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Jurnal Kedokteran Diponegoro
Published by Universitas Diponegoro
ISSN : -     EISSN : 25408844     DOI : -
Core Subject : Health,
Medicine & Pharmacology
JKD : JURNAL KEDOKTERAN DIPONEGORO ( ISSN : 2540-8844 ) adalah jurnal yang berisi tentang artikel bidang kedokteran dan kesehatan karya civitas akademika dari Program Studi Kedokteran Umum, Fakultas Kedokteran, Universitas Diponegoro Semarang dan peneliti dari luar yang membutuhkan publikasi . JURNAL KEDOKTERAN DIPONEGORO terbit empat kali per tahun. JURNAL KEDOKTERAN DIPONEGORO diterbitkan oleh Program Studi Kedokteran Umum, Fakultas Kedokteran, Universitas Diponegoro Semarang.
Arjuna Subject : -
Articles 974 Documents
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CASE PRESENTATION OF 55-YEAR-OLD MAN WITH ACUTE MYELOID LEUKEMIA AND COVID 19 Novita Fajar Sari; Herniah Asti Wulanjani; Ardhea Jaludamascena; Dwi Retnoningrum
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 11, No 3 (2022): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v11i3.33926

Abstract

Background: Acute myeloid leukemia (AML) is a malignancy originating from multipotential hematopoietic cells, which is characterized by clonal proliferation of abnormal blast cells in the bone marrow and failure of normal cell production. Coronavirus disease-19 (COVID-19) is an infectious disease caused by the SARS-CoV-2 virus. COVID-19 infection in AML patients will affect laboratory examinations to support the diagnosis of COVID-19 and the patient's prognosis. Case presentation: A 55-year- old man went to the hospital for chemotherapy and diagnosed of acute myelomonocytic leukemia. Patient complains of his gingival bleeding. The results of the routine haematological examination showed pancytopenia and the patient requires blood transfusion before chemotherapy. On the third day of treatment, the patient complained of fever, after several day patient complained cough, and shortness of breath. Physical examination showed pulse 100x/minutes, respiratory rate 26x/minutes, temperature 39.8˚C, crackles of the lungs. RT-PCR examination from nasopharyngeal swab showed a positive SARS-CoV-2. During treatment, the laboratory tests showed pancytopenia, increased D-Dimer, C-reactive protein, ferritin and procalcitonin. After the 42th day of treatment, the patient had clinical improvement, the fifth evaluation swab showed a negative RT-PCR result. Conclusion: AML patients have a higher risk of infection, especially COVID-19 infection. Correct laboratory examinations and treatment will promote a better prognosis. It is necessary to educate leukemic patients so that they always take precautions against infection, especially the prevention of COVID-19. 
Air Pollution Exposure and Physical Exhaustion in Relation to GSH:GSSG Ratio of Online-Based Motorcycle Drivers Nabilla Nurcahya Junior; Dodik Pramono; Fathur Nur Kholis; Lusiana Batubara
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 11, No 2 (2022): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v11i2.33245

Abstract

Background: Online motorcycle drivers work more than 10 hours a day, surpassing the international working hour regulations. Working hours are directly proportional to air pollution exposure generating reactive oxygen species (ROS). On the other hand, physical exercise also contributes to the generation of ROS due to greater oxygen utilization by mitochondria. The ratio of GSH to GSSG represents the oxidative stress level in body tissues.Objective: This study aimed to analyze the relationship between the length of air pollution exposure and the level of physical exhaustion to GSH:GSSG ratio of online motorcycle drivers.Methods: This research was a cross-sectional study of 16 male online motorcycle drivers. The GSH:GSSG ratio was assessed by ELISA with cyclic DTNB reaction principle. Length of air pollution exposure and level of physical exhaustion data were obtained from the interview. Statistical analysis was done to determine the correlation between variables.Results: The mean GSH:GSSG ratio in studied population is 0.69 ± 0.26, lower than 1 value of GSH:GSSG ratio represents high oxidative stress condition. Based on the correlation test, there are no correlation between length of air pollution exposure (r = -0.464, p = 0.070) and level of physical exhaustion (r = -0.439, p = 0.089) to GSH:GSSG ratio in online motorcycle drivers.Conclusion: Our findings suggested that online motorcycle drivers have a high level of oxidative stress, length of air pollution exposure, and status of physical exhaustion, which is not associated with the GSH:GSSG ratio.
EFFECT OF HIGH INTENSITY CIRCUIT TRAINING IN PEAK EXPIRATORY FLOW RATE VALUE AMONG MALE YOUNG ADULTS Yohana Revi Imanita; Endang Ambarwati; Muflihatul Muniroh; Yosef Purwoko
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 11, No 4 (2022): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v11i3.33114

