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Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Published by Universitas Gadjah Mada

ISSN : 01261312 EISSN : 23563931 DOI : http://dx.doi.org/10.19106/JMedSci005303202101

Core Subject : Science,

Immunology & microbiology Neuroscience

Journal of the Medical Sciences (JMedSci) or Berkala Ilmu Kedokteran (BIK) is an international, open-access, and double-blind peer-reviewed journal, published by Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada Yogyakarta Indonesia. JMedSci aiming to communicate high-quality articles in the areas of biomedical science from basic to clinical sciences.The journal welcomes papers from original articles, case reports, reviews, and book reviews. All papers published in JMedSci are freely available as downloadable pdf files. The journal began its publication on March 1973 and published quarterly (January, April, July, and October). JMedSci is abstracted and indexed in DOAJ, Crossref, Google Scholar, Sinta, Indonesia One Search. JMedSci is accredited by Directorate of General Higher Education, the Ministry of Research, Technology, and Higher Education, Indonesia

Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)

Articles 2,170 Documents

203 204 205 206 207

Infant appendicitis with perforation: a case report Fuad Adi Prasetyo; Ekvan Danang Setya; Supangat Supangat
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 53, No 3 (2021)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Appendicitis is one of the most common surgical emergencies in children. In the USA, there are 70,000 cases are diagnosed each year. Acute appendicitis is a rare case, barely considered in the diagnoses, and probably causes acute abdominal sepsis in neonates. It affects males generally 75% of the time and 25%-50% of all reported cases occur in premature infant. Almost 50 cases have been reported over the last 30 years. We reported a 5 month-old baby girl whom transferred to our hospital from a peripheral hospital. Previously, the baby diagnosis was low-type obstruction. At the time of admission to our hospital, the baby presented with a history of abdominal distension and did not pass stools after 48 h. Oxygen and oral gastric tube were administered. Exploratory laparotomy surgery was performed through a transverse incision. This report is a retrospective review of one patient with appendicitis perforation presented in our hospital.

Comparison of high-intensity and low-level laser therapy effecton combined sensory index, sensory conduction velocity and distal motoric latency: a study in moderate carpal tunnel syndrome patients Nelson Sudiyono; Rudy Handoyo
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 52, No 4 (2020)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Carpal tunnel syndrome (CTS) is the most common neuropathy compression syndrome. The effectiveness of low-level laser therapy (LLLT) as one of the conservative therapy for CTS is still debatable. High-intensity laser therapy (HILT) is developed with higher energy and deeper tissue penetration than LLLT. This study aimed to compare the effect of HILT and LLLT on sensory and motoric electrophysiologic parameters in moderate CTS patients. This was an experimental randomized pre and post-test group study. Sixteen patients (fifteen females and one male) with moderate CTS were randomly assigned into two groups. The HILT group was given HILT with analgesic dosage 10 J/cm2 and biostimulation dosage 120 J/cm2. The LLLT group was given LLLT with dosage 6 J/cm2. All treatments were given for ten sessions in 2 weeks. Combined sensory index (CSI), sensory nerve conduction velocity (SNCV), and distal motoric latency (DML) were recorded before and three days after the last treatment. The mean decrease of CSI was more significant in HILT group (-0.37±0.37 ms; p=0.03). There were no significant differences in the mean increase of SNCV (HILT = 3.16±3.15 m/s, LLLT= 2.74±1.42 m/s; p=0.73) and mean decrease in DML between two groups (HILT = - 0.20 ± 0.18 ms , LLLT = - 0.14 ± 0.21 ms; p=0.52). In conclusion, the HILT is more effective than LLLT in improving the CSI values in moderate CTS patients.

Risk factor of metabolic syndrome in Javanese population based on determinants of anthropometry and metabolic measurement Rosdiana Mus; Ahmad Hamim Sadewa; Pramudji Hastuti; Anggelia Puspasari; Citra Maharani; Ika Setyawati
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 53, No 2 (2021)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

The prevalence of metabolic syndrome (MetS) is high worldwide which it can increase the risk of some diseases such as cardiovascular disease, type 2 diabetes mellitus even mortality. The prevalence pattern and determinants of MetS risk factors might differ among ethnics in Indonesia. This study aimed to determine the anthropometry and metabolic measurements determinants to predict the MetS prevalence of the Javanese population in Yogyakarta. It was a case control study conducted from December 2018 to March 2019 involving 214 Javanese subjects aged 20-74 years resided in Yogyakarta Special Region, Indonesia. NCEP ATP III criteria were used to identify MetS as case and not diagnosed with MetS as control. The results showed that BMI, WC, BP, total cholesterol and HDL-C were significantly different between MetS and non MetS patients (p<0.005). In MetS subjects, prevalence of obesity was 75.3%, visceral fat was 75.3%, WC 92.95%, WHtR 97.64% and total cholesterol/HDL-C ratio 553%, which independently increased the risk of MetS 7.30, 5.32, 13.37, 20.75, and 7.16 times, respectively. Result of logistic regression analysis showed central obesity based on WC increased the risk of Met-S by 17.62 time and the ratio of total cholesterol/HDL-C>5 by 9.54 time. In conclusion, WHtR is a better marker for MetS prediction independently. However, the WHtR in combination with WC and total cholesterol/HDL-C ratio are better for MetS prediction in the Javanese population.

