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Journal of Medical Genetics and Clinical Biology (JMGCB)
Published by Antis Publisher
ISSN : -     EISSN : 30321085     DOI : https://doi.org/10.61796/jmgcB
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing
Journal of Medical Genetics and Clinical Biology is a peer-reviewed forum for advances at the intersection of human genetics and clinical medicine. The journal welcomes original research, reviews, brief reports, and case reports that translate genomic discoveries into clinical utility—spanning diagnostic workflows, risk stratification, therapeutic decision-making, and implementation in real-world care. Areas of interest include Mendelian and complex disorders, cancer genetics, pharmacogenomics, biomarkers, clinical genomics (panel testing, WES/WGS), bioinformatics and data integration, as well as ethical and counseling considerations. By bridging molecular insights and bedside applications, the journal aims to support precision health and improve outcomes across diverse patient populations.
Arjuna Subject : Imunologi dan Mikrobiologi (semua kategori) - Imunologi dan Mikrobiologi (Lain-Lain)
Articles 372 Documents
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THE EFFECT OF THE DRUG MIOSTA H® IN THE TREATMENT OF PURULENT AND NON-PURULENT INFLAMMATORY PROCESSES IN THE JOINTS OF THE LEGS IN HORSES Kh.B., Niyazov; Ruziboev, A.K.; c, Kh.H.; S.B. Abdiev; B. Kokilov; A. Ruziev
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 7 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i7.746

Abstract

In this article, when treating horses with a purulent coffin joint, surgical treatment is performed, enrofloxacin 10% is injected into the muscle, platelet autoserum is injected around the joint, chondrolone is injected into the joint, and Miosta Н® is injected into the muscle, and the wound is treated with levomekol ointment. On the 18-19th day, horses normally experience early formation of scabs, lameness, swelling and a local decrease in leg and body temperature, and when treating horses with chronic non-purulent diseases of the joints of the feet, a sharp tickling ointment is used, massage and paraffin applications are applied around the joint and hydrocortisone 0.5% novocaine. It was also reported that with intramuscular injection of 5 ml of Miosta Н® for the first time and 10 days after intra-articular injection of 5 ml of chondrolone, lameness, swelling and local temperature decreased, and body temperature in horses normalized by day 14.
ANTIBIOFILM SILVER NANOPARTICLES PRODUC BY ESCHERICHIA COLI abdulrazz, Mohammed aqeel; Abas, Ismaal Jmia
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 7 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i7.747

Abstract

coli bacteria were obtained from the soil near the Euphrates River in the northern region of Basra City and cultured on nutrient agar media. The bacterial isolate was subjected to purification and thereafter seen under a microscope. The study revealed that E. coli bacteria has the capacity to synthesize silver nanoparticles when combined with a 1 mM AgNO3 solution. The synthesis of AgNPs was deduced by examining the change in color of the reaction mixture. The UV-vis spectroscopy results indicated that the silver nanoparticles exhibited absorbance at a specific wavelength of 428 nm. Additionally, the FT-IR analysis revealed the presence of active groups in the silver particles, which played a role in maintaining their stability. The SEM and TEM studies revealed that the AgNPs exhibited a spherical morphology, with diameters ranging from 47.66 to 11.68 nm. A cubic crystal structure of silver was confirmed using an X-ray diffraction examination, while an EDX test indicated that the final product was silver (Ag). The antimicrobial efficacy of silver nanoparticles (AgNPs) against bacteria isolated from diseased patients was evaluated using the Well diffusion agar technique. It was shown that nano-silver effectively inhibited the development of the bacteria.The study utilized 96 well Microtiter plates to assess the inhibitory effect of AgNPs on biofilm development in harmful bacteria.
EVALUATION OF WOUND HEALING IN POST-SURGICAL PATIENTS CAESAR THOSE USING ANTIBIOTIC DRUGS AT TANJUNG PURA HOSPITAL Sari, Mayang; Handayani, Sri; Nasution, Rizka Hasmi; Nurmadiah, Nurmadiah
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 7 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i7.749