Abstract

Background: Lung function has mutual correlation with exercise. Abnormal lung function can affect physical ability to exercise. Otherwise, exercise can increase lung function. Peak expiratory flow rate (PEFR) is a parameter to observe the lung function. High Intensity Circuit Training (HICT) is a combination of aerobic and endurance exercise which has total duration only 7-minutes long. High Intensity Circuit Training can be a good choice for young adults because it does not need much time, easy to be practiced, and beneficial for physical health as well. Objective: To analyze a significant increase in PEFR value after High Intensity Circuit Training for 8 weeks. Methods: This study was a quasi-experimental study with pre-test and post-test comparison group method. Samples were taken purposively from medical student of Diponegoro University (n=56, age=18-21 years old), who were divided into two groups, the control and training group. Peak flow meter was used to measure PEFR value before and after intervention. The data were analysed using Paired T test and Independent T test. Results: A significant increase of PEFR value was found after High Intensity Circuit Training for 8 weeks (p=0.000). The mean difference between pre-test and post-test PEFR value was found increased significantly (p=0.001), that training group had higher score as compared to control group. Conclusion: Regular High Intensity Circuit Training can improve lung function particularly PEFR value in male young adults.
MAT PILATES EXERCISE IMPROVES STATIC BALACE OF YOUNG ADULTS WITH OBESITY Yudha Hasya Ardana; Erna Setiawati; Rahmi Isma Asmara Putri; Yuswo Supatmo
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 11, No 3 (2022): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v11i3.32443

Abstract

Background: The prevalence of obesity in women in Semarang at the age over 18 is 29.93%. This high prevalence rate of obesity can have a negative impact on individual health. The condition of obesity is closely related to its complications that can occur in various aspects of the body's physiology, in the example it can reduce functional abilities such as static balance which can interfere with activities and decrease quality of life. One of the methods that can be used to improve static balance is mat pilates. Mat pilates prioritizes stretching and strengthening core muscles with controlled and precise movements so that mat pilates exercises can improve static balance. However, no studies have yet discussed the effect of mat pilates exercise on static balance in obese young adults Aim: To prove that  mat pilates exercise can increase static balance of  female aged 18-23 years old with obesity. Methods: This study used quasi experimental pre and post-test design and was done in August-October 2020. The subjects were 33 female students of Medical Faculty of Diponegoro University aged 18-23 years with  BMI over 27 kg/m², divided in 2 groups. Treatment group (n=15) was instructed to do 8 weeks of mat pilates exercise (3 times a week) and control group (n=18) was instructed to not do any exercise. Static balace  was measured with Flamingo Balance Test (FBT). Data’s significance was analyzed with paired t test and independent t test. Results : There’s  a significant decrease (p<0,001; paired t test) in FBT score before and after of the mat pilates treatment group from 12,31 ± 5,15 to 10,09 ± 5,59. An insignificant increase (p=0,798; paired t test) found in FBT score before and after of the control group from 12,74 ± 4,65 to 12,93 ± 6,29. The score difference of FBT test of the mat pilates treatment group and control group shows significant result (p=0,013). Conclusion: There is an improvement of static balance after mat pilates exercise intervention on female aged 18-23 years old with obesity 
THE RELATIONSHIP OF ACADEMIC PROCRASTINATION WITH STRESS, ANXIETY, AND DEPRESSION DURING THE COVID-19 PANDEMIC IN STUDENTS OF THE MEDICAL STUDY PROGRAM, FACULTY OF MEDICINE, UNDIP Melania Tiara Cahyaratri; Fanti Saktini; Hang Gunawan Asikin; Tanjung Ayu Sumekar
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 11, No 3 (2022): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v11i3.33244