Adjustment of sperm cryopreservation laboratory management during the COVID-19 pandemic Dicky Moch Rizal
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 53, No 1 (2021)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

The COVID-19 pandemic has changed the order of life in all fields, particularlyin medical services. Laboratory services in sperm cryopreservation that partof andrology or in vitro fertilization (IVF) laboratory cannot be separated withhandling sperm from patients. Although the presence of viruses in semenhas been known through various studies, there is scarce evidence regardingwhether sperm fluid can be a medium of COVID-19 transmission. This raisedthe question of whether some adjustments to manage patient sperm shouldbe made. This review described an overview of the various efforts that can bemade to reduce the risk of disease transmission to health workers who handlepatient sperm fluid.

Exercise as part of anxiety coping management in the Covid-19 pandemic era Denny Agustiningsih; Rakhmat Ari Wibowo
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 53, No 3 (2021)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Containment effort in the COVID-19 pandemic could disrupt circadian rhythms which play an essential role in the development of mood and anxiety disorders. Exercise is one of several recommendations for anxiety coping during the COVID-19 pandemic. However, not every person has a similar response to an exercise stimulus and gets the same optimal benefits. For the best exercise results, we must consider individual needs and capacities, including circadian rhythm, in determining the exercise dose. This review briefly summarizes the exercise’ mechanism as an anxiolytic through skeletal muscle-brain crosstalk and designing exercise program with the individual optimal dose as part of anxiety coping management in the COVID-19 pandemic situation, considering exercise as good stress and circadian rhythm.

Prevalence and risk factors of intestinal protozoan infection among child students with disabilities in Bantul District, Yogyakarta Special Region, Indonesia Fahriana Azmi; Elsa Herdiana Murhandarwati; Mahardika Agus Wijayanti
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 53, No 2 (2021)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Children with disabilities are excluded from many aspects of life. Unfortunately, they have an increased risk of infection from many kinds of pathogens including intestinal protozoan. This study aimed to determine the prevalence of intestinal protozoan infections and to evaluate the associated factors among children with disabilities in Bantul District, Yogyakarta Special Region, Indonesia. A cross-sectional study was conducted at school with special needs between June-December, 2019. A total of 150 participants were recruited through simple random sampling. Stool samples were examined microscopically by formalin-ether concentration and Ziehl-Neelsen staining technique. Age was analyzed using the Mann-Whitney tests, while the other variables used chi-square tests. Multivariable logistic regression was conducted to identify factors associated with intestinal protozoan infections. The adjusted prevalence ratio with a 95% confidence interval at a 5% level of significance was used to measure the strength of association. Overall, there were 15 children infected by intestinal protozoan among 130 subjects with mean age of participants of 9.83 ± 3.1 years. The intestinal protozoan species were Entamoeba histolytica 7 (5.38%), Giardia lamblia 4 (3.08%), Blastocystis hominis 7 (5.38%) and Iodamoeba butschlii 1 (0.77%). Prevalence of intestinal protozoan infection among children with disabilities in Bantul District, Yogyakarta, Special Region was 11.54%. There were no significant correlations between the risk factors and intestinal protozoan infection among children with disabilities (p>0.05).

The correlation of HbA1c levels on the healing process of postoperative fractures in diabetes mellitus patients Elanda Putri Madyaningtias; Arman Bausat; Jufri Latief; Nasser Mustari; Joko Hendarto; Prihantono Prihantono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 52, No 4 (2020)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Fracture is defined by the loss of bone or cartilage continuity, either total or partial. Diabetes mellitus (DM) is a group of metabolic diseases characterized by hyperglycaemia resulting from defects in insulin secretion, insulin action, or both. HbA1c could be used as a diagnostic tool and determines the glycaemic control of DM patients. This study aimed to investigate the correlation between serum HbA1c levels and the healing process of postoperative fractures in DM patients. This was an observational study with a retrospective cohort design. The study population was DM patients who were admitted to the Department of Emergency, Dr. Wahidin Sudirohusodo General Hospital, Makassar due to long bone fracture within the period of September 2019-February 2020. The bone fractures healing was evaluated based on the radiographic union scale in tibial fractures (RUST) scores. The results are analysed using the Chi-square test. A total of 70DM patients who underwent fracture reduction surgery were involved in this study. Out of 35 patients with controlled DM (HbA1c <7%), we obtained 24 (68.6%) patients and 11 (31.4%) patients with good and delayed union, respectively. The other 35 patients had uncontrolled DM (HbA1c >7%), and there were 13 (37.1%) patients and 22 (62.9%) patients with good and delayed union, respectively. The Chi-square test showed a significant relationship (p= 0.008). It can be concluded that the increase in HbA1c levels was related to the obstacles in bone fractures healing. Moreover, an infection contributes to the healing status of bone fractures.

