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Journal of the Medical Sciences (Berkala Ilmu Kedokteran)
Core Subject : Science,
Journal of the Medical Sciences (JMedSci) or Berkala Ilmu Kedokteran (BIK) is an international, open-access, and double-blind peer-reviewed journal, published by Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada Yogyakarta Indonesia. JMedSci aiming to communicate high-quality articles in the areas of biomedical science from basic to clinical sciences.The journal welcomes papers from original articles, case reports, reviews, and book reviews. All papers published in JMedSci are freely available as downloadable pdf files. The journal began its publication on March 1973 and published quarterly (January, April, July, and October). JMedSci is abstracted and indexed in DOAJ, Crossref, Google Scholar, Sinta, Indonesia One Search. JMedSci is accredited by Directorate of General Higher Education, the Ministry of Research, Technology, and Higher Education, Indonesia
Articles 2,170 Documents
Correlation between overt hyperthyroid and subclinical hyperthyroid and cognitive impairment in Dr. Sardjito General Hospital, Yogyakarta, Indonesia Berkat Hia Pernodjo Dahlan Abdul Ghofir
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 44, No 01 (2012)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Hyperthyroidism is a metabolic imbalance resulting from excessive production of thyroid hormones.Overt or subclinical hyperthyroid prevalence has reached 20%. The differences in thyroid statusinduce apoptosis in adult cerebral cortex. Triiodothyroxine (T3) acts directly on the cerebralcortex mitochondria and induces the release of cytochrome-c which leads to apoptosis. Theincrease of hormone levels encountered in hyperthyroidism which is associated with an increasein necrotic death of neurons and oxidative stress has a negative effect on cognition. Severalstudies demonstrated the significant association of hyperthyroidism with cognitive impairment,despite remaining as controversial results. The study aimed to evaluate the correlation betweenovert hyperthyroid and subclinical hyperthyroid and cognitive impairment in hyperthyroidismpatients. This was a cross-sectional study involving 68 patients of hyperthyroidism who weretreated in Endocrine Clinic of Dr. Sardjito General Hospital, Yogyakarta. The inclusion criteriawere hyperthyroidism based on anamnesis, clinical examination and laboratory tests, age of 20-60 years, symptoms of hyperthyroidism, and minimum education of elementary school. Therelationship of hyperthyroidism and cognitive impairment, and multivariate analysis was analyzedby Chi-square and logistic regression tests, respectively. The results were considered as statisticallysignificant if the value of p was <0.05. The results showed that overt hyperthyroidism hadsignificantly associated with cognitive impairment (p = 0.021). Another variable associatedwith cognitive impairment was female gender (p = 0.019). In a multivariate analysis, the variablesof overt hyperthyroidism (p = 0.024) and sex (p = 0.025) had independent association withcognitive impairment. In conclusion, this study found that overt hyperthyroidism had a significantassociation with incidence of cognitive impairment compared to subclinical hyperthyroidism.Keywords: hyperthyroidism - overt - subclinical - cognitive - mini-mental state examination
Fibroadenoma of the breast with florid epithelial cells hyperplasia: a case report Irianiwati;, Rahmayani;, E. Soekarti; Soeripto;, J.L. Peterse
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 41, No 04 (2009)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Fibroadenoma is a benign biphasic tumor of the breast, composed of an epithelial and a stroma component. Fibroadenoma with epithelial cells hyperplasia may contribute to the higher risk of breast cancer, especially for florid and atypical hyperplasia. The distinction between fibroadenoma with florid epithelial cells hyperplasia, in-situ carcinoma and invasive duct carcinoma of the breast ban be difficult morphologically. To solve the problem, immunohistochemical staining with specific andibodies will be helpfull in distinguishing usual duct hyperplasia from ductal carcinoma in situ. A case of fibroadenoma with florid epithelial cells hyperplasia has been reported. Morphologically, this tumor is difficult to be differentiated from ductal carcinoma. Immunohistochemical staining with High molecular weight cytokeratins 34BE12, Smooth Muscle Actin (SMA),E-cadherin could be used to determine the diagnosis of this tumor.
