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Journal of Science and Technology Research for Pharmacy
Published by Universitas Negeri Semarang
ISSN : -     EISSN : 27760685     DOI : https://doi.org/10.15294/jstrp
Core Subject : Health,
Medicine & Pharmacology
Journal of Science and Technology Research for Pharmacy is open access, peer-reviewed journal published by Pharmaceutical Science Study Program, Faculty of Medicine, Universitas Negeri Semarang, Indonesia. The journal publishes only papers describing original findings and review articles of all aspects in developing the field of pharmaceutical science and technology.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 25 Documents
 1   2   3 
Comparison of Eco - Scale Between UV - Vis Spectrophotometry and Thin Layer Chromatography - Densitometry Methods on The Determinination of Retinoic Acid in Facial Cream Preparations Zaneta Nur Faida; Mohammad Alauhdin
Journal of Science and Technology Research for Pharmacy Vol. 4 No. 1 (2024): Journal of Science and Technology Research for Pharmacy
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/jstrp.v4i1.5415

Abstract

Retinoic acid, a compound derived from vitamin A and its active metabolites, is often found in cream preparations and can be used without a doctor's prescription. This research aims to analyze the retinoic acid content in facial cream preparations and determine the environmental friendliness of the analytical method used. The materials used in this research were PBFI retinoic acid, methanol, TLC plates, n-hexane, acetone, and three facial cream samples. UV - Vis Spectrophotometry and Thin Layer Chromatography - Densitometry are methods used for assay analysis and Eco - Scale is a method for determining greenness. The research found that three cream samples tested positive for retinoic acid, which has been banned by BPOM since 1999. The UV-Vis Spectrophotometry method measured retinoic acid content of 0.103%, 0.266% and 0.256%, with a total score of 24 points. The Thin Layer Chromatography - Densitometry method measured retinoic acid content of 0.0213%, 0.0314%, and 0.027%, with a score of 50 points. It can be concluded that the UV - Vis Spectrophotometry method is more environmentally friendly compared to the Thin Layer Chromatography - Densitometry method based on Eco - Scale analysis.
Study In Silico of the Activity of Bioactive Compounds from Cinnamon (Cinnamomum verum) Bark as Anti-inflammatory Prima Gita Islami Islami; R Susanti
Journal of Science and Technology Research for Pharmacy Vol. 4 No. 1 (2024): Journal of Science and Technology Research for Pharmacy
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/jstrp.v4i1.6189

Abstract

Cinnamon bark (Cinnamomum verum) contains various bioactive compounds that can be used in drug development, one of which is anti-inflammatory. Inflammation is the body's defense response to the occurrence of an injury from objects unknown to the body, such as bacterial infections, trauma, autoimmune, viruses and toxins. The purpose of this study was to determine the content of bioactive compounds in cinnamon bark. This research method was carried out using the Dr. Duke's Phytochemical database. Duke's Phytochemical database to collect bioactive compounds in cinnamon bark, PubChem to download the ligand structure of bioactive compounds, PASS (Prediction of Activity Spectra for Substance) Online for screening the anti-inflammatory activity value of bioactive compounds, SEA and Swiss Target Prediction are used to determine the target protein, STRING is used to analyze the interaction between target proteins, Cytoscape is used to predict tissue topology, Pyrex is used for molecular docking, and Biovia Discovery Studio is used to visualize docking results. There are 16 cinnamon bark compounds that have a Pa value > 0.5. Based on the docking results, compounds that have a Pa value> 0.5. Based on docking results, beta caryopyhllene, caryopyhllene, fatty acid, and isocaryopyhllene compounds have PPARA activator mechanism with binding affinity of -7.4 kcal/mol, -7.9 kcal/mol, -7.8 kcal/mol, and -5.6 kcal/mol. Caffeic acid compounds have an MMP-9 activator mechanism with a binding affinity of -5.7 kcal/mol. Visualization of docking results shows that isocaryopyhllene and caffeic acid compounds have similar interactions and amino acid residues with control drugs so that they can be used as anti-inflammatory agents.
Anti-Inflammatory Activity Test of Combination Ethanol Extract of Papaya Leaves (Carica papaya L.) and Celery Leaves (Apium Graveolens L.) in Male White Rats Muhammad Athfal Nuransyah; Neli Syahida Ni’ma
Journal of Science and Technology Research for Pharmacy Vol. 4 No. 1 (2024): Journal of Science and Technology Research for Pharmacy
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/jstrp.v4i1.8096

