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Jurnal Kedokteran Diponegoro
Published by Universitas Diponegoro
ISSN : -     EISSN : 25408844     DOI : -
Core Subject : Health,
Medicine & Pharmacology
JKD : JURNAL KEDOKTERAN DIPONEGORO ( ISSN : 2540-8844 ) adalah jurnal yang berisi tentang artikel bidang kedokteran dan kesehatan karya civitas akademika dari Program Studi Kedokteran Umum, Fakultas Kedokteran, Universitas Diponegoro Semarang dan peneliti dari luar yang membutuhkan publikasi . JURNAL KEDOKTERAN DIPONEGORO terbit empat kali per tahun. JURNAL KEDOKTERAN DIPONEGORO diterbitkan oleh Program Studi Kedokteran Umum, Fakultas Kedokteran, Universitas Diponegoro Semarang.
Arjuna Subject : -
Articles 974 Documents
 86   87   88   89   90 
HAND, FOOT AND MOUTH DISEASE: A REVIEW Lisa Lailatannur
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 12, No 1 (2023): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v12i1.36775

Abstract

Abstract Background: Hand, foot and mouth disease or HFMD is a common childhood infectious disease mainly caused by coxsackievirus A16 (CVA 16) and enterovirus 71 (EV71). This HFMD disease can spread throughout the world and also cause outbreaks. Occurrence of this disease is mostly reported in the summer and fall. However, in Indonesia itself, HFMD is still not getting enough attention due to its self-limiting nature, so there is not enough epidemiological data.Objective: This research was conducted to find out the description of hand, foot, and mouth disease or HFMD.Methods: Conducting a literature review of previous journal articles related to hand, foot, and mouth disease or HFMD.Results: HFMD caused by coxsackievirus A16 or CVA16 and enterovirus 71 or EV71 which are self-limiting. Contact with saliva, fluids, and feces of HFMD patients can trigger transmission. Meanwhile, vaccines and antivirals have not been found that can be a way to treat and prevent EV71.Conclusion: One solution that is considered effective for preventing HFMD is to always practice clean living. Keywords: Hand, foot and mouth disease; HFMD; eEV71; CVA16; A16
Case Report: Choledocholithiasis as Risk Factor for Klatskin Tumor: A Rare Cholangiocarcinoma Edward Kurnia Setiawan L; Esa Loyallita Lestari
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 12, No 1 (2023): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v12i1.36780

Abstract

 Background: Klatskin tumor is a rare liver cancer that involves the bile ducts. Its incidence begins to increase over time and is usually only diagnosed in patients who are already at an advanced stage. The annual incidence of klatskin tumors is not more than 1:100,000. Klatskin tumor is suspected based on signs of biliary obstruction, ultrasonography showing a stricture or bile mass, cholangiography with ERCP and MRCP, abnormal liver function tests, and elevated tumor marker CA 19-9. Case Report: A 65-year-old man presented to the hospital with complaints of yellowing of the eyes and body that began one month ago, as well as a lump in the right upper abdomen that had grown larger over the previous five months. Physical examination revealed yellow eyes, and a palpable lump in the upper quadrant of the patient's abdomen. The patient defecates looked like putty and urinates looked like tea. The diagnosis leaded to a klatskin tumor because the results of MRCP showed a mass in the hilar region of the liver that extended to the proximal common bile duct, which described the appearance of a klatskin tumor. There were an increasing CA 19-9 level and liver function tests. Conclusion: Patient has been diagnosed with klatskin tumors, has choledocholithiasis risk factor, supported by appropriate MRCP images and increasing CA 19-9 level 
EFFECT OF MELINJO SEED EXTRACT ON URIC ACID LEVELS OF HYPERURICEMIC MALE WISTAR RATS Al Ghiffari Muhammad Rayhan; Nani Maharani; Endang Mahati; Yora Nindita
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 12, No 1 (2023): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v12i1.37579

