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Jurnal Kedokteran Diponegoro
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Core Subject : Health,
JKD : JURNAL KEDOKTERAN DIPONEGORO ( ISSN : 2540-8844 ) adalah jurnal yang berisi tentang artikel bidang kedokteran dan kesehatan karya civitas akademika dari Program Studi Kedokteran Umum, Fakultas Kedokteran, Universitas Diponegoro Semarang dan peneliti dari luar yang membutuhkan publikasi . JURNAL KEDOKTERAN DIPONEGORO terbit empat kali per tahun. JURNAL KEDOKTERAN DIPONEGORO diterbitkan oleh Program Studi Kedokteran Umum, Fakultas Kedokteran, Universitas Diponegoro Semarang.
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Articles 1,055 Documents
Case Report: Diagnosis and Management of Body Stalk Anomaly Imelda Yunitra; Yusrawati Yusrawati
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 13, No 2 (2024): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v13i2.41097

Abstract

Background: Body stalk anomaly is a rare and severe malformation syndrome , occurring only 1 of 10.000 live births. The patholphysiology and trigger factor of body stalk anomaly are still unknown and characterized by : abdominal wall defects, thoracoo and abdominochisis, Severe kyphoscoliosis, a truncated or absent umbilical cord, and limb irregularities are characteristic features of body stalk anomaly. Potential factors contributing to this condition encompass early amnion rupture due to direct mechanical pressure or the presence of amniotic bands, vascular disruption in the early embryo, or an abnormality in the germinal disk.Early antenatal diagnosis is crucial for patient management despide the low life expectancy, and cooperative teamwork is needed to investigation the abdnormalities encountered at birth. the chromosomal testing is performed for congemital anomaly investigation. Case Presentation: We describe a case of body stalk anomaly that was identified through antenatal ultrasound evaluation during the initial visit. The findings were confirmed during the fetomaternal ultrasound examination, the finding were as follows : a single live fetus in utero in transverse lie position, absent amniotic fluid, scoliosis of the vertebrae, an abdominal wall defect, visceral organs (liver and intestines) protruding from the defect. The patient underwent elective caesarean section due to the tranverse lie positionof the fetus and severe oligohydramnios. The baby was born weigh in 2700 grams, measuring 30 cm in length, and with apgar score of 1/1. The observed congenital anomaly include : the placental adhering to the fetal abdomen, absence of an umbilical, visceral organs ( liver, spleen, small intestine, and large intestine ) protruding from a large abdominal wall defect. Both upper limbs are normal , the right lower limb has short femur with tibia and fibula, four toes and a band from the right foot to the pelvis. The left limb is not formed, with low set ears, placental thicketing, a singke umbilical artery, and undeveloped anus. Conclusion: Ultrasound examination is primary diagnostic tool to detect Body Stalk Anomaly ( BSA) ,with ultrasound , doctors can visualize the internal structure of the fetus and conditions intra uterine. Diagnosis of chromosomal abnormalities in fetus is one of most important challrnge in perinatology.
Histopathological Study of Sinonasal and Nasopharyngeal Lesions in Sumber Waras Hospital Jakarta from 2017-2023 Yunita Dewi; Sony Sugiharto
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 13, No 4 (2024): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v13i4.45913

