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INDONESIA
Jurnal Kedokteran Diponegoro
Published by Universitas Diponegoro
ISSN : -     EISSN : 25408844     DOI : -
Core Subject : Health,
Medicine & Pharmacology
JKD : JURNAL KEDOKTERAN DIPONEGORO ( ISSN : 2540-8844 ) adalah jurnal yang berisi tentang artikel bidang kedokteran dan kesehatan karya civitas akademika dari Program Studi Kedokteran Umum, Fakultas Kedokteran, Universitas Diponegoro Semarang dan peneliti dari luar yang membutuhkan publikasi . JURNAL KEDOKTERAN DIPONEGORO terbit empat kali per tahun. JURNAL KEDOKTERAN DIPONEGORO diterbitkan oleh Program Studi Kedokteran Umum, Fakultas Kedokteran, Universitas Diponegoro Semarang.
Arjuna Subject : -
Articles 974 Documents
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The Effect of Jump Rope Training on Mood Among Senior High School Students Nazilla Jufril; Hardian Hardian; Darmawati Ayu Indraswari; Endang Kumaidah
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 11, No 5 (2022): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v11i5.35479

Abstract

Background: Physical activity has protective effects against the development of depression symptoms for all age groups. Cognitive training and aerobic training are lifestyle interventions that have been shown to have a positive impact on health, reducing cognitive impairment, and delaying the onset of dementia. Jump rope training is one type of aerobic training. Aerobic training is effective in improving mood. Objective: This study aims to prove the effect of jump rope training on adolescent’s mood as measured by the POMS score. Methods: This is an experimental study with 2 parallel groups pre-test and post-test design. The research subjects were 32 students of senior-high school 1 of Gunung Talang, Solok Regency, West Sumatra that were selected by purposive sampling and grouped into 2 groups. The control group without treatment (n=16), and the treatment group (n=16) were given jump rope training for 6 weeks. Mood scores were measured before and after the intervention using a profile of mood state (POMS) questionnaire and expressed as total mood disturbance (TMD) scores. Results: The research shown the significant decreases of TMD scores (p<0.001) on the treatment group rather than the control group. In addition, there was a significant difference between the post-test TMD scores of the control group and the treatment group (p=0.005). Conclusion: Jump rope training for 6 weeks can improve the mood of the adolescent.Keywords: aerobic training, jump rope training, mood, profile of mood state, total mood disturbance
Cost Effectiveness Analysis of Captopril And Amlodipine in Hypertensive Patients with Diabetes Mellitus at Magelang Regency Health Center Meisi Islami Bulan; Eva Annisaa; Intan Rahmania Eka Dini
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 11, No 5 (2022): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v11i5.35368

Abstract

Backgrounds: Hypertension and Diabetes Mellitus are interrelated diseases and have a strong predisposition to the occurrence of cardiovascular disease and atherosclerosis. BPJS Kesehatan states that the cost of hypertension services has increased every year, indicating the need to control costs through pharmacoeconomic studies. One method that can be used is cost-effectiveness analysis. Find out the effective drugs in terms of cost and therapy. Aim: To determine the cost-effectiveness of Captopril and Amlodipine for hypertensive patients with co-morbidities of diabetes mellitus at the Magelang District Health Center. Methods: This study was conducted retrospectively with medical record data for 2019-2020. The sample in this study was 35 with 15 groups of 10 mg/day amlodipine and 20 groups of 25 mg/day captopril. The outcome assessed was the number of patients who achieved the therapeutic target for 1 month using the drug. Results: The percentage of therapeutic effectiveness of amlodipine 10 mg/day was 86,7% while captopril 25 mg was 60%. The average direct medical cost of the amlodipine 10 mg/day is Rp10.429,30 greater than captopril 25 mg/day, which is Rp7.298,80. The ACER value of amlodipine 10 mg/day was Rp. 12.023,00 and captopril 25 mg/day was Rp. 12.164,00. Calculation of ICER value of  the average direct medical cost of the 10 mg/day amlodipine group is Rp10.423,93 greater than captopril 25 mg/day, which is Rp7.298,80. Conclusion : Amlodipine is more cost-effective than captopril with an ACER value of  RP. 12.023,00.
Relationship Between Physical Activity During COVID-19 Pandemic and Depression Rates in College Students: Analytical Observational Studies among First Year Medical Students at Universitas Diponegoro Semarang Salafudin Salafudin; Innawati Jusup; Endang Kumaidah; Lusiana Batubara
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 11, No 6 (2022): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jkd (dmj).v11i6.36250

