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All Journal Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) INDONESIAN JOURNAL OF PHARMACY UNEJ e-Proceeding Jurnal Medik Veteriner Jurnal Ilmu Kefarmasian Indonesia Jurnal Jamu Indonesia Berkala Penelitian Hayati Jurnal Tumbuhan Obat Indonesia Indonesian Journal of Jamu Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)

Sumi WIjaya, Sumi

Fakultas Farmasi Unika Widya Mandala Surabaya

Author-ID : 3515505

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Veterinary Other

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Formulasi Sediaan Pemerah Pipi dari Ekstrak Kelopak Bunga Rosella (Hibiscus sabdariffa Linn.) Sebagai Pewarna dalam Bentuk Compact Powder Bindharawati, Nina; Darsono, Farida Lanawati; Wijaya, Sumi
Jurnal Farmasi Sains dan Terapan Vol 2, No 2 (2015)
Publisher : Jurnal Farmasi Sains dan Terapan

Latar belakang :Dewasa ini, penyalahgunaan pewarna tekstil didalam sediaan pemerah pipi sangat mengkuatirkan. Hal tersebut mengakibatkan dibutuhkannya suatu produk pemerah pipi yang aman dan mempunyai manfaat yang sesuai dengan penggunaannya. Metode :Ekstrak kelopak bunga rosella dijadikan sebagai pewarna dengan konsentrasi 30 % dan digunakan isopropil miristat sebagai pengikat dengan berbagai konsentrasi. Formula I 0,5%, formula II 0,75% dan formula III 1%. Ekstrak kelopak bunga rosella diperoleh dengan cara maserasi etanol 96% dengan penambahan 3% asam asetat glasial, lalu diuapkan di penangas air dengan suhu dibawah 70Âº C. Sediaan pemerah pipi compact powder dibuat dengan cara kempa kering. Hasil dan diskusi :Rendemen ekstrak yang diperoleh sebesar 25,17%. Pada hasil pengamatan ditunjukkan bahwa sediaan dengan konsentrasi isopropil miristat 0,5% lebih rapuh atau mudah pecah. Pada uji pH, sediaan yang memenuhi persyaratan adalah formula I dan formula II. Pada uji oles, sediaan dengan konsentrasi 1% tidak dapat ditempelkan pada kuas dan tidak dapat dilekatkan pada kulit. Kesimpulan :Ekstrak kelopak bunga rosella dapat dijadikan salah satu pewarna alternatif yang baik dengan konsentrasi isopropil miristat yang terbaik adalah 0,75%. Kata kunci :compact powder, isopropil miristat, pemerah pipi, rosella.

Perbandingan Antibakteri dari Ekstrak Etanol dan Fraksi Ekstrak Etanol Tanaman Ceguk (Quisqualis indica L.) Terhadap Staphylococcus aureus dan Escherichia coli Valeri, Sepvan; Soegianto, Lisa; Wijaya, Sumi
Jurnal Farmasi Sains dan Terapan Vol 2, No 2 (2015)
Publisher : Jurnal Farmasi Sains dan Terapan

Tanaman Ceguk merupakan tanaman yang berasal dari Myanmar dan Malaysia. Tanaman ini memiliki beberapa efek farmakologi antara lain immunomodulator, antihiperlipidemia, antipiretik, antioksidan dan antibakteri. Aktivitas antibakteri sebelumnya telah diteliti pada bagian bunga. Pada penelitian ini ekstrak etanol dan fraksi (n-heksana, etil asetat dan air) dari daun tanaman ceguk diuji aktivitas antibakterinya terhadap Staphylococcus aureus dan Escherichia coli. Fraksi aktif terpilih ditentukan dengan bioautografi kontak. Pengujian aktivitas antibakteri meliputi KHM (Kadar Hambat Minimum) dan KBM (Kadar Bunuh Minimum) dilakukan dengan metode mikrodilusi dan trifenil tetrazolium klorida 1% sebagai indikator visual. Golongan senyawa fraksi aktif ditentukan dengan uji kualitatif KLT dengan menggunakan penampak noda. Ekstrak dan fraksi n-heksana tanaman ini menghambat pertumbuhan pada bakteri Gram positif yaitu Staphylococcus aureus dengan nilai KHM 500 ppm pada fraksi n-heksana dan 1000 ppm untuk ekstrak. Ekstrak dan fraksi n-heksana tanaman ini tidak mampu membunuh Staphylococcus aureus dan Escherichia coli. Berdasarkan uji KLT, golongan senyawa fraksi aktif pada fraksi n-heksana yang diduga memiliki potensi sebagai antibakteri adalah golongan triterpenoid dengan harga Rf 0,63. Kata kunci : antibakteri, ceguk, fraksi, kadar hambat minimum, kadar bunuh minimum.