Abstract

Introduction The World Health Organization (WHO) estimates that 5-15% of births globally are surgical cesarean section. Indonesian Health 2017 shows that 17.02% of deliveries in Indonesia are cesarean sections. Surgical wound infections are infections from wounds obtained after surgery. This infection can occur 30-90 days after surgery. Appropriate use of prophylactic antibiotics intraoperatively can reduce Surgical wound infections. Antibiotics are the most widely used class of drugs related to bacterial infectious diseases. Types of research used is prospective survey research with an approach of studying and testing hypotheses related to ongoing experience. Sample studies were 20 respondents. This research uses quantitative descriptive data analysis with a prospective research design. Research results At the Pharmacy Installation at the Tanjung Pura Regional General Hospital, surgical wounds began to close/dry as much as 70% (14 patients) for compliance with the use of antibiotics according to the right indication, right dose, right patient, right drug. Conclusion of this research is that administering antibiotics affects wound healing in patients and can ensure accuracy in suitability. It is recommended that the hospital review the cleanliness of the surgical area in order to improve the quality of the hospital.
STUDY AND ANALYSIS OF FETAL HEART RATE MONITORING SYSTEM Nassar, Amna Abd Al-Hussain; Kazem, Noor Ibrahim; jaafar, Hussain F.; Naser, Mahmoud S .
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 7 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i7.759

Abstract

Analysis of FHR variability, together with uterine muscle contractions and fetal movement activity, subject to cardiotocographic monitoring, currently play a fundamental role in fetal assessment. The strength of cardiotocography lies in that normal ranges of the results of the FHR signal analysis almost always (>95%) confirm fetal wellbeing. Unfortunately, questionable or abnormal signal features may indicate both fetal distress and its absence. The classic fetal heart rate variability analysis consists in determining the FHR baseline and then in identifying bradycardia/tachycardia, acceleration/deceleration patterns as well as the type and amplitude of oscillations. A more advanced FHR analysis is aimed at evaluating instantaneous FHR variability, especially with beat-to-beat approach, which is very important in fetal condition assessment. The most common technique of recording the FHR signal is the Doppler ultrasound method, which makes it difficult to correctly estimate the instantaneous heart rate variability because the measurements are averaged. On the other hand, instantaneous heart rate variability plays a crucial role in the diagnosis of fetal condition [1]. The increased interest in monitoring the fetal cardiac bioelectrical activity is due to the fact that the analysis of the fetal electrocardiogram ensures high efficiency and accuracy of the heart rate measurement even on a beat-to-beat level. The first fetal electrocardiogram was recorded as early as in the 1960-ies by means of a special spiral electrode enabling direct signal registration from a fetal head. Due to the way the electrode is placed, its use is limited only to the advanced labour stage [1]..
EVALUATION OF MODIFIED CONGO RED AGAR FOR DETECTION OF BIOFILM PRODUCING MDR KLEBSIELLA PNEUMONAIE CLINICAL ISOLATES Al-yozbakee, Zinah Makki; Mohammad, Khalid Omar
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 8 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i8.775

Abstract

The notoriety of Multiple Drug Resistant (MDR) K. pneumoniae extends beyond nosocomial or community acquired infections, since it is a major cause of biofilm-related infections. The utilization of a very specific or distinct media, Congo Red Agar (CRA), for detection of biofilm, has significant drawbacks, including inconsistencies in the creation of black pigment. In this study, an assessment of Modified Congo Red Agar (MCRA), for detection of biofilm, was performed on 23 multidrug-resistant (MDR) K. pneumoniae strains obtained from various clinical samples. The aim of this study was to assess the effectiveness and dependability of Modified Congo Red Agar (MCRA) as an alternative medium for studying biofilm production to the non modified Congo Red Agar. Also to examine the prevalence of the fimH gene, which is necessary for biofilm formation among these isolates. Lastly to determine the relationship between antibiotic resistance, the presence of the fimH gene, and the ability to produce biofilm among K. pneumonaie strains. These strains were diagnosed according to their specific bacteriological characteristics. After assessing antibiotic susceptibility, all MDR K. pneumoniae isolates exhibited the presence of the fimH gene using the PCR method. On CRA 20 isolates were strong biofilm producer as they appeared as black colored colonies, two were moderate biofilm producer (pink colored) and only 1 was non biofilm producer ( red colored) colony. On MCR the same results for biofilm production to CRA, except for one colony differed as it appeared red (non biofilm producer) on MCRA and pink (moderate biofilm producer) on CRA. However, the growth of 75% blackness pigment of MDR K. pneumoniae strains on the CRA decreased over time. The phenotypic pigmentation on CRA was enhanced by modifying the contents of the agar that led to the persistent development of a highly concentrated black pigment in isolates containing the fimH gene for 2 to 4 days, with no drop in pigmentation seen over time. The change of the agar ingredient enabled the stable synthesis of black pigment and also resulted in a reduction in the cost of agar preparation. Key Words: Biofilm, Congo Red Agar, fimH gene, Modified Congo Red Agar, MDR K. pneumonaie.
PREDICTING DROUGHT USING ARTIFICIAL INTELLIGENCE TECHNIQUES Salman, Abdul Basit Hamza Jalal; Hamidan, Ahmed Emad Milli; Al-Mousawi, Worood Abdul Redha Sharif Nayef; saadoun, Zainab haider Mussa; Ali, Esraa Ali Hussein
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 7 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i7.778