Abstract

Background: The COVID-19 pandemic has an impact on every individual. Lifestyle changes and reduced physical activity are some of them. Less physical activity will affect a person's psychological problems, one of which is depression. Depression is a common mental disorder with depressed mood, loss of interest or pleasure, decreased energy, feelings of guilt or low self-esteem, sleep or appetite disorders, and reduced concentration. Aim: Determine the relationship of physical activity during the COVID-19 pandemic with the level of depression in first-year students of the Faculty of Medicine, Diponegoro University. Methods: The research design is observational analytics with a cross-sectional approach. The study used the International Physical Activity Questionnaire (IPAQ) and Beck Depression Inventory-II (BDI-II), presented in the google form and disseminated through social media. Respondents filled out one hundred seventy-six questionnaires. The purposive sampling method obtained respondents included in the inclusion and exclusion criteria as many as 114 respondents. The data were tested with the Chi-Square test to assess correlations between variables. Results: We found a significant association between physical activity during the COVID-19 pandemic and depression rates (p=0.043). There is a link between sex and physical activity and depression levels (p=0.007), and there is a significant association between age and physical activity and depression levels during the COVID-19 pandemic (p=0.00).
A REVIEW OF THE MONKEYPOX OUTBREAK IN INDONESIA IN 2022 Meiriani Sari; Nany Hairunisa
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 11, No 5 (2022): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v11i5.35895

Abstract

Monkeypox disease (monkey smallpox) is a disease that has never been found in Indonesia since it was first discovered in humans in the Congo in 1970. So if there is one positive confirmed event, then the disease is an Extraordinary Event (KLB). This disease has become a global concern because since May 13, 2022, WHO has received reports of Monkeypox cases from non-endemic countries. It has expanded to 4 WHO regions: Europe, America, Eastern Mediterranean, and Western Pacific. Until now, further investigations and studies are still being carried out to understand more about the epidemiology, sources of infection, and transmission patterns in non-endemic countries that have reported new cases, such as Indonesia. Until now, no specific treatment has been proven to treat Monkeypox infection. Currently, the therapy used is symptomatic support. The antiviral tecovirimat, or TPOXX, developed by the European Medicines Agency (EMA) as a Monkeypox therapy in 2022 based on research, has not been marketed freely. In addition, antivirals such as cidofovir and brincidofovir have been shown to be effective against orthopox virus in vitro and in animal studies. However, the effectiveness of this drug against monkeypox in humans is not yet known. However, this disease can be prevented by vaccination. In Indonesia, the Modified Vaccinia Ankara-Bavarian Nordic (MVA-BN) vaccine is recommended to prevent Monkeypox disease. The existence of the outbreak report is important to discuss, explore, and understand more about the disease and its management and prevention.
The Infulence of Diabetes Self Management Education with AVA on the Knowledge of Diabetes Mellitus Type 2 Erika Martining Wardani; Riezky Faisal Nugroho
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 11, No 5 (2022): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v11i5.35631

Abstract

Background: High or uncontrolled blood sugar levels are still widely found, one of which is due to the patient's lack of knowledge about the disease, diet and treatment of DM sufferers. Overcoming these problems by providing health education. Diabetes self management education (DSME) is a process to support knowledge, skills and abilities in diabetes self-care. Objective: This study examines the influence of diabetes self management education with ava on the knowledge of diabetes mellitus type 2. Methods: The design of this study used a quasy experiment with a pre-test and post-test nonequivalent control group approach. The population in this study were all elderly people with Diabetes Mellitus as many as 170 people, the sample was 60 respondents who were taken using the simple random sampling technique. The instrument used was a questionnaire given before and after the intervention. Data were analyzed using the Wilcoxon Signed Ranks Test with α = 0.05. Results: The research results obtained that the respondent's knowledge after (post test) giving intervention DSME with AVA obtained a Mean Rank value of 3.00 while the level of knowledge before it was carried out (pre test) obtained a Mean Rank value of 2.50 obtained a Sig value of 0.0001 which means if p
Effect of Plum Fruit Extract (Prunus Domestica L) on Hepar Histology in Male Wistar Rats (Rattus Norvegicus) Induced Alloxan Ganesha Aji Pratama; Indah Saraswati; Desy Armalina; Puspita Kusuma Dewi
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 11, No 6 (2022): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jkd (dmj).v11i6.36243