Formulasi Sediaan Krim Pelembab Ekstrak Air Buah Semangka (Citrullus lanatus) Ekayanti, Ni Luh Putu Serly; Darsono, Farida Lanawati; Wijaya, Sumi
Jurnal Farmasi Sains dan Terapan Vol 6, No 1 (2019)
Publisher : Jurnal Farmasi Sains dan Terapan

Watermelon is a tropical fruit which rich of carbohydrates such as sucrose, glucose and fructose that can moisturized the skin. Carotenoids such as lycopene in watermelons can acts as an antioxidant which protected skin from free radicals. Moisturizer are preparations used to improve dry skin. These preparations may decrease the Trans Epidermal Water Loss (TEWL) by forming a thin layer of fat on the surface of the skin as a barrier and restore skin softness. Watermelon extracts in this study are formulated into moisturizing cream. This study aims to determine the effect of the increasing concentration of the watermelon extract against its physical quality, effectiveness, safety, acceptability and cream stability. The watermelon extract obtained using is fresh fruit juice thickened with waterbath thermostat temperature â‰¤ 800C. Watermelon extract concentration used was 10% (Formula 1), 20% (Formula 2) and 30% (Formula 30. Evaluation of the cream includes the physical quality test; effectiveness test which; safety test; acceptability test and stability test. The results of this study showed the increasing concentrations of watermelon extract affect the results of the evaluation of moisturizing cream were organoleptic, pH, viscosity, dispersive power, adhesion, water washing power, effectiveness, and aseptability. Preparations which have the best quality are formula 3 containing extract 30%.

Standarisasi Simplisia Kering Daun Kelor (Moringa oleifera) Dari Tiga Daerah Berbeda Bata, Maria H C; Wijaya, Sumi; Setiawan, Henry K
Jurnal Farmasi Sains dan Terapan Vol 5, No 1 (2018)
Publisher : Jurnal Farmasi Sains dan Terapan

Miracle tree (Moringa oleifera) is known for its many benefits, and has been used in traditional medicine. This study aims to determine macroscopic and microscopic characteristics of Miracle tree leaves and to determine specific and non specific parameter os standardization of Miracle tree dried powder. Miracle tree dried powder was obtained from three different locations (Batu, Bogor and Pacet). Determination of specific parameter of Miracle tree dried powder include macroscopic, microscopic, determination of soluble extract, chromatogram pattern determination by TLC, determination of infrared spectrum profile (IR), determination of UV spectrum profile and determination of quantitative secondary metabolite compounds. Non specific parameters including determination of total ash content, ash content water soluble, acid soluble ash content, drying shrinkage and pH. Determinations of quantitative secondary metabolite compounds were done using colorimetric method. Based on the results, Miracle tree dried powder contain alkaloid, flavonoids, polyphenols, saponins, tannins, steroids and triterpenoids. Ethyl acetate: n-hexan (7: 3 v / v) can be used as eluent on thin layer chromatography. Miracle tree dried powder gave wave number of 3277 â€“ 3281, 2917 â€“ 2918, 2849 â€“ 2850, 1603 â€“ 1607, 1408, 1235 â€“ 1236, 1048 â€“ 1051, 889, 534 â€“ 536 and 452 - 455. Miracle tree dried powder gave standardization value of dried shrink rate 5.5% w/ w and total alkaloid content> 1.0% w/w.

