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INDONESIA
Jurnal Farmasi Galenika
Published by Universitas Bhakti Kencana
ISSN : 24069299     EISSN : 25794469     DOI : https://doi.org/10.70410/jfg
Core Subject : Health,
Medicine & Pharmacology Public Health
The aim of JFG is to become a media for the publication of articles on Pharmaceutical and related practice-oriented subjects in the pharmaceutical sciences and technology. The scope of the journal is Pharmaceutical sciences, its research and its application. The journal aims to cover the latest outstanding developments in the field of Pharmaceutical science and Technology but not limited to the following branches: Pharmaceutics Pharmaceutical technogy International Regulatory Validation Techniques Industrial Pharmacy Nanotechnology Novel Drug Delivery Systems Quality Control Quality Assurance BioTechnology Bioinformatics Proteomics Biochemistry Pharmacognosy Herbal technology Pharmacology Toxicology Pharmacy Practice Pharmacoinformatics Phytochemistry Pharmaceutical Analysis Chiral Chemistry Synthetic Chemistry Drug Development Clinical Pharmacy Pharmacogenomics Pharmacetical Engineering
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 5 Documents
 1 
Search results for , issue "Vol 10 No 3 (2023): Jurnal Farmasi Galenika Vol 10 No 3" : 5 Documents clear
The Ethanol Extract Fractionation (Peperomia Pellucida (L.) Kunth) On Uric Acid Levels Blood Serum Of Male White Mice Hevira, Linda; Yulion Putra, Rizky; Suciati, Rahma Anggun
JURNAL FARMASI GALENIKA Vol 10 No 3 (2023): Jurnal Farmasi Galenika Vol 10 No 3
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v10i3.278

Abstract

Research has been carried out on the effect of fractionating the ethanol extract of the messenger herbs (Peperomia pellucida (L.) Kunth) to reduce blood serum uric acid levels in male white mice. Ordered herbs containing flavonoid compounds are thought to be used as lowering uric acid levels in the blood. The purpose of this study was to determine the effect of giving the ethanol extract fraction (Peperomia pellucida (L.) Kunth) on blood serum uric acid levels of male white mice. Simplicia extraction was carried out with 96% ethanol and extract fractionation was carried out using n-hexane, ethyl acetate, and water as solvents. The chicken liver inductor was used using experimental methods in vivo. Uric acid levels in mice were measured using a test-strip out. The results of the analysis using statistical tests on the decrease in uric acid levels in the blood were significant with a value (p 0.05) on the 14th day of the ethyl acetate fraction. This study concludes that there are compounds in the messenger herbs that have the potential to reduce uric acid levels in the blood.
Kualitas Hidup Dan Pengetahuan Pasien Dengue Di Rumah Sakit Pku Muhammadiyah Yogyakarta Dewi, Masita Sari; Perwitasari, Dyah Aryani; Supadmi, Woro; Faridah, Imaniar Noor
JURNAL FARMASI GALENIKA Vol 10 No 3 (2023): Jurnal Farmasi Galenika Vol 10 No 3
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v10i3.309

Abstract

Angka kejadian kasus infeksi dengue tahun 2020 di Kota Yogyakarta sebanyak 296 orang. Berdasarkan manifestasi klinis dengue terbagi menjadi 3 diagnosa yaitu dengue fever (DF), dengue haemorrhagic fever (DHF) dan dengue shock syndrome (DSS). Penularan terjadi akibat gigitan nyamuk Aedes aegypti dan mobilitas yang tinggi. Beberapa faktor yang mempengaruhi angka kejadian yaitu kualitas hidup dan pengetahuan terhadapa penyakit yang berdampak pada tingkat kesehatan. Tujuan penelitian untuk mengetahui kualitas hidup dan pengetahuan. Penelitian ini dilakukan secara observasional dengan pengambilan data prosfektif di Rumah Sakit PKU Muhammadiyah Yogyakarta periode April – Desember 2021. Kualitas hidup pasien dinilai menggunakan kuisioner EQ-5D-Y untuk pasien anak dan EQ-5D-5L untuk pasien dewasa dan pengetahuan dinilai menggunakan kuisioner yang terdiri dari pengetahuan penyakit, pengetahuan pencegahan dan prilaku pencegahan. Hasil penelitian di RS PKU Muhammadiyah Yogyakarta pada pasien dengan diagnosa DHF sebanyak 40% merasa amat sangat bermasalah pada kegiataan yang biasa dilakukan dan sebanyak 40% merasa cukup bermasalah pada dimensi rasa cemas, sedih dan depresi sehingga berpengaruh pada kulitas hidup. Pada pengetahuan penyakit, pengetahuan pencegahan dan perilaku pencegahan pasien DF dan DHF tergolong dalam kategori buruk sehingga perlu adanya promosi kesehatan untuk meningkatkan pengetahuan terhadap kesehatan. Penyakit demam dengue berpengaruh pada kulitas hidup. pengetahuan terhadap penyakit demam dengue dalam kategori buruk.
Karakterisasi Pembentukan Ko-kristal Tenoksikam-Asam Malat dan Evaluasi Kompresibilitas dan Tabletabilitasnya Alatas, Fikri; Syahidatul Alamiah, Dzaza; Purnamasari, Nira
JURNAL FARMASI GALENIKA Vol 10 No 3 (2023): Jurnal Farmasi Galenika Vol 10 No 3
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v10i3.320

