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Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)

JFST
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Published by Universitas Katolik Widya Mandala Surabaya

ISSN : 23388404 EISSN : 26572311 DOI : -

Core Subject : Health,

Medicine & Pharmacology

Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) is published twice a year, containing research articles, review, and short communication in pharmacy science field, including medicinal chemistry, analytical chemistry, biologjcal pharmacy, pharmaceutical sciences and clinical pharmacy research and practice of pharmacy in industry, clinic, and community practice, such as pharmacies, distributors, and pharmacy education.

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Articles 8 Documents

Search results for , issue "Vol 4, No 1 (2017)" : 8 Documents clear

Studi Penggunaan Omeprazole pada Pasien Sirosis Hati dengan Hemetamesis Melena Rawat Inap di RSUD Kabupaten Sidoarjo Wiranata, I Made; Hasmono, Didik; Surdijati, Siti
Jurnal Farmasi Sains dan Terapan Vol 4, No 1 (2017)
Publisher : Jurnal Farmasi Sains dan Terapan

Liver cirrhosis is a process of liver cell damage which later becomes fibrosis tissue. Then, the occurrence of liver structural distortion and increased vascularization to the liver resulting in varicose veins or dilation of blood vessels in the gastrointestinal and esophageal areas. Patients with esophageal varices, there is a risk of bleeding from esophageal rupture, the undergone hematemesis (vomiting of blood) and melena (blackish defecate). The therapies used to reduce gastrointestinal bleeding are gastric ulcers drugs such as H2Ras and PPI. The study aimed to determine the pattern of omeprazole use in liver cirrhosis patients with hematemesis melena. The method used was an observational retrospective study in medic record data patients. Sampling was done by consecutive sampling, the period of Juli 1, 2015 until Descember 31, 2015. The results obtained from the study were single use of omeprazole with a dose of 2x40mg/i.v used the most by 22 patients (73.3%). The use of omeprazole with a dose of 2x40mg/i.v combined with other gastric ulcer drugs was 7 patients (23.3%), omeprazole with ranitidin 6 patients, omeprazole with antacid for 1 patient. The use of omeprazole with a dose of 2x40mg was replaced with ranitidin 2x25mg/ml was 1 patient (3.3%). The use of omeprazole given in liver cirrhosis patients with hematemesis melena at the Inpatient Installation of Regional Hospital of Sidoarjo, related dose, route, frequency, interval, and duration of giving was in appropriate with the guidelines contained in the National Formulary.

Penggunaan Carbormer 940 sebagai Gelling Agent dalam Formula Pasta Gigi Ekstrak Buah Apel (Malus sylvestris Mill) dalam Bentuk Gel Wijayanti, Luh Putu Widiasih; Darsono, Farida Lanawati; Ervina, Martha
Jurnal Farmasi Sains dan Terapan Vol 4, No 1 (2017)
Publisher : Jurnal Farmasi Sains dan Terapan

Teeth are often not protected from several diseases, despite having a hard structure. Dental diseases include dental caries (cavities) and diseases of the tooth supporting tissues. Dental caries is defined as a disease that results in damage to the hard tissue of the tooth structure through the process of demineralization. Streptococcus mutans is known as a major microorganism that plays a role in the process of dental caries. One way to reduce the formation of dental caries is to use toothpaste. Apples (Malus sylvestris Mill) Manalagi variety that has catechins, has efficacy as an anti dental caries. The purpose of this study was to formulate ethanol extract from apples as a gel toothpaste using carbomer 940 as a gelling agent. Apple ethanol extract used in this study was 9.6%, while the carbomer concentration of 940 used was 0.75% (formula I), 1.0% (formula II) and 1.5% (formula III). Evaluation of toothpaste formulas includes physical quality including organoleptic, homogeneity, pH, viscosity, dispersibility. Characteristic evaluation includes ease of release from the tube, adhesion and consistency. The stability evaluation includes room temperature stability, high temperature, and cycling tests. Evaluation of aseptability and evaluation of irritation is done in cow's jaws. Increasing the concentration of Carbomer 940 as a gelling agent has a significant effect on viscosity, dispersion, ease of release from the tube, adhesion and consistency. The test results show formula 3 (1.5% carbomer 940) is the best formula because it has produced physical quality in accordance with specifications, the resulting preparation is stable and very preferred and safe to use.