Optimasi Sediaan Pelembab Ekstrak Kering Kulit Buah Manggis (Garcinia mangostana L.) dengan Kombinasi Asam Stearat dan Trietanolamin sebagai Emulgator Chomariyah, Nur; Darsono, Farida Lanawati; Wijaya, Sumi
Jurnal Farmasi Sains dan Terapan Vol 6, No 1 (2019)
Publisher : Jurnal Farmasi Sains dan Terapan

Mangosteen is a plant which has a high antioxidant activity. The mangosteen pericarp contains antioxidant compound alpha mangosteen. Beside as an antioxidant, alpha-mangosteen has the potential as skin moisturizer, which gives protection for dry skin condition. The purpose of this research was to know the influence a combination stearic acid and trietanolamin on the physical characteristics and effectiveness. As the results of this researchs optimum formula was obtained using factorial design expert. The formula divided into 4 groups, formula A 10% of stearic acid and 0.1% trietanolamine, formula B was 16% of staric acid and 0.1% trietanolamine, formula C 10% of stearic acid and 0.5% trietanolamine and formula D 16% of stearic acid and 0.5% trietanolamine. Effectiveness and physical quality results were analyzed using one way anova and post hoc tukey with the level of confidence 95%. The results showed that stearic acid as an emulsifying agent have significant effect on the decrease of spreadibility, effectiveness and an increase in pH, viscosity, stickiness and ease for removal. Triethanolamin as an emulsifying agent had significant effect on them decrease of spreadibility, effectiveness and an increase in pH, viscosity, stickiness, and ease for removal. Interaction of both agents had signifficant effect to increase pH, viscosity, and effectiveness and a decrease in spreadibility, stickiness, and ease to removal of moisturizing cream containing the extract mangosteen pericarp. Optimum formula of moisturizing cream dry extract of mangosteen pericarp was obtained, a combination of 14.02% stearic acid and 0.41% trietanolamine as an anionic emulsifying agents.

Formulasi Sediaan Krim Pelembab Ekstrak Air Buah Pepaya (Carica Papaya L.) Ningsih, Kadek Sri Utami; Darsono, Farida Lanawati; Wijaya, Sumi
Jurnal Farmasi Sains dan Terapan Vol 6, No 1 (2019)
Publisher : Jurnal Farmasi Sains dan Terapan

Sucrose in papaya fruit was used as a moisturizer because it has worked as humectants, which reduce water evaporation on the surface of the skin. The purpose of this research was to determine the effect of the increasing concentrations of water extract of papaya fruit to evaluate its physical quality, effectiveness, safety, acceptability, and stability of the moisturizing cream water extract of papaya (Carica papaya L.). In this study, it used 3 formulas containing the extract of papaya fruit at concentration of 10% (formula 1), 20% (formula 2), 30% (formula 3), also blank containing base only, and base without extract and without moisturizing agent. The physical quality tests include organoleptic, pH, viscosity test, emulsion type test, dispersive power test, homogeneity, water washed power and adhesion test. The effectiveness of mouisturizer effect on the skin was tested with in vitro method: Sorption Desorption Test. Savety testing include irritation test and acceptability test. The data was analyzed using oneway ANOVA then continued with post hoc Tukey. The results showed that the increasing concentrations of the extract provides significant effect on efectivity, wherein the greater the concentration of water extract of papaya fruit (Carica papaya L.) were added, then the higher the ability to moisturize the skin and produce of moisturizer cream with pH test 6.04, viscosity 159710 cps, dispersive power 3.63 cm, water washed power 13.48 ml, adhesion 6005 second, and moisturizer cream stable during storage. The best formula is the formula 3 with a concentration extract of 30%.