The effect of chronic ethanol administration on total number of pyramidal cells in CA 1 and CA3 of hippocampus and spatial working memory in adolescent rats (Rattus norvegicus) Muh. Ihwan Nurwanto Soejono Aswin Mustofa
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 40, No 04 (2008)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Background: Adolescent brain may be more susceptible to damage by ethanol. Chronic ethanol administration may cause morphological changes in the hippocampus, followed by deficit in the hippocampal function, including the impairment of memory.Objective: The aim of this study were to investigate the changes in the total number of pyramidal cells in CA 1 and CA3 of hippocampus, and the relationship between these changes with spatial working memory of rats after chronic ethanol administration at adolescent age.Methods: Twenty five adolescent (30 days of agel male rats (Rattus norvegicusl were classified randomly into 5 groups, that is, namely control without treatment (C1 I, control with treatment (C21, treatment 1(11 I, treatment 2 (T2), and treatment 3 (T31 groups. Each group consisted of 5 rats. C2 group was given physiological saline, while 11, T2, and T3 groups were given ethanol at various doses of 1, 2, and 3 gl kgBW/day, repectively, for 30 days by intraperitoneal injection. After chronic ethanol administration, the spatial working memory of 5 groups were tested using 8 arms radial maze for 12 days. At the end of the experiment, the rats were sacrified and the brains were taken out for histological examination, by paraffin method and Cresyl violet staining.Result: Chronic ethanol administration on adolescent rats caused a decrease in spatial working memory (especially in group T31 (p < 0.051. The total number of pyramidal cells in CA 1 of group T3 was fewer than those of control groups (p < 0.05), but the total numbers of pyramidal cells in CA3 of treatment groups were not different with those of control groups (p > 0.051. Analysis with product moment correlation test showed that there was a positive correlation between the total number of pyramidal cells in CA 1 of hippocampus with spatial working memory of the rats after chronic ethanol administration at adolescent age (p < 0.051.Conclusion: Chronic ethanol administration on adolescent rats caused a decrease in the spatial working memory and the number of pyramidal cells in CA 1 of hippocampus. There was a positive correlation between the number of pyramidal cells in CA 1 and spatial working memory of the rats after chronic ethanol administration at adolescent age.Key words: ethanol - pyramidal cells - spatial working memory - adolescent
The effect of a formulation containing honey, black cumin, propolis and royal jelly on blood glucose level and pancreatic -cells of streptozotocin-induced diabetic rats Sunyoto, Umi Mahmudah, Sindu Oktivasari,Eti Nurwening Sholikhah Setyo Purwono,Sitarina Widyarini,Mus
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 44, No 02 (2012)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

A formulation containing 40% of honey, 30% of black cumin, 20% of propolis and 10% of royaljelly has been available in the market for the treatment of diabetes. Although each content ofthe formulation is proven to possess antioxidant and antihyperglycemic activities, its combinationeffect has not been evaluated yet. The aim of this study was to evaluate the effect of thisformulation on blood glucose level and pancreatic -cells of streptozotocin (STZ)-induced diabeticrats. Thirty six male Wistar rats (Rattus novergicus) aged 11 weeks with body weight 100-150 gwere used in this study. The rats were divided into 6 groups with 6 rats in each group. Group 1was non diabetic rats that were given aquadest. Group 2 was diabetic rats that were givenaquadest. Group 3 was diabetic rats that were given metformin at dose of 45 mg/kg BW. Group4-6 were diabetic rats that were given formulation tested at dose of 3, 6 and 12 mL/kg BW,respectively. All rats were induced by intraperitoneal injection of STZ at 60 mg/kg BW anddiabetic rats were then orally administered the formulation tested or metformin twice daily for14 days. Blood glucose level was monitored on