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The Indonesian Journal of General Medicine
Published by International Medical Journal Corp. Ltd.
ISSN : -     EISSN : 3048104X     DOI : -
Core Subject : Health,
Dentistry Health Professions Medicine & Pharmacology Public Health Veterinary
ims: The Indonesian Journal of General Medicine aims to advance the field of medicine by disseminating high-quality research findings that are accessible to a broad audience of healthcare professionals, researchers, and policymakers. The journal is committed to supporting the development of medical knowledge and practice in Indonesia and globally, fostering innovative research and evidence-based clinical practices. Scope: The journal covers a wide range of topics within the general medical field, including but not limited to: Clinical studies in various medical disciplines Epidemiological research and public health issues Innovations in diagnostic techniques and treatments Reviews on current practices and emerging trends in medicine Case studies and clinical trials Health policy and medical education The Indonesian Journal of General Medicine welcomes submissions from all areas of medicine, particularly those that have significant implications for patient care, public health, and policy-making. The journal encourages submissions that offer new insights, propose novel approaches, or address challenges pertinent to the Indonesian and international medical communities.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 6 Documents
 1 
Search results for , issue "Vol. 1 No. 1 (2024)" : 6 Documents clear
The Correlation Between Body Mass Index Genetic Risk Score and Dietary Intake on Weight Status: A Systematic Review Budi, Agus; Farida, Farida
The Indonesian Journal of General Medicine Vol. 1 No. 1 (2024)
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/g5f4es11

Abstract

Background: Obesity is associated with environmental factors, such as dietary intake and physical activity, as well as genetic factors. Obesity is due to an increase in total energy intake, although the precise contributions of nutrients (for example, carbohydrates, fat, protein and fiber) are not fully understood. Methods: This systematic review focused on full-text English literature published between 2014 and 2024 using the PRISMA 2020 guidelines. Editorials and review pieces published in the same journal as the submission without a DOI were not accepted. The literature was compiled using Medline, Science Direct, Scopus and Embase, among other online venues. Result: Eight publications were found to be directly related to our ongoing systematic examination after a rigorous three-level screening approach. Subsequently, a comprehensive analysis of the complete text was conducted, and additional scrutiny was given to these articles. Conclusion: More controlled clinical trials with robust designs are needed to be able to recommend personalized nutrition based on nutrition for obesity prevention and management.
Efficacy and Safety of Chloroquine in Patient with COVID-19 : A Comprehensive Systematic Review Agustina, Agustina; Rahma, Riah
The Indonesian Journal of General Medicine Vol. 1 No. 1 (2024)
Publisher : International Medical Journal Corp. Ltd

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Abstract

Background: Chloroquine is a potent inhibitor of the SARS Coronavirus (SARS-CoV) and SARS-CoV-2 in in vitro studies, and has been suggested to exhibit antiviral activity against Zika virus, poliovirus, HIV, and influenza viruses A & B. Methods: This systematic review focused on full-text English literature published between 2014 and 2024 using the PRISMA 2020 guidelines. Editorials and review pieces published in the same journal as the submission without a DOI were not accepted. Result: Five publications were found to be directly related to our ongoing systematic examination after a rigorous three-level screening approach. Subsequently, a comprehensive analysis of the complete text was conducted, and additional scrutiny was given to these articles. Conclusion: No significant beneficial effect of using chloroquine on the outcome of patients with COVID-19.
Sensitivity Analysis of Diabetes Mellitus and Tuberculosis for Confounders : A Comprehensive Systematic Review Amelia, Gita; Suryanto, Joko
The Indonesian Journal of General Medicine Vol. 1 No. 1 (2024)
Publisher : International Medical Journal Corp. Ltd

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Abstract

Background: People with diabetes mellitus (DM) have a higher tuberculosis (TB) risk. Tuberculosis (TB) and diabetes mellitus (DM) are two diverse conditions of immense public health importance existing for centuries. TB was traditionally identified with poverty while DM was considered as an entity associated with prosperity. Methods: This systematic review focused on full-text English literature published between 2014 and 2024 using the PRISMA 2020 guidelines. Editorials and review pieces published in the same journal as the submission without a DOI were not accepted. The literature was compiled using PubMed, ScienceDirect, and SagePub, among other online venues. Result: Ten publications were found to be directly related to our ongoing systematic examination after a rigorous three-level screening approach. Subsequently, a comprehensive analysis of the complete text was conducted, and additional scrutiny was given to these articles. Conclusion: Both DM and TB have been associated with significant morbidity and mortality from time immemorial.
Factors Related to Severity of Diabetic Foot Ulcer: A Systematic Review Pratiwi, Niken; Barry, Barry
The Indonesian Journal of General Medicine Vol. 1 No. 1 (2024)
Publisher : International Medical Journal Corp. Ltd

