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Journal of Medical Genetics and Clinical Biology (JMGCB)
Published by Antis Publisher
ISSN : -     EISSN : 30321085     DOI : https://doi.org/10.61796/jmgcB
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing
Journal of Medical Genetics and Clinical Biology is a peer-reviewed forum for advances at the intersection of human genetics and clinical medicine. The journal welcomes original research, reviews, brief reports, and case reports that translate genomic discoveries into clinical utility—spanning diagnostic workflows, risk stratification, therapeutic decision-making, and implementation in real-world care. Areas of interest include Mendelian and complex disorders, cancer genetics, pharmacogenomics, biomarkers, clinical genomics (panel testing, WES/WGS), bioinformatics and data integration, as well as ethical and counseling considerations. By bridging molecular insights and bedside applications, the journal aims to support precision health and improve outcomes across diverse patient populations.
Arjuna Subject : Imunologi dan Mikrobiologi (semua kategori) - Imunologi dan Mikrobiologi (Lain-Lain)
Articles 372 Documents
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STUDY OF THE OPERATION OF SOME MEDICAL DEVICES AND THEIR PHYSICAL APPLICATIONS. A FIELD STUDY ON THE ULTRASOUND DEVICE Mohammed, Dieary Ali; saeed, Sara rafeeq; Ahmed, Khawla Akram
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 7 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i7.714

Abstract

One of the most important branches of applied physics is the application of physics in the medical field, especially in the diagnosis and treatment of human diseases. It is divided into four main branches: (radiation therapy, nuclear medicine, diagnostic imaging, and radiation protection). The Radiation Therapy Physics Division is often the largest, as physicists provide support services to the Department of Radiation Oncology, ensuring that it accurately reaches a patient in the hospital, such as planning radiation doses and X-rays. Classification and MRI oncology. Diagnostic imaging devices such as Important Humans and their treatment. We will also discuss some other medical devices (the EKG device, the EEG device, and the centrifuge). Physics in medicine is of great importance because it is manifested in employing various physical phenomena and making the most of them with devices that allow us to diagnose and treat many diseases, and we see now with the development of these, The devices have become an important possibility in wave therapy without the need to resort to surgical operations
ELEVATE SOME TYPES OF ADIPOKINES IN WOMEN WITH POLYCYSTIC OVARY SYNDROME (PCOS) Alrawi, Nawfal N. R.; Saleh, Ahmed Hamad
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 7 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i7.715

Abstract

The current work aimed to estimate some types of Adipokines (Leptin, adiponectin and the resistin) in PCOS women. The participants belong to both PCOS women and healthy women were selected and examined in Azadi teaching hospital at September 2021 to February 2022. 80 patients with 30 controls were used in this study. The current outcomes show the concentration of Leptin in PCOS patients, where concentration of Leptin demonstrated significant (P <0.05) elevate in PCOS women compared with healthy women. Adiponectin concentration in PCOS women indicated significant (P <0.05) reduce compared with healthy women. Resistin concentration in PCOS women indicated significant (P <0.05) raise compared with healthy women. So, based on this findings, PCOS lead to significant (P <0.05) differences in concentration of some types of Adipokines.
INVESTIGATION INTO THE IMPACT OF CARVCROL EXTRACTS ON BACTERIA ISOLATES FROM OSTEOMYLITIS AFTER SURGERY Tariq, Tamara Ziyad; Al-Sultan, Saba Abdul Salam Hamid; Sulaiman, Aws Ibrahim
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 7 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i7.721

