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Folia Medica Indonesiana The Unit of Journal Consortium and Folia Medica Indonesiana Faculty of Medicine, Universitas Airlangga Jl. Prof. Dr. Moestopo No.47, Pacar Kembang, Kec. Tambaksari, Surabaya, Jawa Timur 60132, Indonesia
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Folia Medica Indonesiana
Published by Universitas Airlangga
ISSN : 23558398     EISSN : 2599056X     DOI : https://doi.org/10.65346/2958-4515.2401
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience
Folia Medica Indonesiana, as indicated by its name, focuses on publishing good quality articles about research and education on health science and medicine in Indonesia. However, due to the fast growth of science and knowledge in these fields, we also welcome submitted articles from around the world, especially the ones that contain related matters from lower-middle income countries. Folia Medica Indonesiana is an open-access, peer-reviewed journal that is published online at least four times a year. The scope covers various aspects of basic medical sciences includes anatomy, physiology, pathology, microbiology, pharmacology, and molecular medicine) and clinical medicine (covers specialties like internal medicine, surgery, pediatrics, oncology, psychiatry, etc). We highlight the pathology and potential treatment of metabolic syndromes and infectious diseases. Folia Medica Indonesiana also encourages the publication of articles about health education. The scope includes, but is not limited to, articles that emphasize on preventive education on certain diseases in a community, also research report of various materials and/or methods to develop medical education. We recognize the importance of this type of articles to be published alongside the assigned topic in each of our yearly issues, to provide our readers with updated information in medical sciences’ research and education simultaneously.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 15 Documents
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Search results for , issue "Vol. 56, No. 2" : 15 Documents clear
The Pattern of Antibiotic Prescription and Antimicrobial Resistance of Gut Flora Escherichia coli at Aisyiyah Hospital, Bojonegoro Hidayah, Ana Nurlaili; Hasmono, Didik; Thayyib, Muqoddar; Kuntaman, K
Folia Medica Indonesiana Vol. 56, No. 2
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Antimicrobial resistance (AMR) is the failure of antibiotic to kill bacteria and becomes ineffective in therapeutic purpose. The AMR bacteria is a major health problem worldwide and Indonesia is not exception. AMR is increased by two factors, higher antibiotic use and low compliance in infection control and prevention. WHO has recommended 7 bacterial indicators as point of view in surveillance, one of these bacteria is Escherichia coli. This study aimed to analyze the correlation between antibiotic use and resistance pattern of gut flora Escherichia coli. The study was conducted at Aisyiyah Hospital, Bojonegoro from June to October 2017. Total 101 patients from internal medicine and surgery department in this hospital were included in this study. Bacterial gut flora were tested against 12 antibiotics by disk diffusion test at the Department of Clinical Microbiology, Universitas Airlangga.. The results showed that the highest quantity of antibiotic use in internal medicine service was cefepime (40,50 DDD) and the highest resistance rate was ciprofloxacin, whereas in the surgical service it was ceftriaxone (132,75 DDD) with the highest E. coli resistance to amoxicillin-clavulanic acid. The antibiotics use has significant correlation against E. coli resistance on cefotaxime (p=0.046), ceftazidime (p=0.046), ceftriaxone (p=0.017), aztreonam (p=0.024), and cefepime (p=0.010).
Impact of Stone Size, Location, and Stone Composition on the Efficacy of Extracorporeal Shock Wave Lithotripsy for Residual Stone after Percutaneous Nephrolithotomy Sawal, Zuhri; Soebadi, Doddy M
Folia Medica Indonesiana Vol. 56, No. 2
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This study aimed to determine the impact of stone size, location and stone composition the efficacy of extracorporeal shock wave lithotripsy (ESWL) in the management of residual stone after percutaneous nephrolithotomy (PCNL). The design of this study was a retrospective that conducted between January 2012 until December 2016. The population in this study were all patients with residual stones post PCNL. Exclusion criteria were patients with multiple stones and patients with a history of previous treatment for residual stones such as nephroscopy, flexible ureterorenoscopy, ESWL or medical therapy). The variables studied in this study were stone size, stone location, and stone composition. Before ESWL was carried out, all patients underwent Kidney Ureter Bladder (KUB). After ESWL, all patients underwent ultrasonography (USG) and KUB to determine the stone clearance status. The sample of this study was 125 patients. The overall stone-free rate (SFR) of ESWL in managing post-PCNL residual stones is 72%. SFR based on stone size variable are 73.7% and 71.3% respectively for stones with a size = 5 mm and >5 mm (p = 0.78). SFR based on stone location variable was 67.1%, 75.8%, and 81.8% respectively for the residual stone located at the upper pole, middle pole and lower pole. There are no significant differences in the entire variable. This study concludes that ESWL can be used as effective additional management to treat post-PCNL residual stones with satisfactory SFR.