Formulasi Sediaan Eyeshadow Ekstrak Air Buah Syzygium cumini dalam Bentuk Compact Powder Dwiwulandari, Fransisca Yunita; Darsono, Farida Lanawati; Wijaya, Sumi
Jurnal Farmasi Sains dan Terapan Vol 5, No 1 (2018)
Publisher : Jurnal Farmasi Sains dan Terapan

Coloring substance are needed in eyeshadow. It is used to give colors, shadows, and glittery effect on eyes. The trend in beauty world nowadays is using a natural dye because of safety issues. Antocyanine, which is contained in â€œjuwetâ€ fruit (Syzygium cumini), is one of the potential natural dyes. The aim of this research is to know the effect of Syzygium cumini in different concentration (20%, 25% dan 30%) on the physical quality and ffectiveness of the eyeshadow. The extract of Syzygium cumini fruit was formulated into compact powder eyeshadow. This type of preparation is the dominant dosage form used because it has good adhesiveness to the skin. The extract was obtained by extracting the juice and evaporated it using thermostatic water bath in the temperature of 40-60Â°C. The result showed that the increase in extract concentration significantly affected the physical quality test results (organoleptic, pH, particle size, friability and hardness), but did not affect the color dispersion and effectiveness. Based on the evaluation, formula II (extract of Syzyium cumini 25 %) was chosen as the best formula.

Standarisasi Spesifik dan Non Spesifik dari Ekstrak Etanol Daun dandang Gendis (Clinacanthus nutans) Wijaya, Sumi; Setiawan, Henry Kurnia; Purnama, Veronica Bella
Jurnal Farmasi Sains dan Terapan Vol 6, No 2 (2019)
Publisher : Jurnal Farmasi Sains dan Terapan

Standardization of natural materials is needed as an effort to improve the quality and safety of products that are expected to further increase trust in medicines derived from natural ingredients. Snake grass leaf has several pharmacological activities including antioxidants, anticancer, anti-inflammatory, analgesic, enhancing the immune system, antibacterial, antivenom, even there are also uses in the cosmetics field. In this study macroscopic and microscopic observation of Snake grass leaves and determination of specific and non-specific standardization on ethanol extracts of Snake grass leaves have been done. The parameters tested on Snake grass leaf extract include the identity of the extract, organoleptic, ethanol soluble extract, water soluble extract, phytochemical screening, chromatogram profile using TLC, spectrum profile using UV-Vis spectrophotometer, spectrum profile using IR (infrared)spectrophotometer, determination of secondary metabolite content, total ash content, water soluble ash content, acid insoluble ash content, water content, pH, and specific gravity. The results showed the characteristics of ethanol extract of Snake grass leaf in the form of green-black extract, aromatic distinctive odor; ethanol soluble extract content> 54%; water soluble extract content> 37%; phytochemical screening results showed the presence of alkaloid compounds, flavonoids, polyphenols, saponins, steroids and terpenoids; the results of IR spectrophotometer analysis show spectrum profiles in the range wave of numbers 3325-3351 cm-1, 2924-2919 cm-1, 1622 -1633 cm-1, 1341-1345 cm-1 and 1020-1047 cm-1; total phenol levels> 0.16%; total flavonoid levels> 0.11%; total alkaloid levels> 0.03%; water content

Standarisasi Spesifik dan Non Spesifik dari Ekstrak Etanol Daun Beluntas (Pluchea indica L. Less.) Wijaya, Sumi; Setiawan, Henry Kurnia; Ano, Lucyanna Ayu Lestari
Jurnal Farmasi Sains dan Terapan Vol 4, No 1 (2017)
Publisher : Jurnal Farmasi Sains dan Terapan

