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Mochamad Nashrullah
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Journal of Medical Genetics and Clinical Biology (JMGCB)
Published by Antis Publisher
ISSN : -     EISSN : 30321085     DOI : https://doi.org/10.61796/jmgcB
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing
Journal of Medical Genetics and Clinical Biology is a peer-reviewed forum for advances at the intersection of human genetics and clinical medicine. The journal welcomes original research, reviews, brief reports, and case reports that translate genomic discoveries into clinical utility—spanning diagnostic workflows, risk stratification, therapeutic decision-making, and implementation in real-world care. Areas of interest include Mendelian and complex disorders, cancer genetics, pharmacogenomics, biomarkers, clinical genomics (panel testing, WES/WGS), bioinformatics and data integration, as well as ethical and counseling considerations. By bridging molecular insights and bedside applications, the journal aims to support precision health and improve outcomes across diverse patient populations.
Arjuna Subject : Imunologi dan Mikrobiologi (semua kategori) - Imunologi dan Mikrobiologi (Lain-Lain)
Articles 372 Documents
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EARLY DETECTION OF CORONA VIRUS BY (COMPUTED TOMOGRAPHY) B IMAGING DEVICES Gaeed, Aya Majeed; jasam, Mariam mohammed; Abd, Haider Ahmed; Hanoun, Mustafa Juma
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 7 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i7.783

Abstract

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A STUDY OF SEASONAL INFLUENZA AND HEALTH GIRLS, AWARENESS ABOUT ITS VACCINE IN AL-RIFAI DISTRICT Gouda, Sarah Aziz Askar; Majeed, Zahraa Jasim Hammoodi; Abbas, Marwa Shaalan Ghali; Malhak, Qayed Darwish ḵhasara; Ali, Zahraa Ahmed Mohsen Muhammad
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 7 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i7.784

Abstract

The influenza virus (IV) is still of great importance as it poses an imminent threat to humans and animals. Among the three IV-types (A, B, and C) influenza A viruses are clinically the most important being responsible for severe epidemics in humans and domestic animals. Aerosol droplets transmit the virus that causes a respiratory disease in humans that can lead to severe pneumonia and ultimately death. The high mutation rate combined with the high replication rate allows the virus to rapidly adapt to changes in the environment. Thereby, IV escape the existing immunity and become resistant to drugs targeting the virus. This causes annual epidemics and demands for new compositions of the yearly vaccines. Furthermore, due to the nature of their segmented genome, IV can recombine segments. This can eventually lead to the generation of a virus with the ability to replicate in humans and with novel antigenic properties that can be the cause of a pandemic outbreak. For its propagation the virus binds to the target cells and enters the cell to replicate its genome. Newly produced viral proteins and genomes are packaged at the cell membrane where progeny virions are released. As all viruses IV depends on cellular functions and factors for their own propagation, and therefore intensively interact with the cells. This dependency opens new possibilities for anti-viral strategies
MULTILEVEL OSTEOSYNTHESIS OF THE LOWER EXTREMITIES BY THE ILIZAROV METHOD TO ELIMINATE DEFORMITIES AND SHORTENINGS IN CHILDREN AND ADOLESCENTS Jumayeva, Jahongirovna Mahlie
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 7 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i7.789

Abstract

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HELICOBACTER PYLORI: FROM DISCOVERY TO MODERN-DAY TREATMENTS Band, Fatima Ahmed; Rashed, Mostafa Mohammed; ABD, mslim ALI; Hashim, Saif Salam; Hussein, Rawnaq Mahdi
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 7 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i7.796

Abstract

Helicobacter pylori, a Gram-negative bacterium, was first identified in the early 1980s as a major cause of chronic gastritis and peptic ulcer disease. Its discovery revolutionized the understanding of gastric pathology, shifting the paradigm from a solely acid-related etiology to one involving bacterial infection. This abstract provides a comprehensive overview of H. pylori, tracing its discovery, pathogenesis, and the evolution of treatment strategies. The initial identification of H. pylori by Barry Marshall and Robin Warren marked a pivotal moment in medical history, leading to widespread recognition of the bacterium's role in gastrointestinal diseases. The bacterium's unique ability to survive in the acidic environment of the stomach, coupled with its association with gastritis, peptic ulcers, and even gastric cancer, has driven extensive research into its biology and pathogenic mechanisms. Modern-day treatments for H. pylori have evolved significantly from the early use of single-agent antibiotics to the current standard of triple or quadruple therapy, which combines proton pump inhibitors (PPIs) with multiple antibiotics. This approach aims to overcome antibiotic resistance and enhance eradication rates. Newer treatment strategies also focus on optimizing therapy duration, minimizing side effects, and addressing resistance patterns. Advancements in diagnostic techniques, such as breath tests, stool antigen tests, and endoscopic biopsy-based methods, have improved the accuracy of H. pylori detection and monitoring. The ongoing research into alternative treatments, including novel antibiotics and probiotics, reflects a growing understanding of the bacterium's role in gastric diseases and the need for effective, personalized therapeutic approaches. In summary, the journey from the discovery of H. pylori to the development of modern treatments illustrates significant progress in gastrointestinal medicine. Continued research and innovation are essential to addressing the challenges of eradication and improving patient outcomes in the management of H. pylori-related diseases.
PHYTOCHEMICAL ANALYSIS AND ANTIBACTERIAL ACTIVITIES OF GUNDELIA TOURNEFORTII AND MALVA SYLVESTRIS LEAF EXTRACTS IN KURDISTAN IRAQ Jalal, Mustafa J.
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 7 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i7.797

