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Fundamental and Applied Research in Medicine and Allied Sciences Indonesia
Published by CV. Get Press Indonesia
ISSN : -     EISSN : 31239374     DOI : https://doi.org/10.69855/farmasi
Core Subject :
Fundamental and Applied Research in Medicine and Allied Sciences Indonesia is an international peer-reviewed open access journal dedicated to publishing high-quality research in public health and related disciplines. The journal provides a platform for researchers, academics, and practitioners worldwide to share evidence-based findings and practical insights for improving public health practice. Fundamental and Applied Research in Medicine and Allied Sciences Indonesia welcomes original research articles, review papers, and case studies in pharmacy, Clinical and community pharmacy, Pharmaceutics and Pharmaceutical Technology, Pharmacology and Toxicology, Pharmaceutical Chemistry and Pharmaceutical Analysis, Pharmacognosy and Phytochemistry, Pharmaceutical Biotechnology, Pharmaceutical Management and Policy, Pharmacy Education and the Profession Fundamental and Applied Research in Medicine and Allied Sciences Indonesia is published by CV. Get Press Indonesia and is published Twice times a year in May and November.
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Articles 17 Documents
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Economic Value Analysis and Waste Burden of Household Unused Medicines in Four Districts of Garut Regency Serli Silviani; Raden Aldizal Mahendra Rizkio Syamsudin; Risrina Nur Ekawati
Fundamental and Applied Research in Medicine and Allied Sciences Indonesia Vol. 1 No. 1 (2025): May, 2025
Publisher : CV. Get Press Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69855/farmasi.v1i1.325

Abstract

Medicines are substances or products including biological products, that play an important role in prevention, treatment, rehabilitation, and health promotion. Leftover medicines are unused medicines resulting from discontinued treatment or expired dates. Purpose: This study aims to analyze the burden of household medicine waste and its economic losses in Garut Regency. Method: the study employs a quantitative survey method with a cross-sectional design, using quota sampling for sample selection, along with specific inclusion and exclusion criteria. Data were collected through a ReDiUM validated questionnaire. The analysis was conducted using descriptive quantitative methods. Result: the results showed that the economic value of unused drugs amounted to Rp6,410,500 or an average of Rp16,026/ household, with a total household pharmaceutical waste burden of 2.6 kg. Drug classification was dominated by prescription drug at 48%. Implications: these findings indicate that improper management of drug waste can result in economic losses and health and environmental risks. Conclusion: Economic loss and environmental risk could be possibly emerged in the nearest future caused by this losses.
Analysis of the Relationship Between MedRiPh (Medication Risk in Pharmacotherapy) Scores and the Incidence of Drug-Related Problems (DRPs) in Geriatric Patients with Comorbidities at Community Health Center X, Surabaya Rissa Maharani Dewi; Lilik Septiana; Diki Aprianto A; Ratna mildawati; Eka Nur Fatmawati
Fundamental and Applied Research in Medicine and Allied Sciences Indonesia Vol. 1 No. 1 (2025): May, 2025
Publisher : CV. Get Press Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69855/farmasi.v1i1.387

Abstract

Drug-Related Problems (DRPs) remain a significant issue in geriatric pharmacotherapy, particularly among older adults with multiple chronic conditions and complex medication regimens. The MedRiPh (Medication Risk in Pharmacotherapy) scoring model has been introduced to identify patients at higher risk of medication related harm, yet its usefulness in Indonesian primary care has not been well evaluated. This cross-sectional study was conducted from October to December 2024 involving 100 geriatric patients aged ≥60 years selected using purposive sampling. MedRiPh scores were calculated using validated criteria, and DRPs were identified based on the Pharmaceutical Care Network Europe (PCNE) version 9.1 system. Statistical analysis included the Shapiro Wilk test, Spearman correlation, and linear regression. A total of 412 DRPs were recorded, with drug interactions, dosing errors, and duplicate therapies being the most common. A strong correlation was found between MedRiPh scores and DRPs (r = 0.82, p < 0.001). These results indicate that MedRiPh may be useful for improving medication safety in geriatric primary care.
Formulation and Characterization of a Dissolvable Microneedle Patch Containing Standardized Temu Mangga (Curcuma mangga) Extract for Hyperpigmentation Therapy: An In Vitro and Ex Vivo Study Zola Efa Harnis; Indri Dwi Rahasasti; Revan Busriano Putra; Nurfitria Junita
Fundamental and Applied Research in Medicine and Allied Sciences Indonesia Vol. 1 No. 1 (2025): May, 2025
Publisher : CV. Get Press Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69855/farmasi.v1i1.388

