cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
-
Contact Email
jstrp@mail.unnes.ac.id
Phone
-
Journal Mail Official
jstrp@mail.unnes.ac.id
Editorial Address
Sekaran, Kec. Gn. Pati, Kota Semarang, Jawa Tengah 50229
Location
Kota semarang,
Jawa tengah
INDONESIA
Journal of Science and Technology Research for Pharmacy
Published by Universitas Negeri Semarang
ISSN : -     EISSN : 27760685     DOI : https://doi.org/10.15294/jstrp
Core Subject : Health,
Medicine & Pharmacology
Journal of Science and Technology Research for Pharmacy is open access, peer-reviewed journal published by Pharmaceutical Science Study Program, Faculty of Medicine, Universitas Negeri Semarang, Indonesia. The journal publishes only papers describing original findings and review articles of all aspects in developing the field of pharmaceutical science and technology.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 25 Documents
 1   2   3 
Optimisation of SSG (Sodium Starch Glycolate) and Avicel PH 102 in the Formula of Orally Disintegrating Acetaminophen Tablets by Simplex Lattice Design Method Oktaviani Himmayatin Nisaa; Tri Minarsih
Journal of Science and Technology Research for Pharmacy Vol. 5 No. 2 (2025): Journal of Science and Technology Research for Pharmacy
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/jstrp.v5i2.27572

Abstract

Background: ODT acetaminophen tablets are an alternative drug therapy for patients who have difficulty in swallowing tablets or capsules. Additional ingredients that play an important role in the ODT tablet formula are disintegrants. The disintegrants used in this study were avicel ph 102 and SSG. The use of disintegrants can help increase the dissolution rate and accelerate the destruction time. Aim: The purpose of this study was to determine the optimum formula of ODT acetaminophen tablets and analyse the effect of SSG and avicel ph 102 on dissolution and disintegration time. Material and Methods: Determination of acetaminophen ODT tablet formula was carried out running in design expert software with the simplex latice design method. Preparation of ODT acetaminophen tablets was carried out by direct felting. The evaluation of ODT acetaminophen tablets was IPC physical evaluation, determination of content, and dissolution. Determination of the optimum formula was done by simplex latice design method. Results: The results showed that all ODT acetaminophen tablet formulas fulfilled all the requirements of the IPC test, physical evaluation, dissolution, and determination of levels according to the Pharmacopoeia VI edition standards. Formula 3 produced the fastest disintegration time of 3 minutes, but the dissolution rate of 100% was reached in the 15th minute. It is suspected that gel formation in the SSG swelling mechanism slowed down the dissolution rate. While formulas 1, 2, and 4 which have a longer disintegration time reached >80% dissolution in the 10th minute. Conclusion: The optimum formula results with the simplex latice design method were SSG 8% and avicel ph 102 7%.  Avicel ph 102 and SSG had the effect of accelerating the destruction time and slowing down the dissolution rate.
Formulation of Lip Balm from Nanoparticles of Beetroot Extract (Beta vulgaris L) and Testing of Sunscreen Activity Nabila Meilani Dewi; Senda Kartika Rakainsa
Journal of Science and Technology Research for Pharmacy Vol. 5 No. 2 (2025): Journal of Science and Technology Research for Pharmacy
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/jstrp.v5i2.29588

Abstract

Background: As a tropical country, Indonesia faces the risk of skin damage due to year-round sun exposure, including on the lips, which are susceptible to UV effects such as dryness, cracking, and hyperpigmentation. This study utilizes the betacyanin content in beetroot (Beta vulgaris L.)—a phenolic compound with photoprotective properties that can counteract UV free radicals. This study applies nanotechnology through the formulation of beetroot extract nanoparticles to optimize sunscreen activity. Aim: This study aims to evaluate and compare the sunscreen activity between lip balm formulations containing beetroot extract nanoparticles and beetroot extract lip balm formulations, as well as to determine the extent of the effectiveness of nanoparticle-based lip balm in providing protection against UV rays. Materials and Methods: This study extracted beetroot (Beta vulgaris L.) using the maceration method with 96% ethanol, yielding a concentrated extract (yield 34%) with a dark red color. Results: Phytochemical analysis revealed the presence of flavonoids, phenolics (20 mg GAE/g), tannins, and alkaloids in beetroot. The nanoparticle extract was successfully formulated with a size of 1.05 nm (PDI 0.403) and a zeta potential of -21.0 mV. Among the seven lip balm formulations, F6 (30% nanoextract) demonstrated the best performance with an SPF of 25.25 (ultra category), %Te of 0.26%, and %Tp of 0.61%, as well as optimal physical stability (homogeneous, melting point 70°C, pH 4.5–6.5). The nanoextract formulas (F4–F6) significantly outperformed conventional extracts (F1–F3) in sunscreen activity, demonstrating the effectiveness of nanotechnology in enhancing UV protection. Conclusion: These findings demonstrate that beetroot nanoparticle extracts have potential as an effective and safe natural sunscreen lip balm for lip protection
Antidiabetic and Antihyperuricemic Activities of Salak Madu (Salacca edulis Reinw) Peel Extract in Alloxan- and High-Purine Diet-Induced Mice Dzulrifaad Ubaidillah Al Afza; Neli Syahida Ni'ma
Journal of Science and Technology Research for Pharmacy Vol. 5 No. 2 (2025): Journal of Science and Technology Research for Pharmacy
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/jstrp.v5i2.29856

