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Nanang Yunarto
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Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan Kementerian Kesehatan RI Jl. Percetakan Negara No. 23 - Jakarta 10560
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INDONESIA
Jurnal Kefarmasian Indonesia
Published by Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan
ISSN : 2085675X     EISSN : 23548770     DOI : -
Core Subject : Health, Science,
Chemistry Medicine & Pharmacology
Pharmaceutical Technology, Pharmacology, Pharmaceutical Chemistry, Traditional Medicines, and Pharmaceutical Care.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 5 Documents
 1 
Search results for , issue "VOLUME 1, NOMOR 1, 2009" : 5 Documents clear
Analisis Kuantitatif Artemisinin dari Ekstrak Metanol Tanaman Artemisia Annua L. Menggunakan Densitometer Isnawati, Ani; Gitawati, Retno
Jurnal Kefarmasian Indonesia VOLUME 1, NOMOR 1, 2009
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v1i1.2833

Abstract

Artemisinin is the best antimalaria for chloroquine resistant P. falciparum recommended by WHO in a combination therapy. Artemisinin is isolated from Artemisia annua L (family: Asteraceae) that can grow as it should be in Indonesia and has cult1'vated by BPTO Tawangmangu in order to self-provide for raw material antimalarial. One of the important analysis is method for measuring artemisinin concentration in extract. The method should be more rapid, accurate, and suitable with the instruments available. Measuring analysis are used to determine cultivated result and to analyze cost benefit raw material malaria medicine. The method will also be validated for accuracy, precision, selectivity, sensitivity and linearity. It is found that maximum wave length of artemisinin is 366 nm with TLC-densitometiy validated method, shown a good linearity, a coeficient of corelation of 0.99976, a detection limit of 0.028 mg/mL, and a quantitative limit of 0.094 mg/mL. Artemisinin concentration obtained from methanol extract is 0. 221% with a recovery concentration of 1 01,08%.
Kajian Toksikologi dan Penanggulangan Senjata Kimia Raini, Mariana
Jurnal Kefarmasian Indonesia VOLUME 1, NOMOR 1, 2009
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v1i1.2834

Abstract

A chemical weapon is defined as a substance that is intended for use in military and non- military operations to kill, seriously injure or otherwise incapacitate people, or to harm or destroy their habitat or economy. Chemical weapons can be made by toxic chemicals reaction. Chemical weapons misused may lead to terror, injury, death and environmental damage The Chemical Weapons Convention (CWC) is an arms control agreement which outlaws the production, stockpiling and use of chemical weapons. C WC is the Convention on the Prohibition of the Development, Production, Stoclqoiling and Use of Chemical Weapons and on their Destruction. This article describe how to idenlijji chemical weapons, sign and symptom of their toxicity, impact and the chemical weapons convention, in order to handle and control chemical weapons release.
Karakterisasi dan Toksisitas Akut pada Minyak Buah Merah Widowati, Lucie; Pudjiastuti, Pudjiastuti; Mudahar, Harfia
Jurnal Kefarmasian Indonesia VOLUME 1, NOMOR 1, 2009
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v1i1.2835

Abstract

Buah Merah (Pandanus conoideus Lam), is an endemic plant from Papua and its surrounding. Oil of buah merah known and claimed for cancer, HIV/AIDS, lung tuberculosis, diabetic and decreased blood cholesterol treatment. Since buah merah oil widlly is used in communities, safety test is needed. There were no toxic effects as abnormal behavior or mortality in rats, even using in high dose of 5 ml/200g body weight or approximately 9.4 times of human dose (1 x HD = 30 ml). Due to this situation, the acute toxicity has been done by Biomedical and Pharmaceutical Research and Development Center, at 2006. The result showed that qualitative test based on chemical group compounds, triterpenoid, phenol and steroid have been found clearly. Basically the oil is not toxic for single dose. Since there ‘s no mortality, the LD;0 will be considered as pseudo LD50, that means that doses of 5 ml/200g body weight of Wistar rat is safe for utilization, or the safety dose for human will bein a very large range.
Pemanfaatan Pengobat Tradisional oleh Masyarakat Gitawati, Retno
Jurnal Kefarmasian Indonesia VOLUME 1, NOMOR 1, 2009
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v1i1.2836

Abstract

Traditional practitioners Pengobatan Tradisional (Battra) are becoming parts of health care services, and are used to overcome certain health problems in rural areas as well as in urban. However, there is not enough nation wide data of how wide are traditional practices being utilized by the population. Further analysis using the nationwide Riskedas-2007 data is conducted to describe how Battra in Indonesia involved in the population's health care. The analysis is done descriptively, using the cleaned Kesmas (public health) data, ana crosssectional designed with the total sample size of 36.584 respondents. The results showea 1.2% of respondents rely on Battra for inpatient and outpatient services. About 10.1% respondents in West Sulawesi province went to in-patient-serviced (hospitalized) Battra jot their health problems, which is the largest proportion among other Battra utilizations in other provinces. While South Kalimantan is the province with the largest proportion of respondents (4. 7%) went to outpatient services of Battra. Access to the nearest conventional/allopalhic health care services (e.g. public hospital, primary health care, clinics) infuenced the respondent ’s preference for going to Battra The proportion of male respondents who went to Battra is greater than the females, and so the lower educated, and the lower economic status of respondents. More respondents in rural areas went to Battra compared to those in urban.
Karakterisasi Kompleks Inklusi Asam Mefenamat - B-Siklodekstrin yang Dibuat dengan Metode Freeze Drying Setyawan, Dwi; Isadiartuti, Dewi
Jurnal Kefarmasian Indonesia VOLUME 1, NOMOR 1, 2009
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v1i1.2837

Abstract

Characterization of mefenamic acid- ,8-cyclodextrin inclusion complexes by freeze dryin method had been studied. Solid state mefenamic acid - B-cyclodextrin inclusion complex prepared by freeze drying method in 1:1 molar ratio. Mefenamlc acid, B-cyclodextrin, mefenamic acid - B-cyclodextrin physical mixture and inclusion complexes were characterized by Powder X-ray Diffraction (PXRD), Fourier Transform Infrared Spectroscop (FTIR) , Dijferential Thermal Analyzer (DT/1) and dissolution studies. The results showed the formation of inclusion complex between mefenamic acid and B-lcyclodextrin. In vitro dissolution rate studies of mefenamic acid, mefenamic acid - B-lcyclodextrin physical mixture and inclusion complex were conducted using basket method and water as dissolution medium. Mefenamic acid - B-lcyclodextrin inclusion complex showed increasing dissolution rate compared to me?znamic acid - B-cyclodextrin physical mixture and mefenamic acid.

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