Abstract

Background: Academic procrastination is defined as a learner's tendency to delay learning-related activities, which in many cases eventually causes anxiety and stress. Studying at home tends to cause a feeling of having a lot of free time, eventually postponing work. Students who often procrastinate tend to experience anxiety and depression more often than students who do not procrastinate.Aim: To prove the relationship between academic procrastination and stress, anxiety, and depression due to the COVID-19 pandemic.Method: This research was a cross-sectional study with 184 respondents. The research was conducted in November 2021. The respondents were UNDIP medical students batch 2020. The questionnaires used were the Procrastination Academic Scale for Student (PASS) and Depression, Anxiety, Stress Scale-21 (DASS-21). Data were taken from the questionnaire after the respondents agreed to the informed consent and were analyzed using the Spearman correlation test.Results: As many as 70,1% of respondents were female. Almost 50% of students have a high level of procrastination. A total of 21.7% of students experienced severe to very severe stress, 55.4% experienced severe to very severe anxiety, and as many as 50.4% experienced severe to very severe depression. The level of academic procrastination was positively correlated with stress levels (r=0.468, p<0.001), anxiety levels (r=0.468, p<0.001), and depression levels (r=0.401, p<0.001).Conclusion: Academic procrastination with stress, anxiety, and depression during the COVID-19 pandemic has a significant relationship with a moderate positive correlation.Keywords: Procrastination ; Stress ; Anxiety ; Depression ; COVID-19 Pandemic.
Air Pollution Exposure Duration and Its Correlation with Triglyceride, HDL, and Atherogenic Index in Online Motorcycle Drivers Adrian Stefanus Herawan; Edward Kurnia Setiawan Limijadi; Donna Hermawati; Lusiana Batubara
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 11, No 2 (2022): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v11i2.33794

Abstract

Background: The most restoration material used currently in dentistry was composite resin. The newest generation of composite resin was bulk-fill composite resin. The bulk-fill composite resin had advantages of lower polymerization contraction and a more straightforward and faster restoration technique. One of the factors which could affect the hardness of composite resin was the consumption of acidic drinks. The acidic beverage that people often consumed is coffee. A few coffee brewing methods were espresso and drip brewing.Objective: This research aimed to identify the effects of coffee soaking through espresso and drip brewing methods on bulk-fill composite resin's hardness.Methods: his research was experimental research, with a post-test control group design and a total sample of 27 samples. The soaking process was taken for seven days at a temperature of 37˚C on artificial saliva, espresso, and drip brewing coffee methods. The hardness of bulk-fill composite resin was measured after seven days by using Vickers hardness. The statistic test exerted One-Way ANOVA.Results: This research found a significant difference in bulk-fill composite resin's hardness among all groups, p-value = 0.00 (p<0.05). The result of the post-hoc LSD test showed a significant difference in the change of bulk-fill composite resin hardness between the artificial saliva group and espresso group (p=0,00) and no significant difference found between the artificial saliva group and drip brewing group (p=0.85).Conclusion: Soaking with espresso coffee has the smallest hardness value compared to soaking with drip brewing coffee and artificial saliva, so soaking with espresso coffee is the most influential on the hardness of the bulk fill composite resin. 
THE INCIDENCE OF RADIATION PNEUMONITIS IN BREAST CANCER PATIENTS WHO RECEIVED RADIOTHERAPY USING 3-DIMENSIONAL TECHNIQUES Salsabila Lutfiarahma; Yan Wisnu Prajoko; Farah Hendara Ningrum; Christina Hari Nawangsih Prihharsanti
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 11, No 4 (2022): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v11i4.31778

Abstract

Background: According to the 2018 Global Cancer Observatory from the World Health Organization (WHO), breast cancer is the most common cancer in Indonesia. 3-dimensional conformal radiotherapy (3D-CRT) is one of the breast cancer treatment planning. Effect of radiation on the lungs can cause radiation pneumonitis. The incidence rate of pneumonitis in breast cancer patients who received radiotherapy using 3D-CRT techniques from several researchers is still varied and there is no accurate data yet at RSUP Dr. Kariadi.Objective: To determine the incidence of pneumonitis in breast cancer patients undergoing breast cancer 3D-CRT.Methods: The research design used in this study was cross sectional. The subject is chosen by consecutive sampling methods. The independent variables of this study was 3D breast cancer radiation therapy, while the dependent variable was radiation pneumonitis. This hypothesis test on this study is analyzed with chi-square test.Results: Forty one subjects were included in this study, two subjects were found with a picture of pneumonitis on chest radiographs. The incidence of radiation pneumonitis in breast cancer patients who received radiotherapy using 3-dimensional techniques was 4.9%. There is no significant relationship between breast cancer radiation therapy 3-dimensional techniques on the incidence of pneumonitis. And there was no significant difference in the proportion of pneumonitis in patients with breast cancer locations on the right and left sides.Conclusion: The incidence of radiation pneumonitis in breast cancer patients who received radiotherapy using a 3-dimensional technique is 4.9%.   Keywords: 3 Dimensional Technique Radiotherapy, Breast Cancer, Radiation Pneumonitis
Toxicity, Side Effects, and Furosemide Interactions in Therapy of Heart Failure Patients (Systematic Review) Diniafelsa Wola; Noor Wijayahadi; Mochamad Ali Sobirin; Erwin Kresnoadi
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 11, No 4 (2022): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v11i3.33706

