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Folia Medica Indonesiana The Unit of Journal Consortium and Folia Medica Indonesiana Faculty of Medicine, Universitas Airlangga Jl. Prof. Dr. Moestopo No.47, Pacar Kembang, Kec. Tambaksari, Surabaya, Jawa Timur 60132, Indonesia
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Folia Medica Indonesiana
Published by Universitas Airlangga
ISSN : 23558398     EISSN : 2599056X     DOI : https://doi.org/10.65346/2958-4515.2401
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience
Folia Medica Indonesiana, as indicated by its name, focuses on publishing good quality articles about research and education on health science and medicine in Indonesia. However, due to the fast growth of science and knowledge in these fields, we also welcome submitted articles from around the world, especially the ones that contain related matters from lower-middle income countries. Folia Medica Indonesiana is an open-access, peer-reviewed journal that is published online at least four times a year. The scope covers various aspects of basic medical sciences includes anatomy, physiology, pathology, microbiology, pharmacology, and molecular medicine) and clinical medicine (covers specialties like internal medicine, surgery, pediatrics, oncology, psychiatry, etc). We highlight the pathology and potential treatment of metabolic syndromes and infectious diseases. Folia Medica Indonesiana also encourages the publication of articles about health education. The scope includes, but is not limited to, articles that emphasize on preventive education on certain diseases in a community, also research report of various materials and/or methods to develop medical education. We recognize the importance of this type of articles to be published alongside the assigned topic in each of our yearly issues, to provide our readers with updated information in medical sciences’ research and education simultaneously.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 571 Documents
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The Effect of Childhood Obesity on Psychomotor Behavior Khalfani, Muhammad Adrian; Rejeki, Purwo Sri; , Sakina; Fathil, Nur Ezza Fazleen Mohd
Folia Medica Indonesiana Vol. 59, No. 3
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Abstract

Childhood obesity is a complex problem, and its prevalence among school-age children has been found to have a greater impact on their physical well-being compared to their learning difficulties. In some cases, teachers or schools may not pay enough attention to issues that have the potential to affect or delay the psychomotor development of children. Therefore, this study aimed to provide enhanced comprehension regarding the effect of childhood obesity on psychomotor behavior. This study used a systematic review methodology to synthesize information regarding the effect of obesity on children's health and development. The information and data presented in this study were obtained from several scientific sources accessed through online libraries such as PubMed, ScienceDirect, and the Cochrane Library. A comprehensive search was conducted to identify scholarly publications, which resulted in a total of 815 papers published between 2013 and 2022. The selected papers exclusively consisted of original research articles that primarily focused on investigating the relationship between obesity in children aged 5–14 years and their psychomotor abilities and development outcomes. Following the screening process, five studies were found to meet the specified criteria. The findings of the selected studies revealed a substantial resemblance, specifically the correlation between childhood obesity and poor motor skills. Furthermore, the selected studies discovered that an increase in body fat is commonly associated with a rise in total body weight, or the relative body mass index (BMI), in both adults and children. Some studies demonstrated significant differences in the performance of diverse psychomotor variables according to children's BMI. According to the results of the studies, children with a higher BMI showed inferior performance in motor activities as a result of compromised body control and balance that inhibited the children's movement. This systematic review concludes that obesity has an effect on the psychomotor behavior of children.
