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Journal of Medical Genetics and Clinical Biology (JMGCB)
Published by Antis Publisher
ISSN : -     EISSN : 30321085     DOI : https://doi.org/10.61796/jmgcB
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing
Journal of Medical Genetics and Clinical Biology is a peer-reviewed forum for advances at the intersection of human genetics and clinical medicine. The journal welcomes original research, reviews, brief reports, and case reports that translate genomic discoveries into clinical utility—spanning diagnostic workflows, risk stratification, therapeutic decision-making, and implementation in real-world care. Areas of interest include Mendelian and complex disorders, cancer genetics, pharmacogenomics, biomarkers, clinical genomics (panel testing, WES/WGS), bioinformatics and data integration, as well as ethical and counseling considerations. By bridging molecular insights and bedside applications, the journal aims to support precision health and improve outcomes across diverse patient populations.
Arjuna Subject : Imunologi dan Mikrobiologi (semua kategori) - Imunologi dan Mikrobiologi (Lain-Lain)
Articles 372 Documents
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REVEAL OF CERTAIN ADIPOKINES (ADIPONECTIN AND LEPTIN) AND PHYSIOLOGICAL PARAMETERS LEVELS IN WOMEN WITH INFERTILITY AlSadoon, Asawer Kareem
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 8 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i8.854

Abstract

Adipose tissue produces adipokines, and adipocytes have an impact on the reproductive organs through the production of adiponectin and leptin. Therefore, it is essential to evaluate adipokines and sex hormones in order to have a deeper understanding of infertility. Thus, the goal of the current study was to assess adipokines and biochemical markers in infertile patients. In this study, 65 women between the ages of 17 and 40 years old (mean: 27.8±4.08 years) were included. All were consecutively admitted to the clinic at AL-Kut Hospital for Gynecology Obstetrics and Pediatrics (infertility center) at February to May 2024. All women had infertility as diagnosed by the physician. also, this study including 40 healthy women as control group. The results showed that the concentrations of follicle stimulating hormone (7.42±0.13) and luteinising hormone (LH) (7.13±0.25) in serum of infertility women indicated a significant (P <0.05) rise in contrast to healthy women (5.037.42±0.29; 3.657.42±0.16). The levels of MDA (1.93±0.11) demonstrated significant (P <0.05) increase and GSH (0.371±0.027) decreased in infertility women compared with healthy women (1.22±0.09; 0.441±0.014). Adiponectin concentration in serum of infertility patients (4.55±0.19) indicated non-significant (P <0.05) variations in contrast to healthy women (4.61 ± 0.23). the concentration of leptin indicated a significant (P <0.05) rise in infertility women (14.83 ±1.92) in contrast to healthy women (5.48 ±0.41). It is concluded from the study that there was also an imbalance in the case of oxidative stress. On the other hand, it was noted that there is a correlation between leptin levels and infertility in women
ISOLATE AND DIAGNOSE CANDIDA ALBICANS FROM WOMEN WITH VULVOVAGINAL CANDIDIASIS AND ESTIMATE THE LEVELS OF SOME CYTOKINES Hussein, Anmar Sael; Ahmad, Ghfran Ayad
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 8 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i8.855

