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Fakultas Kedokteran Universitas Brawijaya Gedung Graha Medika Lt. 1, Ruang 104
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Jurnal Kedokteran Brawijaya
Published by Universitas Brawijaya
ISSN : 02169347     EISSN : 23380772     DOI : http://dx.doi.org/10.21776/ub.jkb
Core Subject : Health,
Medicine & Pharmacology
JKB contains articles from research that focus on basic medicine, clinical medicine, epidemiology, and preventive medicine (social medicine).
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 7 Documents
 1 
Search results for , issue "Vol 25, No 2 (2009)" : 7 Documents clear
Fine Needle Aspiration Biopsy Mempunyai Peranan Penting dan Akurasi Tinggi Sebagai Metode Diagnostik Preoperatif Tumor Tulang Norahmawat, Eviana
Jurnal Kedokteran Brawijaya Vol 25, No 2 (2009)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (63.086 KB) | DOI: 10.21776/ub.jkb.2009.025.02.5

Abstract

ABSTRACTFine Needle Aspiration Biopsy (FNAB) technique is gaining increasing popularity in the diagnosis ofmusculoskeletal lesions because it offers some advantages such as rapid , easy , with minimal complications,but its applicability in diagnosis of bone tumors however has some limitations. This research was aimed toexplore the roles of FNAB and its accuracy as the preoperative diagnostic method compared tohistopathology examination from open biopsy or operation as a gold standard. Research design wasdescriptive study and diagnostic test from cases of bone tumors which were aspirated over a period of threeyears in Anatomic Pathology Laboratory of Saiful Anwar Hospital Malang. The data was collected with crosssectional method. Of the 106 patients who were subjected to FNAB, 22 cases were diagnosed as benignbone tumor,49 were primary malignant bone tumor,24 were metastatic malignant bone tumor,1 cases wassuspicious malignant tumor, 5 cases were non neoplastic lesions, and 5 cases were inadequate/ inconclusivefor diagnosis. Of the 16 cases which was analized with diagnostic test, sensitivity of FNAB as preoperativediagnostic method was 100 %, specificity was 90,91%, positive predictive value was 83,33 % and negativepredictive values was 100 % . Overall, diagnostic accuracy of FNAB was 93,75 %.It can be concluded that
Outer Membrane Protein 49,4 Kda dari Porphyromonas gingivalis Merupakan Protein Hemaglutinin dan Adhesin Terhadap Netrofil Mubarokah, Siti Nurul; Sumarno, Sumarno; Muliartha, I Ketut Gede
Jurnal Kedokteran Brawijaya Vol 25, No 2 (2009)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (581.04 KB) | DOI: 10.21776/ub.jkb.2009.025.02.6

Abstract

ABSTRACTPeriodontitis is caused mostly by P. gingivalis and it is related to acute coronary syndrome. P. gingivalis readilyinvades into blood circulation and potentially induces. Collagenolytic activity of neutrophil which result incollagen vascular degradation lead to atherosclerotic plague rupture (APR). APR is responsible for occurringfatal cardiovascular events such as acute myocardial infarction (AMI). These information brought out notionconcerning the adhesion interaction of P. gingivalis with neutrophil. The aim of this study was to assessadhesion molecule of P. gingivalis outer membrane protein (OMP) by partial characterization took inhemagglutination assay using mice erythrocytes, adhesion inhibition assay by gradual concentration ofadhesion blocked in neutrophil, immunologic assay using Western-blotting and immunocytochemistry. Theresults showed that 49,4 kDa P.gingivalis OMP can agglutinate mice erythrocytes and adherence to netrophilIncrease concentration of OMP P. gingivalis 49,4 kDa reduce adhesion process to netrophil This protein wasrecognized by the polyclonal antibody of 49,4 kDa adhesion molecule. It can be concluded that P gingivalisouter membrane protein is a hemagglutinin and an adhesion molecule to netrophilKeywords : 49,4 kDa P. gingivalis OMP, neutrophil, hemagglutination, adhesin
Susu Kedelai Menurunkan Resistensi Insulin pada Model Diabetes Melitus Tipe 2 Handayani, Wiwik; Rudijanto, Ahmad; Indra, Mohammad Rasjad
Jurnal Kedokteran Brawijaya Vol 25, No 2 (2009)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (76.008 KB) | DOI: 10.21776/ub.jkb.2009.025.02.2

Abstract

Type 2 Diabetes mellitus (T2DM) is characterized by hyperinsulinemia and hyperglicemia. Soy bean Milk ishigh nutrient drink, especially its protein contain. Several researches demonstrated that soy bean proteindecrease plasma insulin and blood glucose level. The aim of this study is to investigate the effect of soy beanmilk in reducing insulin resistance of rat T2DM Model. This experimental study used pre and post test controlgroup design. Male Rattus norvegicus wistar strain 8 week old were used as animal model. T2DM rats wereconstructed by giving high fat diet and continue with injection of low dose of streptozotocin. Rats were dividedinto 7 groups (1) Negative control group (2) Positive control group (T2DM rat without soy bean milk) (3) T2DMrat that treated with genistein 15 g/kgBW (4) T2DM rat that treated with soy bean milk 10 ml/kgBW/day (5)DMT2 rat that treated with soy bean milk 30 ml/kgBW/day (6) T2DM rat that treated with soy bean milk 60ml/kgBW/day and (7) T2DM rat that treated with soy bean milk 90 ml/kgBW/day.
Induksi of Porphyromonas gingivalis Meningkatkan Proporsi Endotelin-1 pada Aorta Mencit yang Diinduksi Diet Aterogenik Elyani, Helmin Elyani; Hernowati, Tinny Endang; Sumarno, Sumarno
Jurnal Kedokteran Brawijaya Vol 25, No 2 (2009)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (583.288 KB) | DOI: 10.21776/ub.jkb.2009.025.02.7

