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Mochamad Nashrullah
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Journal of Medical Genetics and Clinical Biology (JMGCB)
Published by Antis Publisher
ISSN : -     EISSN : 30321085     DOI : https://doi.org/10.61796/jmgcB
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing
Journal of Medical Genetics and Clinical Biology is a peer-reviewed forum for advances at the intersection of human genetics and clinical medicine. The journal welcomes original research, reviews, brief reports, and case reports that translate genomic discoveries into clinical utility—spanning diagnostic workflows, risk stratification, therapeutic decision-making, and implementation in real-world care. Areas of interest include Mendelian and complex disorders, cancer genetics, pharmacogenomics, biomarkers, clinical genomics (panel testing, WES/WGS), bioinformatics and data integration, as well as ethical and counseling considerations. By bridging molecular insights and bedside applications, the journal aims to support precision health and improve outcomes across diverse patient populations.
Arjuna Subject : Imunologi dan Mikrobiologi (semua kategori) - Imunologi dan Mikrobiologi (Lain-Lain)
Articles 372 Documents
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THE ROLE AND IMPORTANCE OF BIOMEDICAL ENGINEERING IN UZBEKISTAN, AND THE PRINCIPLES OF ITS DEVELOPMENT qizi, Olishova Risolat Abduvali
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 1 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i1.1125

Abstract

Objective: This study examines the role, significance, and principles of biomedical engineering (BME) development in Uzbekistan, emphasizing its impact on healthcare modernization and technological innovation. Method: The research employs a multidisciplinary analysis, integrating insights from medical and engineering sciences, to assess the contribution of BME to healthcare technologies and specialist training. Results: The findings reveal that BME is pivotal in equipping Uzbekistan's healthcare sector with advanced technologies, fostering new treatment methods, and supporting local production of competitive medical devices. Furthermore, the integration of multidisciplinary approaches and innovative technologies has enhanced the sector’s capacity to address complex healthcare challenges and expand its international presence. Novelty: This study underscores the strategic importance of BME in bridging medical and engineering disciplines to promote healthcare and economic development in Uzbekistan. It highlights the untapped potential of BME to revolutionize the country's healthcare system and create opportunities for global competitiveness, contributing to a sustainable healthcare infrastructure and economic growth.
OPTICAL COHERENCE TOMOGRAPHY IN DIAGNOSTICS OF OPTIC NERVE DISEASES Dilfuza Zuhridinovna, Jalalova; Abbos, Olimov
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 2 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i2.1132

Abstract

Objective: To evaluate the efficacy of optical coherence tomography (OCT) in detecting early-stage eye diseases by providing high-resolution images of critical eye structures, including the retina, lens, and optic nerve. Methods: The study highlights the use of OCT during routine eye examinations to monitor asymptomatic changes in individuals, particularly those over 35 years old, when age-related structural changes in the eye are more prevalent. Results: OCT delivers detailed imaging of eye tissues, enabling clinicians to identify minor abnormalities that are imperceptible during standard examinations. This capability enhances early detection rates for conditions that develop without visible symptoms. Annual eye exams combined with OCT are particularly valuable for detecting early markers of potentially severe diseases. Novelty: This study underscores the critical role of OCT in preventive ophthalmology, emphasizing its unmatched precision in diagnosing age-related changes in eye structures before symptoms manifest, thus bridging the gap between routine check-ups and advanced diagnostic procedures.
THE PREVALENCE OF URINARY TRACT INFECTIONS AND THE AGENTS RESPONSIBLE FOR THEM IN PREGNANT WOMEN IN THE PROVINCE OF KARBALA Muhanna Redha, Huda; Jawad Hussein , Basim; Abbas Sadiq Alqaisi, Ali; Kadhim Hamadan, Wisam; Hadi Obiad , Zahraa; Jalal Abood , Ali
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 2 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i2.1138

Abstract

Objective: This study aimed to determine the prevalence of urinary tract infections (UTIs) and identify the uropathogens present in pregnant women. Methods: A total of 417 midstream urine samples were collected and examined between December 2021 and August 2022. The diagnosis of UTI was established when a urinary tract pathogen exhibited growth of at least 10510^5105 CFU/ml in culture. Isolated microorganisms were identified using biochemical assays. Results: The findings revealed that 49.4% of the pregnant women had a UTI. Among the isolated organisms, E. coli was the most prevalent (56.79%), followed by Proteus sp. (5.8%), Pseudomonas sp. (6.3%), and Klebsiella sp. (19.9%). Novelty: This study provides updated insights into the prevalence and microbial profile of UTIs among pregnant women, highlighting the dominance of E. coli as the leading uropathogen during pregnancy.
MOLECULAR IDENTIFICATION OF SOME SPECIFIC VIRULENCE GENES IN ESCHERICHIA COLI RESPONSIBLE FOR UTIS Humada, Yasser Hamad
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 2 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i2.1144

