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Journal of Biomedical and Techno Nanomaterials
Published by Yayasan Adra Karima Hubbi
ISSN : 30481120     EISSN : 30481155     DOI : 10.70177/jbtn
Core Subject : Science,
Biochemistry, Genetics & Molecular Biology
Journal of Biomedical and Techno Nanomaterials is an international forum for the publication of peer-reviewed integrative review articles, special thematic issues, reflections or comments on previous research or new research directions, interviews, replications, and intervention articles - all pertaining to the research fields of medicine, pharmaceuticals, biomaterials, biotechnology, diagnosis and prevention of diseases, biomedical devices, bioinformatics, and all other related fields of biomedical and life sciences. All publications provide breadth of coverage appropriate to a wide readership in Biomedical and Techno Nanomaterials research depth to inform specialists in that area. We feel that the rapidly growing Journal of Biomedical and Techno Nanomaterials community is looking for a journal with this profile that we can achieve together. Submitted papers must be written in English for initial review stage by editors and further review process by minimum two international reviewers.
Arjuna Subject : Biokimia, Genetika dan Biologi Molekuler - Biokimia, Genetika dan Biologi Molekuler (Lain-Lain)
Articles 48 Documents
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Negative Impact of Gene Therapy on Melanoma Disease Inzagi, Nadhea Aurel Zalfanisa; Samasta, Nadia Azhar; A’la, Dewi Ghitsatul; Sa’id, Ibrahim Bin
Journal of Biomedical and Techno Nanomaterials Vol. 1 No. 1 (2024)
Publisher : Yayasan Adra Karima Hubbi

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Abstract

The incidence of melanoma is rapidly increasing worldwide, posing a significant public health problem. Gene therapy for treating diseases has been discovered since 1989. Research developments to make gene therapy an effective treatment method are ongoing. Primary extracutaneous melanoma can be ocular, gastrointestinal, mucosal, leptomeningeal, genitourinary, and lymphatic. The relationship between ultraviolet (UV) exposure and the development of melanoma is highly acute and complex, and intermittent sun exposure significantly increases the risk of melanoma. It is the fifth most common type of cancer in men and the sixth in women. Mucosal melanoma is a rare disease that differs from melanoma arising elsewhere in the body. Although melanocytes are most abundant in the skin, they can also be found in smaller numbers in mucous membranes and the eyes. There are epidemiological, genetic, and physiological differences between melanomas arising from melanocytes in these various locations, and these differences have important implications for both disease prognosis and treatment.
Comparative Analysis of Biomaterials and Biodevices Utilized in Cardiac Surgery: A Multinational Study Goldstein, Grace; Rachel, Vaishnaw; Neeshi, Bulczynski
Journal of Biomedical and Techno Nanomaterials Vol. 1 No. 1 (2024)
Publisher : Yayasan Adra Karima Hubbi

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Abstract

Cardiac surgery is a critical field where the selection of biomaterials and biodevices can significantly impact patient outcomes. Different countries utilize various biomaterials and biodevices in cardiac procedures, influenced by factors such as technological advancement, regulatory environments, and healthcare infrastructure. Understanding the comparative effectiveness of these materials and devices across different regions is essential for optimizing patient care. This study aims to conduct a comparative analysis of biomaterials and biodevices used in cardiac surgery across multiple countries. The research seeks to evaluate the effectiveness, safety, and patient outcomes associated with these materials and devices, providing insights into best practices and potential areas for improvement. A mixed-methods approach was employed, combining quantitative data from clinical trials and patient records with qualitative insights from healthcare professionals. Data were collected from cardiac surgery centers in the United States, Germany, Japan, and Brazil. Quantitative measures included patient recovery rates, complication rates, and device longevity. Qualitative data were gathered through interviews and surveys with surgeons and medical staff, focusing on their experiences and perceptions of the materials and devices used. The study found significant variations in the effectiveness and safety of biomaterials and biodevices across different countries. Biomaterials used in Germany and Japan showed higher patient recovery rates and lower complication rates compared to those used in the United States and Brazil. Differences in regulatory standards, technological access, and surgeon preferences were identified as key factors influencing these outcomes. Qualitative data indicated a preference for locally produced devices in Japan and Germany, attributed to higher perceived quality and reliability. This multinational study highlights the disparities in the use and outcomes of biomaterials and biodevices in cardiac surgery. The findings suggest that adopting best practices and high-quality materials from countries with superior outcomes could enhance patient care globally. Further research and international collaboration are recommended to standardize the use of biomaterials and biodevices, ensuring optimal patient outcomes in cardiac surgery.
Innovations in Nanomedicine for Diabetes Management: Insights from Cross-Continental Research Joan, Hullavarad; Braley, Emily; Denise, Zheng
Journal of Biomedical and Techno Nanomaterials Vol. 1 No. 1 (2024)
Publisher : Yayasan Adra Karima Hubbi

