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Journal of Biomedical and Techno Nanomaterials
Published by Yayasan Adra Karima Hubbi
ISSN : 30481120     EISSN : 30481155     DOI : 10.70177/jbtn
Core Subject : Science,
Biochemistry, Genetics & Molecular Biology
Journal of Biomedical and Techno Nanomaterials is an international forum for the publication of peer-reviewed integrative review articles, special thematic issues, reflections or comments on previous research or new research directions, interviews, replications, and intervention articles - all pertaining to the research fields of medicine, pharmaceuticals, biomaterials, biotechnology, diagnosis and prevention of diseases, biomedical devices, bioinformatics, and all other related fields of biomedical and life sciences. All publications provide breadth of coverage appropriate to a wide readership in Biomedical and Techno Nanomaterials research depth to inform specialists in that area. We feel that the rapidly growing Journal of Biomedical and Techno Nanomaterials community is looking for a journal with this profile that we can achieve together. Submitted papers must be written in English for initial review stage by editors and further review process by minimum two international reviewers.
Arjuna Subject : Biokimia, Genetika dan Biologi Molekuler - Biokimia, Genetika dan Biologi Molekuler (Lain-Lain)
Articles 5 Documents
 1 
Search results for , issue "Vol. 2 No. 5 (2025)" : 5 Documents clear
A 3D-PRINTED, GRAPHENE-REINFORCED HYDROGEL SCAFFOLD FOR ENHANCED OSTEOGENIC DIFFERENTIATION OF MESENCHYMAL STEM CELLS Anurogo, Dito
Journal of Biomedical and Techno Nanomaterials Vol. 2 No. 5 (2025)
Publisher : Yayasan Adra Karima Hubbi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70177/jbtn.v2i5.2761

Abstract

Bone tissue engineering requires scaffolds that replicate the mechanical stiffness and electroactive properties of native bone, features that conventional hydrogels lack. This study aimed to design, fabricate, and validate a 3D-printed graphene-reinforced hydrogel scaffold that enhances osteogenic differentiation of human mesenchymal stem cells (hMSCs) via combined mechanical and electrical stimulation. A composite bio-ink was developed by incorporating graphene nanoparticles (0, 0.1, 0.2, and 0.5% w/v) into a biocompatible hydrogel matrix, optimized for extrusion-based 3D printing. Scaffolds with a controlled pore size of 300 ?m were fabricated and analyzed for compressive strength, degradation kinetics, and electrical conductivity using a four-point probe. hMSCs were seeded onto the scaffolds and cultured under osteogenic conditions for 28 days. Osteogenic differentiation was assessed by alkaline phosphatase (ALP) activity (day 14), qPCR for RUNX2 and osteocalcin (OCN) (day 21), and Alizarin Red S staining for mineralization (day 28). Data were analyzed using ANOVA and regression modeling. The 0.2% w/v graphene-reinforced scaffolds showed optimal performance, with compressive strength of 35.0 MPa and electrical conductivity of 0.15 S/m, significantly higher than pure hydrogel controls. hMSCs cultured on these scaffolds exhibited increased ALP activity, upregulation of RUNX2 and OCN, and enhanced mineralization. At 0.5% w/v graphene, excessive viscosity hindered printability and reduced cell viability. Overall, the 3D-printed graphene-reinforced hydrogel scaffold at 0.2% w/v creates a synergistic electromechanical microenvironment, robustly promoting hMSC osteogenesis, and offers a scalable platform for next-generation bone tissue engineering.
LIPID NANOPARTICLE-MEDIATED MRNA DELIVERY FOR A NOVEL UNIVERSAL VACCINE AGAINST INFLUENZA VIRUS SUBTYPES Pradeep, Lakshan; Wijerathna, Kumudu; Perera, Dilshan
Journal of Biomedical and Techno Nanomaterials Vol. 2 No. 5 (2025)
Publisher : Yayasan Adra Karima Hubbi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70177/jbtn.v2i5.2974

Abstract

Influenza viruses continue to pose a major global health challenge due to rapid antigenic drift and shift, which limit the effectiveness of seasonal, strain-specific vaccines. Current vaccine strategies require frequent reformulation and often fail to provide broad and durable protection against diverse influenza virus subtypes. This study aims to develop a lipid nanoparticle–mediated mRNA delivery platform encoding conserved influenza antigens as a novel universal vaccine strategy. An experimental preclinical design was employed, involving in vitro transcription of mRNA, formulation into lipid nanoparticles, physicochemical characterization, and immunological evaluation in animal models. Particle size, encapsulation efficiency, mRNA expression, and stability were systematically assessed, followed by analysis of humoral and cellular immune responses and heterologous viral challenge studies. The mRNA–LNP vaccine exhibited uniform nanoscale properties, high mRNA integrity, and efficient antigen expression. Immunization induced robust cross-reactive antibody responses and strong CD4? and CD8? T-cell activation against multiple influenza subtypes. Vaccinated subjects demonstrated reduced viral loads, attenuated disease severity, and improved survival following heterologous influenza challenge. These findings indicate that lipid nanoparticle–mediated mRNA delivery of conserved influenza antigens represents a promising and adaptable platform for universal influenza vaccination, with significant potential to enhance pandemic preparedness and long-term influenza control.  
BIO-FABRICATION OF A PRE-VASCULARIZED SKIN GRAFT USING A CO-AXIAL ELECTROSPINNING TECHNIQUE AND ENDOTHELIAL PROGENITOR CELLS Rahman, Shahinur; Ahmed, Shakib; Islam, Zahidul
Journal of Biomedical and Techno Nanomaterials Vol. 2 No. 5 (2025)
Publisher : Yayasan Adra Karima Hubbi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70177/jbtn.v2i5.2976