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Abstract

Background: Diabetes mellitus (DM) has become a pressing global health concern, with the number of cases escalating significantly over the past few decades. Diabetic foot ulcers (DFUs), among the complications of DM, present a substantial burden, with prevalence rates ranging from 4 to 10% and severe cases associated with heightened mortality rates. This study aims to consolidate research findings on the factors influencing DFU severity to inform preventive strategies and improve patient care. Methods: This systematic review focused on full-text English literature published between 2014 and 2024 using the PRISMA 2020 guidelines. The literature was compiled using PubMed, ScienceDirect, and SagePub, among other online venues. Result: Five publications were found to be directly related to our ongoing systematic examination after a rigorous three-level screening approach. Subsequently, a comprehensive analysis of the complete text was conducted, and additional scrutiny was given to these articles. Conclusion: Diabetic foot ulcer (DFU) is a serious complication of diabetes, influenced by various factors, including lifestyle and self-care practices. Educating patients on proper foot hygiene and care, along with comprehensive training for healthcare providers, can mitigate DFU severity.
A Systematic Review on Effects of Plant-Based Diets on Outcomes Related to Glucose Metabolism Yanto, Dwi; Michael, Michael
The Indonesian Journal of General Medicine Vol. 1 No. 1 (2024)
Publisher : International Medical Journal Corp. Ltd

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Abstract

Background: The term “plant-based diet” is used for a wide range of dietary patterns, and comprise all diets based mainly on food derived from plants. “Plant food” typically refers to vegetables, fruit, grains, seeds, legumes, pulses, fungi, and nuts, and a similarity among the different plant-based diets is the limited consumption of foods of animal origin. Methods: This systematic review focused on full-text English literature published between 2014 and 2024 using the PRISMA 2020 guidelines. Editorials and review pieces published in the same journal as the submission without a DOI were not accepted. Result: Five publications were found to be directly related to our ongoing systematic examination after a rigorous three-level screening approach. Subsequently, a comprehensive analysis of the complete text was conducted, and additional scrutiny was given to these articles. Conclusion: A dietary pattern excluding foods of animal origin is likely to have beneficial effects on glucose metabolism in individuals with T2DM and overweight/obesity
The Association of Long-Term Metformin Use with Cancer Risk in Type 2 Diabetes: A Systematic Review of the Evidence and Methodological Controversies Satya Agung Nugroho; Hasnan Habib Affifudin; Rizkyta Audrey Candrasmurti
The Indonesian Journal of General Medicine Vol. 1 No. 1 (2024)
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/vptnkj62

Abstract

INTRODUCTION: A substantial body of evidence suggests that type 2 diabetes mellitus (T2DM) is a systemic state that promotes carcinogenesis, with chronic hyperinsulinemia identified as a primary biological mechanism. Metformin, a first-line insulin-sensitizing agent for T2DM, has been investigated for potential anti-neoplastic properties due to its ability to reduce circulating insulin levels and exert direct cellular effects. However, the evidence is conflicting, with observational studies suggesting a protective effect while randomized controlled trials (RCTs) show null results. This systematic review synthesizes the evidence on the association between long-term metformin use and cancer risk in patients with T2DM and critically appraises the methodological controversies that complicate its interpretation. METHODS: A systematic review of key observational studies investigating the association between metformin use and cancer risk in T2DM patients was conducted. Included studies were of cohort and case-control design. The methodological quality of selected studies was assessed using the Newcastle-Ottawa Scale (NOS). Findings were synthesized for overall cancer incidence and mortality, site-specific cancer risks, and dose-duration relationships. A critical appraisal of potential biases, including time-related biases and confounding by comparator, was performed to contextualize the discrepancy between observational and RCT evidence. RESULTS: Observational studies and their meta-analyses consistently reported a significant reduction in overall cancer risk, with summary risk reductions of approximately 30-35% for both incidence and mortality. The strongest protective associations were observed for hepatocellular and pancreatic cancers. The evidence for colorectal and breast cancer was inconsistent, while the association with prostate cancer was weak. A clear dose- and duration-response relationship was a common finding, with benefits becoming significant only after several years of continuous use. In stark contrast, meta-analyses of RCTs have consistently found no association between metformin use and cancer incidence (RR 1.07; 95% CI, 0.87–1.31). Critical appraisal of the observational literature revealed a high potential for methodological flaws, particularly immortal time bias and confounding by comparison to potentially harmful agents (e.g., sulfonylureas), which may account for this discrepancy. DISCUSSION: The evidence regarding metformin's chemopreventive effect is defined by a fundamental conflict between a large body of observational data suggesting a strong protective effect and null findings from RCTs. The magnitude of risk reduction in observational studies is likely an overestimation driven by systematic biases. If a true protective effect exists, it is probably far more modest than initially reported and likely mediated by the systemic reduction of hyperinsulinemia, primarily affecting insulin-sensitive tumors. The alternative hypothesis—that metformin appears protective because it is often compared to agents like sulfonylureas that may increase cancer risk—cannot be dismissed. CONCLUSION: Observational studies and their meta-analyses consistently reported a significant reduction in overall cancer risk, with summary risk reductions of approximately 30-35% for both incidence and mortality. The potential for a modest reduction in the risk of certain cancers is a compelling hypothesis, but definitive conclusions await the results of large-scale, long-term RCTs designed with cancer as a primary endpoint.

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