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Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)

JFST
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Published by Universitas Katolik Widya Mandala Surabaya

ISSN : 23388404 EISSN : 26572311 DOI : -

Core Subject : Health,

Medicine & Pharmacology

Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) is published twice a year, containing research articles, review, and short communication in pharmacy science field, including medicinal chemistry, analytical chemistry, biologjcal pharmacy, pharmaceutical sciences and clinical pharmacy research and practice of pharmacy in industry, clinic, and community practice, such as pharmacies, distributors, and pharmacy education.

Arjuna Subject : -

Articles 8 Documents

Search results for , issue "Vol 4, No 2 (2017)" : 8 Documents clear

Optimasi Formula Tablet Ekstrak Kering Daun Jati Belanda Menggunakan Kombinasi Starch 1500 sebagai Pengikat dan Crospovidone sebagai Penghancur Gunawan, Indra; Darsono, Farida Lanawati; Hermanu, Liliek S.
Jurnal Farmasi Sains dan Terapan Vol 4, No 2 (2017)
Publisher : Jurnal Farmasi Sains dan Terapan

Bastard cedar leaves (Guazuma ulmifolia L.) can lower cholesterol level on blood. Tannins and musilago are the components in bastar cedar leaves that play a role in lowering cholesterol. The purpose of this study was to determine the effect of starch 1500, crospovidone and its interaction on the physical quality of tablets. Tablets were made using wet granulation method. Optimization of tablet formulation consists of two factors. The first factor is the Starch 1500 which is used as a binder with the level (+1) that is 3% and the level (-1) that is 1.5%, and the second factor is the crospovidone used as disintegrant with the level (+1) that is 5% (-1) that is 2%. The response used is tablet hardness, fragility, and time of disintegration. The results of this study indicate that starch 1500 can increase the hardness, but can prolong the disintegration time of the tablet and can decrease the tablet fragility, while crospovidone can decrease the hardness, increase the fragility, and accelerated tablet disintegration time. The interaction of these two factors has a significant effect on tablet hardness, fragility and time of disintegration. The optimum formula was obtained with the combination of Starch 1500 2.22% and crospovidone 3.54% with estimated result of physical hardness test quality of 5.2Kgf; Fragility 0.643%; and disintegration time 11.54 minutes.

Pola Penggunaan Ranitidine pada Pasien HIV & AIDS di UPIPI RSUD DR. Soetomo Surabaya Nurohmawati, Weni; Triyono, Erwin Astha; Surdijati, Siti; Jaya, Halim Priyahau
Jurnal Farmasi Sains dan Terapan Vol 4, No 2 (2017)
Publisher : Jurnal Farmasi Sains dan Terapan

HIV is a retrovirus that attacks CD4 lymphocyte cells. AIDS is a retrovirus disease caused by infection with retrovirus HIV-1 or HIV-2 which causes opportunistic diseases, secondary neoplasms and neurological abnormalities. In patients with HIV & AIDS often experience gastrointestinal disorders such as nausea and vomiting caused by side effects of the use of antiretroviral or due to other factors. Ranitidine is an H2 inhibitory receptor that will selectively and reversibly reduce excess gastric acid secretion. In this study ranitidine was used as a stress ulcer prophylaxis in hospitalized patients. This study aims to display ranitidine therapy data including type, dose, route of drug administration, prevalence, duration of use and qualitative analysis of interactions associated with medical record data at UPIPI RSUD Dr. Soetomo Surabaya. The research method used was observational prospectively on patient medical record with HIV & AIDS. Sampling was carried out by consecutive sampling period from November 1, 2016 to December 31, 2016. The results of this study give information that ranitidine was most widely used for stress ulcer prophylaxis therapy in hospitalized patients in UPIPI RSUD Dr. Soetomo Surabaya in a dose of 50mg / 2ml with a frequency of 2x1 while for oral ranitidine with a dose of 150mg / tablet with a frequency of 2x1. The use of ranitidine on HIV & AIDS patients in UPIPI RSUD Dr Soetomo Surabaya, related to dosage, route, frequency, interval, and duration of administration is in accordance with the existing guidelines.

