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Fundamental and Applied Research in Medicine and Allied Sciences Indonesia
Published by CV. Get Press Indonesia
ISSN : -     EISSN : 31239374     DOI : https://doi.org/10.69855/farmasi
Core Subject :
Fundamental and Applied Research in Medicine and Allied Sciences Indonesia is an international peer-reviewed open access journal dedicated to publishing high-quality research in public health and related disciplines. The journal provides a platform for researchers, academics, and practitioners worldwide to share evidence-based findings and practical insights for improving public health practice. Fundamental and Applied Research in Medicine and Allied Sciences Indonesia welcomes original research articles, review papers, and case studies in pharmacy, Clinical and community pharmacy, Pharmaceutics and Pharmaceutical Technology, Pharmacology and Toxicology, Pharmaceutical Chemistry and Pharmaceutical Analysis, Pharmacognosy and Phytochemistry, Pharmaceutical Biotechnology, Pharmaceutical Management and Policy, Pharmacy Education and the Profession Fundamental and Applied Research in Medicine and Allied Sciences Indonesia is published by CV. Get Press Indonesia and is published Twice times a year in May and November.
Arjuna Subject : -
Articles 17 Documents
 1   2 
Development and Validation of an Instrument to Measure Competency Gaps of Hospital Pharmacists in Facing Telemedicine Integration in Urban Areas of Indonesia Diki Aprianto A; Ratna Mildawati; Lilik Septiana; Rialita Lifiani; Indri Dwi Rahasasti
Fundamental and Applied Research in Medicine and Allied Sciences Indonesia Vol. 1 No. 2 (2025): November, 2025
Publisher : CV. Get Press Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69855/farmasi.v1i2.435

Abstract

The rapid adoption of telemedicine has expanded hospital pharmacists’ roles, particularly in urban areas of developing countries such as Indonesia. However, evidence on pharmacists’ telemedicine-related competency gaps remains limited. This study aimed to develop and validate a hospital-specific instrument to assess such gaps. A methodological design was employed, including instrument development, expert content validation, pilot testing, and psychometric evaluation. The instrument covers six domains: digital health literacy, clinical pharmacy competence in telemedicine, communication skills, legal and ethical awareness, interprofessional collaboration, and telepharmacy service management. Validation involved 210 hospital pharmacists from urban Indonesian hospitals. Exploratory factor analysis confirmed a six-factor structure explaining 72.4% of the variance, with strong internal consistency (Cronbach’s alpha = 0.89). Unlike existing telepharmacy readiness tools, this instrument specifically captures multidimensional competency gaps relevant to hospital-based telemedicine practice. The largest gaps were observed in legal–ethical competencies and digital health literacy. This instrument can support workforce assessment and targeted competency-based training for hospital pharmacists in Indonesia.
Optimization and Stability Testing of a Nanostructured Lipid Carrier (NLC)-Based Emulgel System for Transdermal Delivery of Anti-Inflammatory Drugs Muhammad Nurul Fadel; Emma Jayanti Besan; Dzukharian Munandar; Zola Efa Harnis; Indri Dwi Rahasasti
Fundamental and Applied Research in Medicine and Allied Sciences Indonesia Vol. 2 No. 1 (2026): May, 2026
Publisher : CV. Get Press Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69855/farmasi.v2i1.522

Abstract

Nanostructured Lipid Carriers (NLC) are second-generation lipid nanoparticles composed of solid and liquid lipids that improve drug loading, stability, and controlled release. Incorporating NLC into an emulgel enhances transdermal drug delivery by improving skin permeation and prolonging drug release. This study aimed to optimize an NLC-based emulgel using Design of Experiment (DoE) and evaluate its physicochemical properties, drug release, skin permeation, and stability. Diclofenac sodium was selected as the model drug. NLC was prepared using melt-emulsification ultrasonication and optimized with a three-factor Box–Behnken design before incorporation into Carbopol 940 gel. Characterization included particle size, zeta potential, entrapment efficiency, viscosity, spreadability, and drug release analysis. The optimized formulation showed a particle size of 187.4 ± 5.2 nm, zeta potential of −32.6 ± 1.8 mV, and entrapment efficiency of 91.3 ± 2.1%. Drug release reached 85.6% within 24 hours following the Korsmeyer-Peppas model. Skin permeation was significantly higher than conventional gel, and the formulation remained stable for six months at 25°C/60% RH.
Formulation Study and Evaluation of the Effectiveness of Natural Polymer-Based Dissolving Microneedles for Model Vaccine Delivery Emma Jayanti Besan; Muhammad Nurul Fadel; Nur Masyithah Zamruddin; Dara Sukma Ratmelya; Yuneka Saristiana
Fundamental and Applied Research in Medicine and Allied Sciences Indonesia Vol. 2 No. 1 (2026): May, 2026
Publisher : CV. Get Press Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69855/farmasi.v2i1.524

