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INDONESIA
Jurnal Kedokteran Diponegoro
Published by Universitas Diponegoro
ISSN : -     EISSN : 25408844     DOI : -
Core Subject : Health,
Medicine & Pharmacology
JKD : JURNAL KEDOKTERAN DIPONEGORO ( ISSN : 2540-8844 ) adalah jurnal yang berisi tentang artikel bidang kedokteran dan kesehatan karya civitas akademika dari Program Studi Kedokteran Umum, Fakultas Kedokteran, Universitas Diponegoro Semarang dan peneliti dari luar yang membutuhkan publikasi . JURNAL KEDOKTERAN DIPONEGORO terbit empat kali per tahun. JURNAL KEDOKTERAN DIPONEGORO diterbitkan oleh Program Studi Kedokteran Umum, Fakultas Kedokteran, Universitas Diponegoro Semarang.
Arjuna Subject : -
Articles 974 Documents
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Case Report: Diagnosis and Management of Body Stalk Anomaly Yunitra, Imelda; Yusrawati, Yusrawati
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 13, No 2 (2024): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v13i2.41097

Abstract

Background: Body stalk anomaly is a rare and severe malformation syndrome , occurring only 1 of 10.000 live births. The patholphysiology and trigger factor of body stalk anomaly are still unknown and characterized by : abdominal wall defects, thoracoo and abdominochisis, Severe kyphoscoliosis, a truncated or absent umbilical cord, and limb irregularities are characteristic features of body stalk anomaly. Potential factors contributing to this condition encompass early amnion rupture due to direct mechanical pressure or the presence of amniotic bands, vascular disruption in the early embryo, or an abnormality in the germinal disk.Early antenatal diagnosis is crucial for patient management despide the low life expectancy, and cooperative teamwork is needed to investigation the abdnormalities encountered at birth. the chromosomal testing is performed for congemital anomaly investigation. Case Presentation: We describe a case of body stalk anomaly that was identified through antenatal ultrasound evaluation during the initial visit. The findings were confirmed during the fetomaternal ultrasound examination, the finding were as follows : a single live fetus in utero in transverse lie position, absent amniotic fluid, scoliosis of the vertebrae, an abdominal wall defect, visceral organs (liver and intestines) protruding from the defect. The patient underwent elective caesarean section due to the tranverse lie positionof the fetus and severe oligohydramnios. The baby was born weigh in 2700 grams, measuring 30 cm in length, and with apgar score of 1/1. The observed congenital anomaly include : the placental adhering to the fetal abdomen, absence of an umbilical, visceral organs ( liver, spleen, small intestine, and large intestine ) protruding from a large abdominal wall defect. Both upper limbs are normal , the right lower limb has short femur with tibia and fibula, four toes and a band from the right foot to the pelvis. The left limb is not formed, with low set ears, placental thicketing, a singke umbilical artery, and undeveloped anus. Conclusion: Ultrasound examination is primary diagnostic tool to detect Body Stalk Anomaly ( BSA) ,with ultrasound , doctors can visualize the internal structure of the fetus and conditions intra uterine. Diagnosis of chromosomal abnormalities in fetus is one of most important challrnge in perinatology.
Histopathological Study of Sinonasal and Nasopharyngeal Lesions in Sumber Waras Hospital Jakarta from 2017-2023 Dewi, Yunita; Sugiharto, Sony
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 13, No 4 (2024): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v13i4.45913

Abstract

Background: Various non-neoplastic and neoplastic lesions arise from the sinonasal tract and nasopharynx. Polyps are the most frequently reported sinonasal lesions, with a prevalence of 2 %. Nasopharyngeal carcinoma is a common malignancy in Indonesia, with 19.943 new cases. Histopathological examination is the gold standard for diagnosis because management and prognosis vary among different lesions. Objective: The aim is to determine the incidence of various non-neoplastic and neoplastic lesions and to study the histopathological features with regard to age and gender. Methods: This study was a descriptive observational study with a cross-sectional design. The sample was retrieved from the histopathological records in Sumber Waras Hospital Jakarta from February 2017 to December 2023. The inclusion criteria were all patients with sinonasal or nasopharyngeal lesions that have been biopsied and then done histopathological examination at Sumber Waras Hospital Jakarta. The exclusion criteria were incomplete data and patients with histopathological diagnoses of necrotic tissue and inflammation. The sample consisted of 73 patients with a total of 76 cases, as 3 patients had multiple diagnoses. The data collected were later analyzed with SPSS software. Results: Among 73 patients, 54 were males and 19 were females. A maximum number of cases were diagnosed in the age group of 51-60. Among 43 sinonasal lesions, 25 (58,2%) were non-neoplastic and 18 (42%) were neoplastic lesions. Inflammatory polyps (42%) were the most common among the sinonasal lesions. Of 33 nasopharyngeal lesions, there were 2 (6,1%) non-neoplastic and 31 (93,9%) neoplastic lesions. The majority of these were of nasopharyngeal carcinoma (84,8%). Conclusion: Histopathological examination is essential for diagnosing and classifying sinonasal and nasopharyngeal lesions.
The Effect of Galoba (Hornstedtia sp.) Fruit Extract on Malondialdehyde (MDA) Serum Level of Hyperglycemic Mice (Mus musculus) Streptozotocin-Induced Rumengan, Yuan Ivani; Kusadhiani, Indrawanti; Agustin, Rachmawati Dwi
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 13, No 2 (2024): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v13i2.42144