Abstract

Background: Papaya leaves (Carica papaya L.) and celery leaves (Apium graveolens L.) are suspected to have anti-inflammatory activity due to their secondary metabolites such as flavonoids, tannins, saponins, alkaloids, steroids, and terpenoids. Aim: This study aims to determine the anti-inflammatory activity of a combination of ethanol extracts of papaya leaves and celery leaves compared to the use of single extracts and standard anti-inflammatory drugs. Material and Methods: The method used is the Rat Hit Paw Edema, which induces inflammation in the rat paw using carrageenan. Twenty-five rats were divided into 5 treatment groups: negative control (CMC-Na 1%), positive control (Na Diclofenac 4.5 mg/kgBW), papaya leaf ethanol extract 50 mg/kgBW, celery leaf ethanol extract 200 mg/kgBW, and a combination of papaya leaf ethanol extract 25 mg/kgBW and celery leaf ethanol extract 100 mg/kgBW. Data collection was done by measuring the paw thickness using calipers at 30, 60, 120, 180, 240, 360, and 480 minutes after carrageenan injection. Data were analyzed by calculating the percentage of inflammation, percentage inhibition, anti-inflammatory percentage, and statistical tests to determine the effectiveness of the extract combination. Results: Phytochemical screening results showed that the ethanol extract of papaya leaves contains flavonoids, tannins, saponins, alkaloids, and steroids, while the ethanol extract of celery leaves contains flavonoids, tannins, saponins, and steroids. The combination of ethanol extracts of papaya and celery leaves showed the highest anti-inflammatory effect at 20.80%, compared to papaya leaf extract at 16.40%, celery leaf extract at 16.93%, and the positive control at 18.75%. Conclusion: Statistical analysis showed that the combination of extracts had a synergistic effect, with One Way Anova and LSD results being significantly different compared to the use of single extracts.
Detection and Determination of Captopril Using Silver Nanoparticles Based Colorimetric Method Anida Hasna Rahmatika; Mohammad Alauhdin
Journal of Science and Technology Research for Pharmacy Vol. 4 No. 1 (2024): Journal of Science and Technology Research for Pharmacy
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/jstrp.v4i1.8593

Abstract

Basic Health Research (Riskesdas) in 2018 showed an increase in the prevalence of hypertension in Indonesia. Captopril is one of the antihypertensive drugs that is often prescribed because it is affordable and effective in lowering blood pressure, but captopril also has several side effects. Therefore, the development of sensitive, simple, rapid and cost-effective analytical techniques for the determination of captopril is urgently needed. This research aims to develop a colorimetric detection of captopril using silver nanoparticles and analyze its performance in measuring the captopril in tablet samples. The parameters studied include linearity, sensitivity, accuracy and precision. The results of the research show that silver nanoparticles can be used for qualitative detection of captopril which is characterized by a color change and absorbance decrease of the sample solution. The results of the performance test of the developed method showed good results. The linearity test showed a correlation coefficient (r) of 0.9915 with the regression equation obtained was y = 0.263x + 129.26. The limit of detection (LOD) value is 0.0206 ppm and the limit of quantitation (LOQ) is 0.0687 ppm. In the accuracy test results, the recovery percentage (%recovery) was 95.3% and the precision test with the relative standard deviation (%RSD) obtained was 0.85%. The captopril content obtained in the 50 mg captopril tablet sample preparation was 98.0%.
Antimicrobial Activity of Ethanol Extract of Cucumber (Cucumis Sativus L.) Peels and Formulation as Anti-Acne Cream Nadya Wulan Ramadhani; Siti Harnina Bintari
Journal of Science and Technology Research for Pharmacy Vol. 3 No. 2 (2023): Journal of Science and Technology Research for Pharmacy
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/jstrp.v3i2.9043

Abstract

Background: Cucumber is proven to have pharmacological activities as antimicrobial. Some of the secondary metabolites contained in cucumber fruit have antimicrobial activity. Aim: This study aims to determine the antibacterial activity of ethanol extract of cucumber peels against Staphylococcus epidermidis and to make anti-acne cream using cucumber skin extract. Material and Methods: The extraction of cucumber peels extract with maceration using 96% ethanol solvent. Phytochemical screening to determine the compounds contained in the extract. The antibacterial activity test of the extract was carried out through liquid and solid dilution methods to determine the MIC and MBC values. The extract was then made into a cream with varying concentrations of stearic acid and TEA as an emulsifier and then evaluated and tested for antibacterial activity using the agar diffusion method. Results: Cucumber peels extract contains steroids, alkaloids, flavonoids, phenols, and saponins that have antibacterial activity against Staphylococcus epidermidis with an MIC value of 2.5% and an MBC value of 5%. The results of the cream evaluation test show that formula F(3) is the most optimal formula for inhibiting Staphylococcus epidermidis bacteria with a cucumber skin concentration content of 4.5%. The antibacterial activity test has an inhibition zone of 33-52.70 mm with a very strong category.
Antibacterial Activity of Ethanol Extract of Kersen Bark (Muntingia Calabura L) & It’s Formulation as an Anti-Acne Cream Nanda Sabila Fitriana Putri; Siti Harnina Bintari Bintari
Journal of Science and Technology Research for Pharmacy Vol. 3 No. 2 (2023): Journal of Science and Technology Research for Pharmacy
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/jstrp.v3i2.9044

