achmad Yani, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/kjif.v9i2.695

Abstract

Black Sugar Cane (Saccharum officinarum L.) is an annual plant that is often used for medicine, food and, drink. Black Sugar Cane Root decoction has various pharmacological effects as antibacterial, immunomodulatory and antianemic due to the presence of saponins. This study aims to determine total saponin levels with variations in boiling time for Black Sugar Cane Roots using the UV-Vis Spectrophotometry method. The method for identifying saponin compounds uses the foam method and Liebermann-Burchard reagent. Determination of levels was carried out using the UV-Vis Spectrophotometry method at a wavelength of 543 nm and an operating time of 15 minutes. The comparison standard used is Diosgenin. The results showed that the decoction of Black Sugar Cane Roots positively contained steroid saponins. The results of determining total saponin levels with varying boiling times of 10 minutes, 20 minutes, and 30 minutes were respectively 1.123 mg DE/g with a KV of 0.679%, 2.086 mg DE/g with a KV of 0,276%, and 2.933 mg DE/g with KV 0.196%, the boiling time is 30 minutes, Black Sugar Cane Roots have the highest saponin content. Homogeneity of Variences Test, a significance value of 0.641 > 0.05 was obtained. The Anova test obtained a significance value of 0.000 < 0.05, that there is a significant difference between the saponin content and the boiling time for Black Sugar Cane Roots.
PENAMBATAN MOLEKUL SENYAWA AKTIF CURCUMA XANTHORRHIZA ROXB KANDIDAT ANTI KANKER KOLOREKTAL TERHADAP RESEPTOR LYMPHOCYTE-SPECIFIC PROTEIN TYROSINE KINASE Sativa, Nasywa Oryza; Putri, Adelia Ofira; Natasya, Zaskiya; Rislia, Rana Atikah; Ulfa, Lutfiyana; Karima, Miska Aulia; Balqis, Selvi; Saputro, Anjar Hermadi; Auli, Winni Nur
Kartika : Jurnal Ilmiah Farmasi Vol 9 No 2 (2024)
Publisher : Fakultas Farmasi Universitas Jenderal Achmad Yani, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/kjif.v9i2.702

Abstract

Background: Temulawak (Curcuma xanthorrhiza Roxb) contains essential oils and curcuminoid compounds which have anti-cancer activity. Temulawak (Curcuma xanthorrhiza Roxb) can increase colorectal cancer chemotherapy agents against Lck receptors on colon epithelial cells. Purpose(s): The aim of this research is to identify active compounds that have the potential to act as colorectal anticancer contained in Temulawak (Curcuma xanthorrhiza Roxb) against Lck receptors through in silico studies using molecular docking methods. Methods: This study was carried out of molecular docking using software AutoDock Tools-1.5.6., Lipinski predictions with LigandScout, and visualitation using Biovia Discovery Studio 2021 Client. Results: Xanthorrizol has hydrogen bonds with the same amino acid residues as native ligand and reference compound, namely GLU317 and MET319. The results of the molecular binding energy of the native ligand are -10.12 kcal/mol. Conclusion: Based on research results, the xanthorrizol compound has the best potential to be a colorectal anticancer candidate and qualified of Lipinski's rules so it is safe to be administered orally.
STUDI INTERAKSI OBAT-OBAT JANTUNG YANG DILAKUKAN TERHADAP ORANG SEHAT: TINJAUAN SISTEMATIS Sumartin, Yunita; Sukandar, Elin Yulinah
Kartika : Jurnal Ilmiah Farmasi Vol 9 No 2 (2024)
Publisher : Fakultas Farmasi Universitas Jenderal Achmad Yani, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/kjif.v9i2.669

Abstract

Patients with cardiovascular disease have a higher prevalence of drug interactions than other patient groups. Drug interactions may result from pharmacokinetic or pharmacodynamic mechanisms. This study is a systematic review that aims to identify drug interactions related to cardiac drugs. Article searches were conducted on PubMed and ScienceDirect databases to identify all articles on cardiac drug-drug interaction studies. The search started from articles published in 2013 to 2023. The keywords used in the article search were as follows: drug-drug interactions, cardiac patient, cardiac drug, cardiovascular drug, pharmacokinetics interaction, pharmacodynamic interaction combined with the boolean operator "AND". Study articles that met the requirements were entered into the study for review. The total number of articles identified from the database used was 805 articles; 7 duplicate articles were excluded; 84 articles were available in full text; but only 30 articles in accordance with the inclusion were reviewed. Potential drug interactions related to cardiac drugs were most common in the Angiotensin II Receptor Blocker (ARB) class of drugs. Other cardiac drug interactions occurred with angiotensin receptor-neprilysin inhibitors (ARNI), anticoagulants, antiplatelets, digoxin, calcium channel blockers and beta blockers. The effects of these cardiac drug interactions vary. To avoid the occurrence of drug interactions, co-administration of cardiac drugs should be administered with caution, dose adjustments may be required, and monitoring for possible adverse drug events should be done.
FORMULASI CLAY MASK DAUN BINAHONG (Anredera cordifolia (Ten.) Steenis) DAN UJI INHIBISI Staphylococcus aureus Asthyananda, Michelytha; Bakri, Dzaki Fikri Firdaus
Kartika : Jurnal Ilmiah Farmasi Vol 9 No 2 (2024)
Publisher : Fakultas Farmasi Universitas Jenderal Achmad Yani, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/kjif.v9i2.680

Abstract

Acne is abnormal skin condition is cause by disruption of oil gland production causees in excessive oil production. One of the bacteria that cause acne is Staphylococcus aureus Binahong leaf (Anredera cordifolia (Ten.) Steenis) has been studied and proven to inhibit Staphylococcus aureus bacteria at 20%. Clay mask is one of pharmaceutical formulations to make it easier for using binahong leaf extract. The purpose of this research is to determine the physical quality test and inhibition activity clay mask with binahong leaf extract against Staphylococcus aureusnbacteria. This study uses the maceration extraction method, formulation of clay mask preparations with a concentration of binahong leaf extract of 10%, 12% and 14%, physical quality tests include organoleptical, homogeneity, pH, viscosity, adhesion, spreadability and drying time of preparations and inhibition Staphylococcus aureus bacteria. The results showed that all clay mask formulas of binahong leaf extract give good physical quality results. The clay mask preparation of binahong leaf extract can inhibition Staphylococcus aureus in formula I is 11,87 ± 0,88, formula II is 13,05 ± 0,44 and formula III is 14,006 ± 1,45. The inhibition activity of the three formulas are classified as strong category.

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