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Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Published by Universitas Gadjah Mada

ISSN : 01261312 EISSN : 23563931 DOI : http://dx.doi.org/10.19106/JMedSci005303202101

Core Subject : Science,

Immunology & microbiology Neuroscience

Journal of the Medical Sciences (JMedSci) or Berkala Ilmu Kedokteran (BIK) is an international, open-access, and double-blind peer-reviewed journal, published by Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada Yogyakarta Indonesia. JMedSci aiming to communicate high-quality articles in the areas of biomedical science from basic to clinical sciences.The journal welcomes papers from original articles, case reports, reviews, and book reviews. All papers published in JMedSci are freely available as downloadable pdf files. The journal began its publication on March 1973 and published quarterly (January, April, July, and October). JMedSci is abstracted and indexed in DOAJ, Crossref, Google Scholar, Sinta, Indonesia One Search. JMedSci is accredited by Directorate of General Higher Education, the Ministry of Research, Technology, and Higher Education, Indonesia

Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)

Articles 14 Documents

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Search results for , issue "Vol 50, No 3 (2018)" : 14 Documents clear

The role of Malassezia sp, sebum level and Trans Epidermal Water Loss (TEWL) toward the dandruff severity between hijab and non hijab wearing subjects Kristiana Etnawati; Agnes Sri Siswati; Satiti Retno Pudjiati; Devi Artami Susetiati; Dwi Retno Adiwinarni; Affendi Purbananto
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 3 (2018)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Dandruff is a common symptom in adolescence, which possibly due to increasing ofMalassezia sp. colonization, sebum level as well as skin hydration. Wearing hijab ispredicted to increase the humidity and sebum level lead to increase the number ofMalassezia sp. and dandruff severity. A case-control study was conducted on 19 femalewith dandruff who wear hijab and 19 female with dandruff who do not wear hijab, agebetween 18 and 27 years old. The dandruff severity was defined clinically using ascoring system (0-100), only subjects with minimum score of 28 will be included in thisstudy. The sebum and trans epidermal water loss (TEWL) levels were measured withSebumeter and Tewameter from Courage Khazaka. The Malassezia sp. was examinedusing microscopic examination of the squama and culture in the Saboraud medium.There were no significant differences found between hijab and non-hijab groups fordandruff severity. No difference found between two groups for sebum level, Malasseziasp. number microscopically, and Malassezia sp. colonization. Only TEWL level in hijabgroup that was found to be higher than non-hijab group. Wearing hijab does not increasethe dandruff severity, sebum level and colonization number of Malassezia sp. Wearinghijab is found to increase the TEWL level.

Effect of tonsillectomy with or without adenoidectomy on formant sound frequency Rianto, Bambang Udji Djoko; Jenny, .; Indrasari, Sagung Rai
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 3 (2018)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

ABSTRACT Vocal tract resonance characteristics are reflected by formant frequencies which determined by the size and shape of the vocal tract. Tonsillectomy may cause changes in the structure of the oral cavity as a resonator in the speech process. The aim of this study is to determine the effect of tonsillectomy on formant sound frequency. This study used a pre-test and post-test only design experimental. The study underwent in the Otorhinolaryngology Department between August up to November 2012. Inclusion criteria were: 1) chronic tonsillitis, 2) tonsil size was T3-T4, 3) age up to 5 years. The exclusion criteria were craniofacial abnormality and neurological disorders. All patients performed a sound analysis by recording vowel / a /, / e /, / i /, / o /, and / u / in 1 day before and 4 weeks after surgery. The sample consisted of 24 (60%) women and 16 (40%) men. The T3-T3 tonsil size were 25 (62.5%) samples and the lowest than T3-T4/T4-T3 were 6 (15%) samples. Based on paired T test there was a statistically significant increase of all F1 vowels (p <0.05), except for / i / (p> 0,05) and decrease of F2 / e / and F3 / u / (p >0,05). Based on these results it can be concluded that tonsillectomy affects the F1 mean difference almost in all vowel except the vowels / i /, F2 & F3.

