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Handri Maika Saputra, S.ST
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Fundamental and Applied Research in Medicine and Allied Sciences Indonesia
Published by CV. Get Press Indonesia
ISSN : -     EISSN : 31239374     DOI : https://doi.org/10.69855/farmasi
Core Subject :
Fundamental and Applied Research in Medicine and Allied Sciences Indonesia is an international peer-reviewed open access journal dedicated to publishing high-quality research in public health and related disciplines. The journal provides a platform for researchers, academics, and practitioners worldwide to share evidence-based findings and practical insights for improving public health practice. Fundamental and Applied Research in Medicine and Allied Sciences Indonesia welcomes original research articles, review papers, and case studies in pharmacy, Clinical and community pharmacy, Pharmaceutics and Pharmaceutical Technology, Pharmacology and Toxicology, Pharmaceutical Chemistry and Pharmaceutical Analysis, Pharmacognosy and Phytochemistry, Pharmaceutical Biotechnology, Pharmaceutical Management and Policy, Pharmacy Education and the Profession Fundamental and Applied Research in Medicine and Allied Sciences Indonesia is published by CV. Get Press Indonesia and is published Twice times a year in May and November.
Arjuna Subject : -
Articles 23 Documents
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Specific Standardization and Determination of Curcuminoid Levels in Turmeric (Curcuma longa) Rhizomes from Three Cultivation Centers in Java Using the HPLC Method Ai Rian Julyanti; Sri Rahayu Dwi Purnaningtyas
Fundamental and Applied Research in Medicine and Allied Sciences Indonesia Vol. 2 No. 2 (2026): November, 2026
Publisher : CV. Get Press Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69855/farmasi.v2i2.651

Abstract

Curcuma longa is one of Indonesia's most important medicinal plants, with curcuminoids (curcumin, demethoxycurcumin, and bisdemethoxycurcumin) responsible for its anti-inflammatory, antioxidant, hepatoprotective, and anticancer activities. This study aimed to standardize turmeric rhizomes from Temanggung, Blitar, and Wonogiri and determine curcuminoid levels using a validated HPLC method. Specific standardization parameters were evaluated according to the Indonesian Herbal Pharmacopoeia (FHI) Edition II, while HPLC analysis employed a C18 reversed phase column with UV detection at 425 nm. All samples met FHI physicochemical standards, and the HPLC method showed excellent linearity (r² ≥ 0.9996), precision (%RSD ≤ 0.95%), and accuracy (98.7–99.8%). Curcuminoid content differed significantly among cultivation sites (p < 0.001), with the highest level in Blitar (4.48 ± 0.09%), followed by Temanggung (3.96 ± 0.07%) and Wonogiri (3.39 ± 0.06%). Curcumin levels ranged from 2.46–3.19% w/w, exceeding the FHI minimum standard (≥1.0%). These findings demonstrate that cultivation site significantly influences curcuminoid profiles, emphasizing the importance of region specific quality specifications for herbal raw material procurement.
Formulation and Evaluation of the Physical Stability of an Anti-Inflammatory Gel Preparation Containing a Standardized Extract of Jatropha curcas (Duduk) Leaves with a Carbomer Base Nurul Fitriani; Putri Rovita Sari; Reti Puji Handayani
Fundamental and Applied Research in Medicine and Allied Sciences Indonesia Vol. 2 No. 2 (2026): November, 2026
Publisher : CV. Get Press Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69855/farmasi.v2i2.654

Abstract

Jatropha curcas L. (locally known as “duduk” in East Nusa Tenggara, Indonesia) has traditionally been used as an anti-inflammatory agent. This study aimed to formulate and evaluate the physical stability and anti-inflammatory activity of a topical gel containing standardized ethanolic leaf extract of J. curcas using carbomer 940. The extract was obtained by maceration with 96% ethanol and standardized based on total flavonoid and phenolic contents. Three formulations containing 5% extract and 0.5%, 1.0%, and 1.5% carbomer 940 (F1–F3) were evaluated for organoleptic properties, homogeneity, pH, spreadability, viscosity, adhesion, and accelerated stability over 28 days. All formulations were homogeneous with a pale green color and mild odor. F2 (1.0% carbomer) showed optimal characteristics, with a pH of 6.82, viscosity of 4,850 cPs, spreadability of 6.21 cm, and adhesion of 14.3 s, and remained stable throughout testing. F2 also exhibited anti-inflammatory activity in the BSA protein denaturation assay, with an IC₅₀ of 87.4 µg/mL. The 1.0% carbomer 940 formulation demonstrated optimal physical characteristics, stability, and in vitro anti-inflammatory activity, indicating its potential as a natural topical anti-inflammatory preparation.
Antioxidant Activity Test and Chromatographic Fingerprint Analysis of Secondary Metabolite Profiles of Garcinia Fruit Extract Mangosteen (Mangosteen) from Several Varieties in Indonesia Zola Efa Harnis; Nina Irmayanti Harahap
Fundamental and Applied Research in Medicine and Allied Sciences Indonesia Vol. 2 No. 2 (2026): November, 2026
Publisher : CV. Get Press Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69855/farmasi.v2i2.656

Abstract

Garcinia mangostana L. (mangosteen) is a prominent tropical fruit from Indonesia, widely recognized for its rich xanthone content with strong antioxidant properties. Indonesia hosts several regional varieties with potentially different phytochemical profiles; however, comparative studies remain limited. This study aimed to evaluate and compare antioxidant activity and characterize the secondary metabolite fingerprint profiles of ethanol extracts from mangosteen pericarp collected from five regions: Purwokerto, Kaligesing, Palu, Wanayasa, and Lingga. Extracts were prepared by maceration using 96% ethanol. Antioxidant activity was assessed using DPPH, ABTS, and FRAP assays. TLC fingerprinting was performed on silica gel plates, while HPLC analysis used a C18 column with gradient elution. Alpha-mangostin was quantified at 316 nm, and total phenolic and flavonoid contents were also determined. All samples exhibited strong antioxidant activity. The Palu variety showed the highest DPPH activity (IC₅₀ 12.4 ± 0.6 µg/mL), while Purwokerto showed the highest FRAP value (482.6 ± 14.3 µmol Trolox/g). HPLC profiles revealed 12–16 peaks with alpha-mangostin as the dominant compound (28.4–45.8 mg/g extract). Cluster analysis grouped samples into two chemotypes, indicating phytochemical variation influenced by geographic origin.

Page 3 of 3 | Total Record : 23

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