Abstract

Candida albicans is the opportunistic mucosal infection that causes vulvovaginal candidiasis, which affects a lot of otherwise healthy women who are of childbearing age. So, the current study aimed to isolate and diagnose C. albicans from women with Vulvovaginal candidiasis and estimate the levels of some cytokines. Vaginal and blood samples were collected from women attending Salah al-Din Teaching Hospital, Department of Obstetrics and Gynecology - Consultation Clinic, and two groups of women were selected. The first group includes 200 women suffering from infections and their ages range from 18-59 years, and a second group of healthy women (40 women) whose ages range from 17-50 years for the period from November 2023 to May 2024. 200 samples were directly inspected under a microscope; of these, 58(29.0%) were found to be positive and 142(71.0%) to be negative. On the other hand, the Human C. albicans ELISA Kit was used for the purpose of detecting positive cases and their percentage. The results found that out of 200 women suffering from vaginitis, it was found that 27.5% were positive on the test, while the negative percentage of the test was 72.5%. for cytokines, IL-10 levels in serum of patients (37.15± 5.04) demonstrated significant (P <0.05) increase in compared with healthy subjects (14.94± 1.78). the levels of IFN-γ demonstrated significant (P <0.05) increase in patients (158.74 ± 12.55) compared with healthy subjects (39.13 ± 4.25). It is concluded that using the ELISA method is the best compared to traditional methods for diagnosing C. albicans, and vulvovaginal candidiasis led to an increase in the secretion of both IL-10 and IFN-γ for the purpose of raising the immune response
THE PRESENCE OF HEAVY METALS IN USED CLOTHES AND THEIR IMPACT ON HUMAN HEALTH Odeh , Duha yousif Aziz; jead , Ahmed Radiy shimran jead; hasen, Mohammed taha sahb; Hassoun, Mohammed Taqi Abbas Abboud; Mohammed , Ahmed khuder abd Al Akhwa
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 8 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i8.856

Abstract

The research aims to detect the presence of heavy elements in used clothes and to educate people about their dangers and the diseases they carry in order to provide some solutions and recommendations for this problem. To achieve this goal, laboratory tests (atomic spectrometer) were conducted, which included 12 samples from different areas of Diwaniyah Governorate on 2/2/2021. The samples came in varying proportions. The percentage of arsenic increased in the intersection street by 30% and decreased in Alawi Street by 25%. As for the cadmium element, its concentration increased in Alawi Street by 20% and decreased in Alawi Street by 10%. As for lead, its percentage increased in the intersection street by 15% and decreased in Alawi Street by 10%. This difference is due to the presence of a fuel filling station behind the intersection street, so the percentage was greater. The quality of the clothes was estimated to be low, bad and dangerous to human health. Therefore, we recommend the necessity of carrying out sterilization operations and increasing monitoring of the places of their import and display to ensure the efficiency of the treatment and sterilization facilities
THE EFFECT OF PH ON THE RESISTANCE OF PROTEUS MIRABILIS BACTERIA TO ANTIBIOTICS Soltan, Zahraa Majed Ali; Mohammed, Aisha Muhand Fadhel; Kariz , Wijdan Rahim Abed; Obaid, Yasser Ammar Hussein; Hussein, Saja Abbas Burhi
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 8 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i8.857

Abstract

Twenty-six bacterial isolates of Proteobacteria were isolated from patients with urinary tract infections from several hospitals in Babylon province. Urine samples were collected from patients with urinary tract infections, then these samples were grown on different culture media and identified by several biochemical tests. Also, their drug sensitivity was studied using nine types of antibiotics. The drug sensitivity of these samples was studied at acidic, neutral and basic pH using disk diffusion method. The study showed that ciprofloxacin and azithromycin had high activity against bacteria at both acidic and neutral pH, while amikacin, meropenem, imipenem and ciprofloxacin had high activity at basic pH against these bacteria
IONIZING RADIATION AND ITS BIOLOGICAL EFFECTS rhaif , Maryam zaman jabbar; Fnkhyr, Najlaa Hamed Anad; a’arebe, Dhuha Adnan Sultan; Oda , Naba’a Jabbar Farhan; Ali, Fatima kareem Mohammad
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 8 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i8.858