The effects of furosemide on kidney damage in acute kidney injury rat models Afifah Afifah; . Ngatidjan; Nur Arfian
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 3 (2018)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

The most frequent cause of acute kidney injury (AKI) is ischemia reperfusion injuriesthat causes inflammation. Furosemide is still used in AKI’s therapy. The advantages anddisadvantages of furosemide in AKI remain controversial. The aim of the study was toinvestigate the effect of furosemide on kidney damage in AKI rat models. Twenty-fivemale (2-3 months old) Sprague-Dawley rats were divided into 5 groups; sham operation(SO, n=5), ischemic-reperfusion (IR, n=5), IR+furosemide 3.6 mg/kgBW (IR+F1,n=5), IR+furosemide 7.2 mg/kgBW (IR+F2, n=5), and IR+furosemide 14.4 mg/kgBW(IR+F3, n=5). Abdominal surgery was performed under ketamine anesthesia to produceischemic reperfusion (IR) by mean of renal artery clamping for 45 min. Urine output,serum creatinine level, tubular injury score, and TLR4 gene expression were examinedto investigate kidney damage. Periodic acid-schiff (PAS) staining was measured toexamine kidney tubular injury. Data were analyzed using One-Way ANOVA and Kruskal-Wallis test with significance level of p<0.05. AKI rat models which were given 3.6 and7.2 mg/kgBW of furosemide (0.014±0.001 mL/min; and 0.012±0.007) showed higher(p>0.05) creatinine clearance compared to IR (0.009±0.003) while administration of 14.4mg/kgBW furosemide (0.009±0.004) denoted equal creatinine clearance to IR (p>0,05).Kidney tubular injury score of 3.6 mg/kgBW furosemide (2.89±0.13) was lower (p>0.05)than IR (3.26±0.19) whereas 7.2 mg/kgBW and 14.4 mg/kgBW furosemide (3.55±0.26;3.83±0.19) were higher (p<0.05) than IR. Administration of 3.6 mg/kgBW furosemide(0.99±0.08) indicated lower (p<0.05) TLR4 gene expression than IR (1.20±0.08) whilst7.2 mg/kgBW furosemide (1.23±0.13) was not-significantly higher (p>0.05) and 14.4 mg/kgBW furosemide (1.63±0.12) was significantly higher (p<0.05) than IR. In conclusion,administration of 3.6 mg/kgBW furosemide reduces kidney damage in AKI rat modelswhile higher dosages (7.2 mg/kgBW and 14.4 mg/kgBW) increase kidney damage.

Profile of traumatic brain injury (TBI) in relation with maxillofacial and thoracic injury Dr. Hasan Sadikin General Hospital, Bandung Padmini Laxmi Pathmanathan; Gibran Tristan Alpharian; Agung Budi Sutiono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 3 (2018)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Traumatic brain injury (TBI) has a relation with concomitant injuries, which are mostlymaxillofacial and thoracic injury. This study aimed to know which injury was common inTBI patients and the difference in the severity of TBI when patients were associated withone or both types of injuries. This was a descriptive retrospective study. The data used wasmedical records from Department of Neurosurgery, Dr. Hasan Sadikin General Hospital,Bandung, Indonesia from the period of August 2015 to July 2016. Total sampling methodwas used in this study. The variables were patients with TBI, maxillofacial injury, thoracicinjury, accident related mechanism and non-accident related mechanism and the GlasgowComa Score (GCS). The total cases for this study were 47 patients. The highest case wasmales with 37 cases and 10 for females. Accident related trauma had 23 cases whereasnon accident related trauma had 24 cases. The total cases of maxillofacial injury were 32,thoracic were 6 cases whereby for both injuries were 9 cases. Patients with mild TBI were28 cases, moderate TBI were 13 cases, and severe TBI had 6 cases in total. The rate ofTBI was higher in single injury which was the maxillofacial injury. However, the thoracicand both injuries combined had higher severity of TBI compared to maxillofacial injury.

Precocious puberty in McCune-Albright syndrome: a case report Rianti Puji Lestari; Retno Sutomo; Madarina Julia
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 3 (2018)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

McCune-Albright syndrome (MAS) is a rare disease characterized by a triad of fibrousdysplasia, cafe-au-lait spots and peripheral precocious puberty. We reported a 5-year-8-month old girl with MAS who has been followed-up for 2 years and 8 months. Shewas referred to pediatric endocrinology clinic in our hospital for vaginal bleeding at ageof 2 years 11 months. She had peripheral precocious puberty, i.e. increased estrogenlevel associated with very low gonadotropins, and cafe-au-lait spots on her face and wasdiagnosed as MAS. The patient was treated with estrogen receptor blocker (tamoxifen).She had no menses during the 2 years and 8 months of tamoxifen treatment. Her growthrate and bone maturation were also in normal ranges. However, at the end of tamoxifentreatment she had an episode of vaginal bleeding so that we had to change to othertreatment modalities.