Hirschsprung’s disease: epidemiology, diagnosis, and treatment in a retrospective hospital-based study Andi Sinapati Palissei; Ahmadwirawan Ahmadwirawan; Muhammad Faruk
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 53, No 2 (2021)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Hirschsprung’s disease (HD), or congenital megacolon, is a disease characterizedby the absence of ganglion cells in the myenteric (Auerbach’s) and submucosal(Meissner’s) plexuses of the intestine, causing maximum obstruction inneonates. The purpose of this study was to investigate patient characteristics,clinical presentation, investigations, surgical treatment, and outcome. Thisstudy is a retrospective study of HD cases. Data obtained from medical recordsat the institution. Of the 109 with a positive rectal biopsy diagnosis, 91 werepatients with this disease. There were more cases in boys than girls with aratio of 1.37: 1. The patients were grouped into 4 age groups: neonates 29 cases(26.61%); infants/toddlers/young children 55 cases (50.46%); children over 5years16 cases (14.69%); and teenagers 9 cases (8.24%). The neonates generallypresented with abdominal distension, green vomiting, and a history of delayedmeconium release, while the toddler, child, and adolescent groups experiencedconstipation and abdominal distension. Furthermore, from 37 patients (33.94%)that got barium enema examination, the most common transition zone wasobserved in the rectosigmoid (17 patients, or 45.9%). In addition, The Duhamelprocedure was the most frequent pull-through procedure found in our cohortwhich was performed in 40 patients (36.70%). In conclusion, HD is mostly foundin male infants/toddlers/young children with abdominal distention and chronicconstipation as common symptoms. The barium enema shows the rectosigmoidas the most common transition zone, while the Duhamel pull-through procedureis the primary definitive operative action performed.

Induced pluripotent stem cells and genome editing technology as therapeutic strategies for Duchenne muscular dystrophy Irwan Saputra Batubara
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 53, No 1 (2021)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Duchenne muscular dystrophy (DMD) is a rare genetic, progressiveand devastating skeletal and cardiac muscle disorder due to mutationof the dystrophin gene that affects 1 in 3500 young males. Currently,there is no curative management for this pathology. The development ofinducedpluripotent stem cells (iPSCs) offers a promising cell-based strategyfor the treatment of muscular dystrophy. Several techniques have beenestablished to generate functional myogenic progenitor cells derived fromiPSCs. In addition, technologies in genetic modification using ZFN, TALENs, orCRISPR/Cas9 demonstrate potent methods to restore dystrophin expression.However, current evidence shows that either iPSCs or gene editing carrya risk of oncogenesis caused by the integration of exogenous DNA into therecipient gene. Thus, the safety issue is a major challenge for translatingthis method into human clinical applications. This review briefly discussedrecent developments and progressions of iPSCs as well as genome engineeringtechnologies relevant to regenerative medicine, especially for the treatmentof DMD.

The impact of glucose control index on erectile hardness score among type 2 diabetes mellitus patients Sakti Brodjonegoro; Andy Zulfiqqar; Franky Renato Anthonius; Amanda Cyko; Pandu Ishaq Nandana
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 53, No 1 (2021)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

The prevalence of erectile dysfunction (ED) was reported to vary from 37.5 to52% in men above 40. Type 2 diabetes mellitus (T2DM) maycause the nervesand blood vessels damages that worsened the ED. This study aimed to evaluatethe correlation between the glucose control index and the erection hardnessscore (EHS) among T2DM patients. The cross-sectional observational studywas conducted in two district hospitals i.e. Manambai Abdulkadir DistrictHospital, Sumbawa, and Dompu District Hospital, Dompu, West Nusa Tenggara,Indonesia. Forty-five patients with T2DM were involved in this study. Data werecollected using structural questioners during the period from June 1st to August1st, 2017 and were analyzed using SPSS 24.0. Pearson correlation and logisticregression analysis were used to determine the odds ratio (OR). Among 45patients having age 57.38± 7.22 years involved in this study, 38 (84.4%) patientshad ED, 26 (57.8%) uncontrolled DM, 5 (11.1%) congestive heart failure (CHF),4 (8.9%) chronic kidney diseases (CKD), and 7 (15.6%) neuropathy diabetic.A strong correlation between random glucose level and IIEF-5 score (r=0.91;p=0.01) was observed. The overall odds ratio of ED in this study was 4.3 (95%CI: 0.73 to 25.1) for uncontrolled DM, 2.5 (95% CI: 0.1 to 51.1) for CHF, 2 (95%CI: 0.01 to 41.6) for CKD, and 1.2 (95% CI: 0.1 to 11.5) for neuropathy diabetics.In conclusion, there is a strong correlation between random glucose level,duration of diagnosed DM and EHS. Active screening is recommended for thispopulation.

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Home Page

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Contact Name
Nurhadiyahya

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nurhadiyahya@ugm.ac.id

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+6289672800034

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https://jurnal.ugm.ac.id/bik/about/editorialTeam

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Kab. sleman,

Daerah istimewa yogyakarta

INDONESIA