Abstract

Background: Furosemide as a diuretic loop is one of the main therapies given to heart failure patients with congestion, but in its use furosemide requires a lot of consideration related to toxicity, side effects, and drug interactions.Objective: To determine the toxicity, side effects and drug interactions of furosemide on heart failure patients.Methods: This research is a Systematic Review. Samples were obtained by searching for journals in the online databases of Pubmed, Scopus and Springer Link then adjusted to inclusion criteria and research questions. Data analysis was based on the PRISMA checklist, then searched for similarities and differences.Results: This study found the side effects of furosemide therapy in heart failure patients were: electrolyte disturbance such as: hyponatremia; hypokalemia; and hypomagnesemia, arrythmia, worsening renal function and worsening of AKI, hypotension, increase of plasma renin, and increased risk of fractures. No incidence of furosemid toxicity. The interaction of furosemide on heart failure patients may occur in several drugs like aspirin, digoxin, ACE-inhibitor, and bronchodilator.Conclusion: There is some side effect of furosemide and drug interactions occured in therapy of heart failure patients.Keywords: Furosemide, Toxicity, Side Effects, Interactions, Heart Failure.
The Relationship Between Academic Procrastination and Sleep Quality of Students of Medical Study Program, Faculty of Medicine, Diponegoro University During the COVID-19 Pandemic Athaya Zayyan Pusparini; Fanti Saktini; Hang Gunawan Asikin; Tanjung Ayu Sumekar
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 11, No 3 (2022): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v11i3.33242

Abstract

Background: The COVID-19 pandemic requires the government to take policies by establishing online learning. Online learning has significantly provided changes to students' daily activities, thus resulting in academic procrastination. Academic procrastination is defined as an act of postponing academic activities that may lead to decreased academic performance, increased physical, emotional, mental problems, and unhealthy sleep patterns. Sleep is referred to as a crucial activity of daily routines, and poor sleep quality may contribute to negative impacts on academic success. Aim: To evaluate the relationship between procrastination and sleep quality for students of the Medical Study Program, Faculty of Medicine, Diponegoro University, during the COVID-19 pandemic. Method: This research used a cross-sectional design. Subsequently, 84 active students of the Faculty of Medicine, Diponegoro University, Class of 2020, were found to meet the research criteria, agreed to the informed consent, and filled out the complete questionnaire. The statistical test used was Spearman's test analysis. Results: Referring to the results obtained, there was no significant relationship between academic procrastination and sleep quality for students during the COVID-19 pandemic. Moreover, 39 (46.4%) students were identified as having a high level of academic procrastination. Meanwhile, the majority of students with poor sleep quality during the COVID-19 pandemic was amounted to 52 (61.9%). Conclusion: There was no significant relationship between academic procrastination and sleep quality for students of the Medical Study Program, Faculty of Medicine, Diponegoro University, during the COVID-19 pandemic.
Factors Affecting Patient Adherence to Pharmacological Therapy in Gout Arthritis and Hyperuricemia Dzaki Edmonda Setyawan; Endang Mahati; Nani Maharani
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 11, No 3 (2022): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v11i3.32688

Abstract

Abstract Background: Pharmacological therapy to reduce serum uric acid levels in gouty arthritis and hyperuricemia patients is essential to prevent gout flare and other hyperuricemia-related morbidities. However, only about 50% of gout arthritis patients adhered to their treatment. Knowing the factors influencing adherence to therapy can be used as a reference for health services to improve adherence.Objective: This study aimed to analyze the factors that influenced the patient's adherence to gouty arthritis and hyperuricemia pharmacological therapy.Methods: This was an observational study with a cross-sectional approach. Subjects were the patients in Wuryantoro Community Health Center, Wonogiri Regency, diagnosed with gouty arthritis or hyperuricemia due to a disorder in purine metabolism. Sampling was done by a consecutive sampling method. Questionnaires with the related medical record were used to collect the necessary data. Research variables were knowledge, attitudes and behavior, gender, age, occupation, insurance, distance from residence to health care facilities, and adherence to therapy which was in binary.Results: Sixty-one percent from a total of 41 respondents were found to be non-adherence to pharmacological therapy. Knowledge, attitudes, and behavior towards therapy, educational level, availability of health insurance, and distance to health facilities were significantly correlated to treatment adherence (p < 0.05). Sex, age, and occupation were not correlated to adherence.Conclusion: Factors influencing adherence were knowledge, attitudes and behavior, academic background, insurance, and the distance from residence to health care facilities.

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