Abstract

Background: Various non-neoplastic and neoplastic lesions arise from the sinonasal tract and nasopharynx. Polyps are the most frequently reported sinonasal lesions, with a prevalence of 2 %. Nasopharyngeal carcinoma is a common malignancy in Indonesia, with 19.943 new cases. Histopathological examination is the gold standard for diagnosis because management and prognosis vary among different lesions. Objective: The aim is to determine the incidence of various non-neoplastic and neoplastic lesions and to study the histopathological features with regard to age and gender. Methods: This study was a descriptive observational study with a cross-sectional design. The sample was retrieved from the histopathological records in Sumber Waras Hospital Jakarta from February 2017 to December 2023. The inclusion criteria were all patients with sinonasal or nasopharyngeal lesions that have been biopsied and then done histopathological examination at Sumber Waras Hospital Jakarta. The exclusion criteria were incomplete data and patients with histopathological diagnoses of necrotic tissue and inflammation. The sample consisted of 73 patients with a total of 76 cases, as 3 patients had multiple diagnoses. The data collected were later analyzed with SPSS software. Results: Among 73 patients, 54 were males and 19 were females. A maximum number of cases were diagnosed in the age group of 51-60. Among 43 sinonasal lesions, 25 (58,2%) were non-neoplastic and 18 (42%) were neoplastic lesions. Inflammatory polyps (42%) were the most common among the sinonasal lesions. Of 33 nasopharyngeal lesions, there were 2 (6,1%) non-neoplastic and 31 (93,9%) neoplastic lesions. The majority of these were of nasopharyngeal carcinoma (84,8%). Conclusion: Histopathological examination is essential for diagnosing and classifying sinonasal and nasopharyngeal lesions.
The Effect of Galoba (Hornstedtia sp.) Fruit Extract on Malondialdehyde (MDA) Serum Level of Hyperglycemic Mice (Mus musculus) Streptozotocin-Induced Yuan Ivani Rumengan; Indrawanti Kusadhiani; Rachmawati Dwi Agustin
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 13, No 2 (2024): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v13i2.42144

Abstract

  Background: Hyperglycemia or increased blood sugar levels is a sign of diabetes mellitus. In hyperglycemia, there will be an increase in Reactive Oxygen Species (ROS) in the body so that it will lead to a state of oxidative stress characterized by an increase in malondialdehyde (MDA) levels. Galoba fruit is an endemic fruit in Maluku Province that contains antioxidants. Antioxidants contained in galoba fruit can help endogenous antioxidants to overcome oxidative stress. Objective: This study aims to determine the effect of galoba fruit extract on serum MDA levels of hyperglycemia mice induced by streptozotocin. Methods: This study is an experimental study with post-test only control group design and random sampling. The sample consisted of 24 mice divided into 6 groups, namely normal control (KN), negative control (K-), positive control (K+), treatment 1 (P1), treatment 2 (P2), and treatment 3 (P3). The KN group was only given a standard diet, the K- group was only induced streptozotocin, the K+ group was induced streptozotocin and treated with metformin for 21 days, and the P1, P2, and P3 groups were induced streptozotocin and given galoba fruit extract concentrations of 100%, 75%, and 50% for 21 days. After treatment, the mice were dissected to collect blood serum from the heart of the mice to measure MDA levels. Serum MDA levels were measured by the TBARS method. Results: The average serum MDA levels of the KN, K-, K+, P1, P2, and P3 groups were 358.75 nmol/mg, 1278.75 nmol/mg, 522.08 nmol/mg, 526.16 nmol/mg, 442.66 nmol/mg, and 432.41 nmol/mg. MDA data obtained was then tested with one way ANOVA and obtained a value of p=0.00 (<0.05). Conclusion: Based on the Tukey test, both P1, P2, and P3 have the same effect on reducing serum MDA levels of mice after being induced by streptozotocin with P3 providing the greatest decrease.
The Effect of Moringa Leaves Extracts on MDA Level in Male Mice Exposed to Electromagnetic Radiation of Mobile Phones Nadia Ilmi Amalia; Trianggoro Budisulistyo; Dhega Anindita Wibowo; Tun Paksi Sareharto
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 13, No 4 (2024): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v13i4.43905

