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Mochamad Nashrullah
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Journal of Medical Genetics and Clinical Biology (JMGCB)
Published by Antis Publisher
ISSN : -     EISSN : 30321085     DOI : https://doi.org/10.61796/jmgcB
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing
Journal of Medical Genetics and Clinical Biology is a peer-reviewed forum for advances at the intersection of human genetics and clinical medicine. The journal welcomes original research, reviews, brief reports, and case reports that translate genomic discoveries into clinical utility—spanning diagnostic workflows, risk stratification, therapeutic decision-making, and implementation in real-world care. Areas of interest include Mendelian and complex disorders, cancer genetics, pharmacogenomics, biomarkers, clinical genomics (panel testing, WES/WGS), bioinformatics and data integration, as well as ethical and counseling considerations. By bridging molecular insights and bedside applications, the journal aims to support precision health and improve outcomes across diverse patient populations.
Arjuna Subject : Imunologi dan Mikrobiologi (semua kategori) - Imunologi dan Mikrobiologi (Lain-Lain)
Articles 372 Documents
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SALINE MAPS OF SOME SOILS OF MUTHANNA GOVERNORATE Sabih, Yasser Alaa; Razzaq, Heyder ibraheem Abdul; Khaleq, Maryam Abbas Abdel; Kazem, Zainab Ali; Rasoul, Zainab Abbas; Hakim, Zahra Abbas
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 6 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i6.675

Abstract

performed based on data collected from 15 soil samples from 0 to 20 cm deep. We used salinity of the irrigated soils of Al-Muthana governorate in southern Iraq. These maps were 20% of the world's land. This study was made in order to map the spatial distribution of soil or anthropogenic processes, which is certainly an environmental problem that affects more than environment and agricultural production. The main causes of this salinization come from natural It is important to study the problem of salinization, soil salinity has adverse effects both on the ordinary kriging (OK) to analyze the spatial variability of soil salinity, The results confirmed that the use of saline maps was supportive in giving a clear vision of the of 12.11 dS m-1, for developing probability maps to determine the distribution of risk areas. showed the different classes of salinity with the highest value of 23.17 dS m-1 and lowest value map predicted by the electrical conductivity (EC) values using the ordinary kriging (OK) method while indicator kriging (IK) was used to analyze salinity versus threshold values . The salinity salinity of the soils for the study area
A REVIEW ON EPIGENETIC REGULATION IN BACTERIAL PATHOGENESIS AND RESISTANCE Abdzaid, Ahmed Majeed; Jabbar, Ali Sabri
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 6 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i6.676

Abstract

The study of bacterial Bacterial epigenetics has become important ,because it help to understanding the mechanisms used by bacteria to regulate gene expression with keeping their DNA sequence. This regulation has been known to play an important role in bacterial pathogenesis and resistance mechanisms, which assit the bacteria to easily adapt to the environmental changes and withstand hard conditions, including antibiotic exposures. In this review we clarify the essential mechanism of epigenetic regulation of the bacteria that include, DNA methylation, histone-like protein modifications, and non-coding RNAs. We focus into their importance to bacterial virulence and resistance, focusing on understanding how to use ne therapeutic strategies against antibiotic resistance and invasive diseases
THE EFFECTS OF GENDER, AGE, EYE, AND GROWTH-RELATED FACTORS ON CORNEAL EPITHELIAL AND STROMA THICKNESS IN SCHOOL-AGED-CHILDREN Kamolovna, Bekmurodova Orzigul
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 6 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i6.677

Abstract

Data on corneal epithelium and stroma thickness related to sex, age, eye, and growth parameters of school-age children are limited. In this retrospective study, oct (HUVITZ HOCT-1F, South Korea) corneal epithelial thickness and myopic stroma were measured in 50 men and 60 women (average age 14.12±2.18 years) in the Bukhara region. Regression analysis was used to Decipher the relationship between gender, age, fracture status, axial length, anterior chamber depth, and simple and multiple corneal fracture strength. Age and the thickness of the central angle were positively related to the thickness of the corneal epithelium and negatively related to body weight. In the multiple regression analysis, corneal epithelial thickness was affected by gender and central corneal thickness (CCT), while interstitial thickness was affected by age and gender. The corneal epithelial and stroma thickness was significantly larger in men than in women and was affected by growth. The thickness of the corneal epithelium and stroma was not associated with the severity of myopia, corneal fracture force, or axial length
STUDY THE EFFECT OF HYLOCEREUS POLYRHIZUS SOME ANTIOXIDANT FACTORS IN CHRONIC KIDNEY DISEASE PATIENTS Azzawi, Mohammed Jumaah
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 6 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i6.687