day 10 and 17 after STZ induction. Rats weresacrificed and pancreas samples were taken for histopathological examination. The results showedthat the blood glucose level decreased significantly after seven days of treatment with metforminor fomulation tested and continued after 14 days of treatment. The blood glucose level ofdiabetic rats after 14 days of treatment returned to the normal level. The vacuolization of thepancreatic -cells of diabetic rats treated with metformin or with formulation tested were lowerthan untreated diabetic rats but still higher than non diabetic rats. In conclusion, the formulationtested has antihyperglicemic and protective effect on -cells damage in diabetic rats.Keywords: diabetic rats - honey - black cumin - propolis - royal jelly - antihyperglicemic
Giant fetus in fetu in a female 'child with fever: A case report Hanggoro Tri Rinonce Pieri Kumaladewi, Siti Iqbalwati Rochadi, Mei Neni Sitaresmi, Soeripto
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 41, No 01 (2009)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Fetus in fetu is a form of monozygotic diamniotic twin pregnancy where the parasitic twin installs and grows in the body of its partner. It is a rare condition, with a reported incidence of 1 in 500.000 live births. The majority of these cases occur in children younger than 18 months with the chief complaint of an intraabdominal mass, and have a 2:1 male predominance. The size and weight of the fetus vary, from 4 cm to 24.5 cm and from 1.2 g to 1.8 kg. Whether this entity represents a highly differentiated teratoma versus a parasitic twin remains controversial. The objective of this paper was to report a rare condition of giant fetus in fetu in female child with fever, especially to emphasize the importance of proper examination. Although fetus in fetu is very rare, it should remembered as a possibility in an intraabdominal. In some cases further detailed examinations should be done to confirm the diagnosis. A rare case of giant fetus in fetu in a 20th month female patient with fever was reported. Intrabdominal mass was found as the first sign related to fetus in fetu but was neglected by the parents. USG, plain abdominal photo and CT-scan had revealed the diagnosis preoperatively. Proper examination of the fetus in fetu was done including grossly by doing extensive dissection, and detailed histological tissue examination from several sites to make diagnosis completely. Key words: giant fetus in fetu - fetiform teratoma - congenital abnormality - retroperitoneal, fever
Validity of BI-RADS System Mammography to detect breast cancer at Dr Sardjito Hospital Yogyakarta Indrasto Histopaedianto Lina Choridah Teguh Aryandono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 40, No 01 (2008)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Background: Breast cancer is the second most common cancer among women worldwide and the sixth common cause of mortality in Indonesia. The diagnosis of breast cancer may be established by physical and imaging examinations, but definitive diagnosis should be verified by histopathologic examination. Mammography is an easy non-invasive imaging method to detect breast cancer with good accuracy. The lack of uniformity in mammography reporting has led to confusion as to the interpretation and management recommendation. The American College of Radiology Breast Imaging Reporting and Data System (BIRADS) has provided a standardized reporting system for mammography. The validity of this system at Dr Sardjito Hospital Yogyakarta has not been evaluated.Objective: To know the sensitivity, specificity, positive and negative predictive values, and accuracy of the BI-RADS System Mammography in diagnosing breast cancer.Methods: This study was a diagnostic test with cross sectional design on breast cancer diagnosis based on BI-RADS system mammography. All medical record files of patients with breast lump who underwent mammography and histopatologic examination, at Dr Sardjito Hospital Yogyakarta between December 2003-March 2008, were included in the analysis.Results: BI-RADS System Mammography at Dr Sardjito Hospital Yogyakarta had sensitivity of 87.5%, specificity of 93.7%, positive predictive value of 96.5%, negative predictive value 78.95%, positive likelihood ratio 14, negative likelihood ratio 0.13, prevalence 66.6%, and accuracy 89.6%.Conclusion: Mammography examination using BI-RADS System in Sardjito Hospital Yogyakarta was favourable in detecting breastcancer.Key words: breast cancer - BI-RADS mammography - histopathology - diagnostic value
