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All Journal Majalah Obat Tradisional Jurnal Kartika Kimia Jurnal Aisyah : Jurnal Ilmu Kesehatan Kartika : Jurnal Ilmiah Farmasi Jurnal Farmasi Galenika
Nira Purnamasari, Nira
Universitas Jenderal Achmad Yani
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

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 1 
EVALUASI PENGGUNAAN OBAT PENYAKIT DEGENERATIF DI POLIKLINIK SPESIALIS RAWAT JALAN RUMAH SAKIT UMUM PUSAT Dr. HASAN SADIKIN BANDUNG Pudjiastuti Kartidjo; Ririn Puspadewi; Titta Sutarna; Nira Purnamasari
Kartika : Jurnal Ilmiah Farmasi Vol 2 No 1 (2014)
Publisher : Fakultas Farmasi Universitas Jenderal Achmad Yani, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/kjif.v2i1.10

Abstract

Telah dilakukan penelitian evaluasi penggunaan obat penyakit degeneratif di Poliklinik Spesialis Rawat Jalan Rumah Sakit Umum Pusat Dr. Hasan Sadikin Bandung, dengan tujuan untuk mengetahui kerasionalan penggunaan obat yang diresepkan dan digunakan untuk kasus penyakit degeneratif yaitu penyakit Diabetes Mellitus Tipe 2. Metode penelitian meliputi penelusuran pustaka, penetapan kriteria pasien dan kriteria obat, penyusunan kriteria penggunaan obat untuk penyakit Diabetes Mellitus Tipe 2, pengumpulan data, serta analisis data secara kuantitatif dan kualitatif. Data diambil secara retrospektif dari data Instalasi Farmasi  dan  data rekaman medik selama periode 14 Januari sampai dengan 31 Mei 2013. Analisa kuantitatif dilakukan untuk mengetahui pola penggunaan obat oleh pasien berdasarkan usia, jenis kelamin, pendidikan, pekerjaan, agama, diagnosis, golongan obat, dan bentuk sediaan. Analisa kualitatif dilakukan untuk mengetahui ketepatan indikasi, dosis, aturan pakai, lama pengobatan; kejadian duplikasi, efek samping obat dan interaksi obat. Hasil penelitian menunjukkan bahwa semua obat Anti Diabetes Mellitus yang digunakan tepat indikasi, terdapat 1 kasus yang kurang dosis, dan terdapat 4  aturan pakai yang kurang tepat. Lama pengobatan telah tepat, dan tidak ditemukan kejadian duplikasi pada pemberian obat. Terdapat 33 kejadian interaksi obat yang digolongkan berdasar intensitas interaksi yaitu terdiri dari  3 kejadian interaksi obat serius, 17 signifikan dan 13  minor. Berdasarkan hasil penelitian dapat disimpulkan bahwa perlu selalu dilakukan pengkajian resep lebih mendalam, terutama pada aturan pakai obat dan interaksi obat yang terjadi pada kasus Diabetes Mellitus Tipe 2 dengan komplikasi dan penyakit penyerta.
Formulasi Dan Evaluasi Transdermal Patch Kalium Diklofenak Nira Purnamasari; Fikri Alatas; Dolih Gozali
Kartika : Jurnal Ilmiah Farmasi Vol 7 No 1 (2019)
Publisher : Fakultas Farmasi Universitas Jenderal Achmad Yani, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/kjif.v7i1.209