Abstract

The research dealt with climate drought, its types, the causes that lead to drought, and how to reduce drought. Drought in the city of Mosul, northern Iraq, was also analyzed and studied by obtaining monthly rainfall data for the Mosul climate station located within the study area for the period from 1981-2018. Previous studies and research conducted to study drought in different regions of the world were taken into consideration. Most of these studies and researches use drought indices, which are among the most widely used indices in estimating the amounts of deficit, their use, severity, and their impact on the water balance. The standard rainfall index (SPI) is one of the most widely used indices in estimating climate drought. (SPI) is characterized by many characteristics that distinguish it from other indicators. The standard rainfall index (SPI) technique was used in analyzing rain records. The analysis principle using the standard rainfall index is statistically based on the principle of converting the gamma distribution of the data series to the normal distribution. Positive SPI values mean that there is an increase in rainfall above the average rainfall, i.e. wet years, while negative values mean that there is a decrease in rainfall below the average rainfall, i.e. dry years. SPI values for a period of 12 months were adopted in the analysis because they cover the annual rainfall amount falling on the station during a year. Using the MATLAB program, several networks were created and tested, and the network with the best performance was selected from among the networks. 30 annual rainfall values were used against the SIP values calculated using equations and the Excel program to train the neural network on the data. While the rainfall data for the remaining 8 years were used to verify the results of the neural network by comparing the results of the neural network with the actual values recorded at the measuring station. This network was able to obtain the index value by simply entering the annual rainfall value. By comparing the index value with the drought classification table, the drought class can be determined without resorting to the calculation method. The network with the 1-7-1 structure (input layer, hidden layer containing seven neurons, and output layer) with the TRAINLM training function and the LEARNGDM learning function gave the best performance, as the correlation coefficient between its results and the actual results (which were not included in the training) was equal to 0.99 and the square error rate was 0.014, meaning that the results of this network can be adopted for the purpose of calculating the standard rain index with high confidence in the outputs
EFFECT OF CEFOTAXIME ON ESCHERICHIA COLI ISOLATED FROM URINARY TRACT INFECTION Shaaban, Maher Ali Abdul Hussein; Yasser, Muqtada Hamid Abd; Abed, Zahraa salim saed; Ahmed, Abdulaziz Younis Mahmood
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 7 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i7.779

Abstract

This study aims to detect the effect of cefotaxime antibiotic on Escherichia coli bacteria isolated from urinary tract infections. 27 clinical samples were collected from the urine of women with urinary tract infections caused by Escherichia coli bacteria under the supervision of a specialist doctor at Al-Rifai General Hospital in Al-Rifai District / Dhi Qar Governorate. Escherichia coli bacteria have been diagnosed by conventional methods, which have confirmed infection with Escherichia coli. A drug susceptibility test was conducted for bacterial isolates of E. coli to the antibiotic cefotaxime from 27 female patients believed to have UTIs. The Statistical package for the social sciences (SPSS) system was adopted in this study for the purpose of statistical analysis, which express the negative or positive effect of the antibiotic cefotaxime on female patient samples, according to the target age groups. In the study. If we conclude from the foregoing from the current study that the rate of resistance of E. coli bacteria to the antibiotic cefotaxime has reached 70%, and this is consistent with the study of researcher Harran (2012), which confirmed the high and large resistance of E. coli to the antibiotic cefotaxime of the group of third- generation antibiotics The cephalosporins group, and the rate of resistance to the previous antibiotic was 76.6%. The results of this study also coincided with the results of the researcher’s study SURESH (2016) in India, where the percentage of E. coli resistance to the antibiotic cefotaxime was 100%. This study was also compatible with the researcher’s study HEGAZY (2018), which demonstrated the resistance of E. coli isolates to the antibiotic cefotaxime by 74.4%, and the reason for the aforementioned results of the current study and studies compatible with it is due to the ability of E. coli to resist the antibiotic cefotaxime due to its possession of efficient flow pumps in the elimination of the antibiotic The previous bio outside the cell and the removal of the effect of this antibiotic, and thus the existence of the natural efflux pumps outside the cell (Efflux pums), and perhaps one of the most important efflux systems possessed by E. coli is the AcrAB-ToIC system of the RND family, which is the most common efflux system in E. coli, Through which you can change the permeability of the outer membrane of the germ cell. coli bacteria have many mechanisms to resist beta-lactam antibiotics, as they work to produce beta-lactamase enzymes stationed in the proplasmic vacuole, and these enzymes attack beta-lactam antibiotics before they reach the target, and the bacterial cell works to reduce its permeability to prevent the entry of antibiotics and thus inhibit their action, and it is possible The bacterial cell acts as a pump driving the antibiotic beyond its borders, but the most common mechanism is its production of beta-lactamase enzymes and its importance comes through its ability to open the beta-lactam ring for both penicillins and cephalosporins (Frere et al., 2015; Bush, 2015; Chambers et al., 2005). Several studies indicate that if E. coli bacteria show resistance to ceftriaxone, ceftazidime, azotronam, and cefotaxime, they are considered broad-spectrum to resist many beta-lactams (penicillins, cephalosporins, and monobactams) due to the production of extended spectrum β-lactamases (ESBLs). ] making the treatment menu for patients with UTIs limited
ANTIBIOTICS RESISTANCE RISK ASSOCIATED WITH ANTIBIOTIC OVERUSE Rabat, Hawraa Hadi Ali; Mashed, Fatima Sadiq Abd Al Hussein; Hassoun, Wuroud Saad Muhammed; Tamig, Teba Adnan saber; Abbas, Sabreen sahib Mohsin
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 7 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i7.780