Antiplasmodial Activity of Fractions Isolated from Methanolic Extrac of Meniran Herb (Phyllanthus niruri L) traditionally Used to Treat Malaria Mustofa Esti Nurwening Sholikhah Subagus Wahyuono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 39, No 01 (2007)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Latar belakang: Tanaman meniran (P.niruri L.) secara tradisional telah digunakan untuk mengobati malaria. Penelitian pendahuluan terhadap berbagai ekstrak tanaman meniran menunjukkan bahwa ekstrak metanol adalah aktif terhadap P.falciparum. Namun demikian, fraksi manakah dalam ekstrak metanol yang mempunyai aktivitas antiplasmodium belum pernah dikaji.Tujuan: untuk mengetahui aktivitas antiplasmodium fraksi aktif tanaman meniran.Bahan dan cara: Fraksinasi yang mengacu pada bioassay dilakukan dengan menggunakan pelarut yang sesuai untuk memisahkan fraksi aktif dari ekstrak metanol. Pada awalnya, ekstrak metanol dipisahkan dengan etil asetat sehingga diperoleh fraksi larut etil asetat dan tidak larut etil asetat. Fraksi tidak larut etil asetat selanjutnya dipisahkan dengan kolom kromatografi dengan fase diam Sephadex LH-20 dan fase gerak n-hexan : metanol : asam asetat (7,5 : 12,5 v/v : 10 tetes) sehingga diperoleh 4 fraksi untuk diuji aktivitasnya. Aktivitas antiplasmodium pada strain P. falciparum ditunjukkan dengan nilai IC50 yaitu kadar fraksi aktif yang mampu menghambat pertumbuhan parasit hingga 50%. Identifikasi kandungan senyawa dalam fraksi aktif dilakukan dengan metode kromatografi lapis tipis (KLT).Hasil:Hasil penelitian menunjukkan bahwa fraksi tidak larut etil asetat leih aktif (IC50, 2,2-2,4 mg/mL) dari pada fraksi larut etil asetat (IC50, 4,3-4,8mg/mL). Dan pemisahan fraksi tidak larut etil asetat diperoleh 9 fraksi yang dapat dikelompokkan menjadi 4 fraksi berdasarkan gambaran KLTnya. fraksi III (FIII) merupakan fraksi paling aktif dengan IC50, 3,4-4,1 mg/mL. Identifikasi kandungan aktif F III dengan KLT menunjukkan adanya senyawa polifenol. Penelitian lanjut akan dilakukan untuk mengisolasi dan memurnikan senyawa polifenol dan mengkaji aktivitas antiplasmodiumnya.Simpulan: Fraksi III dari ekstrak metanol meniran yang mengandung senyawa polifenol merupakan fraksi paling aktif secara in vitro terhadap P.falciparum.Key words: Phyllanthus niruri, malaria, antiplasmodial activity, in vitro, polyphenol
The Difference of High Sensitivity-C Reactive Protein in the Diabetic Patient with depression and Diabetic Patiens without Depression A. Siswanto, E. Mudjaddid Hamzah Shatri, Deddy N.W.Achadiono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 41, No 02 (2009)
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Background: Both depression and diabetes mellitus have been related to a higher risk of developing coronary heart disease. Inflammation may be important in the pathogenesis of atherothrombosis. There are many markers of inflammation, one of them is high sensitivity-C reactive protein. Objective: To determine the difference of high sensitivity-C reactive protein in the diabetic patients with depression and in the diabetic patients without depression. Methods: This study used cross-sectional design and examined 64 diabetic patients, aged 30-60 years old. The patients were divided into two groups, Le. with and without depression group.We measured depression using the DSM IV. The diagnosis of diabetes mellitus used PERKENI criteria 2006. We measured the serum concentration of CRP with a high sensitivity assay. Other measured factors included gender, marital status, occupation, blood glucose, HbA 1 c, body mass index, smoking and duration of diabetes. The association between hyperglycemia and hs-CRP were also studied. Results: There were 32 diabetic patients with depression and 32 diabetic patients without depression. Body mass index were corelated with depression in diabetic