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Journal of Medicine and Health
Published by Universitas Kristen Maranatha
ISSN : -     EISSN : 24425257     DOI : 10.28932/jmh
Core Subject : Health,
Medicine & Pharmacology Public Health
Journal of Medicine and Health (JMH) focuses on contributing towards science and research development that can be accessed by researchers and academic practitioners. Journal of Medicine and Health (JMH) is an open access journal, published biannually on every February and August. JMH receives original research articles, case report, and review articles related to biomedical sciences, clinical medicine, public health sciences, nutritional sciences, and medical herbs sciences. Articles should be written in good English or Indonesian language. All articles will be processed through peer review process.
Arjuna Subject : Kedokteran - Patologi dan Kedokteran Kesehatan
Articles 238 Documents
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Potential Effects of Alkaloid vindolicine Substances in Tapak Dara Leafs (Catharanthus roseus (L.) G. Don) in Reducing Blood Glucose Levels Agung B S Satyarsa
Journal of Medicine and Health Vol 2 No 4 (2019)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28932/jmh.v2i4.1057

Abstract

Diabetes mellitus is a degenerative disease that commonly found and related to an unhealthy lifestyle and genetic factors. Current management of diabetes mellitus includes control of blood sugar levels and prevention of complications. Recent studies found that many phytochemicals have the potential to control blood sugar levels in patients with diabetes. Alkaloid substances from leaves of Tapak Dara have an effect on decreasing blood glucose. This review article aims to describe the potential effects of the Alkaloid vindolicine from Tapak Dara leaves (Catharanthus Roseus L.) in reducing blood glucose levels in patients with type 2 diabetes mellitus. The activity of vindolicine alkaloid against ? cells in previous studies has shown to improve ? cells activity and induce insulin secretion thus preventing further hyperglycemia. In addition, the vindolicine alkaloid also has a role in activating pancreatic ?-TC6 cells and carrying out an immediate reaction in blood vessels. As conclusion, further research is needed to prove the maximum effect of the utilization of tread leaf extract as well as the toxicity test to determine the toxic effects of the alkaloid substances in the tread leaf. Keywords: Type 2 Diabetes Mellitus, Vindolicine Alkaloid, Tapak Dara, blood glucoselevels
Potensi Kombinasi Mikrosfer Fukoidan dan MiRNA-200b sebagai Terapi pada Kanker Payudara Kemoresisten Sinta Wiranata; Made VW Yani; Agung Bagus S Satyarsa; I Ketut R Ardiana; Putu AT Adiputra
Journal of Medicine and Health Vol 2 No 5 (2020)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28932/jmh.v2i5.1102

Abstract

Breast cancer still become a major health problem in Indonesia and worldwide until today. Based on WHO 2012, breast cancer incidence is reported as 1.67 million cases with 90% of mortality rate in the metastasis stage. Chemoresistant is one cause of this increased mortality and morbidity. Nowadays, there are many treatment choices for cancer, but 90% incident of chemoresistant breast cancer occur even with prior chemotherapy. This review aimed to describe the potential of microsphere combinations fucoidan and miRNA-200b as a treatment for chemoresistant in breast cancer. Literature review were derived from scientific journals using www.pubmed.com and scholar.google.com database with “chemoresistant breast cancer, Fucoidan, microRNA-200b” as keyword. Fucoidan can induce apoptosis through the extrinsic pathway involving apoptotic receptor, or intrinsic pathway involving changes in mitochondrial membrane potential (MMP) to release cytochrome C and activating the apoptotic signal. Meanwhile, miRNA-200b expression, will decrease Sp1 expression and decrease histone-3 acetylation level in a miRNA-200b promoter, resulting in decreased cancer cell migration and invasion. However, no studies have evaluated this combination clinically. So, further studies are needed to confirm the potential of microsphere combination fucoidan and miRNA-200b in chemoresistant breast cancer. Keywords: chemoresistant breast cancer; Fucoidan; miRNA-200b.
Prevalence of Delirium and Its Clinical Outcome in Adult Filipino Patients Admitted in The Intensive Care Unit Abram P Tanuatmadja; Jacqueline R Vea
Journal of Medicine and Health Vol 2 No 4 (2019)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28932/jmh.v2i4.1106