Abstract

Hyperpigmentation is a common skin disorder associated with Hyperpigmentation is a common skin disorder associated with excessive melanin production, while conventional topical therapies often exhibit limited efficacy due to poor skin permeability. This study aimed to develop and characterize dissolvable microneedle patches containing a standardized Curcuma mangga extract as an alternative transdermal delivery system for hyperpigmentation therapy. Three formulations (F1, F2, and F3) were prepared using varying ratios of hyaluronic acid and polyvinyl alcohol. The microneedles exhibited uniform morphology, sufficient mechanical strength, and effective skin penetration, with complete dissolution occurring within 7–15 minutes. In vitro release studies demonstrated sustained release behavior. Biological evaluation using B16-F10 melanoma cells revealed significant melanin inhibition, with formulation F2 showing the highest activity. Notably, this study is the first to integrate standardized Curcuma mangga extract into a dissolvable microneedle system and to demonstrate its combined transdermal delivery performance and antimelanogenic activity through in vitro and ex vivo evaluations. These findings indicate that Curcuma mangga-loaded microneedles represent a promising and innovative approach for hyperpigmentation therapy, warranting further in vivo investigation.
Evaluation of the Hepatoprotective Effects of the Flavonoid-Containing Ethyl Acetate Fraction Obtained after n-Hexane Defatting of Matoa (Pometia pinnata) Fruit Peel on a DMN-Induced Hepatic Fibrosis Model in Rats: A Histopathological and Serum Biomarker Approach Emma Jayanti Besan; Atun Qowiyyah; Korinus Suweni; Yunita Kristina; Ziza Putri Aisyia Fauzi
Fundamental and Applied Research in Medicine and Allied Sciences Indonesia Vol. 1 No. 2 (2025): November, 2025
Publisher : CV. Get Press Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69855/farmasi.v1i2.389

Abstract

Liver fibrosis is a progressive liver disorder and a major global health concern, prompting increasing interest in natural products with antifibrotic potential. Pometia pinnata, traditionally used to treat liver disorders, lacks sufficient experimental evidence supporting its hepatoprotective effects. This study evaluated the hepatoprotective and antifibrotic activity of a flavonoid-containing ethyl acetate fraction obtained after n-hexane defatting of Pometia pinnata fruit peel in a dimethylnitrosamine (DMN)-induced hepatic fibrosis rat model. Male rats were divided into six groups: normal control, DMN control, three treatment groups receiving the flavonoid fraction at doses of 50, 100, and 200 mg/kg body weight, and a silymarin-treated group (100 mg/kg). Dose selection was based on preliminary toxicity data and previous studies on flavonoid-rich extracts. Liver injury was assessed using serum biochemical markers (ALT, AST, ALP, and bilirubin), histopathological examination, and fibrosis scoring with Masson’s Trichrome staining. Data were analyzed using one-way ANOVA followed by Tukey’s post hoc test (p < 0.05). DMN significantly induced hepatic injury and fibrosis, while flavonoid fraction treatment improved liver function and histological features in a dose-dependent manner. The highest dose showed effects comparable to silymarin and significantly reduced fibrosis scores (r = −0.91, p < 0.001). These findings indicate that Pometia pinnata fruit peel exhibits promising hepatoprotective and antifibrotic potential.
Development of a Microchip Capillary Electrophoresis Method with Amperometric Detection for Rapid and Simultaneous Analysis of Ascorbic Acid and Glutathione in Antioxidant Cocktail Injection Preparations Nina Irmayanti Harahap
Fundamental and Applied Research in Medicine and Allied Sciences Indonesia Vol. 1 No. 1 (2025): May, 2025
Publisher : CV. Get Press Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69855/farmasi.v1i1.390