Standarisasi Spesifik dan Non Spesifik dari Ekstrak Etanol Daun Beluntas (Pluchea indica L. Less.) Wijaya, Sumi; Setiawan, Henry Kurnia; Ano, Lucyanna Ayu Lestari
Jurnal Farmasi Sains dan Terapan Vol 4, No 1 (2017)
Publisher : Jurnal Farmasi Sains dan Terapan

Indian fleabane (Pluchea indica (L.) Less.), on of the species in Asteraceae family, is widely used for traditional medicine. A standardization process is needed as an effort to improve the quality and safety of products, so that it is expected to increase the trust in drugs derived from natural ingredients. This study aims to determine the morphology and anatomy of Indian fleabane leaves and to determine the standardization value of the ethanol extract of Indian fleabane leaves. Dried powder of Indian fleabane leaves are obtained from three different regions (Bogor, Malang and Surabaya). The extract was obtained by maceration method using 96% ethanol as a solvent. Specific standardization includes identity, macroscopic, determination of soluble extract, phytochemical screening, TLC (Thin Layer Chromatography) pattern determination, determination of infrared spectrum profile, determination of UV-Vis spectrum profile, and determination of flavonoid, phenol and alkaloid total content. Nonspecific standardization includes determination of total ash content, water soluble ash content, acid insoluble ash content, drying losses, specific gravity and pH. Organoleptic observations showed the ethanol extract of Indian fleabane leaves has blackish brown and aromatic odour. The mobile phase being used for TLC profile chromatogram was n-hexane: ethyl acetate (7: 3). Based on the results, the screening results of Indian fleabane contain alkaloids, flavonoids, polyphenols, tannins, saponins, steroids and triterpenoids. The Infra red spectrophotometer analysis showed the range of wave numbers of 2924 - 2925, 1515 - 1516, 1259 - 1260, 1159 - 1162, 1112 - 1115, 1046 - 1048, 811 - 812, 505 - 506 and 452 - 454 cm- 1. The standardization value of Indian fleabane ethanol extract showed ethanol soluble extract> 65%, water soluble extract> 49%, water content

Uji Aktivitas Inhibitor Xanthin Oksidase dari Fraksi Ekstrak Etanol Herba Peperomia pellucida Prihastuti, Angelina Ajeng; Wijaya, Sumi; Hartanti, Lanny
Jurnal Farmasi Sains dan Terapan Vol 4, No 1 (2017)
Publisher : Jurnal Farmasi Sains dan Terapan

Peperomia pellucida (L.) Kunth known as Suruhan is a potential medicinal plants, used traditionally to treat gout. Suruhan herb (Peperomia pellucida (L.) Kunth) had been studied in vivo, and found to be able to lowering uric acid levels in the blood. Ethanol extract of Peperomia pellucida (L.) Kunth herb also had been studied in vitro, and found to be potential to inhibit xanthine oxidase. The purpose of this study is to know the potential of fraction from ethanol extract of Peperomia pellucida (L.) Kunth. herb as xanthine oxidase inhibitor compared to allopurinol and its ethanolic extract. Ethanol extract of Peperomia pellucida (L.) Kunth herb was obtained by percolation method using ethanol 96%. The fractionation is done by column chromatography method using silica as stationary phase and n-hexane, n-hexane-ethyl acetate, ethyl acetate, ethyl acetate-ethanol, and ethanol as mobile phases. The fraction which contained flavonoid compounds was tested its xanthine oxidase inhibition potency using UV spectrophotometer at Î» 290 nm. The absorbance was observed every 10 seconds for 10 minutes for extract and fraction with the concentration of 0.25 ppm - 5 ppm, while allopurinol was determined with the concentration of 0.2 ppm - 3.2 ppm. The result showed that ethyl acetate-ethanol fraction potentially inhibited xanthine oxidase with IC50 value of 5.00 Â± 0.06 ppm, while ethanolic extract of Peperomia pellucida (L.) Kunth herb and allopurinol have IC50 value 0.33Â± 0.07 ppm and 0.84 Â± 0.02 ppm respectively. Thus it can be concluded that ethyl acetateethanol fraction had potential as xanthine oxidase inhibitor, but the potential is lower than the ethanolic extract of Peperomia pellucida (L.) Kunth herb.

Studi Penggunaan Antiemetik pada Pasien Demam Tifoid Rawat Inap di RSUD Kabupaten Sidoarjo Wardhani, Hety Setya; Surdijati, Siti; Hasmono, Didik
Jurnal Farmasi Sains dan Terapan Vol 4, No 1 (2017)
Publisher : Jurnal Farmasi Sains dan Terapan

Typhoid fever is an infection of the small intestine caused by Salmonella thypi bacteria with symptoms of fever at night. This disease is a contagious disease that can affect many people and is still a health problem, especially in developing countries. This study aims to analyze patterns of antiemetic use in typhoid fever patients. This research was conducted at Sidoarjo District General Hospital using a retrospective method in the period of January 1 to December 31, 2015. The sample was typhoid fever patients who were treated at the Sidoarjo District Hospital. The results obtained using the Health Medical Record (RMK) of patients who have been validated, 161 patients was detected and only 30 patients who is using antiemetic therapy. The antiemetic used is ondansetron. Ondansetron in single dose (3x4mg) iv used in 7 patients (23%) and (3x8mg) iv in 23 patients (77%). The duration of ondansetron use in typhoid fever patients in Sidoarjo District Hospital â‰¤ 2 days was 10 patients and â‰¥ 2 days was 20 patients. Antiemetics used were in accordance with the guidelines and no Drug Related Problems (DRPs) were obtained in typhoid fever patients as seen from their interactions with other drugs, the interval of administration, frequency of administration, duration of treatment, and dose of administration.