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Abstract

Diabetes is a global health challenge affecting millions worldwide. Traditional diabetes management approaches, while effective, often face limitations in terms of precision, efficacy, and patient compliance. Recent advancements in nanomedicine offer promising solutions to these challenges by enabling targeted drug delivery, enhanced monitoring, and improved therapeutic outcomes. This study aims to explore the latest innovations in nanomedicine for diabetes management and evaluate their effectiveness through cross-continental research. The aim is to identify critical advancements, compare their efficacy across different populations, and provide insights into their potential global impact. A comprehensive literature review and meta-analysis covered research studies from North America, Europe, and Asia. Data were collected on various nanomedicine-based interventions, including nanoparticle drug delivery systems, nano biosensors, and nanotherapeutics. The effectiveness of these innovations was assessed based on parameters such as blood glucose control, complication reduction, patient adherence, and overall health outcomes. The analysis revealed that nanomedicine-based interventions significantly improve diabetes management across all studied populations. Nanoparticle drug delivery systems demonstrated enhanced bioavailability and sustained insulin release, improving blood glucose control. Nanobiosensors provided high accuracy in real-time monitoring of glucose levels, improving patient adherence to treatment regimens. Nanotherapeutics showed potential in reducing diabetes-related complications, such as neuropathy and retinopathy, through targeted action and minimal side effects. Innovations in nanomedicine present a transformative approach to diabetes management, offering improved efficacy, precision, and patient compliance. The cross-continental research highlights the universal benefits of these advancements despite regional differences in healthcare infrastructure and patient demographics. Further research and collaboration are recommended to optimize these technologies for broader clinical applications and address remaining implementation challenges.
Structural Variations in Nucleic Acids Across Different Populations: A Comparative Study Sahil, Ziming
Journal of Biomedical and Techno Nanomaterials Vol. 1 No. 1 (2024)
Publisher : Yayasan Adra Karima Hubbi

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Abstract

Structural variations in nucleic acids play a crucial role in genetic diversity and disease susceptibility among different populations. Understanding these variations provides valuable insights into human evolution, genetic predisposition to diseases, and responses to treatments. A comparative study of structural variations across populations is essential to identify population-specific genetic patterns. This study aims to analyze structural variations in nucleic acids across different populations, identify key differences among them, and understand the biological and medical implications of these variations. The ultimate goal is to provide comprehensive data that can be used for further research in population genetics and public health. The study employed a comparative approach using bioinformatics analysis of genomic data from various populations worldwide. Genomic data were obtained from public genomic databases and analyzed to identify structural variations, including deletions, duplications, inversions, and translocations. Next-Generation Sequencing (NGS) techniques were utilized to ensure high accuracy and resolution in identifying structural variations. The results revealed significant differences in structural variations among the populations studied. Certain structural variations were found to be more prevalent in specific populations, indicating natural selection and local adaptation. Additionally, variations associated with genetic diseases showed varying frequencies across populations. This study highlights the importance of structural variations in nucleic acids as a determinant of genetic diversity among different populations. The findings contribute valuable insights into human evolution and have significant implications for health, particularly in developing personalized medical strategies. Further research is needed to explore the impact of these structural variations on biological functions and human health.
Cross-Country Evaluation of Protein Engineering Techniques for Disease Treatment Eduardom, Charles; Amanda, Joo
Journal of Biomedical and Techno Nanomaterials Vol. 1 No. 1 (2024)
Publisher : Yayasan Adra Karima Hubbi

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Abstract

Chronic and degenerative diseases have posed global challenges in the healthcare domain. Protein engineering techniques have emerged as a promising approach for developing effective protein-based therapies to address various diseases. However, the application of these techniques can vary across countries, depending on available resources, research infrastructure, and regulatory policies. This research aims to evaluate and compare the implementation of protein engineering techniques for disease treatment across different countries. Specifically, it analyzes the factors influencing the adoption of these techniques and identifies best practices and challenges faced in each country. This cross-country study involves data collection from various sources, including literature reviews, surveys, and interviews with experts in protein engineering and drug development. The data is analyzed both qualitatively and quantitatively to assess the level of adoption of protein engineering techniques, success in therapy development, and factors influencing progress in each country. The findings reveal that the adoption and success of protein engineering techniques for disease treatment vary across countries. Countries with adequate research resources, strong infrastructure, and supportive regulatory policies tend to have higher levels of adoption and success. In contrast, countries with limited resources and stringent regulations face challenges in effectively implementing these techniques. This research highlights the importance of international collaboration, technology transfer, and regulatory harmonization in promoting the global adoption of protein engineering techniques for disease treatment. By identifying best practices and addressing existing challenges, the potential of protein engineering techniques can be more widely leveraged to develop more effective and affordable therapies for patients worldwide.
Differences in the Life Cycle and Growth of Plasmodium Knowlesi, Inui, Vivax, Malariae, Falciparum, Ovale Fatmaningsih, Lidiya; Samasta, Nadia Azhar; Octa, Linda
Journal of Biomedical and Techno Nanomaterials Vol. 1 No. 2 (2024)
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Abstract