Abstract

Severe skin injuries caused by burns, chronic wounds, and trauma remain a major clinical challenge due to limited graft survival and delayed vascular integration following transplantation. Insufficient early vascularization frequently leads to ischemia and graft failure, restricting the effectiveness of conventional tissue-engineered skin substitutes. This study aims to develop a pre-vascularized skin graft using a co-axial electrospinning technique integrated with endothelial progenitor cells to enhance early vascular functionality and graft viability. An experimental biofabrication approach was employed, involving the fabrication of core–shell electrospun fibrous scaffolds, encapsulation of endothelial progenitor cells, and comprehensive structural and biological evaluation in vitro. Scaffold morphology, porosity, and integrity were characterized, followed by assessment of cell viability, proliferation, endothelial marker expression, and formation of vascular-like networks. The results demonstrated that co-axial electrospinning produced uniform, highly porous fibrous scaffolds capable of maintaining endothelial progenitor cell viability and supporting their angiogenic behavior. Encapsulated cells exhibited sustained proliferation and organized into capillary-like structures within the scaffold matrix, while scaffold architecture remained structurally stable. These findings indicate that the proposed biofabrication strategy enables intrinsic pre-vascularization of engineered skin grafts prior to implantation. In conclusion, co-axial electrospinning combined with endothelial progenitor cells represents a promising and scalable approach for generating pre-vascularized skin grafts, with significant potential to improve graft integration and clinical outcomes in regenerative skin therapy.
BIOMIMETIC MINERALIZATION OF HYDROXYAPATITE ON A COLLAGEN-NANOFIBER COMPOSITE SCAFFOLD FOR BONE TISSUE ENGINEERING APPLICATIONS Murat Arslan; Erdo?an, Aylin; Akbulut, Baran
Journal of Biomedical and Techno Nanomaterials Vol. 2 No. 5 (2025)
Publisher : Yayasan Adra Karima Hubbi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70177/jbtn.v2i5.2977

Abstract

Bone tissue engineering seeks to develop biomaterial scaffolds that can replicate the complex hierarchical structure and biological functionality of native bone extracellular matrix. Conventional bone substitutes often fail to simultaneously achieve sufficient mechanical strength, osteoconductivity, and biological integration, limiting their effectiveness in repairing critical-sized bone defects. This study aims to develop a collagen–nanofiber composite scaffold functionalized through biomimetic mineralization of hydroxyapatite to enhance its suitability for bone tissue engineering applications. An experimental biomaterials approach was employed, involving fabrication of collagen nanofiber scaffolds followed by controlled biomimetic mineralization in simulated physiological conditions. The resulting scaffolds were characterized for morphology, mineral composition, crystallinity, and mechanical properties, and subsequently evaluated in vitro using osteogenic cell models to assess cell adhesion, proliferation, differentiation, and matrix mineralization. The mineralized scaffolds exhibited uniform nanoscale hydroxyapatite deposition, physiologically relevant Ca/P ratios, and significantly enhanced mechanical stiffness compared to non-mineralized controls. Biological assays demonstrated improved osteogenic cell attachment, elevated alkaline phosphatase activity, and increased calcium deposition on mineralized scaffolds. These findings indicate that biomimetic mineralization effectively integrates inorganic and organic phases to produce a scaffold that closely mimics native bone structure and function. In conclusion, collagen–nanofiber scaffolds mineralized with hydroxyapatite using a biomimetic approach represent a promising platform for bone tissue engineering and warrant further in vivo investigation.
QUANTUM DOTS AS NEAR-INFRARED FLUORESCENT PROBES FOR REAL-TIME IN VIVO BIOIMAGING OF CANCER CELL METASTASIS Traore, Oumar; Konate, Binta; Diarra, Fatiata
Journal of Biomedical and Techno Nanomaterials Vol. 2 No. 5 (2025)
Publisher : Yayasan Adra Karima Hubbi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70177/jbtn.v2i5.2978

Abstract

Cancer metastasis is the primary cause of cancer-related mortality, yet its dynamic progression in living systems remains difficult to visualize due to limitations of existing imaging probes. Conventional fluorescent dyes used for in vivo bioimaging often suffer from poor photostability, limited brightness, and insufficient tissue penetration, restricting their ability to capture metastatic events in real time. This study aims to develop and evaluate near-infrared-emitting quantum dots as fluorescent probes for real-time in vivo bioimaging of cancer cell metastasis. An experimental nanobiotechnology approach was employed, involving the synthesis of near-infrared quantum dots, surface functionalization to enhance biocompatibility, physicochemical and optical characterization, and biological evaluation using metastatic cancer cell lines and small animal models. Optical analysis demonstrated high quantum yield, narrow emission bandwidth, and excellent photostability within the near-infrared window. In vitro assays confirmed high cell-labeling efficiency with minimal cytotoxicity, while in vivo imaging revealed sustained and high-contrast fluorescence signals that enabled continuous tracking of cancer cell migration and organ colonization. Ex vivo validation corroborated in vivo imaging findings. These results indicate that near-infrared quantum dots provide superior performance compared to conventional fluorescent probes for dynamic metastasis imaging. In conclusion, quantum dot–based near-infrared probes represent a powerful and versatile platform for real-time in vivo visualization of cancer metastasis, offering significant potential for advancing cancer research and diagnostic imaging.

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