Factors influencing plateletpheresis donations in Yogyakarta, Indonesia Aditya Wicaksana; Teguh Triyono; Umi Intansari
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 3 (2018)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Despite its life saving potential, regrettably, blood transfusion has yet to be optimally applied in Indonesia. Funding difficulties and both public and professional lack of knowledge hinders its progress. More lives can be saved by using a safer, more proper, and specialized blood transfusion procedure. Plateletpheresis, one method to obtain platelet products, requires a different donation procedure than that of whole blood-derived platelet. High quality plateletpheresis product donation will positively impact the transfusion efficacy and platelet recovery of the recipient, improving patient’s clinical state. This study analyzes factors from both the donor and donation procedure that influence the quality of plateletpheresis product. The study analyzes data of plateletpheresis donations from blood transfusion service and plateletpheresis transfusions from medical records at Dr. Sardjito General Hospital, Yogyakarta, Indonesia, within the period of August 2012 to January 2013 using cross sectional design. Forty-four plateletpheresis donations were obtained during the study. All donors were male with the following mean values; age 31.9 ± 9.9 years, weight 70.2 ± 10.2 kg, body mass index (BMI) 24.7 ± 3.2 kg/m2, hematocrit 44 ± 3.2 %, and procedure time 84.2 ± 19.2 min. The median value of platelet yield was 3.2x1011 (2.1x1011 – 4x1011). The median value of pre-donation platelet count was 248.5x103/μL (204x103/μL – 391x103/μL) and the mean value of product volume was 275 ± 22.9 mL. The results showed that pre-donation platelet count (r = 0.329; p < 0.05) and product volume (r = 0.661; p < 0.05) positively correlated to the yield of platetetpheresis products. However, the yield of plateletpheresis products was not correlated to the post-transfusion platelet count (r = 0.327; p > 0.05). In conclusion, pre-donation platelet count and product volume of plateletpheresis influence the yield of plateletpheresis. However, the yield is not correlated to the post-donation platelet count. Thus, other clinical factors should be considered

Peppermint oil prevented oxidative stress in experimental animal – induced acute single bout of eccentric exercise (ASBEE): study on blood catalase and hydrogen peroxide (H2O2) and glucose transporter-4 (GLUT-4) expression on the muscle cells Dewi Aryanti; Denny Agustiningsih; Mae Sri Hartati Wahyuningsih
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 3 (2018)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Peppermint oil is one of the essential oils with antioxidant activity that can reduce levels of reactive oxygen species (ROS). An acute single bout of eccentric exercise (ASBEE) is an acute exercise activity that can lead to increased ROS and cause skeletal muscle injury. This study aimed to assess the effect of peppermint oil in experimental animals induced with ASBEE with the purpose to measure catalase, hydrogen peroxide (H2O2) blood and glucose transporter-4 (GLUT-4) expression of skeletal muscle cells. A total of 30 Wistar rats (Rattus norvegicus) aged 20-24 weeks, weighing 160-350 g were divided into six groups i.e. T1 (n =5), T2 (n =4) and T3 (n =5) given peppermint oil orally at different dose of 0.25, 0.5 and 1.0 g/kg, respectively, one hour before inducing with ASBEE; C0 (n=5) not given peppermint oil and not induced with ASBEE; CA (n=5) not given peppermint oil and induced with ASBEE and CE (n=5) given vitamin E 400 mg/kg one h before induced with ASBEE. ASBEE induction was done by downhill running on a rat treadmill -50 with a load index of 70% VO2 max for 30 min. Twenty four h after induction of ASBEE, blood samples and muscle tissue were taken for examination of catalase, H2O2 and GLUT-4 expression. The results showed increased levels of blood catalase and decreased blood H2O2 levels in groups T1, T2, T3, and CE. The opposite occurred in the group CA. The GLUT-4 expression did not show any significant difference between groups. It was concluded that peppermint oil can improve the condition of oxidative stress caused by ASBEE.