Abstract

Delirium is common in the ICU setting and is associated with increased morbidity, manpower requirement, and costs. This study aims to investigate the prevalence of delirium and its outcome in terms of 14-days mortality and length of ICU stay in ICU patients. The study was done at a 150-bed tertiary teaching hospital, located in Quezon City, Metro Manila, February to September 2016. This is a prospective studyinvolving 136 adults. Screening for delirium was done within 24 hours of ICU admission using both CAM-ICU scoring method and DSM-IV-TR criteria for delirium. Delirium prevalence was found to be 5.15%. The average age was higher in the subjects positive for delirium (70.14 + 21.15 years versus 60.43 + 16.10 years, p=0.1286). At the time of ICU admission, 11.54% of sedated patients were positive for delirium compared to 3.64% of non-sedated patients, p=0.1513 ;OR 3.457. Delirium was associated with higher 14 days mortality (OR 16.8, p=0.0212). Subjects positive for delirium had 2.74 longer days average ICU stay compared to the other group, with p=0.026. We concluded delirium was associated with higher 14-days mortality and longer ICU stay. Keywords : delirium, prevalence, Intensive Care Unit
Gambaran Penderita Diabetes Mellitus tipe 2 dengan Obat Antidiabetik Oral Grace Y Irene; Kuswinarti Kuswinarti; Maya Kusumawati
Journal of Medicine and Health Vol 2 No 5 (2020)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28932/jmh.v2i5.1110

Abstract

Uncontrolled hyperglycemia in people with diabetes mellitus can increase the risk of diabetes complications and comorbidities. This study aimed to determine the demographic, clinical, history, complications, and comorbid characteristics of diabetes. The study was conducted with a descriptive method and cross-sectional research design. Data were collected retrospectively using medical record data and using the Finite Population Correction formula with a sample of 115. The results showed the majority of patients were female (67.8%), aged ? 65 years (40.0%), residing in urban (87.6%), high school graduates (35.2%), and unemployed (63.6%). Patients generally have a normal BMI (45.9%) and have several variables that reach the target, namely fasting blood glucose (50.4%), triglycerides (55.3%), and creatinine (69.6%). Patients also had several variables that did not reach the target, namely postprandial 2 hour blood glucose (51.3%), blood pressure (65.8%), total cholesterol (55.6%), HDL cholesterol (54.5%), LDL cholesterol (80.0%), and urea (56.0%). Patients who use oral anti-diabetes generally have used it <5 years (76.3%) and used monotherapy (63.5%). Neuropathy (42.6%) and hypertension (85.9%) were the most common complications and comorbidities of diabetes in this study. Strict glycemic control is an important management for people with diabetes mellitus. Keywords: oral antidiabetic drugs; diabetes mellitus; comorbid
Mozart’s Sonata for Two Pianos K448 in D-Major 2nd Movement Improves Short-Term Memory and Concentration Yenni Limyati; Roro Wahyudianingsih; Revy D Maharani; Maria T Christabella
Journal of Medicine and Health Vol 2 No 4 (2019)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28932/jmh.v2i4.1127