Abstract

Carvacrol is one of the most ancient medicinal herbs. Carvacrol contains different alkaloids, flavonoids and saponins. In present studies the antimicrobial activity of Carvacrol alcoholic extract against Gram-negative bacterial and Gram-positive bacterial were determined by the microtiter plate method. Gram-negative bacterial and Gram-positive bacterial strains isolated from osteomyelitis patients after surgery in Mosul city , A total of 60 samples were collected from various sources in Mosul hospitals, during the period from January 10, 2024 , to May 1, 2024. The Aim of this study is determining the effectiveness and effect of alcoholic extract of carvacrol on bacterial isolates taken from a Osteomyelitis after surgery. Bacterial culture results on blood agar, MacConkey agar and nutreint agar revealed 54 positive samples for bacterial growth. Among these, Staphylococcus aureus 22 isolates (32.8%), Pseudomonas aeruginosa 12 isolates (17.9%), Enterobacter cloacae 5 isolates (7.5%) Klebsiella pneumoniae 4 isolates (5.9%), Escherichia coli 4 isolates (5.9%), Proteus mirabilis 3 isolates (4.5%), Streptococcus viridans 3 isolates (4.5%), Corynebacterium spp 2 isolates (3%). As for the following bacterial isolates, each of them constituted one isolate out of a total of 67 isolates, at a rate of 1.5% for each: Providencia spp. , Acinetobacter spp., Staphylococcus saprophyticus , Klebsiella oxytoca , Enterococcus spp. , Enterococcus faecium , Citrobacter freundii , Streptococcus groups C , Bacillus cereus , Enterobacter spp. , Acinetobacter baumannii , Morganella morganii, using vitek-2. High-performance liquid chromatography (HPLC) analysis of Oregano plant revealed the presence of active compounds such as Carvacrol, thymol. Plant extracts from carvacrol demonstrated a substantial inhibitory effect. Results: study indicated that plant extracts exhibited higher inhibition than antibiotics. The minimum inhibitory concentration (MIC) while the results of the lowest inhibitory concentration of carvacrol for the bacterial species under study showed that it had an effect at a concentration of 615 µg/ml against Escherichia coli, 307.5 µg/ml for the species Corynebacterium stratium, Morganella morganii and Pseudomonas aeruginosa, and the least effect was 76.875 µg/ml on Staphylococcus aureus, it gave less results than the antibiotic used Carvacrol (Absorbance was measured at Wavelength 600) .
STUDY OF THE LONG-TERM EFFECTS OF DIABETES ON THE OVERALL HEALTH AND QUALITY OF LIFE IN THALASSEMIA PATIENTS ahmed, Abdulhameed Rashid Hameed; Abdullah, Rasha Ahmed; wasmi, Maha Saddam; Alush, Rawaa Abd Alkareem; Mehsun, Ammar Abbass
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 7 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i7.727

Abstract

Thalassemia is a genetic blood disorder characterized by chronic anemia, requiring regular blood transfusions and chelation therapy. Diabetes mellitus is a common complication in thalassemia patients, primarily due to iron overload affecting the pancreas. This study investigates the long-term effects of diabetes on the overall health and quality of life in thalassemia patients. The research aims to understand how diabetes exacerbates complications associated with thalassemia and to identify strategies for improved management and care. The study includes a cohort of thalassemia patients with diabetes, compared to a control group of thalassemia patients without diabetes. Parameters assessed include glycemic control, incidence of diabetes-related complications, and overall health markers such as liver function, cardiovascular health, and renal function. Quality of life is measured using standardized questionnaires addressing physical, emotional, and social well-being. Preliminary findings indicate that thalassemia patients with diabetes have a significantly higher incidence of comorbid conditions, including cardiovascular disease and renal impairment (De Sanctis et al., 2016). Additionally, the quality of life in these patients is notably lower, with increased reports of fatigue, pain, and psychological distress (Haines et al., 2013). Effective management of diabetes in thalassemia patients, through regular monitoring and tailored treatment plans, is crucial in mitigating these adverse effects and improving patient outcomes (Farmaki et al., 2006). This study underscores the importance of integrated care approaches for thalassemia patients with diabetes, emphasizing the need for multidisciplinary teams to address the complex interplay of these conditions. Further research is needed to develop targeted interventions that can enhance the long-term health and quality of life for this vulnerable patient population. Results: study indicated that plant extracts exhibited higher inhibition than antibiotics. The minimum inhibitory concentration (MIC) while the results of the lowest inhibitory concentration of carvacrol for the bacterial species under study showed that it had an effect at a concentration of 615 µg/ml against Escherichia coli, 307.5 µg/ml for the species Corynebacterium stratium, Morganella morganii and Pseudomonas aeruginosa, and the least effect was 76.875 µg/ml on Staphylococcus aureus, it gave less results than the antibiotic used Carvacrol (Absorbance was measured at Wavelength 600) .
IDENTIFICATION AND EXTRACTION PROCESS OF CARDIAC GLYCOSIDES FROM FOXGLOVE PLANTS Febrianti, Susi; Farhan, Fathi; Juarfianti, Juarfianti; Salfa, Sabrina Audry; Elviona, Rema; Kusuma, Ika Meruya
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 7 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i7.737