Abstract

Objective: This study aimed to determine the phylogroups and specific virulence genes of uropathogenic Escherichia coli (UPEC) in patients suspected of urinary tract infections (UTIs) at Al-Hawija General Hospital in Kirkuk. Methods: A total of 120 urine samples were collected from patients exhibiting clinical signs of UTIs. The presence of bacteria was confirmed using light microscopy and bacterial cell identification techniques. Positive samples underwent bacterial cultivation and DNA extraction using a specialized kit. Polymerase chain reaction (PCR) analysis was performed to identify virulence factor genes (chuA, fimH, uidA, and arpA) associated with pathogenicity. Results: Of the 120 analyzed samples, 90 (75%) showed bacterial growth, with 25 (27.78%) from males and 65 (72.22%) from females. PCR analysis confirmed the presence of virulence genes in E. coli isolates, linking these genes to the bacteria's role in causing UTIs. Novelty: This study provides a comprehensive analysis of UPEC phylogroups and virulence genes in UTI patients, highlighting gender-based prevalence. The use of PCR to identify pathogenic genes offers valuable insights into the molecular mechanisms of UPEC, which could inform future diagnostic and treatment strategies.
THE SPECTRUM OF SENSITIZATION TO AEROALLERGENS AS ONE OF THE RISK FACTORS FOR UNCONTROLLED SEVERE BRONCHIAL ASTHMA Shakhnoza Abdurasulovna, Ikramova
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 2 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i2.1146

Abstract

Objective: To evaluate the significance of the spectrum of sensitization to aeroallergens in adult patients with severe bronchial asthma as risk factors for uncontrolled disease progression. Methods: An observational, single-center, cross-sectional study was conducted involving 93 patients diagnosed with severe bronchial asthma. The study examined qualitative and quantitative indicators, including demographic characteristics and comorbid diseases. These factors were analyzed to identify their impact on achieving controlled disease progression. Results: The analysis identified a significant association between aeroallergen sensitization and the difficulty of achieving disease control in patients with severe bronchial asthma. Specific aeroallergens were found to exacerbate symptoms, complicating disease management and increasing the likelihood of uncontrolled progression. Demographic and comorbid factors further amplified these risks, highlighting the multifactorial nature of disease management challenges in this patient population. Novelty: This study underscores the critical role of aeroallergen sensitization in the progression of severe bronchial asthma. By isolating the impact of aeroallergens and integrating demographic and comorbid factors, this research provides a comprehensive perspective on risk assessment and offers potential pathways for improved disease management strategies.
COMPARISON OF TOTAL SERUM GLUCOSE AND CREATININE LEVELS IN DIABETES MELLITUS PATIENTS WITH COMPLICATIONS AND WITHOUT COMPLICATIONS OF CHRONIC KIDNEY DISEASE Jannah , Shofiatul; Ardiansyah, Syahrul
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 1 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i1.1147

Abstract

Objective: Diabetes is a chronic metabolic condition characterized by blood sugar levels that exceed the normal threshold. This increase in blood sugar levels is caused by insulin abnormalities. In diabetes mellitus, glucose and creatinine levels increase due to thickening of the basement membrane and enlargement of the glomerulus. This research used a laboratory experimental design using quantitative methods. The research subjects were Diabetes Mellitus sufferers aged over 60 years and over with a total of 30 diabetes mellitus patients accompanied by complications and 30 diabetes mellitus patients without Chronic Kidney Disease complications. The research data shows a significant value of p=0.00 (p<0.05), which means there is a comparison between the total levels of fasting blood glucose and serum creatinine in Diabetes Mellitus patients with complications and those without Chronic Kidney Disease complications.
HELICOBACTER PYLORI VACA, CAGA, ICEA1, AND ICEA2 GENOTYPES IN GASTROINTESTINAL DISEASES PATIENTS FROM MOSUL/IRAQ Abdul-Ghani Muhammad, Muhammad; Ahmed Abdullah, Basima; Ahmed Altaie, Anmar
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 2 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i2.1152

Abstract

Objective: Helicobacter pylori is a key cause of gastroduodenal disorders, with cagA-positive strains linked to gastric cancer primarily in Western populations. Other virulent genes may enhance the effects of cagA in disease development. This study sought to identify common H. pylori virulence genes in patients with gastrointestinal disorders. Methods: Biopsy specimens were collected from 100 patients. All DNA samples underwent PCR to confirm H. pylori infection, with positive samples further genotyped. Each PCR reaction used specific primers. Results: EGD findings indicated abnormalities in 89% of patients and normal results in 11%. The gene detection rate was 77%. Analysis of 77 samples showed virulence gene prevalence as 40.3% for cagA, 46.8% for iceA1, and 31.2% for iceA2, with 76.6% containing vacA. The vacA gene was the most common, except in normal findings, where iceA1 was second, followed by cagA and iceA2. High vacA positivity was noted across various conditions, while cagA and iceA2 were absent in some patient groups. A 100% positivity rate for iceA1 was observed in patients with combined gastritis and gastric ulcers. The combination of cagA, iceA1, and vacA was observed in 20.8% of cases, while vacA and iceA1 appeared in 18.2% and vacA and iceA2 in 14.3%. Furthermore, the combination of cagA, iceA2, and vacA was found in 9.1% of cases. Conversely, the combined genotypes of cagA with iceA1, iceA2, and vacA were present at lower frequencies of 2.6%, 3.9%, and 3.9%, respectively. The individual occurrence of virulence factors varied, with vacA present in 10.4% of cases, iceA1 in 5.2%, and iceA2 in 3.9%. Additionally, cagA, iceA1, iceA2, and vacA genes were absent in 7.8% of cases. Novelty: This study reveals unique H. pylori virulence gene combinations and prevalence in Mosul, Iraq, offering regional-specific insights.
ISOLATION AND MOLECULAR DIAGNOSIS OF ACINETOBACTER BAUMANNII STRAINS FROM VARIOUS CLINICAL SAMPLES AND THEIR CULTURAL PROPERTIES Waleed Hadi, Huda; AL Sammak , Essra Ghanim
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 2 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i2.1153