Plasmodium is a parasite that causes malaria in humans. Various Plasmodium species have differences in their life cycles and growth, which influence the clinical characteristics and management of malaria. This article explains the differences in the life and growth cycles of the six Plasmodium species most commonly found in humans, namely Plasmodium knowlesi, Plasmodium inui, Plasmodium vivax, Plasmodium malariae, Plasmodium falciparum, and Plasmodium ovale. Each species has differences in its life cycle, including pre-erythrocytic, erythrocytic, and extracellular duration. In addition, these differences also influence clinical symptoms, disease severity, and response to treatment. A thorough understanding of these differences is important for accurate diagnosis and effective treatment of malaria.
Genetic Engineering of Mosquitoes Causes Malaria Maghfiro, Nur'Afni Maulina; Fatmaningsih, Lidiya; Aulia, Maulidatul; Sa’id, Ibrahim Bin
Journal of Biomedical and Techno Nanomaterials Vol. 1 No. 2 (2024)
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Abstract

Malaria is still a health problem in the world and in Indonesia in particular. Malaria vector control is an important strategy in efforts to control and eliminate malaria because it is very effective in preventing infection and reducing disease transmission. The CRISPR/Casnuclease system is a potent new genome editing system and tool for species-specific diagnosis, drug resistance research for Plasmodium species, and gene driver for Anopheles population control, according to an assessment of earlier genome editimg techniques. This Anopheles mosquito CRISPR/Cas9 technique on plasmodium has been applied in research to detect malaria parasites by inhibiting their growth throughout the life cycle, allowing evaluation of the effectiveness of antimalarial drugs or vaccines at various stages of the parasite life cycle. In addition, CRISPR/Cas9 in Anopheles mosquitoes allows identification and double-strand breaks in target DNA, which can then be modified through genome changes. So, with the development of gene editing technology, the spread of Anopheles mosquitoes can be controlled and reduced.
The Relationship Between God Particles: Dark Matter and Time Dimensions Chandri Maharani, Fareza; Aulia, Maulidatul; Maharani, Fareza Chandri; A’la, Dewi Ghitsatul
Journal of Biomedical and Techno Nanomaterials Vol. 1 No. 2 (2024)
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Abstract

The God particle or Higgs Boson is a subatomic particle first proposed in 1964 and discovered in 2012 at CERN. It is an integral part of the Standard Model of Particle Physics, which explains the relationship between subatomic particles and the fundamental force. Dark Matter is hypothetical matter that interacts gravitationally with baryonic matter, but does not interact with the electromagnetic or strong and weak nuclear forces. Although invisible, dark matter is believed to make up the majority of matter in the universe. The Time Dimension is a dimension where objects move through time, indicating multiple points in space and time. In theoretical physics, the concepts of dark matter and the God Particle have been associated with additional dimensions of time. Some theories propose that additional time dimensions can be used to explain phenomena such as Dark Matter and the Higgs Boson. However, there has been no direct experimental evidence of additional time dimensions or how the God Particle and Dark Matter are related to additional time dimensions. In conclusion, the relationship between the God Particle, Dark Matter, and the Dimension of Time is still a topic of intense research in theoretical and experimental physics.
Potential of Nanotechnology Treatment for Genetic Disorders Aulia , Fanesa Oktavianes; Febrianti, Siti Khofifah Dwi; Nisak, Ainun Rahmatun
Journal of Biomedical and Techno Nanomaterials Vol. 1 No. 2 (2024)
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Abstract

Genetic disorders are complex health problems and are often difficult to treat conventionally. However, developments in the field of nanotechnology have opened up new opportunities for handling genetic diseases. Nanotechnology, or the creation of systems/devices at the molecular level, is a multidisciplinary scientific field that is experiencing rapid development. Nanotechnology offers innovative approaches to treating genetic disorders using the scale of nano-technology for drug delivery, gene therapy, and diagnostic molecular diagnostics to treat genetic disorders. Leveraging unique characteristics of a nanomachite, such as its size, shape, and functionality, can open a new path for more effective treatment and personalization for individuals suffering from genetic disorders. While still in the development stage, these developments promise a revolution in treatment of future genetic diseases
Differences in the Wavelength of Sound that Can be Received and Heard by Bats, Dolphins and Humans and Their Positive and Negative Impacts nisa, khoirun; Maghfiro, Nur’afnimaulina; Nurlaili, Eva; Khofifah, Siti
Journal of Biomedical and Techno Nanomaterials Vol. 1 No. 2 (2024)
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Abstract

Sound is a longitudinal wave. Sound has a frequency, based on the number of frequencies sound is divided into 3, infrasonic, audiosonic, and ultrasonic. Humans can hear audiosonic sounds while dolphins and bats hear ultrasonic sounds. This difference in frequency also affects the wavelength of the sound produced. The relationship between frequency and wavelength is an inverse ratio, which means that the higher the frequency, the lower the sound waves, and vice versa. Infrasonic sound for humans and ultrasonic for dolphins and bats each have positive and negative impacts. In humans, infrasonic sound has the benefit of being comfortable in hearing, but when the sound is too high it can also reduce brain balance which results in ear damage. While the ultrasonic sound in the hearing of dolphins and bats has the advantage of helping them find food, even in dolphins can help communicate. But in bats this ultrasonic sound cannot be used to communicate like dolphins

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