Abstract

Background: The condition of blood glucose levels exceeding normal limits is hyperglycemia. Hyperglycemia can lead to complications in organs. Glucose levels that exceed normal limits can be reduced by chemical drugs but have side effects such as hypoglycemia and hepar damage. Therefore, the public needs safe alternative treatment with minimal side effects. Consuming fruit is an alternative treatment for plums. Plums contain flavonoids that can increase adiponectin levels which play an important role in regulating blood glucose levels. Researchers are interested in conducting this study because there has been no research on the influence of plums on hyperglycemia. Objective: Analyzing the effect of giving plum (Prunus domestica L) extract on hepar histology of male Wistar rats (Rattus norvegicus) hyperglycemic with alloxan induction. Method: The type of research is experimental, with a posttest design and only a control group design. Total of 35 Wistar were divided into five groups i.e., negative control (K-) was given aquadest, positive control (K+) and treatment group induced with intraperitoneal alloxan 150 mg/kgBW/day, treatment group 1 (KP 1), treatment group 2 (KP 2), treatment group 3 (KP 3) given peroral 100, 200, 300 mg/kgBW/day plum extract. Days 0, 3, 7 and 14 measure blood glucose levels. On the 14th day the Wistar was dissected and made a preparatory block followed by hematoxylin-eosin staining. Observations were conducted under the microscope with magnification of 100x and or 400x and assessed necrosis on hepar using Mordue scores. Result: The group that was given plum extract after being given Alloxan (KP 1, KP 2, and KP 3) had significant differences from the group given only Alloxan (K+), which means the administration of plum extract can suppress blood sugar levels and lower the necrosis rate of hepar rats. Conclusion: Blood sugar levels and necrosis rates in the rat group with the administration of the plum extract at a dose of 300 mg/kgBW/day were lower than doses of 100 mg/kgBW/day and 200 mg/kgBW/day.
Bibliometric Analysis of Publication on Protein Nanoparticle Using VOSviewer Riska Kurnelia Ananda; Asep Bayu Dani Nandiyanto
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 11, No 6 (2022): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v11i6.35942

Abstract

Background: A Study to determine the development of research can be done by bibliometric analysis technique. There are many studies that have been carried out on bibliometric analysis. However, research on bibliometric analysis of published data in the field of protein nanoparticles that has been carried out specifically to determine research development has not been carried out. Objective: This study aims to examine the development of protein nanoparticle research through a bibliometric approach. Methods: The article data was obtained from the Google Scholar database using the publish or perish reference manager software. The keyword "Protein Nanoparticles" is used with a publication time span from 2012 to 2022. Data processing uses Microsoft Excel. Computational mapping using VOSviewer. Results: The article data obtained and considered relevant were 390 articles. The results of the analysis of the development of protein nanoparticle publications in the last 10 years show quite frequent fluctuations. Research fluctuations occurred in 2012 to 2020. There was a decline in 2020-2022 from 35 in 2020 to 19 in 2022. In 2012 and 2014 research on protein nanoparticles became popular, with 47 studies each. Conclusion: Based on the results of mapping the collected article data, it can be seen that the keyword protein nanoparticles is still rarely used in research. It can be concluded that the field of protein nanoparticles is still very likely to be researched and associated with other terms, this will have a higher impact on the novelty of the research.
Baricitinib as Treatment Option for Corona Virus Disease-19: a Literature Review Thomas Handoyo; Nur Farhanah; Gianina Dinda Pamungkas
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 11, No 5 (2022): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v11i5.35628

Abstract

Background : Treatment of COVID-19 using IL-6 inhibitors, including Sarilumab or Tocilizumab, significantly decreased mortality risk. Though, Remdesivir therapy gave benefits, morbidity and mortality remained high. Baricitinib, a JAK inhibitor, can inhibit IL-6 activation pathway and has a potential effect of inhibiting disease progression to become severe. Objective : This study aimed to evaluate the use of Baricitinib for COVID-19 patients. Methods : This study was conducted by searching for observational and randomized controlled trial studies through online databases, “PubMed” and “Google Scholar”. Studies included must evaluate Baricitinib effectivity as therapy for hospitalized COVID-19 patients. This study included 11 studies (9 observational and 2 randomized controlled trial). Patients included had moderate-to-severe symptoms of COVID-19. Results : Standard dose of Baricitinib was administered at 4 mg daily dose. Length of therapy was varied between 5-14 days, or up to patients’ discharge. Baricitinib therapy among included studies was administered with intravenous Remdesivir, Steroid, Tocilizumab, or other complement therapies. Mortality rate within 7-day of hospitalization with Baricitinib was 4.4%. Requirement of invasive mechanic ventilation rate after Baricitinib administration was approximately 4%. Laboratory parameters were significantly getting better after Baricitinib administration: IL-6; CRP; ferritin; and D-dimer. Serious adverse events in a randomized controlled trial, occurred more often in placebo treated compared to Baricitinib treated group. Conclusion : Baricitinib as therapy for COVID-19 patients can decrease progression, morbidity, and mortality of the disease. Further studies are needed to evaluate the benefit of Baricitinib as main therapy for COVID-19.
Mat Pilates Exercise Increase Hip Flexibility in Young Adults with Obesity Naufal Prima Wianto; Erna Setiawati; Dwi Pudjonarko; Tanti Ajoe Kesoema
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 11, No 6 (2022): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jkd (dmj).v11i6.32278