Abstract

This study aims to evaluate the phytochemical composition and antibacterial activities of Gundelia tournefortii and Malva sylvestris leaf extracts from the Kurdistan region of Iraq. Phytochemical screening was performed to identify the presence of key compounds, while the antibacterial activity was assessed against various bacterial strains. The results indicated significant phytochemical constituents and promising antibacterial properties, suggesting potential uses in traditional and modern medicine.
STUDYING THE IMPACT OF THE SCIENTIFIC MIRACLES OF THE HOLY QURAN ON THE PHENOTYPIC AND GENETIC INDICATORS OF SOME PATHOGENIC BACTERIAL ISOLATES Alsugmiany, Rafea zaidan mukhlif; Salih, Riyam ameen; Alwan, Asmaa Abdulkareem; Alwan, Maryam AbdulKareem
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 8 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i8.812

Abstract

Background : This study explores the novel application of the Holy Qur'an and Shariah ruqyah in affecting the genome of bacteria. Conducted for the first time in Iraq and the Arab world, this research seeks to investigate the potential impact of these treatments on bacterial DNA, leveraging RAPD-PCR markers for mutation detection. Materials and Methods : Genomic DNA was extracted from four bacterial isolates using established protocols. The study employed 10 RAPD primers to identify mutations in the bacterial genomes. The bacterial samples were subjected to treatments with the Qur'an and Shariah ruqyah, and the resulting genomic changes were analyzed. RAPD-PCR reactions were conducted, and the products were separated on agarose gel electrophoresis. The mutations were identified by comparing the banding patterns of treated samples with control samples. Results and Discussion : The results indicated significant genomic alterations in the bacterial samples treated with the Qur'an and Shariah ruqyah. Staphylococcus hemolyticus exhibited the highest number of mutant bands (29) compared to the control sample, followed by Proteus bacteria (25), another strain of Staphylococcus hemolyticus (22), and Staphylococcus aureus (10). These findings demonstrate the high efficiency of RAPD markers in detecting mutations with a limited number of primers. The study revealed that the magnetic field significantly affects the genome of faba beans, causing mutations that increase with longer exposure periods. The induced mutations could potentially be utilized to improve antibiotic quality and track harmful bacterial genes, rendering them non-pathogenic. The differences in results between the strains are attributed to their different genomic backgrounds, originating from various sources. Conclusions : The findings underscore the significant impact of the Qur'an and Shariah ruqyah on bacterial genomes, suggesting their potential use as alternative therapeutic methods. The study recommends applying this approach to other pathogenic bacterial species, using specialized primers for gene-specific investigations, and integrating Qur'anic and Shariah-based treatments in medical practices. Additionally, the research emphasizes the importance of employing genetic techniques to enhance bacterial species diagnosis and determine antibiotic resistance. This pioneering study paves the way for future investigations into the interplay between religious practices and genetic modifications in microorganisms, highlighting the absence of prior literature on this subject within the region.
EVALUATING ADHERENCE TO LIFESTYLE AMONG BREASTFEEDING WOMEN IN BABIL PROVINCE, IRAQ Shabib, M.Sc, Mahmoud Abbas; Ahmed, PH.D, Jabbar Taresh; Alshawi, Ph.D, Raya Habeeb Abdil Imam
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 8 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i8.813

Abstract

Background: Lactating mothers are more likely to have nutritional deficiencies and changes in lifestyle during breastfeeding because of altered eating habits, physiological changes, and a variety of sociodemographic variables. Objective: The study aims to assess the impact of lifestyle factors on lactating women and to determine the relationship between socio-demographic variables and the overall lifestyle score. Materials and methods: This study is a descriptive cross-sectional study conducted on 348 mothers selected randomly to evaluate the impact of lifestyle factors on lactating mothers and their infants lower six months during 2023 in primary health care centers in Babylon governorate. The study period was conducted from August 1st to December 1st, 2023. Results: The results of this research indicate that 86% (n=301) of participants had poor lifestyle scores. 14% (n=47) of them have a good lifestyle score, which is the lowest number. Also, these results reveal that urban residents had much higher lifestyle scores than rural. Higher education levels correlated with higher lifestyle scores. Read-and-white students had the fewest high scores compared to high educational level (P. value <0.05). Conclusion: The study indicated that the majority of breastfeeding mothers have poor levels of adherence to a healthy lifestyle. Targeted educational initiatives should educate and assist nursing moms, especially those with lesser education, on the significance of a healthy lifestyle during lactation.
EVALUATION FOR MOTHERS' PRACTICES TOWARDS CARING FOR THEIR CHILDREN WITH EPILEPSY Sadiq, Israa Musa Jaafar; Al-Ogaili, Professor Dr. Shukriya Shadhan
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 8 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i8.815