Abstract

Ionizing radiation is a type of energy released by certain atoms in the form of electromagnetic waves or particles. People are exposed to natural sources of ionizing radiation, including those found in soil, water, and plants, and to other man-made sources such as X-ray machines and medical devices. Ionizing radiation has many useful applications, including its uses in areas such as medicine, industry, agriculture, and research. As the use of ionizing radiation increases, so does the potential for health risks if it is not used or contained properly. Acute health effects such as skin burns or acute radiation syndrome can occur when radiation doses exceed very high levels. Exposure to low doses of ionizing radiation can increase the risk of long-term effects, such as cancer. The first chapter discussed the importance of radiation, its sources, types, and methods of protection from it. The second chapter discussed the effects of radiation, including biological effects and their impact on humans. In the third chapter, we discussed in detail how to protect against radiation. Finally, through what we discussed in the research, we reached the most important conclusions and also the most important recommendations
STUDY OF BIOCHEMICAL CHANGES IN KIDNEY AND LIVER FUNCTIONS IN THE BLOOD SERUM OF RATS TREATED WITH DIANABOL Eidan, Akram Hussein Rahim; awesy, Mohammed Abdulamer dayan; khalel , Amna ghanam ahmad; Shaalan , Teeba Taha Abd; Touma, Samah Hadi Khalibis
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 8 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i8.859

Abstract

The current study aimed to reveal the cytogenetic effects of Methandienone in white mice Mus Musculus, which is widely used in gyms, by studying some blood images through tests by choosing a third of the dose (0.8) mg/kg of the body weight of the laboratory mouse. The results showed that the increase in the drug has the ability to produce _____ white blood cells and ___ red blood cells at an equal rate. In conclusion, the results of this study show that the drug has mutagenic effects.
VITEK2 BASED DIAGNOSIS AND CHARACTERIZATION STAPHYLOCOCCI AERUS STRAIN CAUSING URINARY TRACT INFECATION IN FEMAL AND MALE Jaber, Salim Abdul Amir
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 8 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i8.860

Abstract

Background, The aim of this study was to assess the clinical presentation, risk factors, and comorbidities of the patients with Staphylococcus aureus bacteriuria, and to analyze the antimicrobial susceptibility data of S. aureus isolated from their urine samples. Methods, A total of 80 isolates of S. aureus were collected from patients with urinary tract infections (UTIs)in hospital Refai. Urinalysis was performed manually, including macroscopic examination of color and appearance, and microscopic examination for the presence of urinary pus cells, and bacteria and culture on MaCconky agar,Blood agar. Full diagnosis and susceptibility testing of S. aureus were performed by the VITEK 2 system (BioMérieux, Marcy-l'Étoile, France) using standard criteria. Results, The majority of the patients were female (50), with a mean age of 30 years and male(30) mean ageof45 years . Most of the patients were inhospatial . Seventy positive urine cultures were associated with UTI symptoms. ButTen negative urine cultures. Conclusion, Although S. aureus UTI is known to be associated with other risk factors such as urinary catheterization, long hospital stay, or complicated UTI, our results show the community-acquired presentation of UTI. Trimethoprim-sulfamethoxazole may be used as an effective treatment for UTI caused by S. aureus. S. aureus UTI could be an alarming sign of more invasive infections such as S. aureus bacteremia, though clinical evaluation and finding the source of S. aureus are crucial for effective treatment and prevention of further complications
THE ASSOCIATION OF SERUM VITAMIN D AND SUPEROXIDE DISMUTASE LEVEL IN WOMEN WITH POLYCYSTIC OVARY SYNDROME Muhammad, Muhammad Abd al-Qahar; Zughair, Nada Khaled; Mahdi, Ruqayyah Khalil; Mohsen, Amna Farouk; Blais, Roaa Qasim; Blais, Russul Qasim
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 8 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i8.863