Abstract

  Background: Hyperglycemia or increased blood sugar levels is a sign of diabetes mellitus. In hyperglycemia, there will be an increase in Reactive Oxygen Species (ROS) in the body so that it will lead to a state of oxidative stress characterized by an increase in malondialdehyde (MDA) levels. Galoba fruit is an endemic fruit in Maluku Province that contains antioxidants. Antioxidants contained in galoba fruit can help endogenous antioxidants to overcome oxidative stress. Objective: This study aims to determine the effect of galoba fruit extract on serum MDA levels of hyperglycemia mice induced by streptozotocin. Methods: This study is an experimental study with post-test only control group design and random sampling. The sample consisted of 24 mice divided into 6 groups, namely normal control (KN), negative control (K-), positive control (K+), treatment 1 (P1), treatment 2 (P2), and treatment 3 (P3). The KN group was only given a standard diet, the K- group was only induced streptozotocin, the K+ group was induced streptozotocin and treated with metformin for 21 days, and the P1, P2, and P3 groups were induced streptozotocin and given galoba fruit extract concentrations of 100%, 75%, and 50% for 21 days. After treatment, the mice were dissected to collect blood serum from the heart of the mice to measure MDA levels. Serum MDA levels were measured by the TBARS method. Results: The average serum MDA levels of the KN, K-, K+, P1, P2, and P3 groups were 358.75 nmol/mg, 1278.75 nmol/mg, 522.08 nmol/mg, 526.16 nmol/mg, 442.66 nmol/mg, and 432.41 nmol/mg. MDA data obtained was then tested with one way ANOVA and obtained a value of p=0.00 (<0.05). Conclusion: Based on the Tukey test, both P1, P2, and P3 have the same effect on reducing serum MDA levels of mice after being induced by streptozotocin with P3 providing the greatest decrease.
The Effect of Moringa Leaves Extracts on MDA Level in Male Mice Exposed to Electromagnetic Radiation of Mobile Phones Amalia, Nadia Ilmi; Budisulistyo, Trianggoro; Wibowo, Dhega Anindita; Sareharto, Tun Paksi
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 13, No 4 (2024): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v13i4.43905

Abstract

Background: The use of cell phones causes anxiety about the effects of electromagnetic wave radiation emitted because of the production of free radicals in the body is increased by cell phone electromagnetic wave radiation. This escalation results in an elevated production of Reactive Oxygen Species (ROS), resulting in elevated Malondialdehyde (MDA) levels due to lipid peroxidation, which is toxic to the body. One way to reduce MDA levels is to introduce antioxidants into the body. Previous studies have found that Moringa leaf extract can be used as a good source of antioxidants.Objective: The aim of this research was to assess the impact of Moringa leaf extract administration on the MDA levels in BALB/C mice subjected to electromagnetic waves emitted by cell phones.Methods: This study employed an experimental study with a post-test only control group design. The research involved 23 male BALB/c mice, divided into four groups. The healthy control group received no treatment, while the negative control group was exposed to cell phone electromagnetic waves for 2 hours/day. Groups P1 and P2 received Moringa leaf extract at doses of 100 mg/kgBW and 400 mg/kgBW, respectively, in addition to being exposed to cellular phone electromagnetic waves for 2 hours/day. The treatment was administered for 30 days following a 7-dayadaptation period. On the 31st day, blood plasma samples were takenfrom all mice and examined for MDA levels. The data underwent analysis through non-parametric One-Way ANOVA and subsequent Pos Hoc LSD tests. Significance is acknowledged for p-values less than 0.05.Results: The highest MDA levels were found in the K (-) group, namely 0.43 ± 0.18 ppm, and the lowest MDA levels were observed in the P1 group, with values of 0.19 ± 0.08 ppm. A significant difference was noted between the K (-) group and the P1 group (p = 0.05), while no significant difference were observed in the other groups.Conclusion: Administering Moringa leaf extract at a dose of 100 mg/kgBW/day can reduce MDA levels in mice exposed to electromagnetic waves from cell phones.

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