Abstract

Background: Kersen (Muntinga calabura) bark is one of the medicinal plants that can be used to treat acne. The ethanol extract of kersen bark contains alkaloid, flavonoid, tannin, saponin, and terpenoid compounds that have potential as antibacterials. Objective: This study aims to make a cream preparation from ethanol extract of kersen bark and to determine the antibacterial activity against acne-causing bacteria Staphylococcus epidermidis. Methods: Extraction was done by remaceration method and 96% ethanol solvent was used to obtain the extract of kersen stem bark. Phytochemical screening was carried out to determine the secondary metabolites in the extract. The antibacterial activity test of the extract was carried out using the solid liquid dilution method to determine the KHM and KBM values. The extracts were then formulated into M/A (oil in water) cream preparations, then physically evaluated and tested for antibacterial activity using the pitting diffusion method. Results: Kersen bark contains alkaloids, flavonoids, tannins, saponins, and terpenoids that show antibacterial activity against Staphylococcus epidermidis with KHM and KBM values at a concentration of 3.125%. The physical properties of the creams showed that all creams met the requirements with 5% concentration as the minimum limit for the preparation to have antibacterial activity. Conclusion: Kersen bark extract cream formulation with the greatest antibacterial activity was obtained at a concentration of 10%, where the higher the concentration of extract used, the higher the antibacterial activity.
Optimization of The Concentration of Precipitation Reagent in Cyclamate Analysis and Determination of Cyclamate Contents in Jamu Sistia Asfa Fiqrotinnisa; Mohammad Alauhdin
Journal of Science and Technology Research for Pharmacy Vol. 3 No. 2 (2023): Journal of Science and Technology Research for Pharmacy
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/jstrp.v3i2.9329

Abstract

: Sodium cyclamate is one of the food additives sweeteners that are often added to food products including jamu. It has a low price and a taste 30 - 50 times sweeter than natural sugar. It is known that excessive & longterm use of sodium cyclamate can cause adverse health effects. Currently, the standard method used to detect the presence of cyclamate refers to the precipitation method of SNI 01-2893. However, the level of sensitivity of the method is unknown. This study aims to determine the sensitivity of the precipitation method of SNI 01-2893, as well as to optimize reagents that have better sensitivity to be used as a reference for cyclamate precipitation reagents and applied to measure cyclamate in jamu. The determination the method’s sensitivity is based on the smallest concentration of cyclamate standard that can be detected by the method. Optimization of the precipitation reagent was carried out on 6 variations of precipitation reagent concentration to obtain a new formula that has a better sensitivity than the SNI 01-2893 method. Jamu samples were tested using the new optimized reagent formula. The result showed the detection limit of the of SNI 01-2893 method is 5 ppm. Optimization of the precipitation reagent formula with the composition of HCl 10%, BaCl2 10%, and NaNO2 20% showed as the highest sensitivity. It was marked by an increase in the amount of precipitate formed and had a detection limit of up to 0.9 ppm. Based on testing using the new reagent, 9 out of 10 jamu samples were positive for cyclamate. The cyclamate levels of the 9 jamu samples were measured using the spectrophotometric method, the results showed cyclamate levels are in the range of 4.3 - 6.32 mg/kg sample and meeting BPOM requirements.
Sunscreen Activity Test on Iler Leaf Ethanol Extract Cream (Coleus Scutellarioides (L) Benth) In Vivo Zalza Zalzabila Adelya Putri; Endah Widhihastuti
Journal of Science and Technology Research for Pharmacy Vol. 3 No. 2 (2023): Journal of Science and Technology Research for Pharmacy
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/jstrp.v3i2.9665