Abstract

Abstrak Kalium diklofenak adalah salah satu obat golongan anti-inflamasi non steroid (AINS) yang memberikan efek samping iritasi pada saluran pencernaan. Tujuan penelitian ini adalah melakukan formulasi dan evaluasi sediaan dengan rute alternatif lain penggunaan kalium diklofenak melalui transdermal patch. Patch dibuat dengan metode penguapan pelarut. Polivinil pirolidon (PVP) digunakan sebagai polimer untuk pembentukan patch transdermal kalium diklofenak dengan dibutil ftalat (DBP) sebagai plasticizer dan mentol sebagai peningkat penetrasi. Uji in vitro dilakukan dengan alat difusi modifikasi Franz dan ditentukan dengan spektroskopi UV-sinar tampak. Kadar zat aktif, berat, ketebalan dan organoleptis dari patch juga ditentukan. Hasil penelitian menunjukan bahwa rata-rata uji laju difusi sediaan patch 1,3884 mg/cm2 dengan persen permeasi sebesar 8,9 % selama 180 menit.           Kata Kunci : Transdermal; Patch; kalium diklofenak; mentol. Formulation and Evaluation Patch Transdermal Diclofenac Potassium Abstract Diclofenac potassium is one of the non-steroidal anti-inflammatory drugs (NSAIDs) that provides irritating side effects to the digestive tract. The purpose of this study is to formulate and evaluate preparations with alternative routes of using potassium diclofenac through the transdermal patch. Preparation of the matrix patches used the solvent casting method. Polyvinyl pyrrolidone (PVP) was used as a matrix for the formation of transdermal diclofenac potassium patches, dibutyl phthalate (DBP) as the plasticizer and menthol as the permeation enhancer. The in vitro assay was carried out in a modified Franz diffusion cell and the rates of diffusion were determined by UV spectroscopy. The average drug content, thickness, organoleptic, weight uniformity of the matrix patches was also determined. The results showed that the average dosage rate of diffusion test Patch is 1,3884 mg/cm2 with permeation percentage 8,9 % for 180 minutes.  Keywords: Transdermal; Patch; diclofenac potassium; menthol
Utilization rhizome of jahe merah (Zingiber officinale Roscoe) as a bioreductant in the manufacture of gold nanoparticles with addition of polyvinylpyrrolidone 90 (PVP K90) as a stabilizer Titta Hartyana Sutarna; Fikri Alatas; Nira Purnamasari; Mutia Alifah Rachmah
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 8, No 3: September 2023
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30604/jika.v8i3.1964

Abstract

Thel making of gold nanoparticlels (AuNPs) by thel biosyntheltic melthod using plants as biorelductors is onel of thel nanoparticlel synthelsis melthods that is beling carrield out belcausel it is elnvironmelntally frielndly and non-toxic to thel body. Elxtract rhizomel of Reld Gingelr ( Zingibelr officinalel Roscoel ) contains selcondary meltabolitels that function as antioxidants that can bel useld as biorelductor in thel making of gold nanoparticlels. Thel relselarch belgan with thel elxamination of IC50, thel manufacturel of gold nanoparticlels and thel addition of PVP K90 stabilizelr. Thel formation of gold nanoparticlels was madel in selvelral concelntrations, namelly 600 g/mL, 900 g/mL and 1200 g/mL. Theln thel relsults of thel synthelsis of gold nanoparticlels welrel charactelrizeld by visual obselrvation solution color, UV-Vis spelctrophotomeltry, particlel sizel analyzelr and polarization microscopel. Thel relsults obtaineld arel all variations in concelntration can form gold nanoparticlels, but 600 g/mL was choseln belcausel it has thel smallelst particlel sizel compareld to othelr concelntrations. Howelvelr, belcausel gold nanoparticlels elasily and quickly aggrelgatel to form largelr particlel sizels, in this study a stabilizelr in thel form of Polyvinylpyrrolidonel 90 (PVP K90) was addeld. PVP K90 was useld with various concelntrations of 0.5%, 1%, 2% and 5%. Gold nanoparticlels that havel beleln addeld to PVP K90 arel charactelrizeld by visual obselrvation thel color changel of thel solution, thel maximum wavellelngth with spelctrophotomeltry UV-Vis and particlel sizel distribution with a particlel sizel analyzelr, thel relsults obtaineld arel thel addition of 1% concelntration of PVP K90 melt all standards as a stabilizelr of gold nanoparticlels with elxtract rhizomel of reld gingelr.
Karakteristik Fisik dan Laju Difusi In Vitro Sediaan Transdermal Patch Domperidon Menggunakan Polimer Turunan Metil Metakrilat-Asam Metakrilat Purnamasari, Nira; Sutarna, Titta Hartyana; Angraeni, Wulan; Karin, Amada; Qotrunnada, Daffa; Alatas, Fikri
Jurnal Kartika Kimia Vol 6 No 2 (2023): Jurnal Kartika Kimia
Publisher : Department of Chemistry, Faculty of Sciences and Informatics, University of Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/jkk.v6i2.235