Abstract

Rhythm, melody, and high frequencies in Mozart’s music are capable to stimulate creativity and motivation regions of the brain and activate brain’s areas, especially the prefrontal area of the brain, which contributes to short-term memory. Listening to Mozart ‘s music can enhance concentration because it stimulates alpha brain waves which induce relaxation and peaceful mood. The objectives of this study were to determine the Mozart’s effect towards short-term memory and concentration. This is a quasi-experimental study using pre- and post-test design, performed to 30 adult women aged between 19-24 years old. The measured data were memorized words from recall memory test and duration to finish traffic jam puzzle, before and after listening to Mozart Sonata K448 for Two Pianos in D-major 2nd Movement. Data were analyzed using paired t-test with ? = 0.05.The results showed that there is a significant difference of words remembered before and after listening to music (35,43±6,70444 vs 73±4,727; p<0,01) and duration to finish traffic jam puzzle (125,60±149,939vs 53,67±69,652 seconds ; p<0,01). We concluded that Mozart’s music improves short-term memory and concentration. Keywords: Mozart’s sonata, short-term memory,concentration
Kombinasi Nanopartikel Cisplatin-Withaferin Berbasis PEGylated Liposome Sebagai Terapi Alternatif Kanker Ovarium Made VW Yani; Ida Ayu W Anjani; I Gede S Narayana; Desak M Wihandani; I Gede P Supadmanaba
Journal of Medicine and Health Vol 2 No 5 (2020)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28932/jmh.v2i5.1129

Abstract

Ovarian cancer is one of the major health problems in gynecology worldwide. Globocan 2012 data shows that ovarian cancer occurs in 239.000 cases, and is placed fourth as the most malignancy occurred in Indonesia. So far, cisplatin is the most effective therapeutic agent, but the high dosage of administration often caused side effects. A new alternative therapy to overcome the problems by using withaferin-A and nanoparticle PEGylated liposome. WFA has the potential effect to reduce cisplatin resistance but has low bioavailability thus, it needs to be encapsulated. This review’s goal is to depict the potency of withaferin-A, cisplatin, and PEGylated liposome combination as a therapeutic agent to treat ovarian cancer. The combination of Cisplatin-Withaferin PEGylated Liposome is constructed by the modified thin lipid film hydration method then administered orally. This combination suppresses 70-80% of the ovarian cancer cell growth in vivo and inhibits NGFR from binding to TRKA, prevents cell migration as much as 50%. Nano-Cisferin-Liposome, inhibits migration of ovarian cancer cell significantly through ?-catenin signaling through ALDH1 that disturb the spheroid formation, and increase apoptosis event as much 70-80% by increasing ROS production up to 2,5 times. Thus, Nano-Cisferin-Liposome (NCL) has potential as a therapeutic agent for treating ovarian cancer. Keywords: Cisplatin; Ovarian Cancer; PEGylated Liposome; Withaferin A
Correlation of Glasgow Coma Scale Score at Hospital Admission with Stroke Hemorrhagic Patient Mortality at Hasan Sadikin Hospital Ary Setio Hartanto; Andi Basuki; Cep Juli
Journal of Medicine and Health Vol 2 No 4 (2019)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28932/jmh.v2i4.1139

Abstract

Stroke is the most common cause of death in Indonesia. Stroke is divided into ischemic and hemorrhagic stroke. Hemorrhagic stroke has a higher risk of death than ischemic stroke. Hemorrhagic stroke can disrupt patient’s consciousness. The Glasgow Coma Scale (GCS) is a scale that is widely used to assess level of consciousness. Accurate predictors can help doctors determine prognosis and treatment for stroke patient. This study was conducted to determine the correlation of GCS scores at the time of hospital admission and mortality of hemorrhagic stroke patients at Hasan Sadikin Hospital. This study is a retrospective cohort analytic study involving 134 subjects. Data were analyzed using Kolmogorov-Smirnov’s and Fisher's analysis test with significance of p <0.05. From the results of the study, the p value was 0.00, subjects with GCS score somnolence (12-14) had six times higher risk in mortality (P = 0.02, RR = 6.38) and subjects with GCS score sopor and coma (3 - 11) had twenty four times higher risk in mortality (P = 0.00, RR = 23.85). We concluded that decreased score of SKG at the time of hospital admission was associated with increased risk of death in hemorrhagic stroke patients at Hasan Sadikin Hospital. Keywords: Glasgow Coma Scale, hemorrhagic stroke, mortality
The Detection of Pathogenic Fungi on Prayer Rugs of The Mosques at Jatinangor Campus of Universitas Padjadjaran Faturrachman Faturrachman; Yanti Mulyana
Journal of Medicine and Health Vol 2 No 3 (2019)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28932/jmh.v2i3.1220