Abstract

Background: The use of cell phones causes anxiety about the effects of electromagnetic wave radiation emitted because of the production of free radicals in the body is increased by cell phone electromagnetic wave radiation. This escalation results in an elevated production of Reactive Oxygen Species (ROS), resulting in elevated Malondialdehyde (MDA) levels due to lipid peroxidation, which is toxic to the body. One way to reduce MDA levels is to introduce antioxidants into the body. Previous studies have found that Moringa leaf extract can be used as a good source of antioxidants.Objective: The aim of this research was to assess the impact of Moringa leaf extract administration on the MDA levels in BALB/C mice subjected to electromagnetic waves emitted by cell phones.Methods: This study employed an experimental study with a post-test only control group design. The research involved 23 male BALB/c mice, divided into four groups. The healthy control group received no treatment, while the negative control group was exposed to cell phone electromagnetic waves for 2 hours/day. Groups P1 and P2 received Moringa leaf extract at doses of 100 mg/kgBW and 400 mg/kgBW, respectively, in addition to being exposed to cellular phone electromagnetic waves for 2 hours/day. The treatment was administered for 30 days following a 7-dayadaptation period. On the 31st day, blood plasma samples were takenfrom all mice and examined for MDA levels. The data underwent analysis through non-parametric One-Way ANOVA and subsequent Pos Hoc LSD tests. Significance is acknowledged for p-values less than 0.05.Results: The highest MDA levels were found in the K (-) group, namely 0.43 ± 0.18 ppm, and the lowest MDA levels were observed in the P1 group, with values of 0.19 ± 0.08 ppm. A significant difference was noted between the K (-) group and the P1 group (p = 0.05), while no significant difference were observed in the other groups.Conclusion: Administering Moringa leaf extract at a dose of 100 mg/kgBW/day can reduce MDA levels in mice exposed to electromagnetic waves from cell phones.
The Relationship between Chemotherapy Treatment and the Incidence of Seborrheic Dermatitis in Cancer Patients at Dr. Kariadi Hospital Dhiya Nasywa Ananda Giany; Liza Afriliana; Widyawati Widyawati; Buwono Puruhito
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 14, No 1 (2025): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v14i1.47014

Abstract

Background: Seborrheic dermatitis is a chronic inflammation of sebaceous gland-rich areas in the form of reddish, well-demarcated plaques and yellowish flaking scabs that can interfere with the patient's comfort and quality of life. Immune system suppression such as chemotherapy in cancer patients is thought to be one of the contributing factors. When seborrheic dermatitis is caused by chemotherapy, it will add to the suffering of patients both in terms of quality of life and treatment costs. Objective: To find out the difference in the incidence of seborrheic dermatitis in cancer patients who are undergoing chemotherapy and cancer patients who are not receiving chemotherapy. Methods: This study was an analytic observational study with a cross-sectional design. The study subjects were 40 people who were cancer patients at Dr. Kariadi Hospital who were selected by consecutive sampling method. The questionnaire used to determine the details of chemotherapy actions and the incidence of seborrheic dermatitis made by the author has been tested validity. Data processing used Chi Square or Fisher Exact analysis test and multivariate logistic regression test. Results: There was 73.3% incidence of seborrheic dermatitis in patients who were undergoing chemotherapy, 26.7% incidence of seborrheic dermatitis in patients who were not. The Chi Square test found a significant association between chemotherapy treatment and the incidence of seborrheic dermatitis with p = 0.022. The bivariate analysis test did not show a significant relationship between age, gender, and personal hygiene with the incidence of seborrheic dermatitis. There was a significant and additive relationship between chemotherapy treatment and personal hygiene with the incidence of seborrheic dermatitis. Conclusion: Chemotherapy treatment is a risk factor for Seborrheic Dermatitis. Age, gender and personal hygiene are not independent risk factors for seborrheic dermatitis. Poor personal hygiene is also a risk factor when combined with chemotherapy.Keywords: Age, Chemotherapy, Gender, Personal hygiene, Seborrheic dermatitis
POTENTIAL OF MIRNA-183, MIRNA-29B, AND MIRNA-34A COMBINATION AS A NOVEL ADVANCED SENSORINEURAL HEARING LOSS DIAGNOSTIC AND THERAPEUTIC (THERAGNOSTIC) AGENT Agyta Hanifa Faiza; Gabriela Valencia Putri Husodho; Anatalya Diah Ayu Kumalasari
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 14, No 3 (2025): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v14i3.47640