Abstract

Indonesia is one of the countries known as a tropical climate country with a high intensity of sun exposure. The sun's UV rays have health benefits. However, UV rays also have negative effects on skin health. Therefore, additional protection against solar UV rays is needed, namely by using sunscreen preparations derived from Iler Leaves (Coleus scutellarioides (L) Benth) which contain flavonoid and phenolic compounds. The purpose of this study was to determine the most optimal ethanol extract cream formula of iler leaf (Coleus scutellarioides (L) Benth) after preparation evaluation and determine the sunscreen activity of iler leaf ethanol extract cream (Coleus scutellarioides (L) Benth) in vivo. This research is a real pure experiment or also called True Experimental Research and uses The post test Only Control Group Design method. The results obtained from the evaluation of the ethanol extract of iler leaf cream preparation formula are with a cream formula consisting of 1.5% iler leaf extract, 18% stearic acid, 2% TEA, 2% cetyl alcohol, 8% glycerin, 0.2% metal paraben, 0.02% propyl paraben and aquadest. And after in vivo testing on white rats, it was found that the ethanol extract cream preparation of iler leaves had sunscreen activity as evidenced by the erythema effect that appeared after exposure under sunlight. So it can be concluded that the most optimum cream formula is a formula containing 18% stearic acid and 2% TEA. And the iler leaf ethanol extract cream has sunscreen activity after in vivo testing.
Formulation of Peel-Off Gel Mask From Manilkara Zapota (L) P. Royen Leaves Extract and Antibacterial Activity Against K Syifa Fauziyah; Senda Kartika Rakainsa
Journal of Science and Technology Research for Pharmacy Vol. 3 No. 2 (2023): Journal of Science and Technology Research for Pharmacy
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/jstrp.v3i2.9891

Abstract

Sawo leaves contain alkaloids, flavonoids, tannins, saponins and steroids which are antibacterial. This study aims to obtain the best concentration of Sawo leaf ethanol extract (Manilkara zapota (L) P. Royen) formulated as a peel-off gel mask preparation based on antibacterial activity test against Staphylococcus epidermidis bacteria. This study used laboratory experimental method. Sawo leaf extract peel-off gel mask preparation formula was made with concentration variations of 0.1%; 0.3%; 0.6%; 2.5%; 5% and 10%. Sawo leaf plant extract was obtained by maceration using 96% ethanol solvent. Identification of compounds was carried out using phytochemical screening, spray TLC and Bioautography TLC. Antibacterial testing of extracts was carried out using solid dilution and liquid dilution methods. The antibacterial test of the preparation using the wells diffusion method had the largest diameter of the inhibition zone at a concentration of 8% with an inhibition zone diameter of 14.1 mm and the inhibition ability was categorized as strong. It can be concluded that the concentration of 2%; 4%; 6%; 8% is good to be formulated as a peel-off gel mask preparation and is categorized as strong inhibition ability.
Antibacterial Activity Test of Guava Leaf Ethanol Extract against Staphylococcus epidermidis and its Formulation as Anti-Acne Serum Tristania Magdalena Dumatubun; Senda Kartika Rakainsa
Journal of Science and Technology Research for Pharmacy Vol. 4 No. 2 (2024): Journal of Science and Technology Research for Pharmacy
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/jstrp.v4i2.9903

Abstract

Skin is a layer of tissue that spreads over the entire surface of the body. On the surface of the skin, sweat glands secrete waste products through the skin pores in the form of sweat. Acne (Acne vulgaris) is a condition where the pores are clogged and cause pockets of pus to become inflamed. Guava leaves (Psidium guajava L.) contain alkaloid, flavonoid, tannin, saponin and steroid compounds that are believed to have antibacterial activity. The purpose of this study was to determine the antibacterial activity of guava leaves (Psidium guajava L.) against Staphylococcus epidermidis made in serum dosage form. In this study, guava leaf extract was tested to determine the value of MIC (Minimum Inhibitory Level) using the liquid dilution method and MBC (Minimum Bactericidal Level) using the solid dilution method by measuring the diameter of the inhibition zone. The results showed that the MIC of guava leaf extract was obtained at a concentration of 0.05 while the MBC results of guava leaf extract were obtained at a concentration of 5%. Serum preparation is a low viscosity preparation that delivers active substances through the skin surface which has more active ingredients and less solvent content. Serum preparation formulations were made in several concentrations, namely F0 0%, F1 2%, F2 4%, and F3 6%. Physical evaluation of the preparation included organoleptic, homogeneity, adhesion, spreadability, pH, and viscosity. The antibacterial activity test of serum preparations was carried out by the pitting diffusion method. The results showed that F3 had the largest inhibition zone of 13 mm and was included in the strong category.  

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