Abstract

Background:Young adult with obesity may experience in decreased hip flexibility. Decreased hip flexibility can be caused by excessive fat mass around the joint, lack of physical activity, resulting in muscle stiffness. Flexibility can be improved by Mat Pilates exercises which combined static and dynamic movements. Objective:To prove increasing hip joint flexibility of young adult with obesity after doing Mat PilatesMethods:This study used experimental study with comparison group pre-test and post-test design. The participants were 38 young adults with obesity lived in Semarang selected by purposive sampling technique. The participants were divided into experiment group and control group. The experiment group was instructed to do Mat Pilates (3 times a week) for 4 weeks and the control group was instructed to do their usual activity. The hip flexibility was measured with sideward leg splits before and after experiment. The collected data was analyzed using paired t, independent t test.Results:There was a significant increase in the value of sideward leg splits after doing Mat Pilates (p < 0,05), from 98,46±9,73 to 112,82±11,22 for left sideward leg splits and from 99,63±10,20 to 111,39±12,99 for right sideward leg splits. The increase in the value of sideward leg splits in the experiment group was higher than the control group (p < 0,05). It was occured for both left sideward leg splits and right sideward leg splits.Conclusion:Mat Pilates increased hip joint flexibility of young adult with obesityBackground:Young adult with obesity may experience in decreased hip flexibility. Decreased hip flexibility can be caused by excessive fat mass around the joint, lack of physical activity, resulting in muscle stiffness. Flexibility can be improved by Mat Pilates exercises which combined static and dynamic movements. Objective:To prove increasing hip joint flexibility of young adult with obesity after doing Mat PilatesMethods:This study used experimental study with comparison group pre-test and post-test design. The participants were 38 young adults with obesity lived in Semarang selected by purposive sampling technique. The participants were divided into experiment group and control group. The experiment group was instructed to do Mat Pilates (3 times a week) for 4 weeks and the control group was instructed to do their usual activity. The hip flexibility was measured with sideward leg splits before and after experiment. The collected data was analyzed using paired t, independent t test.Results:There was a significant increase in the value of sideward leg splits after doing Mat Pilates (p < 0,05), from 98,46±9,73 to 112,82±11,22 for left sideward leg splits and from 99,63±10,20 to 111,39±12,99 for right sideward leg splits. The increase in the value of sideward leg splits in the experiment group was higher than the control group (p < 0,05). It was occured for both left sideward leg splits and right sideward leg splits.Conclusion:Mat Pilates increased hip joint flexibility of young adult with obesity
A 28-Year-Old Male Patient With Right Heart Failure Due To Pulmonary Hypertension Yuri Savitri; Wina Yunida M Siregar; Viola Septina; M Fathul Arif; Arini Nashirah; Narisha Amelia Putri
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 11, No 6 (2022): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v11i6.35882

Abstract

Abstract Right Heart Failure (RHF) as a rapidly progressive syndrome with systemic congestion in the setting of impaired RV filling and/or decreased RV outflow output. A 28-year-old male patient, a photographer, lived in North Aceh was admitted to the ED of Cut Meutia Hospital. He was admitted with worsening dyspnea since 2 days before, initiated after a periode of fever. He also complained of fatigue, palpitations in ordinary activities and chest pain occasionally. He had history of presyncope and syncope. He denied any history of hypertension, type 2 diabetes, allergies, and active smoking. He had no congenital or family history of heart disease. Physical examination revealed full of conciousness with slightly abnormal vital sign. He had malar rash, dilated jugular vein. The apex of the heart shifts to the axilla anterior line, S1>S2 with systolic murmur (+). ECG showed complete RBBB with RAD and chest x-ray showed cardiomegaly. The transthoracic echocardiogram revealed severe TR (Tricuspid Regurgitation), dilatation of RARV (Right Atrium Right Ventricle), with severe PH (Pulmonary Hypertension). The patient was diagnosed with RHF (Right Heart Failure) caused by primary PH. The patient was placed on intravenous furosemide, spironolacton, digoxin, and sildenafil. Treatment and lifestyle modification were expected to improve the quality of life.

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