Abstract

Background: Sensorineural hearing loss (SNHL) is a hearing disability that makes up 90% of all hearing loss in general. This condition reduces quality of life and causes lifelong disability. Current diagnostic and therapeutic agents are considered less than optimal and need to be developed further. MicroRNAs (miRNAs), such as miRNA-34a, miRNA-29b, and miRNA-183, play a role in the pathogenesis of SNHL and thus have potential as specific biomarkers and therapeutic agents. Objective: To open a new perspective regarding the use of diagnostic biomarkers and miRNA therapy as a new step towards the era of personalized medicine in SNHL patients. Methods: This literature review used a non-systematic review method using the search engines PubMed, Science Direct, and ProQuest. Results: Increased expression of miRNA-34a, miRNA-29b, and miRNA-183 causes a decrease in the number of inner hair cells hence causing hearing loss. This means that these miRNAs can be used as biomarkers in the diagnosis of SNHL. Suppression of these miRNAs to certain levels could potentially be a therapy for SNHL, as it showed reduced oxidative stress and apoptosis. Suppression of miRNA-29b expression causes increased proliferation and reduced oxidative stress. However, knock out of miRNA-183 shows disruption in stereociliary bundle development and hair cell maturation hence when using miRNA inhibitors as therapy it is important to take note of dosage. Conclusion: miRNA-34a, miRNA-29b, and miRNA-183 have potential as diagnostic biomarkers and therapeutic agents for SNHL by regulating levels of oxidative stress, apoptosis, and the number of inner hair cells. Utilizing these three miRNAs simultaneously can increase the specificity, sensitivity and effectiveness in the diagnosis and therapy of SNHL.
THE RELATIONSHIP BETWEEN CLINICAL STAGE AND THERAPEUTIC RESPONSE AFTER COMPLETE RADIOCHEMOTHERAPY IN NASOPHARYNGEAL CARCINOMA WHO TYPE III IN NGOERAH HOSPITAL DENPASAR Ida Bagus Gede Hendra Kusuma; I Gde Ardika Nuaba; Sari Wulan Dwi Sutanegara; Komang Andi Dwi Saputra; Made Lely Rahayu; Agus Rudi Asthuta
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 14, No 5 (2025): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v14i5.49227

Abstract

Background: Nasopharyngeal cancer (NPC) is the fourth most common cancer in Indonesia, with WHO type III being the most aggressive yet highly responsive to radiochemotherapy. Various factors can impact treatment outcomes. Objective: To determine the relationship between clinical stage and therapeutic response after complete radiochemotherapy in patients with WHO type III NPC. Methods: This retrospective cohort study evaluated 148 WHO type III NPC patients who completed radiochemotherapy at Ngoerah Hospital (2020–2023). Patients were classified into early-stage (stage I-II, n=74) and advanced-stage (stage III-IVB, n=74) groups. Three months post-treatment, therapeutic response was assessed using RECIST 1.1 criteria (CR, PR, PD, SD) following re-staging procedures (imaging and diagnostics). A comparative analysis examined CR rates between the two groups and the relationship between clinical stage and treatment response. Results: The overall therapeutic response in this study was 27.7% CR, 22.3% PR, 25.0% SD, and 25.0% SD. Pre-radiochemotherapy clinical stage was significantly associated with the therapeutic response after complete radiochemotherapy. WHO type III NPC patients with advanced stage had a 37 times higher risk of non-CR than patients with early stage after adjustment for age, gender, and main symptoms (adjusted RR = 37.404; IK95% 8.308-168.393; p<0.001). Conclusion: Clinicians should prioritize early detection in high-risk patients with WHO type III NPC, as advanced-stage cases have poorer therapeutic responses. Patient education is crucial to ensure understanding of the disease progression and therapy prognosis, especially for advanced stages.
INJURY-RELATED FACTORS ASSOCIATED WITH THE CONTINUATION OF ASSAULT CASES TO COURT BASED ON VISUM ET REPERTUM FINDINGS I Made Raditya Mahardika; Intarniati Nur Rohmah; RP Uva Utomo; Gatot Suharto; Wian Pisia Anggreliana
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 15, No 1 (2026): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v15i1.47659