Abstract

Background : Uric acid is the end product of purine catabolism carried out in the liver. Increased level of uric acid in blood is called hyperuricemia, which might cause gout if it is not treated properly. Melinjo (Gnetum gnemon L.) plant is a native plant of Indonesia that contains flavonoids and stilbenoid potential as antihyperuricemia. Aim : This paper aimed to study the effect of melinjo seed extract on uric acid levels. Methods : Thirty-six male wistar rats were randomly divided into 6 groups, consists of healthy control group, hyperuricemic control, Allopurinol control, and treatment groups (3 groups).  Hyperuricemia was induced by the administration of block broth and potassium oxonate for 4 weeks. Melinjo seed extract doses of 250, 500, and 2000 mg/kg BW, and allopurinol 90 mg/kg BW was given orally for 2 weeks. Statistical analysis was conducted to evaluate differences among groups before and after the intervention. Results : Three doses could significantly reduce uric acid levels (p<0.05) from 5.61±0.95 to 2.45±1.21; 5.86±1.84 to 2.04±1.11; and 5.95±0.91 to 3.59±1.58, respectively. However, there is no significant difference between the three doses. The effectiveness of melinjo seed extract at a dose of 500 mg/kg BW reduced uric acid levels by 65%, a dose of 250 mg/kg BW by 56%, and allopurinol 90 mg/kg BW by 10%. Conlusion : Melinjo seed extract can reduce uric acid levels even though there is no effect of graded dose. 
Case Report: Diagnosis and Treatment Esophageal Varices Risa Ayu Nilmarani; Indra Zachreini; Diana Novita
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 12, No 1 (2023): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v12i1.37004

Abstract

Background: Esophageal varices are dilated submucosal veins that connect the portal and systemic circulations to the esophagus. It occurs because of portal hypertension (most caused by cirrhosis), portal blood flow resistance, and increased portal vein blood flow. Esophageal variceal bleeding has a higher morbidity and mortality rate than other upper gastrointestinal bleeding types. In cases of esophageal variceal bleeding, an endoscopic examination is required to make a diagnosis, assess varicose veins, and plan management based on the underlying disease. This case report reviews the diagnosis and management of the esophageal varices at ENT-KL department. Case Presentation: We present a case in which a 54-year-old woman presented to the emergency department of Cut Meutia Hospital with complaints of painful swallowing and a swollen neck. The patient has had this complaint for 5 years, and is getting worse by the day. A barium swallow examination revealed esophageal varices in one-third of the distal esophagus between the seventh and ninth thoracic vertebrae. Conclusion: The patient was diagnosed with esophageal varices and was treated several times before being transferred to a gastroenterology department. 
THE EFFECT OF KAFFIR LIME PEEL EXTRACT (Citrus hystrix) ON SPATIAL MEMORY OF MICE WITH DEMENTIA USING MORRIS WATER MAZE Florentina Anindita Christiyanto; Endang Mahati; Noor Wijayahadi; Yora Nindita
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 12, No 2 (2023): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v12i2.37788

Abstract

Background: Antioxidants are a group of chemicals that protect biological systems against the potential harmful effects of oxidation processes or its reactions. Kaffir lime peel (Citrus hystrix) contains various potential antioxidants substances those are able to protect neurons from free radical-induced damage. Objective: To evaluate the effect of kaffir lime peel extract (Citrus hystrix) on the spatial memory of mice induced by Scopolamine (SCM). Methods: This research was a true experimental study with a post-test-only controlled group design. Thirty mice were randomly divided into 5 groups. SCM was injected intraperitoneally on day 1-7 and kaffir lime peel extract was given orally on day 2-7, the spatial memory testing of mice using Morris Water Maze on day 8. Data analysis used One-Way ANOVA test (α = 0.05) and continued with Post Hoc LSD test (α = 0.05). Results: The mean spatial memory of K+, K-, P1, P2,P3 were 16,33 ± 7,42; 70,00 ± 32,24; 25,66 ± 24,43; 23,00 ± 19,39; 25,00 ± 19,50 seconds respectively. There were significant differences in spatial memory in P1, P2, dan P3 to the negative control group, but there is no significant differences between treatment grups. Conclusion: Kaffir lime peel extract (Citrus hystrix) can improve the spatial memory of scopolamine-induced dementia (SCM) mice. There is no dose effect relationship between the treatment groups
CORRELATION BETWEEN KNOWLEDGE AND BEHAVIOR OF USING VITAMIN C SUPPLEMENTS AMONG HEALTH AND NON-HEALTH STUDENTS IN CENTRAL JAVA DURING THE COVID-19 PANDEMIC Isnaini Nur Jannah; Eva Annisaa&#039;; Intan Rahmania Eka Dini
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 12, No 2 (2023): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v12i2.37549

