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Contact Name
mahardika
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+62 878-5969-8383
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Jl. Mojopahit No.666B, Sidoarjo, Jawa Timur
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INDONESIA
House of Wisdom: Journal on Library and Information Sciences
ISSN : -     EISSN : 30896002     DOI : https://doi.org/10.21070/how
Core Subject : Social,
House of Wisdom Journal on Library and Information Sciences seeks to publish high quality, peer-reviewed articles that contribute to the understanding and development of library and information sciences, while also addressing the United Nations Sustainable Development Goals SDGs. The journal welcomes submissions on a wide range of topics, including but not limited to Information Management studies on the organization, storage, retrieval, and dissemination of information, with an emphasis on ensuring inclusive and equitable access to information for all SDG 10 Reduced Inequalities. Library Technology innovations in library systems, digital libraries, and the impact of technology on library services, particularly in promoting sustainable development and reducing inequalities SDG 9 Industry, Innovation, and Infrastructure. Information Literacy research on programs and strategies to improve information literacy among various user groups, supporting quality education and lifelong learning opportunities SDG 4 Quality Education. Library Administration and Management best practices, case studies, and research on effective library management and administration that contribute to sustainable community development SDG 11 Sustainable Cities and Communities. Preservation and Conservation articles on the preservation of digital and physical collections, ensuring cultural heritage and knowledge are maintained for future generations SDG 11 Sustainable Cities and Communities. User Behavior and Information Seeking insights into user behavior, information needs, and the effectiveness of library services in meeting these needs, fostering inclusive societies SDG 10 Reduced Inequalities. Collection Development strategies and policies for developing library collections that meet the needs of diverse user communities, supporting diverse and inclusive knowledge bases SDG 4 Quality Education, SDG 10 Reduced Inequalities. Scholarly Communication studies on the changing landscape of scholarly publishing and its implications for libraries, promoting inclusive and transparent communication of research findings SDG 16 Peace, Justice, and Strong Institutions. Library Services innovations and improvements in services provided by libraries to various user groups, contributing to community well-being and lifelong learning SDG 4 Quality Education, SDG 11 Sustainable Cities and Communities. - Bibliometrics Analysis and Systematic Literature Reviews comprehensive reviews and quantitative analysis of academic literature in the field, providing insights into research trends and impact SDG 17 Partnerships for the Goals.
Articles 42 Documents
Nano-Structured Lipid Carriers (NLCs) as a Novel Nanotechnological Strategy for Improving the Oral Drug Bioavailability Thamer, Saad M.; Allami , Mohammed S.
House of Wisdom: Journal on Library and Information Sciences Vol. 2 No. 4: Desember
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/how.v2i4.269

Abstract

General Background Nanotechnology has transformed pharmaceutical science by enabling nanoscale delivery systems that overcome major limitations in conventional oral drug administration, including poor solubility, instability, and extensive first-pass metabolism. Specific Background Among lipid-based nanocarriers, nanostructured lipid carriers (NLCs) have emerged as a second-generation advancement over solid lipid nanoparticles due to their mixed solid–liquid lipid matrix. Knowledge Gap Despite extensive research, the mechanisms by which NLCs enhance oral bioavailability and their comparative advantages across formulation techniques remain insufficiently synthesized. Aims This work consolidates current evidence on the structure, preparation, stability, and functional performance of NLCs as oral drug delivery systems. Results The review indicates that the imperfect or amorphous NLC matrix increases drug loading, modulates release kinetics, improves physicochemical stability, reduces required surfactant concentrations, and promotes lymphatic uptake while attenuating P-glycoprotein efflux. Novelty By integrating mechanistic, formulation, and biopharmaceutical insights, this synthesis highlights the multidimensional superiority of NLCs in enhancing the oral absorption of poorly soluble and labile drugs. Implications NLCs represent a promising platform for next-generation oral therapeutics, with potential to improve clinical efficacy, reduce dosing frequency, and expand the applicability of challenging drug molecules despite remaining manufacturing and regulatory hurdles.Highlight : NLCs provide higher drug loading and reduce crystallization-related leakage. Their small particle size and lipid composition enhance oral absorption and lymphatic uptake. Scalable manufacturing methods support consistent, controlled drug release. Keywords : Nanotechnology, Oral Drug Delivery, Lipid-Based Nanocarriers, Nanostructured Lipid Carriers, Bioavailability
A Review on Manufacturing and Characterization Oro-Dispersible Tablet Ali, Hiba Muhammed Suza; Al-Khedairy, Eman Bekir
House of Wisdom: Journal on Library and Information Sciences Vol. 2 No. 4: Desember
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/how.v2i4.270

Abstract

General Background: Oro-dispersible tablets have emerged as an important advancement in oral solid dosage forms due to their ability to rapidly disintegrate in the oral cavity without water. Specific Background: Their development is driven by patient demand for convenient medication, especially for pediatric, geriatric, and dysphagic populations who experience difficulty swallowing conventional tablets. Knowledge Gap: Despite wide application, comprehensive evaluation of fabrication methods, excipient functions, and characterization parameters across traditional and modern manufacturing technologies remains limited. Aims: This review analyzes the terminology, advantages, limitations, commonly used excipients, manufacturing techniques, and critical quality assessments of ODTs. Results: The study highlights diverse preparation approaches including lyophilization, sublimation, wet granulation, direct compression, mass extrusion, and emerging three-dimensional printing, each offering unique benefits related to disintegration behavior, mechanical strength, and processing efficiency. Novelty: The article synthesizes conventional pharmaceutics knowledge with recent technological innovations such as selective laser sintering and fused deposition modeling, demonstrating how modern techniques enhance precision and personalization of dosage forms. Implications: Findings underscore that optimized excipient selection and manufacturing strategies are fundamental to ensuring rapid disintegration, mechanical stability, acceptable taste, and enhanced bioavailability, reinforcing ODTs as a growing platform for patient-centered drug delivery.Highlight : Oro-dispersible tablets dissolve rapidly on the tongue, improving convenience for patients with swallowing difficulties. Formulation uses specific excipients—especially superdisintegrants—to achieve fast disintegration and effective performance. Can be produced using various traditional and modern manufacturing methods such as direct compression, sublimation, and 3D printing. Keywords : Disintegration, Oral solid dosage form, Oro-dispersible tablet, Patients’ compliance, Manufacturing techniques