Abstract

The current work was aimed to study the effect of Hylocereus polyrhizus some antioxidant factors in CKD patients and healthy persons. An overall total of (80) CKD patients were included in this study. The patients were between the ages of 20 and 60. Each patient's case information sheet was compiled with information on their name, age, sex, marital status, place of residence, history of chronic diseases, history of drug use, history of smoking, and type of operation. These patients were hospitalized to Kirkuk, Iraq's Kirkuk Teaching Hospital between April and July 2022. 50 healthy individuals served as the control group in this experiment. testing for a few biological elements. The analysis of the peel extract from H. polyrhizus revealed the presence of saponin, flavonoid, tannin, polyphenol, alkaloid, quinone, and terpenoid compounds. Total antioxidant capacity level in male and female were showed significant (P≤0.05) reduced in comparison to the heath group. After using dragon fruits extract, Total antioxidant capacity level were improved and there was non-significant (P≤0.05) changes in comparison to the heath group. Total oxidant status level in male and female were showed significant (P<0.05) elevated in comparison to the heath group. After using dragon fruits extract, Total oxidant status level (951.8±57.4) were improved and there was non-significant (P≤0.05) changes in comparison to the heath group. Based on the results of the current study, it was found that dragon fruits extract has an effective role as an antioxidant.
STUDIES ON THE DETERMINATION OF THE CUMULATIVE PROPERTIES OF THE DRY EXTRACT "HELMINTH-ART" Khabibullaevna, Yuldasheva Shahlo; Rakhmanovich, Tukhtaev Hakim
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 7 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i7.696

Abstract

The object of this study was the dry extract of "Helminth-ART". The cumulative properties of the anthelmintic dry extract "Helminth-ART" were studied in an experiment on mice. It was also found that it does not have cumulative properties.
NONALCOHOLIC FATTY LIVER DISEASE IS A CORNERSTONE OF THE CARDIOVASCULAR CONTINUUM D. B., Yusupalieva; U. I., Nizamov; S.M., Shukurjanova; N. M., Nurillaeva; A. B., Shek
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 7 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i7.697

Abstract

Cardiovascular diseases (CVD) are the leading cause of mortality in most countries worldwide, including Uzbekistan. The main direction in preventing diseases and complications of the cardiovascular system (CVS) is the timely detection and correction of risk factors (RF). Non-alcoholic fatty liver disease (NAFLD) is considered one of the RFs of CVD development, including coronary artery disease (CAD). Data from numerous studies demonstrate increased cardiovascular risks and accelerated progression of liver pathology in the combination of NAFLD and CAD, however, some studies have not confirmed the worsening of outcomes. An association between NAFLD and CAD, atherosclerosis, cardiac rhythm disturbances, arterial hypertension, chronic heart failure and other CVDs has been identified. However, data from meta-analyses should be interpreted with caution due to the use of different diagnostic methods and the heterogeneity of studies included in them. Further studies are needed to clarify the relationship between CVDs and NAFLD further
PREVALENCE OF TOXOPLASMA GONDII IN DIFFERENT MAMMALIAN HOSTS RUSUL JASIM JAMEEL Jameel, Rusul Jasim; alrubaie, Thakaa hassan sadiq; Altoby, Sawsan Awad Fraj; bashar, Teba majid; fadhel, Hawra'a Eyad
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 7 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i7.698