Formulasi Sediaan Pemerah Pipi Ekstrak Air Buah Syzygium cumini dalam Bentuk Compact Powder Letelay, Yulia Riani; Darsono, Farida Lanawati; Wijaya, Sumi
Jurnal Farmasi Sains dan Terapan Vol 4, No 1 (2017)
Publisher : Jurnal Farmasi Sains dan Terapan

One of the fruits in Indonesia that can be used in the field of decorative cosmetics is Syzygium cumini. Blackish purple appearance of the fruit indicates the high content of anthocyanin, a natural pigment dye in decorative cosmetic formulations, especially for blusher. Compact powder blusher has the advantage of easy to use and has a better adhesion to the skin. Isopropyl myristate is a binder that is commonly used for compact powder blusher because of its properties which can increase adhesivity. The purpose of this study was to determine the effect of the concentration of isopropyl myristate as a binder on physical quality and effectiveness and to determine the best formula that fulfil the requirement of the physical quality, effectiveness, safety and acceptability. The compact powder blusher containing water extract of Syzygum cumini was formulated using wet granulation method with varying concentrations of isopropyl myristate 0.5%, 0.75% and 1.0%. The Evaluation of the product includes organoleptic, homogeneity, particle size, pH, friability and hardness, rubbing test, irritation test and acceptability test. The results showed an increase in the concentration of isopropyl myristate had a significant effect on decreasing the pH value, decreasing particle size, and affecting the ability of the blusher to be smeared. The compact powder blusher with 0.75% isopropyl myristate was the best formula that meets the specifications based on physical quality, effectiveness, and safety parameters.

Potensi Antibakteri dan Antibiofilm Ekstrak Etanol Bunga Bintaro (Cerbera odollam) terhadap Staphylococcus aureus ATCC 6538 Lestari, Dwi Rahma Suci; Soegianto, Lisa; Hermanu, Liliek S.
Jurnal Farmasi Sains dan Terapan Vol 4, No 1 (2017)
Publisher : Jurnal Farmasi Sains dan Terapan

Cerbera odollam was one of the plants that can inhibit the growth of bacteria that cause infectious diseases. The misuse of antibiotic in the treatment of infection frequent caused bacterial resistance. One of the forms of antibiotic resistance was the capability of microorganism forming biofilm. This study was conducted to determine the antibacterial and anti-biofilm activity of ethanolic extract from Cerbera odollam flower against Staphylococcus aureus. The ethanolic extract obtained by maceration method using 96% ethanol as a solvent. The ethanol extract of Suicide tree (10, 20 and 30%) were tested for antibacterial activity against Staphylococcus aureus using well diffusion method and anti-biofilm activity using microdilution method. Based on the results, ethanol extract of flowers Cerbera odollam inhibit the growth of Staphylococcus aureus with inhibition zone of 21.66Â±0.73 mm (10%), 25.66Â±1.50 mm (20%) and 27.10Â±1.06 mm (30%). The ethanol extract of Suicide tree flower inhibit biofilm formation 98.29% at the concentration of 3.75%. The bio autography results showed that alkaloid and tannin responsible as bioactive compounds from the ethanol extract Suicide tree flower.

Perbandingan Sintesis antara Senyawa 4â€™-Nitrokhalkon dan 2,4- Dimetoksi-4â€™-Nitrokhalkon dengan Bantuan Iradiasi Gelombang Mikro Shien, Ong Cong; Soewandi, Ami; Caroline, Catherin
Jurnal Farmasi Sains dan Terapan Vol 4, No 1 (2017)
Publisher : Jurnal Farmasi Sains dan Terapan

Chalcone (1,3-diphenylprop-2-en-1-one) is a precursor compound of flavonoids that have two aromatic rings connected by three Î±, Î²-unsaturated carbons. Chalcone can be synthesized by the base-catalysed crossed aldol condensation (Claisen-Schmidt) using the reaction between aromatic aldehyde with aryl ketone. In this research, synthesize of 4-nitrochalcone and 2,4-dimethoxy-4â€™-nitrochalcone compounds with microwave irradiation assistance had been done. 4-nitrochalcone was synthesized from acetophenone and 4â€™-nitrobenzaldehyde, while 2,4-dimethoxy-4â€™-nitrochalcone was synthesized from 2,4-dimethoxyacetophenone and 4â€™-nitrobenzaldehyde. The purity of the synthesis compounds were shown from the data of melting point and thin layer chromatography. Identification of structure was shown from infrared spectral data and proton nuclear magnetic resonance. From the obtained results, 4-nitrochalcone and 2,4-dimethoxy-4â€™-nitrochalcone compounds can be synthesized by microwave irradiation assistance. The yield of 4â€™-nitrochalcone was 58.19%, while 2,4-dimethoxy-4â€™-nitrochalcone was 19.07%. The effect of methoxy groups (-OCH3) on acetophenoe ease the reaction of the formation of chalcone compounds in terms of yield of the synthesis product.

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