Abstract

Antimicrobial resistance is a global public health challenge, which has accelerated by the overuse of antibiotics worldwide. Increased antimicrobial resistance is the cause of severe infections, complications, longer hospital stays and increased mortality. Overprescribing of antibiotics is associated with an increased risk of adverse effects, more frequent re-attendance and increased medicalization of self-limiting conditions. Antibiotic overprescribing is a particular problem in primary care, where bacteria cause most infections. About 90% of all antibiotic prescriptions are issued by general practitioners, and respiratory tract infections are the leading reason for prescribing. Multifaceted interventions to reduce overuse of antibiotics have been found to be effective and better than single initiatives. Interventions should encompass the enforcement of the policy of prohibiting the over-thecounter sale of antibiotics, the use of antimicrobial stewardship programmes, the active participation of clinicians in audits, the utilization of valid rapid point-of- care tests, the promotion of delayed antibiotic prescribing strategies, the enhancement of communication skills with patients with the aid of information brochures and the performance of more pragmatic studies in primary care with outcomes that are of clinicians’ interest, such as complications and clinical outcomes.
EFFECT OF VITAMIN D DEFICIENCY IN PREGNANT WOMEN Hamad, Sadiq Nazim Abdel Amir; Aswad, Sarah Ibrahim Mutar; Al-Qadisiyah, Hawraa Ayed Halil Khanzeer; Yahya, Alina Shahab Qahtan; Ali, Mohammed Jassim Mohammed
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 7 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i7.781

Abstract

Vitamin D deficiency (VDD) in pregnant women and their children is an important health problem with severe consequences for the health of both. Thus, the objectives of this review were to reassess the magnitude and consequences of VDD during pregnancy, lactation and infancy, associated risk factors, prevention methods, and to explore epigenetic mechanisms in early fetal life capable of explaining many of the non-skeletal benefits of vitamin D (ViD)..
REVIEW ABOUT DIABETIC NEPHROPATHY Neama, Sabah Kamel; Talib, Alaa Muhannad; Coz, Athraa Kadhem; Abad, Saja Hadi
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 7 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i7.782

Abstract

The main function of the kidney is to filter the blood, purify it, and then return it to the body. This is done by taking the blood into the kidney through the renal arteries. About one liter of blood is pumped to the kidney, and 1/5 of what the blood pumps is returned. After filtering, the blood returns back to the body through the renal veins diabetes, damage Figure 4: A scan showing the basic structure and function of the kidney: The kidney is associated with to the capillaries, and changes in the afferent and afferent arteries, which interfere with the blood pressure furnace of the capillary and renal blood vessels of many tissues, including the infiltration of the umbilical cord. This can be caused by kidney weakness or kidney failure, and if the kidneys do not function properly for a long period of, When the t and kidney capacity time, this may be the result of diarrhea, diabetes, or high blood pressure. Sometimes this is due to genetic factors, hormones in the body, which help in regulating blood pressure. And the regulates the consumption of calcium in the intestines, and maintains the amount production of red blood cells, in addition to romaine, which of water in the body, which is responsible for the body’s general functions, including blood sugar and controlling the amount of water and salt in the blood and some chemicals (F Walter, 2004). Diabetes Mellitus, Diabetes is known to be a disruption in the process of sugar metabolism, leading to high blood sugar levels (glycolysis).

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