Indian fleabane (Pluchea indica (L.) Less.), on of the species in Asteraceae family, is widely used for traditional medicine. A standardization process is needed as an effort to improve the quality and safety of products, so that it is expected to increase the trust in drugs derived from natural ingredients. This study aims to determine the morphology and anatomy of Indian fleabane leaves and to determine the standardization value of the ethanol extract of Indian fleabane leaves. Dried powder of Indian fleabane leaves are obtained from three different regions (Bogor, Malang and Surabaya). The extract was obtained by maceration method using 96% ethanol as a solvent. Specific standardization includes identity, macroscopic, determination of soluble extract, phytochemical screening, TLC (Thin Layer Chromatography) pattern determination, determination of infrared spectrum profile, determination of UV-Vis spectrum profile, and determination of flavonoid, phenol and alkaloid total content. Nonspecific standardization includes determination of total ash content, water soluble ash content, acid insoluble ash content, drying losses, specific gravity and pH. Organoleptic observations showed the ethanol extract of Indian fleabane leaves has blackish brown and aromatic odour. The mobile phase being used for TLC profile chromatogram was n-hexane: ethyl acetate (7: 3). Based on the results, the screening results of Indian fleabane contain alkaloids, flavonoids, polyphenols, tannins, saponins, steroids and triterpenoids. The Infra red spectrophotometer analysis showed the range of wave numbers of 2924 - 2925, 1515 - 1516, 1259 - 1260, 1159 - 1162, 1112 - 1115, 1046 - 1048, 811 - 812, 505 - 506 and 452 - 454 cm- 1. The standardization value of Indian fleabane ethanol extract showed ethanol soluble extract> 65%, water soluble extract> 49%, water content

Studi pendahuluan: Korelasi Aktivitas Antikolesterol dengan Aktivitas Antioksidan Ekstrak Etanol Daun Salam (Syzygium polyanthum) Wijaya, Sumi; Yonas, Stefani Maureen Kasih; Hartanti, Lanny; Setiawan, Henry K.; Soegianto, Lisa
Jurnal Farmasi Sains dan Terapan Vol 5, No 2 (2018)
Publisher : Jurnal Farmasi Sains dan Terapan

Bay leaf leaves (Syzygium polyanthum) are known to have anti-cholesterol activity, with the mechanism inhibited HMG-CoA Reductase enzyme. The purpose of this study was to determine the correlation between anticholesterol activity of bay leaf ethanol extract obtained by percolation method and its antioxidant activity. The parameter used to measure anticolesterol activity is the IC50 value. Antioxidant activity was evaluated by DPPH and Frap methods. The results showed that the ethanolic extract of bay leaves had an IC50 value of 49.50 Â± 0.70 ppm. Ethanol extract of bay leaf showed antioxidant activity with IC50 value of 888.0835 ppm and equality of values with 1 mM FeSO4 of 295 ppm. Based on the results of the analysis, the anticholesterol activity of Bay leaf ethanol extract in inhibiting the HMG-CoA Reductase enzyme did not have a linear correlation with its antioxidant activity.

Co-Authors Albrian, Diga Ance, Paulina Erlianda Ano, Lucyanna Ayu Lestari Ardani, Yonas Bianityo Bata, Maria H C Bata, Maria H C Bindharawati, Nina Bindharawati, Nina Chomariyah, Nur Chomariyah, Nur Dwiwulandari, Fransisca Yunita Dwiwulandari, Fransisca Yunita Ekayanti, Ni Luh Putu Serly Ekayanti, Ni Luh Putu Serly Farida L Darsono Farida Lanawati Darsono Filania S. Kanja Hendrata, Adi Pramono Henry Kurnia Setiawan Kuncorojakti, Suryo Kurnia Setiawan, Henry Lanny Hartanti Letelay, Yulia Riani Lisa Soegianto Lisa Soegianto Lisa Soegianto Martha Ervina Mellisa Laura Mintoro Miftahul Jannah Monica S.W Ningsih, Kadek Sri Utami Ningsih, Kadek Sri Utami Novita, Bernadette Dian Paul L Tahalele Prasety, Oda Shantina Prihastuti, Angelina Ajeng Purnama, Veronica Bella Sari, Diyan Maya Sari, Dwi Augusnita Setiawan, Henry K Setiawan, Henry K Setiawan, Henry K. Sianty Dewi Soediono, Endang Isbandiati Talia, Sela Tjahjono, Yudy Valeri, Sepvan Valeri, Sepvan Wedharga, I Gede Putu Adhi Wijaya, Hendy Yonas, Stefani Maureen Kasih

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