Abstract

Sediaan patch transdermal merupakan pilihan yang tepat untuk menghindari proses metabolisme lintas pertama pada zat aktif domperidon. Tujuan penelitian ini adalah untuk mengetahui karakteristik fisik dan laju difusi in vitro sediaan transdermal patchdomperidon yang dibuat dengan menggunakan dua matriks polimer turunan metil metakrilat-asam metakrilat, yaitu Eudragit E100 dan Eudragit L 100-55. Sediaan patch transdermal domperidon dipreparasi dengan metode penguapan pelarut menggunakan variasi konsentrasi Eudragit E100 dan Eudragit L100-55 5-20%. Evaluasi karakteristik fisik patch meliputi organoleptis, ketebalan, kandungan lembab, keseragaman bobot, dan ketahanan lipat, dan uji kekuatan mekanik. Uji difusi in vitro dilakukan menggunakan metode flow-through menggunakan sel difusi Franz yang dimodifikasi. Transdermal patch dengan polimer Eudragit E100 menunjukkan homogenitas baik tanpa adanya kristalisasi domperidon diperoleh pada konsentrasi 10% (F2) dan 20% (F3), sementara transdermal patch dengan polimer Eudragit L100-55 menunjukkan homogenitas baik hanya di konsentrasi 20% (F6). Ketahanan lipat dan kandungan lembab seluruh formula menunjukkan hasil yang memenuhi persyaratan ketahanan lipat dan kandungan lembab yang baik. Persentase elongasi dan tensile strength transdermal patch dengan polimer Eudragit E100 cenderung meningkat dengan kenaikan konsentrasi polimer, sementara transdermal patch dengan polimer Eudragit L100-55 menunjukkan penurunan persentase elongasi dan kenaikan tensile strength dengan meningkatnya konsentrasi polimer. Penurunan Laju difusi in vitro transdermal patchterjadi ketika konsentrasi polimer ditingkatkan, baik pada transdermal patch yang menggunakan Eudragit E100 maupun Eudragit L100-55.
Formulation and Physical Evaluation of Sleeping Mask Gel Preparation of Mahogany Leaf Extract (Swietenia Mahagoni (L.) Jacq) As Antioxidant Ratih, Hestiary; Sutarna, Titta Hartyana; Febrianti, Mia; Alatas, Fikri; Purnamasari, Nira
Jurnal Kartika Kimia Vol 7 No 1 (2024): Jurnal Kartika Kimia
Publisher : Department of Chemistry, Faculty of Sciences and Informatics, University of Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/jkk.v7i1.265

Abstract

Antioxidants are used to neutralize free radicals. Mahogany leaves (Swietenia mahagoni (L.) Jacq) contain flavonoid chemicals that exhibit antioxidant properties. The purpose of the study was to determine the physical characteristics and antioxidant activity of sleeping mask gel preparations with the addition of mahogany leaf extract. Mahogany leaf extract is made using the maceration process. Determination of antioxidant activity using the DPPH method. The formulation is made by varying the concentration of mahogany leaf extract into 4 formulas, F0 (bases, F1 (0.0195%, IC50), F2 (0.0975%, 5xIC50) and F3 (0.195%, 10xIC50). There were several tests used to evaluate formulas, including homogeneity, dispersion, viscosity, pH, and organoleptic (odor, color, and shape) testing. IC50 value of mahogany leaf extract was 19.48 μg / mL. Mahogany leaf extract antioxidant gel sleeping mask preparations F0, F1, F2 and F3 was evaluated such as organoleptic testing requirements, homogeneity and pH produced between 6.15-6.65 including the skin's normal pH range of 4.0-7.0 during 28-day storage. F2 exhibits the best antioxidant stability, with an inhibition value of 54.59%.
Karakterisasi Pembentukan Ko-kristal Tenoksikam-Asam Malat dan Evaluasi Kompresibilitas dan Tabletabilitasnya Fikri Alatas; Dzaza Syahidatul Alamiah; Nira Purnamasari
JURNAL FARMASI GALENIKA Vol 10 No 3 (2023): Jurnal Farmasi Galenika Vol 10 No 3
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v10i3.320