Hypertension and Lipid Profiles in Middle-Aged Male Patients: A Study at a Tertiary Hospital in Surabaya, Indonesia Nurtya, Arin; Tjempakasari, Artaria; Maimunah, Ummi; , Sulistiawati; Harsa, I Made Subhawa
Folia Medica Indonesiana Vol. 59, No. 4
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Highlights: 1. Uncertainty regarding the association between hypertension and the levels of low-density lipoprotein (LDL) and high-density lipoprotein (HDL) signifies the need for more research, particularly in the realm of sex-specific analysis. 2. Our study uncovered significant associations between hypertension and the levels of total cholesterol and triglycerides, expanding our understanding of the impact of lipid profiles on hypertension. 3. This research may potentially pave the way for personalized diagnostic and therapeutic strategies, ultimately enhancing hypertension management and patient outcomes. Abstract Hypertension is one of the most frequent non-communicable diseases and a risk factor for cardiovascular disease, contributing to most deaths globally. The risk of hypertension is higher in those with uncontrolled lipids. In this study, the incidence of hypertension and lipid profiles were examined from March 2020 to March 2022. The aim of this study was to determine the relationship between hypertension in men aged 45–60 years and their lipid profiles, which include total cholesterol, triglycerides, low-density lipoprotein (LDL), and high-density lipoprotein (HDL). This study used an analytical observational design with a cross-sectional approach. Medical records were utilized as secondary data. Statistical analysis was conducted using the Spearman rank correlation test. Statistical significance was determined at p<0.05. This research examined 115 patients with hypertension. The results showed that the stage of hypertension was correlated with total cholesterol (r=0.317; p=0.001) and triglyceride levels (r=0.217; p=0.02). However, the stage of hypertension was not significantly correlated with LDL (r=0.158; p=0.91) and HDL (r=0.75; p=0.423). Hence, this current study underscores the nuanced relationship between lipid profiles and the stage of hypertension in middle-aged male patients. This study highlights the importance of sex-specific analysis in hypertensive research. It also provides promising avenues for further investigation.
Mortality among Heart Failure Patients in the Presence of Cachexia , Andrianto; Karman, Ula Nur Pramesti; Mudjanarko, Sony Wibisono; Ardiana, Meity; Hermawan, Hanestya Oky
Folia Medica Indonesiana Vol. 59, No. 1
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Highlights: • Around 38.8% of heart failure patients with cachexia died during the 180-1,876-day follow-up period. • Cachexia increases the risk of mortality in heart failure patients. Abstract: Despite the fact that obesity has long been recognized as a risk factor for cardiovascular disease, the mortality rate of heart failure (HF) patients with cachexia is still high. Several studies have been conducted to investigate the association between cachexia and mortality in HF patients. However, the research results vary, as do the diagnostic criteria employed to assess cachexia. This meta-analysis aimed to conclusively summarize the association between cachexia and mortality in HF patients. The data were obtained from prospective or retrospective cohort studies with full texts in English or Indonesian and keywords related to "cachexia," "heart failure," and/ or "mortality". Studies that did not assess mortality in HF patients with cachexia and had no full text accessible were omitted. A literature search was conducted through four databases (PubMed, Web of Science, Scopus, and SAGE Journals) using keywords, reference searches, and/ or other methods on April 2022 in accordance with the Preferred Reported Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Data from the selected studies were presented and analyzed using qualitative and quantitative synthesis methods. The Newcastle-Ottawa Scale (NOS) was used to assess the risk of bias in the selected cohort studies. The qualitative synthesis contained nine studies, whereas the quantitative synthesis (meta-analysis) included six studies. Cachexia was found in 16.0% of the 4,697 patients studied. During the 180-1,876-day follow-up period, 33.0% of the patients died, with a mortality rate of 38.8% among the patients with cachexia. The pooled analysis revealed cachexia to be a significant predictor of mortality in HF patients (hazard ratio (HR)=3.84; 95% CI=2.28-6.45; p<0.00001), but with significant heterogeneity (p<0.00001; I2=88%). In conclusion, cachexia worsens HF prognosis.