Abstract

Toxoplasma gondii is an obligate intracellular protozoan parasite with a global distribution across diverse mammals affecting human and animal health. This review compiles the current information on the incidences of T. gondii in various mammals; companion animals like cats and dogs, farm animals like cattle and sheep, and wild animals like deer and rodents. Research shows that it is more common in cats, the definite host in which the parasite attains sexual maturity (Dubey, 2010). It has been reported that the prevalence in livestock depends on geographical location, farming practice and environmental factors and relatively high in sheep and pigs because of their grazing and feeding behavior and direct contact with oocyst containing environment (Tenter et al. , 2000). Wildlife species remain hosts and keep the life cycle of the parasite in natural systems (Robert-Gangneux & Dardé, 2012). This compilation therefore highlights the need for constant monitoring and provision of control measures for the prevention of zoonotic transmission of T. gondii while reflecting on the various factors in host biology, the environment and human activities
TOXICOLOGICAL ASSESSMENT OF COPPER SULPHATE ON CHANNA ORIENTALIS AND HETEROPNEUSTES FOSSILIS: LC50 VALUES AND MORTALITY ANALYSIS Prasad, Nayan K.; Shachi, Kumari; Sahani, Suresh Kumar
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 7 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i7.701

Abstract

The adverse effects of heavy metals, particularly copper sulphate, released from industrial effluents on aquatic life are well-documented. In this study, we determined the LC50 values of copper sulphate for two freshwater air-breathing fish species, Channa orientalis (Bloch) and Heteropneustes fossilis (Bloch). The LC50 values for Channa orientalis were determined to be 33 ppm at 24 hours, 32 ppm at 48 hours, 21 ppm at 72 hours, and 7.5 ppm at 96 hours. For Heteropneustes fossilis, the corresponding LC50 values were 15 ppm at 24 hours, 13 ppm at 48 hours, 9.5 ppm at 72 hours, and 5 ppm at 96 hours. We observed a significant increase in mucus secretion at higher concentrations of copper sulphate as compared to lower concentrations. The potential mechanisms of fish mortality under these conditions are also discussed in detail
EXPLORING THE NEUROENDOCRINE CONTROL OF REPRODUCTION IN VERTEBRATES: FROM GONADOTROPIN-RELEASING HORMONE TO FERTILITY Najim, Taghreed Ghali; Ali, Ameer Ahmed; awadh, Rawaa saad; skhail, Elaf hussein
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 7 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i7.712

Abstract

The aims of this study are to review the neuroendocrine control of reproduction in vertebrates with specific emphasis on Gonadotropin-Releasing Hormone (GnRH) expression, hormone secretion, gene up regulation, and reproduction behavior in different vertebrates which includes chickens and rats. There was a highly statistically significant rise in Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH) levels in the: GnRH prompted gonadotropin release – The results from this study confirm the releasing hormone’s action in stimulating the gonadotropic hormones. These results showed that there were significant improvements in the reproductive function related genes, and the pathway analysis was conducted, which presented the activation of the GnRH signaling, MAPK signaling, and ovarian steroidogenesis etc. IHC and IF experiments corroborated those findings and revealed increased levels of LH, FSH, and GnRH receptors. As for behavioral interactions of the three species, all of them exhibited eventual copulatory behaviors following GnRH treatment. These results are in concordance with previous reports published in the literature and corroborate the fact that GnRH is evolutionarily conserved in all the classes of vertebrates and thus, it may have therapeutic applications in the management of reproductive diseases in humans. Thus, the findings obtained contribute to the creation of a stably developing foundation for further investigation of the neuroendocrine regulation of reproduction and the development of approaches to address reproductive health issues
DISEASES THAT ARE DIAGNOSED AND TREATED BY X-RAYS AND GAMMA RAYS Hassan, Sajad Kareem Khalaf; Hajm, Sajad Riad Kiridi; Haithem Malek , Montazer; Mohammed, Zahraa Jasim
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 7 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i7.713

Abstract

rays have long been one of the most effective tools in detecting and diagnosing diseases because of their effective and practical properties in diagnosing the various diseases that appear in the x-ray image. Diagnostic x- rays are considered an examination carried out using To see the internal anatomy of the body Accurately and pinpoint the tiny spots. The x-ray beam passes through the body, and is absorbed in different quantities, depending on the absorption capacity of the material. Dense materials such as bones and metal appear in white in the x-ray image, while air in the lungs appears in black, and muscles and fat appear in shades of grey. In some tests, we resort to introducing contrast dyes such as iodine or barium into the body to provide more details of the part to be imaged, such as imaging the bile ducts, spinal cord (myelography), urinary tract, and other parts that need the use of contrast dyes. in These methods enabled us to diagnose various diseases such as chest diseases and various cancers If a foreign body is detected or calcium calcifications are seen.

Page 14 of 38 | Total Record : 372

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