Abstract

Antioxidant cocktail injections containing ascorbic acid (AA) and glutathione (GSH) require precise and reliable analytical methods to ensure product safety and therapeutic consistency. Conventional methods such as HPLC tend to be time-consuming, require a large number of reagents, and are less suitable for rapid pharmaceutical quality control or at production sites. This study aimed to develop and validate a microchip capillary electrophoresis with amperometric detection (MCE-AD) method for the simultaneous quantification of AA and GSH in injectable preparations. Method optimization included the selection of running buffer, voltage, sample injection parameters, and detection potential to achieve stable separation and optimal electrochemical response. The validated method showed excellent linearity over the concentration range of 1–150 mg/L for AA and 2–200 mg/L for GSH, with correlation coefficients of 0.9989 and 0.9991, respectively. The detection limits were recorded at 0.42 mg/L for AA and 0.61 mg/L for GSH, while the quantification limits were 1.39 mg/L and 2.04 mg/L, respectively. Precision testing yielded a %RSD of <3%, and accuracy testing demonstrated recoveries between 97–103%. Analysis of commercial injection samples demonstrated compliance with pharmacopoeial requirements, supporting the practical application of this method. With an analysis time of <60 seconds and very low sample consumption (<10µL per analysis), the developed MCE-AD technique provides a rapid, economical, and reliable alternative to conventional analytical platforms. These findings confirm the suitability of the method for routine quality testing and its potential integration into portable and automated pharmaceutical analysis systems.
Integration of LC-HRMS-Based Metabolomics, INS-1 Cell Assays, and Molecular Docking to Elucidate the Synergistic Antidiabetic Mechanism of the Kunyit–Asam Herbal Formulation Muhammad Nurul Fadel; Emma Jayanti Besan; Nur Masyithah Zamruddin; Cut Intan Annisa Puteri; Nina Irmayanti Harahap
Fundamental and Applied Research in Medicine and Allied Sciences Indonesia Vol. 1 No. 1 (2025): May, 2025
Publisher : CV. Get Press Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69855/farmasi.v1i1.391

Abstract

Diabetes mellitus remains a major global health burden, leading to growing interest in herbal formulations as complementary antidiabetic therapies. This study aimed to elucidate the synergistic antidiabetic mechanism of the traditional Kunyit–Asam herbal formulation by integrating LC-HRMS-based metabolomics, in vitro INS-1 pancreatic β-cell assays, and molecular docking analysis. Metabolomic profiling using LC-HRMS identified a diverse array of bioactive secondary metabolites, predominantly phenolic acids, flavonoids, and curcuminoids, which are associated with antidiabetic and antioxidant activities. Functional evaluation in INS-1 cells demonstrated that the Kunyit–Asam extract significantly enhanced glucose-stimulated insulin secretion (GSIS) and improved β-cell viability, indicating insulinotropic and cytoprotective effects. Furthermore, molecular docking analysis revealed that several identified metabolites exhibited strong binding affinities toward key diabetes-related molecular targets, including α-glucosidase, α-amylase, AMP-activated protein kinase (AMPK), insulin receptor substrate-1 (IRS-1), phosphoinositide 3-kinase (PI3K), and GLUT4 regulatory proteins. Integration of metabolomic, biological, and in silico findings suggests that the antidiabetic activity of Kunyit–Asam is mediated through multi-target modulation of insulin signaling pathways, inhibition of postprandial glucose-regulating enzymes, and protection against oxidative stress. These results support a synergistic pharmacological mechanism driven by multiple phytoconstituents rather than a single dominant compound. This study provides scientific evidence supporting the traditional use of Kunyit–Asam as an antidiabetic herbal formulation and offers valuable insights for future herbal-based drug development.
Optimization of Dengue-EDIII – Hepatitis B-VLP Fusion Antigen Protein Expression in Mammalian Cell Systems and Preliminary Immunogenicity Testing in Mice Ziza Putri Aisyia Fauzi; Eka Nur Fatmawati; Putri Tri Hartini; Yuneka Saristiana; Husnunnisa
Fundamental and Applied Research in Medicine and Allied Sciences Indonesia Vol. 1 No. 2 (2025): November, 2025
Publisher : CV. Get Press Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69855/farmasi.v1i2.430

Abstract

The development of a safe and effective dengue vaccine remains challenging due to the risk of antibody-dependent enhancement (ADE) associated with imbalanced immune responses. This study aimed to optimize the expression of a dengue virus envelope domain III (EDIII) fusion antigen displayed on Hepatitis B core antigen virus-like particles (VLPs) and to evaluate its preliminary immunogenicity in a murine model. Optimization of antigen design and expression conditions resulted in a substantial increase in VLP production compared with the non-optimized construct. The purified VLPs showed uniform size, proper particle assembly, and preserved antigenic integrity. Immunization of mice induced high titers of EDIII-specific IgG and strong serotype-specific neutralizing antibodies against dengue virus serotype 2, while no antibody-dependent enhancement was detected in vitro. These findings indicate that the optimized EDIII–HBcAg VLP platform is highly immunogenic and demonstrates a favorable safety profile, supporting its potential as a promising subunit vaccine candidate for dengue virus.
Vulnerability of Critical Medicine Supply Chains in Remote Islands: A System Dynamics Study in Maluku, Indonesia Fendy Prasetyawan; Emma Jayanti Besan; Muhammad Nurul Fadel; Ika Lismayani Ilyas
Fundamental and Applied Research in Medicine and Allied Sciences Indonesia Vol. 1 No. 2 (2025): November, 2025
Publisher : CV. Get Press Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69855/farmasi.v1i2.431

