cover
Contact Name
mahardika
Contact Email
p3i@umsida.ac.id
Phone
6282143483630
Journal Mail Official
perpus@umsida.ac.id
Editorial Address
jl. Mojopahit No. 666B Sidoarjo, Jawa Timur
Location
Kab. sidoarjo,
Jawa timur
INDONESIA
Indonesian Journal Health Science and Medicine
ISSN : -     EISSN : 30638186     DOI : https://doi.org/10.21070/ijhsm
Core Subject : Health,
Focus: The Indonesian Journal on Health Science and Medicine (IJHSM) focus to advance the field of health science and medicine by publishing high-quality, peer-reviewed research articles, reviews, and case studies. Our journal serves as a platform for researchers, clinicians, and healthcare professionals to share innovative findings, critical insights, and emerging trends in the broad domain of health science and medicine. Scope: Clinical Research and Practice Studies on the diagnosis, treatment, and prevention of diseases. Clinical trials and evidence-based practices. Advances in medical technology and therapeutics. Public Health Epidemiology and health statistics. Health policy and management. Community health initiatives and health education. Biomedical Science Research on cellular and molecular biology. Genetics and genomics. Pharmacology and toxicology. Health Care Systems and Services Health care delivery and management. Quality improvement in health care services. Health economics and health informatics. Global Health Health issues affecting populations worldwide. International health regulations and practices. Global health governance and diplomacy. Health Promotion and Disease Prevention Lifestyle and behavioral interventions. Preventive medicine and early detection. Nutritional science and physical activity. Mental Health Research on mental health disorders and treatments. Psychological well-being and mental health promotion. Integration of mental health services in primary care. Innovations in Health Education and Training Medical and health science education methodologies. Training programs for health professionals. Continuing education and professional development.
Articles 311 Documents
Association of Age with Metabolic Biomarkers and Insulin Resistance in Patients with Type 2 Diabetes in Basrah, Iraq Mohammed Adil Abdulhassan; Shurok Namah khudair; Khairallah A.S Mohammed; Abdulaziz Qadori Abdulsada
Indonesian Journal on Health Science and Medicine Vol. 3 No. 1 (2026): July
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

General Background: Type 2 diabetes mellitus (T2DM) is an age-related metabolic disorder characterized by progressive metabolic deterioration. Specific Background: Orexin-A and cathepsin-D have been implicated in hypothalamic regulation and cellular quality control, yet their age-related alterations in T2DM remain insufficiently characterized. Knowledge Gap: The interplay between aging, hypothalamic dysfunction, and cellular stress markers in relation to insulin resistance has not been comprehensively explored. Aims: This study investigated age-associated changes in orexin-A and cathepsin-D and their correlations with insulin resistance in T2DM patients. Results: A cross-sectional analysis of 110 T2DM patients and 70 controls revealed a significant age-related decline in orexin-A levels (69% reduction, p=0.001) and an increase in cathepsin-D levels (p=0.005). Orexin-A showed a negative correlation with insulin resistance (r = -0.26, p = 0.005), whereas age and cathepsin-D were positively correlated with HOMA-IR. Traditional metabolic markers, including HbA1c, triglycerides, and LDL, worsened with age. Regression analysis identified age, BMI, and cathepsin-D as positive predictors, while orexin-A was a negative predictor of insulin resistance. Novelty: This study identifies a previously unreported relationship between declining orexin-A and increasing cathepsin-D levels as age progresses in T2DM. Implications: These findings highlight the relevance of age-specific metabolic pathways and suggest the need for tailored therapeutic approaches in older diabetic populations. Highlights:• Progressive reduction of orexin-A observed across advancing age groups• Increasing cathepsin-D levels linked to worsening metabolic profiles• Age and biomarker patterns associated with higher insulin resistance Keywords: Type 2 Diabetes Mellitus, Aging, Orexin-A, Cathepsin-D, Insulin Resistance