The effect of measurable and regular exercise on ovariectomized Sprague Dawley rats in improving skin quality Lutfi Nurdian Asnindari; Sri Kadarsih Soejono; . Hariyadi
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 3 (2018)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

The decline of estrogen level causes various skin changes including amount of fibroblast, the thickness of epidermis and dermis. Physical exercise is believed can increase the estrogen level and give benefit impacts on skin. It mechanism is often associated with the increase of extragonadal aromatization and estrogen serum, the activation of insulin-like growth factor (IGF), and the expression of estrogen receptor (ER). This study was conducted to investigate the effect of physical exercise in ovariectomized rat on the amount of fibroblast, the thickness of epidermis and dermis, the levels of ER β in skin and serum estrogen. Eight female Sprague Dawley rats aged 3 months were used in this study. Rats were divided into two groups i.e. Group 1 consisted of ovariectomized rats without physical exercise and Group 2 consisted of ovariectomized rats and given measurable and regular physical exercise. Rats ran on treadmill with the speed 18 m/min, the tilt of 5%, duration for 60 min/experiment/day, 5 times a week for 12 weeks. The amount of fibroblast, the thickness of epidermis and dermis, the levels of ERβ in skin and serum estrogen were measured after physical exercise. The result showed that there was a significant difference amount of fibroblast between group 1 and group 2 (p<0.05). However, no significant difference the levels of serum estrogen, ERβ, and the thickness of epidermis and dermis between Group 1 and Group 2 (p>0.05). There was a significant positive correlation between the level of serum estrogen and the thickness of epidermis (p<0.05), and negative correlation between the serum estrogen level and the level of ERβ (p<0.05), and negative significant correlation between the level of ERβ and the thickness of epidermis (p<0.05). In conclusion, the amount of dermal fibroblast of ovariectomized rats increase after underwent measurable and regular exercise. There is correlation between the serum estrogen level and the thickness of epidermis as well as ERβ.

Cervical cancer screening coverage in urban and rural areas in Southeast Sulawesi: its determinants Saimin, Juminten; Wicaksono, Satrio; Ashaeryanto, .
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 3 (2018)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Cervical cancer is a woman’s health problem that is still widespread throughout the world, especially in developing countries such as Indonesia. The high incidence of cervical cancer is related with early detection program. Visual inspection of acetic acid (VIA) is used as an alternative screening method because it is easier, cheaper and its effectiveness is not much different from the Pap test. There are differences on coverage of VIA test in urban and rural areas. This study aimed to identify determinants of cervical cancer screening coverage in urban and rural areas. The study was a cross sectional study. Total of 372 women who did the VIA test in urban areas of Kendari and rural areas of South Konawe in January to June 2016 were included in this study. Coverage of cervical cancer screening was examined in relation to the level of education, knowledge, distance of health facilities and family support. The data was analyzed using Chi-square test with a significance value p < 0.05. The majority of respondents were the age groupof 31-40 years old, low parity, and first intercourse at ≥ 17 years old. There were significant difference of education level (p=0.000), knowledge (p=0.000) and distance of health facilitiesin urban and rural areas (p=0.000). There was no significant differences between family support in urban and rural areas (p=0.224). In conclusions, education level, knowledge, and distance of health facilities are determinants of cervical cancer screening coverage in urban and rural areas in Southeast Sulawesi.

Outcomes of surgical management of intracerebral hemorrhagic stroke at a tertiary care center in Yogyakarta, Indonesia Rahmat Andi Hartanto; Teuku Jauhardin
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 3 (2018)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (406.422 KB)

Hemorrhagic stroke remains a significant cause of morbidity and mortality worldwide. However, the role of surgical treatment for hemorrhagic stroke remains controversial. Previous studies had proposed surgery can prevent herniation, lowering intracranial pressure (ICP) and reducing mass effect and cellular toxicity. Outcome in previous studies are conflicting. Studies concerning outcomes of surgical management of hemorrhagic stroke in Indonesia are limited. This study aimed to compare the outcome of hemorrhagic stroke treatment between surgical evacuation and conservative management in Dr. Sardjito General Hospital, Yogyakarta, Indonesia. Retrospective cohort study was conducted. Eighty spontaneous intracerebral hemorrhagic (ICH) stroke patients involved in this study during January 2014 to August 2015. Of whom 36 (45%) male and 44 (55%) female. There were 45 and 35 patients underwent surgical treatment and conservative management, respectively. Surgical treatment group survival was 74%, whereas the survival in the conservative group was 26%. There was a statistically significant difference between surgery group and conservative group (p

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