Abstract

Dissolving microneedle (DMN) arrays made from biocompatible natural polymers offer a promising transdermal vaccine delivery system that can reduce pain, eliminate cold-chain dependence, and minimize the need for trained healthcare workers compared to conventional injections. This study aimed to formulate and characterize natural polymer-based DMNs containing ovalbumin (OVA) as a model antigen and evaluate their immunogenicity in mice. DMNs (F1–F5) were prepared using polyvinyl alcohol (PVA), polyvinylpyrrolidone (PVP K30), and hyaluronic acid (HA) at different concentrations through spin-casting into PDMS molds. The formulations were evaluated for morphology, mechanical strength, dissolution time, encapsulation efficiency, antigen release, and immunogenicity in BALB/c mice. The optimized formulation (F4; PVA 15%, PVP K30 10%, HA 1%) showed needle heights of 544.9 ± 15.1 µm, mechanical strength of 0.52 ± 0.04 N/needle, complete dissolution within 15 minutes, and encapsulation efficiency of 94.8 ± 1.8%. Immunogenicity testing demonstrated IgG titers comparable to subcutaneous injection controls. These findings indicate that natural polymer-based DMNs are a promising needle-free and patient-friendly vaccine delivery platform.
Development of Rapid Dispersible Tablet Preparations Using Synthetic and Natural Superdisintegrant Disintegrants: Comparative Performance Analysis putri tri hartini; pertiwi awilda; Ratna mildawati; Khazanah Nurain Nurdin; Dara Sukma Ratmelya
Fundamental and Applied Research in Medicine and Allied Sciences Indonesia Vol. 2 No. 1 (2026): May, 2026
Publisher : CV. Get Press Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69855/farmasi.v2i1.525

Abstract

Rapid dispersible tablets (RDTs) are patient-friendly oral dosage forms designed to disintegrate rapidly in the oral cavity or in the presence of a small amount of water, thereby improving patient compliance, particularly among pediatric, geriatric, and dysphagic populations. The performance of RDTs is highly dependent on the type and concentration of superdisintegrants used, as these excipients play a critical role in governing tablet disintegration behavior, wetting characteristics, mechanical strength, and drug release kinetics. Synthetic superdisintegrants such as croscarmellose sodium (CCS) and crospovidone (CPVP) are widely utilized due to their high swelling capacity and capillary action, whereas natural superdisintegrants like Plantago ovata husk (ispaghula husk) have gained increasing interest as eco-friendly and biocompatible alternatives. However, comparative information regarding the efficiency of synthetic and natural superdisintegrants in high-dose drug formulations remains limited. In this study, metformin hydrochloride (500 mg), a high-dose and highly water-soluble antidiabetic drug, was formulated into RDTs using different superdisintegrants via direct compression. The results demonstrated that the optimized formulation containing crospovidone exhibited the fastest disintegration time of 29.1 seconds, along with rapid tablet breakup and efficient drug release, compared to formulations containing croscarmellose sodium and Plantago ovata husk.
Formulation and Characterization of PEGylated Liposomes as a Targeted Delivery System for the Chemotherapy Drug Doxorubicin putri tri hartini; Arbayah; Ziza Putri Aisyia Fauzi; Fendy Prasetyawa; Revan Busriano Putra
Fundamental and Applied Research in Medicine and Allied Sciences Indonesia Vol. 2 No. 1 (2026): May, 2026
Publisher : CV. Get Press Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69855/farmasi.v2i1.526