Abstract

Tenoxicam is a non-steroidal anti-inflammatory drug which has poor compressibility and compactibility. One way to change the compressibility and compactibility of a material is to use co-crystallization techniques The aim of this research is to characterize the formation of co-crystal between tenoxicam and malic acid and evaluate their compressibility and tabletability. Tenoxicam-malic acid co-crystal were prepared using the ultrasound-assisted solution co-crystallisation (USSC) method with the addition of ethanol solvent at the same molar ratio. The USSC result was characterized by polarization microscopy, powder X-ray diffraction, and thermal analysis methods. Evaluation of compressibility and tabletability (tensile strength and elactic recovery) was carried out on tenoxicam-malic acid co-crystal and intact tenoxicam. Characterization of the USSC result indicated the formation of tenoxicam-malic acid co-crystal, which were characterized by crystal habit, powder X-ray diffraction patterns, and DSC thermograms that were specific and different from intact tenoxicam and malic acid. Compressibility evaluation results show that the tenoxicam-malic acid co-crystal is in the good flow properties category, while the intact tenoxicam is in the poor flow properties category. The tensile strength of tenoxicam-malic acid co-crystal is higher than that of intact tenoxicam at the same compression strength (40 kg/cm2). Tenoxicam-malic acid co-crystal showed lower elastic recovery compared to intact tenoxicam. These results can be concluded that tenoxicam-malic acid co-crystals have been successfully prepared using the USSC method and have better compressibility and tabletability than intact tenoxicam.
Formulation and Physical Evaluation of Orthosiphon aristatus Leaf Extract Granule Preparation as Herbal Beverage Candidate Al-Hakim, Nur Achsan; Nur Fauziyyah, Salma Alifia; Purnamasari, Nira; Faramayuda, Fahrauk
Majalah Obat Tradisional Vol 29, No 3 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.91009

Abstract

Developing Orthosiphon aristatus (Blume) Miq. leaf extract of purple varieties into granule dosage forms is expected to facilitate consumption, storage, and can extend the shelf life of the product. This study aims to develop the formulation and evaluation of granule preparations of O. aristatus leaf extract of purple varieties, with a comparison of lactose and maltodextrin fillers to produce the best formula. The granule dosage forms were prepared using wet granulation method. Furthermore, the variation of granule preparation formula consists of F1 (extract with lactose), F2 (extract with maltodextrin), F3 (extract with a combination of lactose and maltodextrin 1:1), F4 (freeze dried extract with lactose), F5 (freeze dried extract with maltodextrin), and F6 (freeze dried extract with a combination of lactose and maltodextrin 1:1). The physical evaluation of granules comprised moisture content testing, flowability, compressibility index, particle size distribution, and granule dissolving time. Results from the physical evaluation of granules over 28 days of storage indicated that all six formulas met the criteria for good granules, with F3 emerging as the optimal formula due to its superior physical stability and visually appealing appearance upon dissolution. To conclude, this study demonstrates that O. aristatus leaf extract can be effectively formulated into instant granule preparations suitable for herbal beverage or alternative medicine. Moreover, by modifying the filler material, the physical stability of the granule preparation can be maintained.
Co-Authors Angraeni, Wulan Dolih Gozali Dzaza Syahidatul Alamiah Fahrauk Faramayuda, Fahrauk Febrianti, Mia Fikri Alatas Hartyana Sutarna, Titta Hestiary Ratih Karin, Amada Mutia Alifah Rachmah Nur Achsan Al-Hakim Nur Fauziyyah, Salma Alifia Pudjiastuti Kartidjo Pudjiastuti Kartidjo, Pudjiastuti Qotrunnada, Daffa Ririn Puspadewi, Ririn Titta Sutarna Titta Sutarna, Titta