The Role of Antiapoptotic Erythropoietin on Ultraviolet B-Induced Photodamaged Skin Through Inhibition of Sunburn Cells Suyono, Handi; Sanjaya, Kristian; Susanti, Deby
Folia Medica Indonesiana Vol. 56, No. 2
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Ultraviolet light causes photodamaged skin leading to photoaging skin. Ultraviolet-B (UV-B) causes epidermal keratinocyte apoptosis, namely sunburn cell, through apoptotic intrinsic pathway. Erythropoietin (EPO) has a role in cytoprotection in various tissues but its role to epidermal skin is not clear yet. This study was designed pretest-posttest control group design. Thirty two male mice Mus musculus, strain Balbc, were divided into control and treatment group, 16 mice each group. All mice were exposured by UV-B light 16mJ/cm2, distance 30 cm, duration 90 seconds, for 3 consecutive days. Four mice each group were randomly sacrificed as pretest data. The control mice were given aquadest subcutaneous injection 0.1 mL, and treatment mice were given EPO subcutaneous injection 0.1 mL (100 IU/kg BW). UVB were given everyday with same protocol above. Treatments were given 4 times, interval 3 days. All mice were sacrificed to examine sunburn cells. Data were performed as mean ± SD and analyzed by t-test using SPSS 17.0 with significant value p<0.05. Sunburn cells of pretest control were 25.00 ± 4.85% and treatment group were 24.83 ± 5.15%. Sunburn cells significantly decreased (p=0.002) in treatment group (31.5 ± 9.39%) than control (50.83 ± 6.70%). UV-B causes sunburn cells formation. EPO inhibits apoptosis through increasing NO production and eNOS expression, inhibiting caspase and proinflammatory cytokines, and increasing antiapoptotic protein. EPO has a role in skin apoptosis inhibition which is shown by decreased sunburn cells
Front Matter Vol. 56, No. 2 June (2020) Matter, Front
Folia Medica Indonesiana Vol. 56, No. 2
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Back Matter Vol. 56, No. 2 June (2020) Matter, Back
Folia Medica Indonesiana Vol. 56, No. 2
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Review Article: Presepsin: New Biomaker to Evaluate Empirical Antibiotic Therapy Outcome in Septic Condition Puspitasari, Aldita Cahyani; Mawari, Ayu
Folia Medica Indonesiana Vol. 56, No. 2
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This review presents key publications from the research field of new biomarker of sepsis and other relevant journals during 2009-2015. The results of these experimental studies and clinical trials are discussed in the context of biomarker for sepsis and the accuracy of presepsin for optimising antibiotic therapy. The discussion highlights and summarises articles on three main topics: diagnostic and prognostic biomarkers, presepsin as new biomarkers, and outcome studies. According to the review, presepsin is specific biomarker for bacterial infections compare with CRP and PCT. It may be useful to evaluate the empirical antibiotic outcome in sepsis condition.
High Sensitive Troponin I and Extended Range C-Reactive Protein as Markers to Predict Cardiotoxicity in Locally Advanced Breast Cancer with Neoadjuvant CAF (Cyclophoshpamide, Adriamycin/Doxorubicin, 5Fluorouracil) Therapy Hidayat, Yusfik Helmi; Ishardyanto, Hantoro; Anniwati, Leonita
Folia Medica Indonesiana Vol. 56, No. 2
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The limitation of echocardiography to measure chemotherapy cardiotoxicity at left locally advanced breast cancer with large ulcer is still serious problem. HsTnI and erCRP are biomarkers to detect cardiotoxicity that are cheap, easy to examine and available at Dr.Soetomo Hospital Surabaya. This study was to compare HsTnI, erCRP and echocardiography as cardiotoxicity predictors in locally advanced breast cancer with neoadjuvant CAF therapy. This study used one group pretest and posttest design among 23 locally advanced breast cancer patients. All patients underwent echocardiography, HsTnI, and erCRP examinations before and after 3 times chemotherapy and compared. The average age was 49.78±8.7. Statistically significant decrease in LVEF was found after treatment (67.98%±4.06 and 64.07%±3.53, p=0.000). HsTnI was significantly increased after treatment (0.007 µg/mL±0.004 and 0.043 µg/mL±0.051 p=0.000). erCRP was significantly decreased after treatment (1.043mg/dL±0.913 and 0.573mg/dL±0.444 p=0.044). Decreased LVEF and increased HsTnI was compared by its cardiotoxic cut-off. HsTnI was significantly better and faster to detect cardiotoxicity (0.033±0.051 p=0.002). In conclusion, strong correlation is present in the detection of cardiotoxicity between HsTnI and LVEF. HsTnI is faster than echocardiography, and could be alternative diagnostic to detect early cardiotoxicity.