Abstract

Foxglove (Digitalis spp.) is a plant known for its cardiac glycoside content, which has been used in medicine for centuries. Cardiac glycosides, such as digoxin and digitoxin, are the main components that have a therapeutic effect on the cardiovascular system. This research examines the cardiac glycoside content of various Digitalis species, with a focus on extraction methods, isolation and characteristics of these compounds. Methods used include high-performance liquid chromatography (HPLC), mass spectrometry (MS), and nuclear magnetic resonance (NMR). The analysis results showed that Digitalis purpurea and Digitalis lanata were the main sources of cardiac glycosides. Digoxin and digitoxin were isolated and identified as the main active components. Pharmacological studies show that this compound interacts with the sodium-potassium ATPase pump, which increases cardiac contractility and is used in the treatment of heart failure and arrhythmias. Cardiac glycosides from the foxglove plant play an important role in cardiovascular therapy. Further research is needed to develop more efficient extraction methods and understand the deeper mechanisms of action, as well as potential side effects associated with long-term use.
COMPARATIVE STUDY OF THE PANCREAS HISTOLOGICAL AND HISTOCHEMICAL IN BARN OWL (TYTO ALBA) AND BLACK FRANCOLIN (FRANCOLINUS) Al-samawy, Eyhab R.; Hasan, Mustafa Salah; Mishal, Hawraa Faisal
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 7 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i7.738

Abstract

The present study aimed at the pancreas of two bird species differs in their classification, habitat, nutrition, and activity. The birds were omnivorous Black Francolin(francolinus) and carnivorous Barn Owl (Tyto alba). Histologically the pancreas of these birds was covered by a thin layer of connective tissue capsule formed from reticular, elastic, and few collagenous fibers, this capsule in barn owl appear thicker than that found in black francolin birds. The parenchyma of pancreas in both birds were composed mainly from exocrine portion represented by serous acini and endocrine portion which distributed among acini which represented by islets of Langerhans. The endocrine gland of the pancreas showed that the islets of Langerhans, have two types of cells, the first one is alpha cells shown as a spindle in shape with oval nuclei, located periphery of the islets of Langerhans. The second type was beta cells show as rows or irregular polygonal cells with spherical nuclei that is slightly larger than the nuclei of alpha cells and found in the center of islets. These cells were located in the periphery of the island of Langerhans in both birds. Histochemical results reveal that the pancreatic cells, whether the acinar cells or islets cells are moderately positive in both species of birds.
PROTECTING GROUPS FOR ORGANIC SYNTHESIS Saleh, Asmaa Najeeb Ahmad; Noori, Khadija Nasser Mohammed; Sulamin, Saja Huusin Ali; Hasan, Ghufran Kadhum Abed; Mohammad, Qahtan Adnan Jassim
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 7 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i7.739

Abstract

A protecting group (English protecting group - therefore often referred to as common abbreviation in formula schemes PG) is in chemistry a substituent which, during a more complicated, multi-step chemical synthesis in a molecule is introduced to a specific functional group to protect temporarily and so an undesirable reaction to prevent this group. After the desired reaction has been carried out elsewhere on the molecule, the protective group is split off again. For many functional groups several possible protective groups are known which differ in their stability and the conditions for their cleavage. In the synthesis of special classes of compounds with repeating functional groups - usually biomolecules such as peptides, oligosaccharides or nucleotides - standard sets of protective groups have become established. Protecting groups have become an important tool in the synthesis of complex compounds today. The requirements for a protection group are quite high. This includes that it can be introduced specifically to a functional group with very good vield and that it must also be able to be split off yield and that it must also be able to be split off again under mild conditions. It should be possible to standardize the reaction conditions for both steps. In addition, the protective group must be stable under as many reaction conditions as possible. If possible, the resulting reaction products should be easily separable, and optimally the protective group reagent is also inexpensive. The broader the experience with a protective group, the better the predictability of the reactivity of the protective group.
THE RELATIONSHIP BETWEEN FLAVONOIDS AND CANCER Al anisi, Ayam; Hami, Hasan Jasim; Barrak, Mohammed M.
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 7 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i7.740