Uji Potensi Antibakteri dan Antibiofilm Minyak Atsiri Umbi Teki (Cyperus rotundus L.) terhadap Staphylococcus aureus ATCC 6538 Uthari, Ni Made; Soegianto, Lisa; Hermanu, Liliek S.
Jurnal Farmasi Sains dan Terapan Vol 4, No 2 (2017)
Publisher : Jurnal Farmasi Sains dan Terapan

Infectious disease is a disease that is caused by an invasion of pathogenic microorganisms in the body. Biofilm is a group of microorganisms that are able to differentiate and proliferate in the complex way as well as being able to communicate between cells through a matrix of polysaccharides. In chronic infection, biofilm has an important role to maintain the bacteria which can cause resistance to antibiotics. Teki (Cyperus rotundus L.) is one of the plants that has many benefits for different treatment. The aim of this study was to determine the antibacterial activity and inhibition of biofilm activity of essential oil of Cyperus rotundus L. tubers against Staphylococcus aureus. Essential oil was extracted by distillation using Stahl with water as the solvent and the yield of essential oil obtained was 0.22%. Determination of antibacterial activity and antibiofilm activity were carried out by microdilution method using microplate 96 U-PVC bottom wells against Staphylococcus aureus which is equivalent to the solution standard of Â½ Mc Farland I. The results of antibacterial activity tests showed that MIC (Minimum Inhibitory Concentration) and MBC (Minimum Bactericidal Concentration) values were 0.05% (v/v) and 12.5% (v/v). Antibiofilm activity test showed that the essential oil of Cyperus rotundus L. tubers is able to inhibit 89.01% of the biofilm formation of Staphylococcus aureus on the concentration of 0.09% (v/v).

Formulasi Sediaan Lipstik Ekstrak Air Buah Syzygium cumini Dalam Bentuk Liquid Sari, Dwi Augusnita; Darsono, Farida Lanawati; Wijaya, Sumi
Jurnal Farmasi Sains dan Terapan Vol 4, No 2 (2017)
Publisher : Jurnal Farmasi Sains dan Terapan

Now-a-days decorative cosmetics are essential needs for women especially lipstick. Lipstick is one of the cosmetics products which is used to increasing the aesthetic of facial make-up. A local tradable fruit called Syzygium cumini can be used as an alternative in conventional lipstick. Syzygium cumini anthocyanin-rich fruit contain 892 mg anthocyanins per 100g of fresh fruit. The purpose of this research was to find out the increasing of difference (HPMC) in liquid lipstick and to find out influence of the best formulation based on physical test, effectiveness test, safety test and acceptability test. Lipstick in liquid form was chosen because it has advantages such as can be easy to attached, easy to apply and easy to dry so that the formulation required a thickening agent that has properties to fulfill the characteristics of liquid lipstick. HPMC is a thickening agent and can help improve the viscosity of formulation liquid lipstick. The concentration of Syzygium cumini fruit extract was used 20% formulated using HPMC at a concentration of 0.75%; 1% and 2%. The results showed that the increasing concentration of HPMC significantly affect on pH test, viscosity, adhesion, and drying time; the decreasing of spreadness and the smearness of liquid lipstick. The best formula was the formula contained HPMC 2%, based on physical test (viscosity, homogeneity), effectiveness test (smearness, spreadness, stickiness, drying time), safety test and acceptability test.