Abstract

Objective: For the optimal and accurate isolation of Acinetobacter baumannii bacteria, which are considered bacteria are increasingly serious health problem in the healthcare community, especially immunosuppressed people and residents' patients' hospital, due to its high resistance to antibiotics. Methods: Accordingly, 300 clinical samples were collected from different hospitals in Mosul city from January to June 2023. They were grown on culture media such as MacConkey and Hichrome Agar for isolation purposes, the number and percentage of all isolated strains for each medium were recorded. Molecular screening was also done by recA  gene and 16S rRNA to confirm the diagnosis. Morphological and physiological characteristics were observed on other different media. Results: the 130/43.3% of A. baumannii were isolated from MacConkey medium and 119/91.5% were isolated on Hichrome medium. However, the isolation rate decreased to 15/11.5% in the case of molecular diagnosis with conservative recA gene. The highest isolation rate was from wound samples at 8.3%, followed by urine and burns at the same rate of 7.5%, then throat swabs at 6.6%, followed by sputum at 1.4%, while the bacteria were not isolated from blood, CSF and medical equipment. The morphological characteristics of the bacteria varied greatly on many media such as Eosin –methylene blue EMB medium, Mueller medium, and Nutrient Agar medium in addition to the previous media. Novelty: This research proves the molecular diagnostic ability of the recA gene in A. baumannii bacteria. While highlighting the isolation of these bacteria at the same time on a selective diagnostic medium and comparing the data of these results with each other.
THE IDENTIFICATION OF PSEUDOMONAS AERUGINOSA IN DIVERSE CLINICAL SPECIMENS AND THE PATTERN OF ANTIBIOTIC RESISTANCE IN HUMANS Muhanna Redha, Huda; Jawad Hussein, Basim; Sadiq Alqaisi, Ali Abbas; Kadhim Hamadan, Wisam; Hadi Obiad, Zahraa; Jalal Abood, Ali
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 2 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i2.1158

Abstract

Objective: This study aims to identify the pollution foci of Pseudomonas aeruginosa (P. aeruginosa) in hospital environments, utilizing a random sampling approach to collect diagnostic data from various sources in Al-Karama Teaching Hospital and Al-Hey Hospital. Methods: Eighty samples were collected, evenly distributed with 40 samples from each hospital. Biochemical and agronomic tests were conducted to identify P. aeruginosa isolates. Antibiotic sensitivity was assessed for ten isolates using the Kirby-Bauer disc diffusion method across ten antibiotic classes. Results: The tests identified ten isolates of P. aeruginosa. The antibiotic sensitivity evaluation revealed that nearly all isolates exhibited considerable resistance to the antibiotics tested, demonstrating a broad spectrum of resistance to multiple antibiotic classes. Novelty: This study highlights the prevalence of P. aeruginosa in hospital settings and its significant resistance to commonly used antibiotics, emphasizing the critical need for enhanced infection control measures and antibiotic stewardship in healthcare facilities.
NERVOUS SYSTEM DAMAGE IN HIV INFECTION AND AIDS Jasur Mukhammadi Oʻgʻli, Egamberdiev; Umid Arzikulovich, Qodirov; Sokhiba Ziyadulloyevna, Khakimova
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 2 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i2.1176

Abstract

Objective: This study aims to explore the neurological complications of HIV infection, specifically the impact of HIV on the nervous system, including the role of the glycoprotein gp120 in neuronal damage. Methods: A review of HIV-related neurological impairments, focusing on the mechanisms of viral infection and the consequences on glial and neuronal cells, was conducted. The study examines the direct and indirect damage caused by the virus and associated factors such as opportunistic infections, tumors, and the effects of antiretroviral drugs. Results: : The study finds that HIV infection affects approximately one in every hundred cells in brain tissue, significantly impacting glial cells, neurons, and other cells possessing the CD4 receptor. HIV damages these cells through direct infection and by the destructive effects of the gp120 glycoprotein, which leads to membrane lysis and neurotoxic consequences such as an increased Ca2+ ion load in astrocytes. Novelty: This research highlights the critical role of gp120 in the pathogenesis of HIV-induced neuronal damage, specifically its interference with neuroleukin and the glutamate retention mechanisms in astrocytes, which are key to understanding HIV-related neurological disorders.

Page 27 of 38 | Total Record : 372

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