Abstract

Background: During the COVID-19 pandemic, 57.1% of students used vitamin C. Everyone's behavior/actions in using vitamin C are different. This is influenced by several factors, one of which is knowledge. Objective: Knowing the differences in the level of knowledge and the different levels of behavior in using vitamin C supplements and the correlation between knowledge and behavior in using vitamin C supplements among health and non-health students in Central Java. Methods: Cross sectional analytic research using a questionnaire with purposive sampling technique. Data were analyzed using Chi-Square difference test and Rank Spearman correlation test. Results: The level of knowledge of health students related to vitamin C was in the good category (75%) and non-health students was in the sufficient category (42%). The behavior level of health students related to the use of vitamin C was in the good category (83.3%) and non-health students was in the poor category (58%). Chi-Square test showed that there were differences in the level of knowledge and behavior in using vitamin C between health students and non-health students with a p value = 0.000. There was a correlation between knowledge and the behavior of using vitamin C with a p value = 0.000. The Spearman correlation coefficient (r) obtained was 0.612. Conclusion: There were differences in the level of knowledge and different levels of behavior between health students and non-health students. There was a correlation between knowledge and behavior in using vitamin C supplements among health and non-health students in Central Java.
Case Report: Non-Cirrhotic Hepatoma BCLC-C With Vertebrae Metastasis Bonfilio Neltio Ariobimo; Nurun Nujum Nujum; Daniel Ponco Harto Saputro
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 12, No 2 (2023): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v12i2.36748

Abstract

  Background: Hepatocellular carcinoma (HCC) can arise from either cirrhosis or non-cirrhosis of the liver. HCC in non-cirrhotic livers is still uncommon and can present insidiously in patients. HCC may develop in people with non-cirrhotic chronic liver illness, such as chronic hepatitis B virus infection and chronic HCV infection. More than half of non-cirrhotic individuals with HCC may not exhibit any symptoms, and the disease is frequently detected when it is advanced and incurable. Case Report: Here we presented a 47-year-old man went to the emergency room complaining of upper right side abdominal discomfort that suddenly arose and spread to the back and right shoulder. He also experiencing upper right abdominal fullness for the past two months, along with a sense of a lump growing larger and harder. Hepatic stigmata were not discovered, whole blood revealed a thrombocytosis and significant rising AFP from the expected result of 71,000 ng/dL, with hepatitis B testing was positive. Abdominal ultrasound revealed hepatomegaly and several hypo-hyperechoic nodules. CT scan revealed multiple solid lesions and lytic lesions of the vertebrae bodies. The patient recieved palliative treatment.. Conclusion: This case study demonstrates a non-cirrhotic hepatoma that came at an80 tan advanced stage and was more likely to be asymptomatic than a cirrhotic hepatoma that showed signs of liver failure, such as hepatic stigmata and other physiologic abnormalities. This case report demonstrates the This case study demonstrates the importance of strengthening general HHC preventative measures in order to lower non-cirrhotic HHC's incidence and fatality rate.
Comparison of Caffeine Intake and Brain Training Effect on Performance Intelligence Gianina Dinda Pamungkas; Hardian Hardian; Tanjung Ayu Sumekar; Ainun Rahmasari Gumay; Innawati Jusup
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 12, No 2 (2023): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v12i2.36921