Abstract

Background: A significant number of physical assault cases in Indonesia do not proceed to court, despite victims undergoing forensic medical examinations. The Visum et Repertum (VeR), a legal medical report describing a victim’s injuries, plays a crucial role in the judicial process. However, it remains unclear which aspects of the documented injuries are associated with the continuation of legal proceedings. Objective: To identify injury-related factors in Visum et Repertum that influence whether assault cases proceed to trial. Methods: A cross-sectional analytical study was conducted using secondary data from 67 Visum et Repertum reports of living victims of assault examined at Dr. Kariadi General Hospital Semarang between 2018 and 2022. Only cases with an official police request for VeR were included. Cases related to traffic accidents, psychological violence, domestic violence, or with incomplete documentation were excluded. Bivariate and multivariate analyses were performed to assess the association between injury characteristics and case continuation to trial. Results: Among 67 cases, only 11 (16.4%) proceeded to court. Injury severity (p<0.001; r=0.557) and the type of medical intervention (p<0.001; r=0.440) were significantly associated with case continuation. Other variables, such as age, gender, wound type, number of wounds, wound size, and perpetrator-victim relationship, showed no significant associations. Severe injuries had the strongest influence on trial continuation (OR=222.0; p<0.001). Conclusion: Injury severity and medical interventions recorded in the Visum et Repertum are key predictors of whether assault cases proceed to court.
Characteristics of Intracerebral Hemorrhage at Dr. Kariadi General Hospital: A Serial Case Nadhira Faizah Putri Priambodo; Kayana Zahra Kallista Rambey; Amira Cinta Maharani; Diah Satyaningrum; Nuzulur Rakhmah Nurulyana; Gibran Chandra Syarif Hidayatullah; Maria Belladonna Rahmawati Sugianto; Santoso Jaeri
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 13, No 6 (2024): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v13i6.45097

Abstract

Background: Stroke is an acute neurological deficit caused by sudden or rapid disruption of blood circulation to the brain. Intracerebral hemorrhage is the subtype of stroke with the highest mortality and disability rate. Several risk factors may be related to the clinical outcome of intracerebral hemorrhage. Herewith we present a case series regarding the characteristics of intracerebral hemorrhage. Methods: A case series among three intracerebral hemorrhage cases in January - February 2024 at Dr. Kariadi Hospital. Epidemiological, and clinical data were recorded and reported. Case Presentations: Three cases were studied, the main complaint of the patient was decreased consciousness. These patients had different risk factors for stroke. According to the Siriraj score, NIHSS score, and neuroimaging findings, these patients had hemorrhagic strokes with different brain lesions. Two-thirds of the patients had uncontrolled hypertension and one patient was accompanied by uncontrolled diabetes mellitus. Conclusion: Overall, all patients were >45 years old and the risk factors of these patients were modified risk factors that is uncontrolled hypertension and diabetes mellitus over a long period resulting in ganglionic hemorrhage.
Influence of Nutrition and Hygiene Education for Stunting Prevention to Support the Acceleration of SDG`s Diah Rahayu Wulandari; Dodik Pramono; Teddy Wahyu Nugroho; Maridjo Maridjo
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 14, No 2 (2025): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v14i2.48006

Abstract

  Background: Sustainable Development Goals (SDGs) aim to ensure healthy lives and promote well-being for all ages. Stunting and other malnutrition in the First 1,000 Days of Life not only increase the risk of inhibiting physical growth and causing children's vulnerability to disease but also inhibit cognitive development, which will affect the level of intelligence and productivity of children in the future. Providing nutrition and hygiene education to adolescent girls is one of the solutions. As a result, they can prepare sufficient nutrients for themselves and their families after getting married or pregnant and having children. Moreover, Islamic boarding schools could be the right place for them to get an education. Aim: The present study aimed to determine the effect of counseling on increasing knowledge about balanced nutrition and hygiene in female students. Methods: We used quasi-experimental research with one pretest-posttest group on one female student, while data were analyzed using the Wilcoxon test. Results: The study showed that the average of the pretest and posttest in nutritional knowledge was 61.56 and 64.23, respectively. These results significantly increased (2.67 points) with a p-value of 0.019. On the other hand, there was no significant increase in hygiene knowledge, with a difference of 1.7 points between the pretest and posttest groups (p = 0.132). Conclusion: In conclusion, counseling using the lecture method can improve nutritional knowledge in female students. 

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