Abstract

Doxorubicin (DOX) is an effective anticancer agent, but its clinical use is limited by severe systemic toxicity. This study developed and optimized PEGylated liposomes containing DOX to improve therapeutic efficacy and safety. Liposomes were prepared using thin-film hydration and active loading via an ammonium sulfate gradient, and optimized using a Box-Behnken Design. The optimized formulation showed a particle size of ~112 nm, high encapsulation efficiency (94.7%), good stability, and pH-responsive drug release, with greater release under acidic conditions. In vitro studies demonstrated enhanced cytotoxicity against MCF-7 and MDA-MB-231 breast cancer cells compared to free DOX. The formulation also remained stable for 6 months under ICH conditions. Overall, DOX-loaded PEGylated liposomes exhibited favorable physicochemical characteristics, improved anticancer activity, and strong potential as a targeted nanocarrier for breast cancer therapy.
Formulation and Characterization of Curcumin-Loaded Microsponge Gel for Controlled Release and Enhanced Stability in Topical Antioxidant Therapy Emma Jayanti Besan; Muhammad Nurul Fadel; Nur Masyithah Zamruddin; Husnunnisa; Cut Intan Annisa Puteri
Fundamental and Applied Research in Medicine and Allied Sciences Indonesia Vol. 2 No. 1 (2026): May, 2026
Publisher : CV. Get Press Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69855/farmasi.v2i1.543

Abstract

Curcumin possesses strong antioxidant and photoprotective activities, but its poor aqueous solubility, limited skin penetration, and high photoinstability restrict topical efficacy. This study developed curcumin-loaded microsponges using Eudragit RS100 by the quasi-emulsion solvent diffusion method. The optimized formulation (MS-F5) showed high encapsulation efficiency (91.7 ± 1.6%), porosity (61.3 ± 2.8%), positive zeta potential (+28.3 ± 2.1 mV), and sustained 24-h drug release following Higuchi kinetics (R² = 0.9952). Incorporated into a 2% Carbopol gel, MS-F5 significantly enhanced skin permeation (2.89-fold), epidermal retention (3.52-fold), antioxidant activity (IC₅₀ 12.4 ± 0.8 vs. 18.7 ± 1.2 µg/mL), and photostability (72.4% vs. 18.3%) compared with plain curcumin gel (p < 0.05). Stability studies following ICH Q1A(R2) and Q1B guidelines confirmed acceptable physicochemical and microbiological stability over six months. These findings demonstrate that microsponge technology improves curcumin stability, controlled release, skin delivery, and antioxidant performance, highlighting its potential for dermatological and cosmeceutical applications.
Evaluation of the Potential of Self-Nanoemulsifying Drug Delivery System (SNEDDS) in Increasing Oral Bioavailability of Low-Solubility Drugs Muhammad Nurul Fadel; Emma Jayanti Besan; Dzukharian Munandar; Husnunnisa; Cut Intan Annisa Puteri
Fundamental and Applied Research in Medicine and Allied Sciences Indonesia Vol. 2 No. 1 (2026): May, 2026
Publisher : CV. Get Press Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69855/farmasi.v2i1.544

Abstract

Losartan potassium, a Biopharmaceutics Classification System (BCS) Class II drug, exhibits poor aqueous solubility and limited oral bioavailability. This study aimed to develop and optimize a Self-Nanoemulsifying Drug Delivery System (SNEDDS) to enhance its dissolution and absorption. SNEDDS formulations were prepared using Capmul MCM C8, Tween 80, and PEG 400 based on solubility screening and ternary phase diagram analysis. The optimized formulation (F3) was evaluated for droplet size, polydispersity index (PDI), in vitro drug release, pharmacokinetics, and stability. Pharmacokinetic studies were conducted in experimental rats Pharmacokinetic studies were conducted in experimental rats (n = 3 per group) to assess bioavailability. The optimized SNEDDS produced nanoemulsions with a droplet size of 68.3 nm, low PDI, and good dilution stability. In vitro studies demonstrated rapid drug release (>96% within 30 minutes), significantly higher than the plain suspension. Pharmacokinetic results showed a 3.09-fold increase in bioavailability and a 2.79-fold increase in Cmax without altering Tmax. Stability studies confirmed good physicochemical stability over six months under ICH conditions. In conclusion, SNEDDS is a promising strategy to improve the oral bioavailability of poorly water-soluble drugs such as losartan potassium.

Page 2 of 2 | Total Record : 17

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