Abstract

Background: Epilepsy is classified as a neurological condition impacting the nervous system, characterized by spontaneous seizures that occur on a regular basis with varying occurrence and severity. The study aimed to assess the level of mother’s practices regarding epileptic among children in Babylon province. Materials and methods: This descriptive and analytical cross-sectional study was conducted at Babil Teaching Hospital for Maternity and Children's EEG unit, emergency wards, and neurological consultation ward. A purposive sample of 100 mothers was selected. Closed-ended questions were asked to each woman in direct interviews. The study was conducted for period from November 2023 to February 2024 is the study period. Results: The results found that 35.0% of mothers belonging to age group (29-34 years). The results found that the highest percentage was 71% of those with moderate practice, followed by 17% with poor practice, and 12% with good practice. Also, the results report that the mothers whom were sufficient family income, live in urban and have higher education level, were with the better practices score (P. value <0.05). Conclusion: The study concluded that the majority of mothers in Babil Governorate have moderate practices of epilepsy. The results also revealed that sufficient family income, mothers living in urban areas, and higher education were associated with a good degree of practices. Educating the public about epilepsy through the mass media could go a long way in reducing the morbidity and mortality associated with this problem
ASSOCIATION BETWEEN SERUM FERRITIN LEVEL AND LIVER FUNCTION TESTS IN CHILDREN WITH BETA-THALASSEMIAIN THALASSEMIA CENTER OF KUT HOSPITAL Jabbar, Hawraa Fadhil; Attafi, Fadhil J; Kadhim, Emad Jawad; Jarallah, Kareem Raheel
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 8 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i8.816

Abstract

Background:Thalassemia represents a heterogeneous autosomal recessive hereditary anemia.Ferritin is a 450 KDa soluble protein. It can be found in all of the body's cells, but it's particularly abundant in marrow macrophages, spleen, and liver. Objective:In patients with β thalassemia major and β thalassemia Intermedia, serum ferritin levels are measured, and their correlation with bilirubin levels, liver enzymes AST (aspartate transaminase) and ALT (alanine transaminase), in beta-thalassemia major and β thalassemia Intermedia. Patients and Methods:A cross-section study that involved 90 patientsincluded 50 Thalassemia Major (TM) and 40 Thalassemia intermediate(TI). Patients who were randomly chosen for this study would be gathered from the Kut Hospital Thalassemia Center. Every patient's are kid, aged 5 to 17, regardless of gender. Abbott C4000 Architect Additionally, the TSB, ALT, AST, and serum ferritin were determined using the Cobas c 111 analyzer. Results:The studies include both genders 52.9% of the females had B-thalassemia major and 47.1% had β-thalassemia intermediate, whereas 57.1% of the men had βTM and 42.9% had βTI. There were 37.8% of females and 62.2% of males in the sample.Patients with severe thalassemia exhibited a statistically significant increase in the mean± SD of serum ferritin (4016.54 ± 2500.81 ng/ml) compared to the mean ± SD of β-thalassemia intermedia (1629.48 ± 1235.33 ng/ml), with a p-value of 0.000. Patients with major β-thalassemia had a mean TSB level that was statistically significantly lower (1.32 ± 0.69 mg/dl) than the mean level of β-thalassemia intermedia (2.10 ± 0.86 mg/dl), with a p-value of 0.000. In the B-thalassemia major group, serum hepcidin did not exhibit a statistically significant association with serum ferritin (r=-0.04), while in the B-thalassemia intermedia group, serum ferritin exhibited a statistically significant moderate negative correlation with TSB (r=-0.38), p-value. 0.01.Conclusions:Ferritin levels may be useful in thalassemia syndrome diagnosis and prognosis determination
BIOCHEMISTRY OF DNA: A STUDY OF CHEMICAL EFFECTS ON GENE EXPRESSION Ubead, Mina Hussein; Mahdi, Haneen Hussein Rahim; Abbass, Haneen Abbass Majeed; Faisal, Eman Maher Khalil; Faisal, NoorAl-Huda Maher Khalil; nayel, Athraa Bassem Mohammed
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 8 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i8.820

Abstract

The study of DNA biochemistry is pivotal to understanding the molecular mechanisms that govern gene expression. This research delves into the intricate chemical processes that influence DNA structure, function, and regulation. By examining the interplay between DNA and various chemical agents, such as methylating and acetylating compounds, we explore how these modifications impact gene expression. Our investigation encompasses both endogenous factors, like natural metabolic byproducts, and exogenous influences, including environmental toxins and pharmaceuticals. Through a combination of advanced biochemical techniques and computational modeling, we aim to elucidate the pathways through which chemical modifications alter gene expression patterns. This comprehensive analysis not only enhances our understanding of fundamental genetic processes but also provides insights into the development of novel therapeutic strategies for genetic and epigenetic disorders. The findings underscore the significance of chemical interactions in gene regulation and highlight potential avenues for targeted interventions in disease treatment and prevention.

Page 17 of 38 | Total Record : 372

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