Hypnopressure as a Non-Invasive Method for Anxiety and Pain Management in Primigravidae during Active Labor Fitrianingsih, Yeni; Prasetya, Hanung; Widiyanti, Rani
Folia Medica Indonesiana Vol. 60, No. 4
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Highlights: 1. This study applied hypnopressure, an innovative method that combines auditory hypnosis with acupressure on effective uterine points, namely the Hegu (LI4) and Sanyinjiao (Sp6) points. 2. This innovation offers an effective method for managing labor pain in primigravidae during the active phase of the first labor stage compared to hypnotherapy and acupressure administered separately. AbstractPsychological factors, such as fear and anxiety, are often responsible for prolonged labor. Anxiety affects 58% of primigravidae, while 2–4% experience pain with scores ranging from 30 to 40 out of 50. Hypnopressure is an innovative combination of hypnotherapy and acupressure applied on the Sanyinjiao (SP6) and Hegu (LI4) points for 3–5 seconds in 20 repetitions during the first stage of labor contractions. This study aimed to determine the effect of hypnopressure on the LI4 and Sp6 points in reducing primigravidae's anxiety levels and pain degrees during the active phase of the first labor stage. This research used a double-blind randomized controlled trial methodology with a pretest-posttest design. Eighty subjects were divided into four groups to compare the effects of different interventions and determine which one demonstrated the most effectiveness. Each of the hypnopressure, hypnotherapy, acupressure, and control groups comprised 20 subjects. The treatment interventions were administered during the active phase of the first labor stage, which was subsequently analyzed using the Wilcoxon and Kruskal-Wallis statistical tests (p<0.05). The hypnopressure (p=0.000), hypnotherapy (p=0.000), and acupressure (p=0.002) groups experienced decreasing anxiety levels. The Kruskal-Wallis post-test indicated a significant difference (p=0.000) after treatment, revealing that hypnotherapy resulted in the lowest decrease in anxiety compared to the other three groups. Additionally, the degree of labor pain (p=0.000) was lower in the hypnopressure group (4.00±1.496) than in the other three groups. There was a significant difference across the four groups (p=0.000), with subjects in the hypnopressure group reporting lower pain degrees compared to those in the hypnotherapy (p=0.000), acupressure (0.000), and control (p=0.000) groups. In conclusion, this study suggests that hypnopressure treatment can decrease anxiety levels and pain in primigravidae during active labor.
Rehabilitation Impact of Vivifrail Exercise Program Type C on the Cognitive Function of Pre-Frail Elderly People in the Community Soenarti, Sri; Lestari, Dwi Indriani; Nugroho, Muhammad Barlian; Lestari, Harien
Folia Medica Indonesiana Vol. 60, No. 3
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Highlights: 1. This study emphasizes the importance of providing physical exercises to pre-frail elderly individuals, especially in a community setting. 2. This study establishes a foundation for future research to explore the relationship between physical exercise, particularly the Vivifrail Type C Protocol, and cognitive function in pre-frail elderly individuals. Abstract Frailty is a clinical syndrome that increases vulnerability, potentially leading to disability or death. The pre-frail phase is ideal for preventing frailty and improving quality-adjusted life years, particularly through physical exercises that reduce the risk of dementia and cognitive impairment. Multicomponent exercises, such as the Vivifrail Exercise Program, may enhance cognitive function and daily independence by preventing and mitigating frailty through tailored routines. However, its impact on cognitive function in pre-frail elderly people had not been well studied. This study aimed to determine the effect of the Vivifrail Exercise Program Type C on the cognitive function of pre-frail elderly people. This study was a quasi-experiment with a non-randomized control group pretest-posttest design. The sample was chosen by the quota sampling method. Twenty-seven subjects were analyzed, comprising 16 individuals in the exercise group and 11 individuals in the control group. The exercise group participated in the Vivivfrail Type C Exercise Program, with 45-minute sessions conducted biweekly for 12 weeks. The evaluated parameters included the Montreal Cognitive Assessment-Indonesian Version (MoCA-INA) and the Loewenstein Occupational Therapy Cognitive Assessment (LOTCA). The statistical analysis utilized the Kruskal-Wallis test, followed by the post-hoc Mann-Whitney test and independent t-test (p<0.05). A path analysis was performed using simple linear regression. The subjects' average ages were 72.2 years in the control group and 67.47 years in the exercise group. The Vivifrail Exercises Program Type C significantly improved the MoCA-INA scores from 20.25 to 24.06. It also increased the LOTCA scores in several domains, i.e., thinking operations and visual perception. The exercise group demonstrated more improvement than the control group (p=0.032). An enhancement in cognitive function was particularly observed in elderly women with pre-frailty. In conclusion, the Vivifrail Exercise Program Type C can help improve the cognitive function of the elderly within the community.