Abstract

Diabetes mellitus (DM) is a chronic metabolic disorder characterized by impaired carbohydrate, lipid, and protein metabolism. Hyperuricemia is a condition in which serum uric‑acid levels exceed normal values, namely > 7.0 mg/dL in men and > 6.0 mg/dL in women. Both antidiabetic and antihyperuricemic therapies can be administered pharmacologically and non‑pharmacologically; however, synthetic drugs often produce undesirable side effects. Concerns regarding these adverse effects have led many people to favour herbal remedies that are perceived as safer, one of which is the Salak Madu fruit. Salak Madu (Salacca edulis Reinw.), an emerging premium variety cultivated in Sleman, Yogyakarta, is rich in flavonoids with potential antihyperglycaemic and antihyperuricaemic properties. The present study evaluated the antidiabetic and antihyperuricemic activities of Salak Madu peel extract in vivo using alloxan‑induced and high‑purine‑diet mouse models. Mice were observed over 14 days and treated orally with peel extract at doses of 100, 200, and 400 mg/kg body weight (BW). On day 14, the 100 and 200 mg/kg BW doses produced significant reductions in blood‑glucose levels (P < 0.05), indicating a marked antihyperglycaemic effect in hyperglycaemic mice. For serum uric‑acid reduction, significant effects were observed on day 7 at doses of 200 and 400 mg/kg BW (P < 0.05), demonstrating a pronounced antihyperuricemic action in hyperuricemic mice.
Comparison of Lead (Pb) Content Analysis Using Atomic Absorption Spectrophotometry with Wet and Dry Destruction Methods in Body Lotion Preparations in Semarang City Muhammad Shidqi Naufal Athalla; Endah Widhihastuti
Journal of Science and Technology Research for Pharmacy Vol. 5 No. 2 (2025): Journal of Science and Technology Research for Pharmacy
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/jstrp.v5i2.31998

Abstract

Many body lotions are found in circulation without a BPOM RI registration number, which can raise concerns about lead metal contamination. The lead metal content in body lotion can be sourced from the raw material, namely water. Lead metal levels in water range from 0,011 mg/L to 0,076 mg/L. Determination of lead levels uses an Atomic Absorption Spectrophotometry instrument. The requirement for analysis using Atomic Absorption Spectrophotometry is that the sample must be in solution form, so a destruction process is necessary because the body lotion sample is in semi-solid form. This study aims to compare two commonly used destruction methods, namely wet and dry destruction. The methodology in this study consists of qualitative analysis, method validation, and quantitative analysis. The test results with qualitative analysis showed negative lead metal content. The results of the Atomic Absorption Spectrophotometry method validation were: linearity (R2) of 0,9999; LoD of 0,024 mg/L; LoQ of 0,080 mg/L; precision (%RSD) of 0,61%; accuracy (%Recovery) of 100,09% with quantitative results of the percentage of wet digestion sample content, results were: 1,2264 ± 2,96%; 1,7687 ± 4,24%; 1,5036 ± 3,75%; 1,1807 ± 2,92%; and 1,5606 ± 3,88%. This can happen because the wet destruction method is better to use than the dry destruction method which can be seen from the %Recovery.
The Effect of Alginate-Chitosan/Quaternary Chitosan Concentration on The Release of Propolis (Tetragonula Spp.) in Hydrogel Wound Dressings Iqbal Nugroho; Priskilla Meliana Hutahaean; Melania Diu; Aulya Indah Purwanty; Annisa Aulia Savitri
Journal of Science and Technology Research for Pharmacy Vol. 5 No. 2 (2025): Journal of Science and Technology Research for Pharmacy
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/jstrp.v5i2.35129

Abstract

The increasing incidence of acute and chronic wounds globally requires the development of effective wound dressings. This study aims to formulate and analyze the release profile of propolis extract (Tetragonula spp.), which has potential biological activity for wound healing, from a hydrogel wound dressing (HWD) based on alginate-chitosan/quaternary chitosan biocomposite as a delivery system that can control its release. Propolis extract, which has been tested positive for alkaloids, flavonoids, tannins, and steroids/triterpenoids, was formulated into four HWD formulas (F1-F4) with varying ratios using the solvent casting method. The results of the release test in PBS medium at pH 7.4 at 37 C for 48 hours showed that all formulas produced a gradual release. The results of the One-Way ANOVA test on the final cumulative release showed no statistically significant differences (p>0.05). However, descriptively, Formula F2 (4% alginate-8% quaternary chitosan) showed the highest release percentage (99.85%) with the most stable rate, followed by F4 (98.71%), while F3 with high chitosan showed the lowest percentage (86.65%). The best release kinetics analysis followed the Higuchi model (R² ≥ 0.95), indicating that the release mechanism was controlled by diffusion. It was concluded that variations in the alginate and chitosan/quaternary chitosan ratios affected the release pattern and rate, and Formula F2 with a balanced ratio produced an optimal controlled release profile, making it the most ideal candidate for further development as a therapeutic hydrogel wound dressing.

Page 3 of 3 | Total Record : 25

 1   2   3 

Filter by Year

2023 2025


Reset
Filter By Issues
All Issue Vol. 5 No. 2 (2025): Journal of Science and Technology Research for Pharmacy Vol. 5 No. 1 (2025): Journal of Science and Technology Research for Pharmacy Vol. 4 No. 2 (2024): Journal of Science and Technology Research for Pharmacy Vol. 4 No. 1 (2024): Journal of Science and Technology Research for Pharmacy Vol. 3 No. 2 (2023): Journal of Science and Technology Research for Pharmacy