Abstract

Tenoxicam is a non-steroidal anti-inflammatory drug which has poor compressibility and compactibility. One way to change the compressibility and compactibility of a material is to use co-crystallization techniques The aim of this research is to characterize the formation of co-crystal between tenoxicam and malic acid and evaluate their compressibility and tabletability. Tenoxicam-malic acid co-crystal were prepared using the ultrasound-assisted solution co-crystallisation (USSC) method with the addition of ethanol solvent at the same molar ratio. The USSC result was characterized by polarization microscopy, powder X-ray diffraction, and thermal analysis methods. Evaluation of compressibility and tabletability (tensile strength and elactic recovery) was carried out on tenoxicam-malic acid co-crystal and intact tenoxicam. Characterization of the USSC result indicated the formation of tenoxicam-malic acid co-crystal, which were characterized by crystal habit, powder X-ray diffraction patterns, and DSC thermograms that were specific and different from intact tenoxicam and malic acid. Compressibility evaluation results show that the tenoxicam-malic acid co-crystal is in the good flow properties category, while the intact tenoxicam is in the poor flow properties category. The tensile strength of tenoxicam-malic acid co-crystal is higher than that of intact tenoxicam at the same compression strength (40 kg/cm2). Tenoxicam-malic acid co-crystal showed lower elastic recovery compared to intact tenoxicam. These results can be concluded that tenoxicam-malic acid co-crystals have been successfully prepared using the USSC method and have better compressibility and tabletability than intact tenoxicam.
Review Artikel : Evaluasi Hasil Pembentukan Senyawa Kompleks Inklusi Siklodekstrin Untuk Meningkatkan Kelarutan Di Dalam Air Rismawanti, Rusi; Jafar, Garnadi; Herni Kusriani, R.
JURNAL FARMASI GALENIKA Vol 10 No 3 (2023): Jurnal Farmasi Galenika Vol 10 No 3
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v10i3.321

Abstract

Cyclodextrin is one of the compounds that can increase the solubility of a compound in water by forming inclusion complexes. Almost 70% of new drug candidates discovered recently are compounds that have poor solubility in water, so many researchers are conducting research using cyclodextrin as one of the developments in improving compounds in new drug discovery. However, the results of this complex formation must still be reviewed by researchers, whether the inclusion complex formed has succeeded in changing a compound into water soluble, and stable during its application. This article review summarizes the explanation of the evaluation of the results of the formation of cyclodextrin inclusion complexes with several water-insoluble compounds by searching scientific journals that have been published nationally and internationally in the last 10 (ten) years from 2013-2023 through the google scholar database, Pubchem, and Science Direct. Evaluation of the results of cyclodextrin inclusion complex formation can be done by several methods both computationally and laboratory testing.
Studi Penambatan Molekul Senyawa Turunan Kurkuminoid Terhadap Enzim Penicillin Binding Protein 2A Pada Bakteri MRSA Mulki Irpani, Abdul; Indra Dinata, Deden
JURNAL FARMASI GALENIKA Vol 10 No 3 (2023): Jurnal Farmasi Galenika Vol 10 No 3
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v10i3.322

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) is a bacterium that is resistant to ?-lactam antibiotics such as methicillins, a clinical problem that continues to affect the entire world. Resistance occurs as a result of the structural modification of Penicillin Binding Protein Penicilin Binding (PBP) MRSA. An organic active compound with antibacterial properties has sparked public interest, one of which is curcumin, which is known to have powerful antibacteric potential and can damage bacterial membranes. The aim of this study is to identify a compound of curcuminoid derivatives that could potentially be an antibacterial drug candidate for MRSA with in silico studies using molecular docking methods. The results obtained curcumin compounds have a free-binding energy of -5,56 kcal/mol, de-methoxy curcumine -6,25 kcal /mol and bis-demethoxy curcumin -6,24 kkal /mol. The interactions formed indicate the affinity of binding, from the data obtained all ligans possess good affinities even though the value of free-binding energy is lower than natural ligans.

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