patients (p = 0.008) but the other factors such as gender, age, marital status, occupation, blood glucose, HbA 1 c, duration of diabetes were not corellated with depression in diabetic patients (p > 0.05). The mean of hs-CRP consentration was higher in diabetic patients with depression (5183.44:t3974.66 vs 2103,17:t1502.94 mg II, p=0.001) than in diabetic patients without depression. There was no association between blood glucose control (HbA 1 c) and hs-CRP concentration. Conclusion: High sensitivity-C reactive protein concentration was higher in diabetic patiens with depression compared with diabetic patients without depression.Key words: hs-CRP - with and without depression diabetes mellitus type II
Evaluation of substrate metabolism in critically ill pediatric patients Nurnaningsih Antonius H Pudjiadi
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 40, No 02 (2008)
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Background: Critically ill pediatric patients are characterized by a hypermetabolic state, a catabolic response, and a decreased capacity to utilize substrate. Metabolic state of critically ill pediatric patients can be detected by analyzing substrate utilization.Objective: To determine the metabolic state of critically ill pediatric patients using PRISM III Score, blood glucose level, and urinary nitrogen excretion.Methods: A cross sectional study was conducted in Pediatric Intensive Care Unit (PICU) of Cipto Mangunkusumo Hospital Jakarta between May and September 2006. All admitted PICU patients, except those with renal or hepatic failure, burns, diabetic ketoacidosis and died in the first 24 hours, were included. PRISM III Scores were measured in the first 24-hours of admission. Blood glucose level was observed at random within the first hour of hospitalization, while urinary nitrogen excretion was measured using urine collected in the second 24-hours of admission.Results: Fifteen cases were eligible for this study. Their age ranged between 1 to 96 months. The median (01 ;03) for PRISM III Scores, random blood glucose, and urinary nitrogen excretion were 6.0 (3.0;11.0), 123.0 (100.0;227.0), and 279.4 (124.3;408.4) mg/dL, respectively. There were no significant correlations between PRISM III Scores and random blood glucose (r=0.40;p=0.14), and between PRISM III Scores and urinary nitrogen excretion (r = -0.27;p = 0.33). There was significant correlation between random blood glucose and urinary nitrogen excretion (r=0.56;p=0.03).Conclusion: Critically ill pediatric patients had a catabolic state that had no association with PRISM III Scores. Random blood glucose level within the first hour of admission predicted the increasing protein catabolism.Key words: critically ill pediatric patients - blood glucose level - urinary nitrogen excretion - PRISM III Score.
Head, chest and abdominal circumferences for predicting gestational age in newborn infants Nengah Supatra Nengah Supatra
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 24, No 02 (1992)
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The purpose of this study is to examine head, chest dan abdominal circumferences as measurements for predicting gestational age of the newborn infant.During the period of August 1989 to December 1990, 1033 newborns with known gestational age were studied. Anthropometric measurements were done in the first two hours after birth, using measuring tapes by two examiners.High correlations were found between head, chest and abdominal circumferences with gestational age, and the linear aquations were Y= 0,075 X + 14,310 (Coefficient of Correlation/r = 0,72); Y= 0,066 X + 18,33 (r = 0,71) and Y= 0,056 X + 22,34 (r = 0,67) respectively. Further analysis by multiple regression revealed that gestational age (in weeks) as function of head, chest and abdominal circumferences (in millimeter) was Y= 0,036 X1 + 0,023 X2 + 0,020 X3 + 13,699.Measurements of head, chest and abdominal circumferences in the first two hours after birth can be used for estimating gestational age in the newborn infant.Key Words: head circumference - trunk circumference - abdominal circumference - gestational age - newborns

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