Abstract

One of the risk factor of atherosclerosis is associated with activation of the inflammatory process in infection,as evidence by systemic elevations of molecules such as MCP-1,PAI-1 and ET-1. Recent evidence suggeststhat infectious agents, including those that cause periodontal disease, may also important role inatherosclerosis. The aim of this study was to determine if recurrent intravenous injections with P. gingivalis for14 weeks promotes endothelial smooth muscle ET-1 proportion in aortic mice. Twenty four weeks old mice(n=6 per group for each time point) were divided in two groups, there were normal diet and atherogenic diet,each of them were inoculated intravenously with live P. gingivalis (10 cell/50µl PBS) injections or vehicle (50µl PBS) once per week for 14 weeks. The Immunohistochemistry for aortic ET-1 proportion were performed.The result of RAK with 3 interaction and Tukey test using SPSS 14 for windows showed that at 14 weeks, theET-1 proportion in aortic endothelial cell was higher than in aortic smooth muscle cell.
Identifikasi Forensik Berdasarkan Pemeriksaan Primer dan Sekunder Sebagai Penentu Identitas Korban pada Dua Kasus Bencana Massal Prawestiningtyas, Eriko; Algozi, Agus Mochammad
Jurnal Kedokteran Brawijaya Vol 25, No 2 (2009)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (338.071 KB) | DOI: 10.21776/ub.jkb.2009.025.02.3

Abstract

ABSTRACTThe main purposes of identification process in mass disaster is to find the corpses identity in order to give itback to their family by doing some identification methods such as primer identification which must do at thefirst time because they have highly and accurate result as the identifiers. There are many differencesbetween the burned corpses on the the tragedy of the burning of Garuda Airlines and the drowned corpses onthe tragedy of the sinking of Senopati Nusantara ship , many difference characteristic that influence theprocess of forensic identification. In the burned corpses, teeths are still intact and relatives still could beexamined than another primery identifiers. It makes difference priority between one to another cases. So,from the two different cases, we can choose the different primer identifiers as the priority depend on thecondition of the dead bodies related to the accident in order to make the right identity for giving back to therelatives.
Penggunaan Suksinilkolin Setelah Tidak Meningkatkan Kadar Kalium Plasma Pasien dengan Cedera Kepala Berat Purwati, Wahyuni Dian; Wardhani, Viera; Mahameru, Gunung; Istiadjid, Mohamad
Jurnal Kedokteran Brawijaya Vol 25, No 2 (2009)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (68.622 KB) | DOI: 10.21776/ub.jkb.2009.025.02.4

Abstract

This study aimed to identify the changes of plasma potassium level after intubation with rapid sequenceintubation method in severe head injury patients using succinylcholine as muscle relaxant. Subjects aresevere head injury patients with glasgow coma scale (GCS) ≤ 8. Plasma potassium level was measured twice,before intubation and (minutes 5, 10, 15, 20) after intubation. Another variable that also measured were bloodgas analyze, time intubated and injury in another organ. There were 34 patients who came to EmergencyDepartment (ED) of Saiful Anwar General Hospital since January until April 2009. Mean level of plasmapotassium changes after intubation minute 5 (-0.01529); minute 10 (-0.01971); minute 15 (0.04147); minute20 (0.00059). Statistical analysis using paired t test revealed no significance of this difference (p>0.05). Therewere no changes of plasma potassium level in severe head injury patients after intubation withsuccinylcholine
Aromaterapi Bunga Lavender Memperbaiki Kualitas Tidur pada Lansia Kurnia, Anggraini Dwi; Wardhani, Viera; Rusca, Kuswantoro Tri
Jurnal Kedokteran Brawijaya Vol 25, No 2 (2009)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (49.094 KB) | DOI: 10.21776/ub.jkb.2009.025.02.1

Abstract

Sleep is a basic human need, characterized by minimal physical activity, change in physiological process ofthe body and decrease respon from external stimulus. Most of the elderly have high risk to suffer sleepproblem because of some factors. Aromatherapy is a therapy using essential oil which produces comfortableeffect, more steady emotion and feeling, calmer thought and feeling. This research was aimed to identify theeffectivity of Lavender (Lavendula L) Aromatherapy in improving quality of sleep of the elderly in Panti WerdhaMalang. A quasi experiment study was implemented with randomized control group pretest posttest using 18subjects divided into two groups.and treatment. The sleep quality was measured by interview developedbased on PSQI (Pittsburgh Sleep Quality Index). The data were then analyzed using Wilcoxon test and Mann-Whitney test. A significant improvement of sleep quality score was identified in treatment group (3,89, p=0,07) but not in the control group (0,78;p=0,317). These improvement is significantly different between the twogroups (p=.0,001). It can be concluded that Lavender aromatherapy is significantly improve the quality ofsleep in elderly people

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