Abstract

Background: Intelligence is the ability to comprehend complex ideas and reasoning. Caffeine is a psychoactive substance that is known to possess an effect on improving cognitive function, memory, and attention. Brain training is a digital training process which holds the purpose of enhancing cognitive function.Objective: This study aimed to compare the effect of caffeine and brain training on performance  intelligence.Methods: This research is an experimental study with two groups pre test and post test design. The research sample was the college students of Faculty of Medicine, Universitas Diponegoro (n=42) aged between 18-22 years old, which then categorized into: the caffeine group (n=21) which received 50 ml once daily of caffeinated beverage for two weeks, and brain training group (n=21) which received 30-minute-session of NeuroNationTM brain training every day for two weeks. Performance intelligence was measured before and after treatment by using The Raven Progressive Matrices test. The statistical analysis used was The Mann-Whitney test and The Wilcoxon test.Results: The average score of performance intelligence on the group caffeine treatment increased from 48,81±9,30 to 55,90±2,95 (p<0,001). In brain training group, increased from 54,95±1,91 to 57,29±1,68 (p<0,001). The two groups were tested for Mann-Whitney Test and it was found that the caffeine group's performance intelligence score was significantly higher than brain training (p = 0.005).Conclusion: There was a significantly higher increase performance intelligence score shown in the caffeine group rather than in the brain training group.Keywords: brain training, caffeine, NeuroNationTM, performance intelligence, Raven Progressive Matrices test
CASE REPORT: PANCYTOPENIA IN SEVERE MALARIA WITH SUSPECTED HEMOPHAGOCYTIC SYNDROME AT ATAMBUA HOSPITAL Krisdianto Putra Lainy; Geraldo Laurus; Yosef Samon Sugi
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 12, No 2 (2023): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v12i2.36945

Abstract

Background: Malaria is a parasitic infectious disease caused by Plasmodium falciparum, Plasmodium vivax, Plasmodium ovale, and Plasmodium malaria. The signs of a malaria infection include fever, chills, anemia, and splenomegaly. In the Belu district, the incidence of malaria is still high. It’s about 10,6 per 1000 population. Objective: To describe a case of Malaria in one of patient in Indonesia.Methods: Case reportResults: A 61-year-old woman with Malaria with clinical manifestations as follow, fever, body aches, and chills felt since 3 days before hospital admissions. On the 4th day of treatment, plasmodium falciparum was found.Conclusion: A combination of anti-malarial medications (OAM) is used in the treatment of malaria with the goal of reducing plasmodium resistance to anti-malarial medications.
A 52-Years Old Male Patient With Aorta Regurgitation Et Causa Rheumatic Heart Desease In Cut Meutia Regional General Hospital Yuri Savitri; Jauza Raudhatul Jannah Mendrofa
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 12, No 2 (2023): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v12i2.35990

Abstract

 Rheumatic heart disease (RHD) is an acquired heart disease with heart valve disorder that persists due to previous acute rheumatic fever, mainly affecting the mitral valve (75%), the aorta (25%), rarely affecting the tricuspid valve, and never affecting the valves lungs. A 52-year-old male patient, domiciled in Mutiara (Alue Awe) Lhokseumawe City, Indonesia. Come for outpatient treatment at Polyclinic of Cut Meutia Hospital. Patients are who routinely go to the polyclinic every month to take medicine. The patient complains of left chest pain, shortness of breath, heart palpitations, cough, tired easily during activities, especially during strenuous activities. History of Diabetes Mellitus is denied, history of hypertension (+). The patient admitted that he was diagnosed with rheumatic heart disease at the age of 19 years. The patient has been undergoing treatment for 33 years by routinely complete checks related to his heart every year and regularly taking medication at the polyclinic every month. The patient admitted at junior high school age he often experienced attacks of fever that went up and down accompanied by pain in the throat. Physical examination found: Compos Mentis (E4V5M6), BP:140/40 mmHg, HR : 92x/i, RR: 23x/i, T; 37.1°C, SpO2 : 95%. Chest examination showed vesicular breath sounds, Rhonki (-), Wheezing (-), Diastolic murmur (+).Echocardiography showed an EF of 70%. AR Severe, MR Moderate. AML Prolapse, Calcification (+), LV Dilatation, LVH Eccentric 

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