Reduction of Postoperative Nausea and Vomiting Induced by Spinal Anesthesia: Peppermint and Lavender Aromatherapies as Complementary Therapies Arif, Taufan; Ciptaningtyas, Maria Diah; Mudviyanti, Navalia Nailin; Solikhah, Fitriana Kurniasari
Folia Medica Indonesiana Vol. 60, No. 4
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Highlights: 1. This study provides insight into the effectiveness of peppermint and lavender aromatherapies in reducing postoperative nausea and vomiting in patients following spinal anesthesia. 2. Aromatherapies with peppermint and lavender administered three times within six hours have demonstrated potential as an easy-to-apply intervention that reduces postoperative nausea and vomiting. 3. In terms of effectiveness, however, peppermint aromatherapy exhibits a higher effectiveness in reducing nausea and vomiting compared to lavender aromatherapy. AbstractNausea and vomiting are common occurrences after surgery with spinal anesthesia, potentially leading to complications and delayed recovery. Hypotension associated with spinal, epidural, and combined spinal-epidural anesthesia is a significant factor contributing to postoperative nausea and vomiting (PONV). This study aimed to determine the difference in effectiveness between peppermint and lavender aromatherapies for reducing PONV in patients receiving spinal anesthesia. This study used a pretest-posttest design with a control group. The research sample comprised at least 12 respondents in each group, resulting in a total of 36 respondents selected by a random sampling technique utilizing a wheel spinner. The inclusion criteria were respondents who experienced moderate to severe PONV, as indicated by scores of 9–24. The Rhodes Index of Nausea, Vomiting, and Retching (RINVR) instrument was utilized to measure the level of nausea and vomiting over six hours. The statistical analysis included the Mann-Whitney test and the Wilcoxon test, with a significance level set at p
Hemoglobin A1c (HbA1c) Levels from the Examination of Different Blood Proportions in K2EDTA Tubes using an Enzymatic Method , Museyaroh; Nabilah, Musholli Himmatun; Werdiningsih, Retno
Folia Medica Indonesiana Vol. 59, No. 3
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Highlights: 1. Research on the effect of blood volume proportion in the examination of HbA1c levels using K2EDTA anticoagulantvhas yet to be widely carried out in Indonesia. 2. The analysis conducted utilizing K2EDTA tubes revealed that the varying proportions of blood samples had no effectvon HbA1c levels. 3. This article highlights the necessity of evaluating the pre-analytical phase (sample preparation) of a laboratory process to improve the accuracy of the results and minimize false high or low results in the HbA1c test. Abstract Hemoglobin A1c (HbA1c) examination is the gold standard for diagnosing and monitoring diabetes mellitus patients. In the examination, the pre-analytical phase has the most considerable error rate at 61%. One of the contributing factors is the use of anticoagulants that do not adhere to established guidelines. Additionally, the incompatibility of the sample volume proportions and the anticoagulants in K2EDTA tubes has been observed in numerous cases. The significance of HbA1c testing, particularly in the prevention of diabetes complications, underscores the need for appropriate procedures to be followed throughout the sampling and pre-analytical phases. This study aimed to determine the effect of differences in the proportion of blood sample volume and anticoagulants in K2EDTA tubes on HbA1c levels. This research was conducted in August–September 2022. The research samples were collected from the staff and students at the Department of Medical Laboratory Technology, Politeknik Kesehatan Kemenkes Surabaya, Surabaya, Indonesia. The blood samples were divided into K2EDTA tubes with varying volumes of 1 mL, 2 mL, 3 mL, and 4 mL. The HbA1c levels were then examined at the Clinical Chemistry Laboratory of Politeknik Kesehatan Kemenkes Surabaya. The data were analyzed using a one-way ANOVA test. The statistical test results (p>0.05) indicated that the proportion of samples containing anticoagulants in the K2EDTA tubes did not have any significant effect on HbA1c levels. In conclusion, it is acceptable to utilize K2EDTA tubes with varying blood sample volumes for the measurement of HbA1c levels.
Risk Factors of Central Obesity in Indonesian Men: A Cross-Sectional Data Study of The Indonesia Family Life Survey 5 (IFLS 5) , Dahlia; Pribadi, Gracia Satyawestri; Martini, Santi; Yi-Li, Chung
Folia Medica Indonesiana Vol. 58, No. 3
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Highlights: • Low levels o physical activity are the major risk factor of central obesity among Indonesian men. • There was a relationship between smoking status, smoker type, cigarette type, physical activity, and meat consumption frequency and the incidence of central obesity. Abstract: Obesity is one of the leading health problems in both developed and developing countries. Central obesity can be defined as a condition where excess fat has accumulated in the abdominal area. There are several risk factors that may cause central obesity in men such as smoking habits, physical activity, and dietary habits. This study aimed to analyse the risk factors of central obesity in Indonesian men. This was an analytical observational study using a cross-sectional design. It used secondary data from the Indonesia Family Life Survey (IFLS 5) with a sample size of 4,648 respondents. The variables studied here were smoking status, type of smoker, type of cigarette, physical activity, and meat consumption frequency. Logistic regression analysis was used. The results of this study showed that the mean age of the respondents was 51 years old. There was a relationship between smoking status (p=0.000), type of smoker (p=0.002), type of cigarette (p=0.000), physical activity (p=0.000), and meat consumption frequency (p=0.024) and the incidence of central obesity. The conclusion of the study was that there was a relationship between smoking status, type of smoker, type of cigarette, physical activity, meat consumption frequency, and the incidence of central obesity, all of which were risk factors of central obesity in Indonesian men. A low level of physical activity was the most prominent risk factor associated with central obesity among Indonesian men. From this study, we suggested controlling the risk factors of central obesity by providing education on the dangers of smoking and the importance of physical activity and a balanced nutritional diet.
