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Folia Medica Indonesiana The Unit of Journal Consortium and Folia Medica Indonesiana Faculty of Medicine, Universitas Airlangga Jl. Prof. Dr. Moestopo No.47, Pacar Kembang, Kec. Tambaksari, Surabaya, Jawa Timur 60132, Indonesia
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Folia Medica Indonesiana
Published by Universitas Airlangga
ISSN : 23558398     EISSN : 2599056X     DOI : https://doi.org/10.65346/2958-4515.2401
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience
Folia Medica Indonesiana, as indicated by its name, focuses on publishing good quality articles about research and education on health science and medicine in Indonesia. However, due to the fast growth of science and knowledge in these fields, we also welcome submitted articles from around the world, especially the ones that contain related matters from lower-middle income countries. Folia Medica Indonesiana is an open-access, peer-reviewed journal that is published online at least four times a year. The scope covers various aspects of basic medical sciences includes anatomy, physiology, pathology, microbiology, pharmacology, and molecular medicine) and clinical medicine (covers specialties like internal medicine, surgery, pediatrics, oncology, psychiatry, etc). We highlight the pathology and potential treatment of metabolic syndromes and infectious diseases. Folia Medica Indonesiana also encourages the publication of articles about health education. The scope includes, but is not limited to, articles that emphasize on preventive education on certain diseases in a community, also research report of various materials and/or methods to develop medical education. We recognize the importance of this type of articles to be published alongside the assigned topic in each of our yearly issues, to provide our readers with updated information in medical sciences’ research and education simultaneously.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 571 Documents
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COMPARISON OF INTRAPERITONEAL AND INTRADUCTAL ROUTES IN THE GROWTH OF N-METHYL-N-NITROSOUREA-INDUCED BREAST CANCER IN SPRAGUE DAWLEY RATS: A SYSTEMATIC REVIEW 2014–2024 Prameswari, Adilla Soraya; Sompokan, Ruendhita Azzahra Sari; Annisa, Annisa; Putri, Rachma Greta Perdana; Yuniasih, Dewi; Danian, Muhamad; Tianotak, Muhammad Tri Yoga
Folia Medica Indonesiana Vol. 61, No. 2
Publisher : Folia Medica Indonesiana

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Abstract

Breast cancer is one of the[-6pc]AU: Please provide affiliations for your paper. leading causes of death for women worldwide, characterized by malignant tumors in the mammary epithelium. Breast cancer modelling using Sprague Dawley animals induced by N-Methyl-N-Nitrosourea (MNU) compounds is commonly used through various administration routes. The intraperitoneal route is the conventional route and the intraductal route is a new route capable of directly targeting the mammary ducts. Both routes affect the speed and characteristics of breast cancer cells in experimental animals. This systematic review using PubMed and Scopus databases from 2014-2024 aims to compare the effects of intraperitoneal and intraductal administration routes on breast cancer induction and the similarities in histopathological characteristics and biomarkers with human breast cancer cells. Of the 324 articles, 15 met the inclusion criteria showing that the intraductal route induces tumors faster (6–8 weeks) with Ductal Carcinoma In Situ (DCIS) type, ER+/PgR+ expression, and low Ki-67 index, resembling the luminal A subtype. The intraperitoneal route requires 8–12 weeks, producing multiple tumors with a high Ki-67 index, resembling luminal B. Administration of additional substances such as PF4, white tea, and physical activity are anti-tumorigenic, while radiation and a high-fat diet are pro-tumorigenic. Therefore, the intraductal route can be used as the main choice in selecting the route of administration of MNU induction.

Page 58 of 58 | Total Record : 571

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