Abstract

Fungus easily grows in the plateau area with warm moist air. The fungus can enter and contaminate mosque rooms, especially on the surface of prayer rugs. If pathogenic fungi grow on prayer rugs, they can increase the health risk of those who come into contact with them. This research aimed to detect and identify pathogenic fungi on prayer rugs of the mosques in Jatinangor campus of Universitas Padjadjaran using laboratoric descriptive method. The data was collected by sampling of dust from the surface of prayer rugs, fungal culturing and mold identification. The existence of pathogenic fungi has been investigated and observed in twenty-eight samples of thirty mosques using simple random sampling. Sabouraud Dextrose Agar was the chosen medium to grow pathogenic fungi. We found fungal growth in all samples with a total of 8 fungal species (Alternaria spp, Aspergillus spp, Candida spp, Fonsecaea spp, Mucor spp, Penicillium spp, Rhizopus spp, Rhodotorula spp) which are opportunistic fungi; however, no pathogenic fungi were found.Keywords : pathogenic fungi, prayer rugs, fungus, Aspergillus spp., Candida spp.
Clinical Profile of TB in Children at Pediatric Outpatient Clinic Hasan Sadikin Hospital Bandung 2016 Fadiya N Soekotjo; Sri Sudarwati; Anggraini Alam
Journal of Medicine and Health Vol 2 No 3 (2019)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28932/jmh.v2i3.1221

Abstract

The diagnosis process of TB in children is complicated. Bacteriological exam is needed to establish diagnosis, but it is not possible to be done in children. Clinical symptoms are the main criteria for TB diagnosis in children. This study aimed to provide clinical profile of TB in children and was conducted using descriptive design. The data was taken from medical record of children with TB at RSHS pediatric outpatient clinic from January 2016 to December 2016. We collected 104 subjects using simple random sampling method. We found out that 64 subjects (61.54%) was diagnosed as lung TB and 40 (38.46%) with extra-pulmonary TB. Contact with the source of transmission was found in 33 patients (60%). We found that clinical symptoms of the subjects were fever 2 weeks (62.5%), weight increase difficulty (49%), lymphnode enlargement (36.5%), cough >= 2 weeks (14.4%), chest tightness (7.7%), bone swelling (4%), and night sweats (2%). We concluded that clinical symptoms that are found mostly in children with TB are fever >= 2 weeks, weight increase difficulty, lymphnode enlargement, cough >= 2 week, chest tightness, bony swelling, and night sweats. Keywords: clinical profile, tuberculosis, TB infection in children
The Influence of Obesity on Blood Pressure in Early Adulthood and Middle Adulthood Males Muhammad O A Eusman; Hana Ratnawati; Mariska Elisabeth
Journal of Medicine and Health Vol 2 No 3 (2019)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28932/jmh.v2i3.1222

Abstract

Hypertension is commonly found in obesity patients. Age affects the occurrence of hypertension. The aim of this study is to determine the effect of obesity on blood pressure levels in early adulthood males (<35 years) and middle adulthood males (?35 years). This is an observational analytic study using data from medical check-up records of male adult office workers in Bandung. The data was analyzed with Mann-Whitney test (? = 0.05) and Chi-Square to find the odds ratio (OR). The results showed that out of 110 data in medical records, there were 79 (71.82%) obese and 31 (28.18%) non-obese. In early adulthood males (<35 years) there is no significant difference between non-obese with obese in systolic blood pressure (p=0.779) and diastolic blood pressure (p=0.779). In middle adulthood males (?35 years) there was a highly significant difference between non-obese with obese on systolic blood pressure (p=0.001) and diastolic blood pressure (p=0.003). There was a significant relationship between obesity and hypertension (p=0.048) with OR=3.73. In conclusion, in early adulthood males (<35 years) obese does not have an effect on the development of hypertension, while in middle adulthood males, obesity increases the risk of developing hypertension by 3.73 times. Keywords: obesity, blood pressure, early adulthood males, middle adulthood males

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