Percutaneous Nephrolithotomy (PCNL) in Older and Younger Patients at a Tertiary Hospital in Surabaya, Indonesia Ali, Muhammad Wahyu; Azmi, Yufi Aulia; , Tarmono; Soebadi, Doddy M.
Folia Medica Indonesiana Vol. 59, No. 1
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Highlights: • Percutaneous nephrolithotomy (PCNL) in older patients is as effective and safe as in younger patients. • It is a viable option for managing renal stones in older patients with indications, although blood transfusions are frequently required. Abstract: Percutaneous nephrolithotomy (PCNL) for renal and proximal ureteral stone treatment among the elder population is considered challenging due to the complication risk associated with comorbidity and lower functional reserve. Patients older and younger than 60 years old were compared for efficacy and safety in following PCNL procedures. Consecutive patients who underwent PCNL from 2019-2021 in a single center were divided into patients aged at least 60 years (group I) and patients aged under 60 years (group II). Single stage fluoroscopic-guided PCNL were used for the entire study population. Patients' habitus, stone-related, and operative characteristics were compared. The two groups' PCNL success and complication rates were evaluated. A total of 245 patients, comprising 65 in group I and 180 in group II, were included for analysis. Diabetes mellitus prevalence was higher in group I (30.8% vs 18.9%). However, the study population did not show a significant difference in regard to comorbidity. Operative time, success rate (80% vs 74.4%), and complication rate (16.9% vs 15.6%) did not statistically differ (p>0.05). Transfusion rate was higher among patients aged at least 60 years (p=0.018). Based on the multivariate analysis, stones located in the renal pelvis was the factor which contributed to the success rate. In conclusion, percutaneous nephrolithotomy is a safe and effective procedure for treating renal and proximal ureteral stones in the older population. Blood transfusions are more frequently given, in part, due to bleeding risk among older patients.
The Effect of Cabbage (Brassica oleracea var. capitata L.) Extract on Macrophage and Blood Vessel Counts in Clean Wound Tissue of Male Rats (Rattus norvegicus) Tsania, Nidya Ulfana; Sandhika, Willy; , Sawitri
Folia Medica Indonesiana Vol. 59, No. 2
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Highlights : • Cabbage extract application accelerates wound healing and has anti-inflammatory effect. • Cabbage extract serves as an affordable source material for wound healing and anti-inflammation. Abstract Cabbage is a widely consumed vegetable known for its health benefits due to its rich nutrients and phytochemicals, especially phenolic compounds, which are known to have potent anti-inflammatory and antioxidant effects. This study aimed to investigate the effects of cabbage extract on wound healing by observing inflammatory responses in wound tissue. A total of 24 male rats were divided into four groups, with six rats in each group. The experiment was conducted for five days by administering cabbage extract to the treatment group and distilled water to the control group. Skin wound tissues were collected from all rats for histological observation by counting the number of macrophages and blood vessels. The results of the observation were analyzed statistically using an independent sample t-test with p<0.05. The results showed that the number of macrophages and blood vessels in the treatment group was significantly higher than the control group on the third day and significantly lower on the fifth day. In conclusion, the administration of cabbage extract can accelerate the inflammatory and proliferative phases of wound healing by promoting the migration of cells, including macrophages, resulting in accelerated angiogenesis. In addition, the decreased number of macrophages and blood vessels during the proliferative phase showed that the healing phase had reached a more advanced stage.

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