Abstract

Ensuring the continuous availability of critical medicines in remote island regions remains a major challenge in decentralized health systems. This study examines the pharmaceutical supply chain in the remote islands of Maluku Province, Indonesia, through a supply chain mapping and vulnerability analysis using a System Dynamics (SD) approach. The findings indicate that fragmented governance structures, combined with extreme geographical dispersion, generate persistent vulnerabilities across procurement, distribution, and service delivery levels. Key reinforcing mechanisms driving medicine stockouts include delayed quantification and procurement processes, logistical bottlenecks in inter-island transportation, and shortages of skilled pharmaceutical personnel. The analysis further shows that interventions focused solely at the health facility level are insufficient to resolve systemic weaknesses. Instead, strengthening medicine security in Maluku requires integrated strategies at higher administrative levels, including investment in human capital, diversification of supply routes, strategic buffer management, and the use of transparent, data-driven logistics information systems. By adopting a systems-based analytical framework, this study provides evidence to support more resilient policy design for improving equitable access to essential medicines in Eastern Indonesia.
Association of Medication Adherence and VKORC1 Polymorphisms with Stable Warfarin Dose Requirements in Patients with Mechanical Heart Valves Syilvi Rinda Sari; Fendy Prasetyawan; Restu Anisa Putri
Fundamental and Applied Research in Medicine and Allied Sciences Indonesia Vol. 1 No. 2 (2025): November, 2025
Publisher : CV. Get Press Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69855/farmasi.v1i2.433

Abstract

Warfarin remains the primary oral anticoagulant for patients with mechanical heart valves, but considerable interindividual variability in stable dose requirements poses a clinical challenge. Although VKORC1 gene polymorphisms are well-established determinants of dose variability, the impact of objectively measured medication adherence is less clear. This study aimed to evaluate the independent and combined effects of VKORC1 polymorphisms and objectively measured medication adherence on stable warfarin dose requirements in patients with mechanical heart valves. Genotyping of VKORC1 −1639G>A (rs9923231) and 1173C>T (rs9934438) was performed using PCR–RFLP. Adherence over 90 days was expressed as the percentage of prescribed doses taken. The −1639A allele frequency was 81.7%, and patients with the AA genotype required significantly lower daily doses than GA or GG genotypes (p<0.001). Mean adherence was 89.4±11.2%. Multivariate regression showed that VKORC1 genotype, age, and adherence independently predicted stable dose,explaining 45.2% of variability. Stable warfarin dose was defined as an unchanged maintenance dose with a therapeutic INR (2.0–3.5) for ≥3 months.Adherence below 80% was associated with increased INR fluctuations and dose adjustments, highlighting adherence as a key clinical modifier alongside genetic factors.
Green Synthesis of Silver Nanoparticles Using Tamarind (Tamarindus indica) Leaf Extract and Their Application as an Antibiofilm Agent in Pseudomonas aeruginosa Infected Wounds Emma Jayanti Besan; Muhammad Nurul Fadel; Cut Intan Annisa Puteri; Dzukharian Munandar; Putri Tri Hartini
Fundamental and Applied Research in Medicine and Allied Sciences Indonesia Vol. 1 No. 2 (2025): November, 2025
Publisher : CV. Get Press Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69855/farmasi.v1i2.434

Abstract

Multidrug-resistant Pseudomonas aeruginosa poses a significant challenge in chronic wound management due to its robust biofilm formation and antibiotic resistance. Green-synthesized silver nanoparticles (AgNPs) using Tamarindus indica (tamarind) leaf extract offer an eco-friendly and effective approach to combat these infections. The bioactive phytochemicals in tamarind leaves function as both reducing and stabilizing agents, producing biocompatible AgNPs with potent antimicrobial and antibiofilm activities. These nanoparticles disrupt bacterial membranes, generate reactive oxygen species, inhibit virulence factors such as pyocyanin, and compromise biofilm integrity. Incorporation of tamarind-derived AgNPs into hydrogels or composite wound dressings further enhances wound healing by maintaining a moist environment and providing sustained antimicrobial release. Although in vivo studies specifically using tamarind AgNPs against P. aeruginosa are limited, evidence from other plant-derived AgNPs supports their promising potential for treating biofilm-associated wound infections. Green synthesis using tamarind thus represents a sustainable strategy for developing next-generation antimicrobial wound therapies.

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