Body Mass Index and Urinalysis Markers in the Seemingly Healthy Young Adults Pradana, Krisnawan Andy; Kalanjati, Viskasari P; Tirthaningsih, Ni Wajan
Folia Medica Indonesiana Vol. 56, No. 2
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Higher prevalence of albuminuria, glycosuria, and haematuria was reported in the obese people than control. We aimed to analyze the BMI and urinalysis markers among the university students aged 18-21 years old in the IIKBW, Kediri to study any correlations and differences between these variables, which to the best of our knowledge has yet widely reported in Indonesia. This study has ethics approval from Universitas Airlangga, Surabaya. The BMI was analyzed from the body weight and height of male (n=74) and female (n=76) students with no health problems recorded. The pH, nitrites, protein, erythrocytes, glucose in the urine were measured qualitatively with a dip-stick method, blinded, using the midstream urine sample collected in the morning. Data were analyzed using SPSS 17, with a level of significance of p<0.05. Abnormal pH (n=75), positive nitrites (n=24), haematuria (n=6), and proteinuria (n=149) were recorded. About 22% of students suffered from type I obesity, and 8.7% of type II. Males were significantly suffered from the obesity whilst females from the overweight (p<0.05). No significant correlations between the BMI and each urinalysis marker (BMI and nitrites p=0.936; BMI and protein p=1; BMI and pH p=0.835; BMI and blood, p=0.486; respectively); no one were found with glycosuria. No significant differences either on the BMI or the 5 urinalysis markers between male and female groups (p>0.05). Whilst no positive glycosuria samples were identified; 18.9% of males and 13.2% of females have positive nitrites, 100% of males and 98.7% of females have positive proteinuria, 2.7% of males and 7.9% of females have positive haematuria. There were 7.33% of males and 6% of females having an increased pH; whilst 20.66% of males and 16% of females having a decreased pH. Amongst the seemingly healthy university students, we found cases of urinalysis marker impairment, although no significant correlations on the BMI to the urinalysis markers that may be representing early detection for renal diseases were observed.
A Study on Knowledge Towards Brain Death among Residents in Indonesia Fauzi, Asra Al; Waloejo, Christrijogo Sumartono; Machin, Abdulloh; Shodiq, Muhammad Ja'far
Folia Medica Indonesiana Vol. 56, No. 2
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This research was conducted to evaluate the knowledge and diagnosis of brain death among resident in Indonesia. This study used an observational analytic study with a cross-sectional study design using a questionnaire. The research subjects consisted of 132 level 2 (after 2 years of residency) and level 3 (after 4 years of residency) residents, the total sampling for which was taken from the departments of Neurosurgery, Anesthesiology, and Neurology at Dr. Soetomo Academic Medical Center Hospital, Surabaya, Indonesia. Data were taken from November 2018 to January 2019. A total of 132 residents of Neurosurgery, Neurology, and Anesthesiology participated in this study. From the series of studies, residents' knowledge of the concept of brain death was in the sufficient category (41.7%), residents' knowledge of the technical diagnosis of brain death was in the good category (40.2%), residents' knowledge of brain death examination was in the less category (43.2%), and finally, it was found that the resident's knowledge of brain death was in a good category (35.6%). There were also significant differences in knowledge of brain death between Neurosurgery, Neurology, and Anesthesiologist Resident (P <0.001) and knowledge of brain death between level 2 and level 3 residents (P=0.032). In general, the Indonesian resident doctors' knowledge of brain death is adequate, but knowledge of the clinical examination of brain death is still lacking. Further research must be carried out to promote knowledge of brain death in residents as well as professional doctors/specialists, so that the number of organ transplants, especially in Indonesia, will increase.
Case Report: Cranial Vault Reduction Cranioplasty for Severe Hydrocephalus Suryaningtyas, Wihasto; Parenrengi, Muhammad Arifin
Folia Medica Indonesiana Vol. 56, No. 2
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Extreme hydrocephalic macrocephaly is still encountered in developing countries due to delayed treatment, rapidly progressing hydrocephalus and family socioeconomic problems. Reduction cranioplasty was used with several techniques to address the issue. The study aimed to determine the safety and feasibility of barrel-stave technique for reducing the size of extreme hydrocephalic macrocephaly. Three post-diversion patients underwent surgical reconstruction. Children with head circumference more or equal to two standard deviation above mean on given age, no active wound at the area of surgery, presentation of sufficient "potential removable fluid” that allows dura reduction and no active shunt infection were eligible. The surgical procedure includes modified pi, barrel-stave technique, and diversion of the cerebrospinal fluid and subdural collection. Clinical data were recorded. Three patients with age range of 2 month to 2 years old underwent the surgery. Two patients had shunt implanted at least 1 month before the surgery and 1 patient had an ETV procedure 3 months before the reduction. The frontal-occipital circumference before surgery ranged from 50 to 63 cm. The maximum reduction that could be achieved was 15 cm. One patient (2 months old) died within 24 hour due to failure to cope with excessive blood loss. Two patients were followed up for 3 months and 6 months without complications. Reduction cranioplasty using barrel-stave techniques is an option for children with extreme large head that poses a mechanical or cosmetic problem. Risk and pitfalls should be considered and taken care meticulously, especially the age and blood loss.

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