Abstract

Flavonoids are the effective ingredients of the compounds found in grains, vegetables, fruits, seeds and some drinks that have medicinal, free radical reducing and anti-cancer functions. In plants, flavonoids play an important role in multiple functions including color formation, growth, and protection against damage and microorganisms. Articles have stated that the molecular functions of flavonoids may improve health and reduce disease symptoms, reduce antibiotic resistance and reduce inflammation in humans. One of the features of such research is the potential effect of flavonoids on cancer risk.Chemically, flavonoids have an overall 15-carbon skeletal structure consisting of two phenyl rings and one heterocyclic ring. This carbon structure can be abbreviated as C6-C3-C6. Flavonoids are the effective ingredients of the compounds found in grains, vegetables, fruits, seeds and some drinks that have medicinal, free radical reducing and anti-cancer functions. In plants, flavonoids play an important role in multiple functions including color formation, growth, and protection against damage and microorganisms. Articles have stated that the molecular functions of flavonoids may improve health and reduce disease symptoms, reduce antibiotic resistance and reduce inflammation in humans. One of the features of such research is the potential effect of flavonoids on cancer risk.
NOVEL CHEMICAL METHODS FOR IDENTIFICATION AND DETERMINATION OF TRIPTANS IN PHARMACEUTICAL PREPARATIONS Ahmed, Ahmed Othman
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 7 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i7.741

Abstract

Triptans referred as 5-HT1-receptor agonists are groups of medicines, that are utilized to treat migraine and certain other headaches. İn this study, zolmitriptan and Sumatriptan as a selective serotonin receptor agonist for the 1B and 1D subtypes have been studied. This study was conducted to investigate the qualitative determination of triptan drugs (sumatriptan and zolmitriptan) from their pharmaceutical preparation by using oxidation coupling reaction. We studied the interaction of drugs by using five different type of coupling reactions in the presence of potassium permanganate as an oxidizing agent. The final product was analysed under Uv-VIs spectrophotometer, and it was found that, the resultant product of zol-shc, zol-azo, zol-oxi, zol-chro and zol-blrch give maximum absorbance at 510 nm, 540 nm, 490 nm, 520 nm, 505 nm of wavelength repectively, compare to zolmitriptan at 240 nm. Similar results were observed for suma-shc, suma-azo, suma-oxi, suma-chro and suma-blrch 525 nm, 540nm, 515 nm, 530nm, 520 nm and 480 nm of wavelength respectively compared to pure sumatriptan of 280 nm. These methods provides an effective and less expensive method for measurement of the triptans specially for developing countries
COMPARISON BETWEEN THE TYPES OF HYDROPONICS AND REGULAR CULTIVATION IN THE SOIL AND THEIR IMPACT ON THE GROWTH OF THE LETTUCE CROP Arak, Ali Asim Mutar; Hussein, Zainab Thamer obeis; Qadir, Baraa Amer Hamid; Abd, Haider Abbas Shadhan; alhasan, Mohammed Abbas Hamza Abd; Hamoud, Riyam Kareem Tlayyip
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 7 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i7.742

Abstract

This study aimed compare the morphological properties of lettuce growth in different model of cultivation (soil, cork and water pipes). Samples of lettuce plants were cultivated in three models of cultivation. The first model was regular cultivation in soil, the second model was agriculture using water pipes and the third model was hydroponic using cork. After two months, the properties of each sample, including total length of plant, length of stem to end of leaf, length of root, length of leaves and number of roots. According to the result in this study, length of total plant, root, leaves and stem to end as well as number of leaves and roots were significantly greater in water pipes than in hydroponic with cork and soil, respectively..

Page 15 of 38 | Total Record : 372

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