Abstract

Objective: This study aimed at investigating the association of serum vitamin D and superoxide dismutase level in women with polycystic ovary syndrome (PCOS) as well as non-PCOS healthy ovulatory women. Methods: A total of 20 patients with polycystic ovaries and 20 of their age matched healthy control participates was included in this study. The patient samples were collected from women who reproductive age between 18 and 40 with PCOS. Results: The results of the current study showed a high level of SOD enzyme concentration versus decrease in the level of vitamin D in the PCOS patients compared to the healthy group. Conclusion: There is an opposite effect of superoxide dismutase level and vitamin D on polycystic ovary syndrome (PCOS).
MUTATIONS AND DRUG RESISTANCE IN MALARIA, TOXOPLASMOSIS AND GIARDIASIS: A REVIEW OF CURRENT CHALLENGES AND MECHANISMS Mohammed, Othman M; Noori, Saif Subhi; Salam, Ibrahim
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 8 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i8.878

Abstract

This study addresses the growing threat of drug resistance in malaria, toxoplasmosis, and giardiasis by analyzing the underlying genetic mutations that compromise the efficacy of current treatments. Understanding these mechanisms is crucial for developing more effective therapeutic strategies. A comprehensive review of literature was conducted to identify key mutations associated with drug resistance. In malaria, the focus was on mutations in genes like Pfmdr1, Pfcrt, Pfmrp, and Pfnhe1, which are linked to resistance against antimalarials, particularly the K76T mutation in PfCRT for chloroquine resistance. For toxoplasmosis, mutations in the DHFR-TS and DHPS genes were analyzed, particularly the T83N mutation in DHFR-TS, which confers resistance to pyrimethamine. In giardiasis, the study reviewed mutations in the ferredoxin oxidoreductase gene that reduce the efficacy of metronidazole. The analysis revealed that specific mutations in these parasites significantly contribute to the development of drug resistance, complicating treatment protocols. In malaria, PfMRP1 mutations are particularly concerning due to their role in resistance to both chloroquine and quinine. Toxoplasmosis resistance is notably influenced by DHFR-TS and DHPS mutations, while giardiasis resistance is linked to alterations in drug transport and enzyme function. This study synthesizes the most recent findings on genetic resistance mechanisms in these three parasitic diseases, offering insights that could inform the development of next-generation therapies and improve resistance management strategies, ultimately contributing to better health outcomes.
ESTIMATE OF BONE BIOMARKER ON OSTEOPOROSIS IN IRAQI POSTMENOPAUSAL WOMEN AlSahib, Zainab qasim Abd; Ali, Muataz Hussein
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 8 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i8.886

Abstract

Background; Osteoporosis (OP) is a chronic and a progressive disease characterized by low bone mass and micro-architectural deterioration of bone tissue, resulting in an increased risk of fracture .Dual-energy X-ray absorptiometry (DXA) is commonly used for diagnosis of osteoporosis. Bone turnover markers have advantages over DXA, as they are cheap, non-invasive and can detect changes in bone turnover rates earlier. Aims of the study: to investigate the significance of bone turnover biochemical markers; serum parathyroid, serum osteopontin and Vitamin D3 in evaluating osteoporosis for postmenopausal Iraqi women with and without history of vertebral fracture, as well as to explore the relationship of these markers with bone mineral density (BMD). Methodology: Forty-four (85) postmenopausal women were included in this study with age range (45-70years). Subjects were divided into three groups: osteoporosis postmenopausal women: (n=45), osteopenia postmenopausal women: (n=24) and healthy postmenopausal women (n=16) (serve as controls). Patients were diagnosed as osteoporosis and controls as normal by measuring bone mineral density (BMD), using dual energy x-ray absorptiometry (DXA). In addition, serum calcium, phosphorous and alkaline phosphatase measured by spectrophotometer. Result; BMD and T-score were significantly lower in osteoporotic postmenopausal group as compared with healthy group (p=0.009) (p=<0.001). Serum ALP levels were elevated significantly in osteoporotic postmenopausal group as compared with healthy group (p=<0.001). Serum Ca levels and serum PO4 levels were elevated significantly in Healthy postmenopausal group as compared with osteoporotic group (p=0.65) (p=0.957). Conclusions: The levels of ALP in serum could be used as a biochemical indicator in the early diagnosis of osteoporosis postmenopausal women.

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