Profil Terapi Diare Akut pada Pasien Anak Rawat Inap di Rumah Sakit Bhayangkara Surabaya Sandra, Pipit; Hasmono, Didik; Kasih, Elisabeth; Hartono, Ruddy
Jurnal Farmasi Sains dan Terapan Vol 4, No 2 (2017)
Publisher : Jurnal Farmasi Sains dan Terapan

Acute diarrhea in children is defined as defecation more than 3 times per day, with changes in the consistency of feces into fluids with or without mucus and blood lasting either less than a week or up to 14 days, but not more than 14 days in children or infant. Treatment of acute diarrhea can shorten the duration of diarrhea and eradicate the organism which causes the disease. The purpose of this research was to analyze the profile of acute diarrhea treatment in hospitalized pediatric patients at Bhayangkara Hospital Surabaya including the type, dosage, route and the timing of administration which is related to the patientâ€™s medical record data. This research is an observational study in the form of retrospective study in patients with acute diarrhea with a t o t a l sampling technique. The results showed the most commonly used medications for acute diarrhea in children were parenteral rehydration fluid of KDN-1 of (41 patients, 80%) with the most widely used dose (500 cc / 4 hours â†’ 1000 cc / 24 h) IV, t h e pa t t e r n o f single antibiotic use was (43 patients, 84%), the penicillin group, ampicillin, as many as (22 patients, 44%) with the most widely used dose (4 x 250 mg) IV, the most commonly prescribed single antibiotic when discharged from the hospital was cephalosporin group, cefixime, with 17 patients (33%), with the most widely used dose (2 x 20 mg) P.O, sinbiotic with (36 patients, 70%) and the most widely used was dose (1 x 1 sachet) P.O, zinc with (49 patients, 96%) and the most widely used was dose (1 x 1 cth) P.O, vitamin A with (21 patients, 41%), and the most widely used was dose (1 x 500 IU) P.O, antidiarrhea dioctahedral smectite was (43 patients, 84%) and the most commonly used was dose (3 x 1/3 sachets) P.O.

Studi Penggunaan Obat Phenytoin Kurang dari Tiga Bulan terhadap Kadar Magnesium Serum dan Jumlah Kejang Pasien Epilepsi di RSUD DR. Soetomo Surabaya Sanjiwani, Kadek Siska Febri; Sugianto, Paulus; Kasih, Elisabeth
Jurnal Farmasi Sains dan Terapan Vol 4, No 2 (2017)
Publisher : Jurnal Farmasi Sains dan Terapan

Epilepsy is a clinical phenomenon associated with an electrical explosion or excessive abnormal depolarization, which occurs in focus in the brain which causes a paroxysmal awakening. One of the anti-epilepsy drugs is phenytoin which belongs to the hydantoin class. This study aims to describe the serum Mg levels in epilepsy patients with phenytoin drug therapy in Dr. Soetomo General Hospital with a treatment period of less than three months and to identify DRP problems (Drug Related Problems). The method used in this study is prospectively presented by descriptive method (observational). The population in this study were epilepsy patients who were treated at the RSUD dr. Soetomo Surabaya with a sample of 28 epilepsy patients treated at the Outpatient and EEG Neurology Room at Dr. Soetomo General Hospital Surabaya. Results showed that Mg2+ levels in 28 patients with the highest magnesium levels were 2.46 mg / dL. While the lowest magnesium content is 1.78 mg / dL. Conclusions Patients' magnesium levels are still within the normal range but it has not been concluded that phenytoin can increase serum Mg2+ levels and there is no significant difference between phenytoin therapy in epilepsy patients

Studi Penggunaan Antihipertensi Golongan Angiotensin Receptor Blockers Terhadap Pasien Gagal Ginjal Kronik Stadium V di Rumah Sakit Bhayangkara Surabaya Bura, Ursula Dua Klowe; Hasmono, Didik; Surdijati, Siti; Hartono, Ruddy
Jurnal Farmasi Sains dan Terapan Vol 4, No 2 (2017)
Publisher : Jurnal Farmasi Sains dan Terapan

Chronic renal failure is functional or structural kidney damage for more than 3 (three) months with or without a decrease in the Glomerular Filtration Rate (GFR), manifested as one of the pathological abnormalities or a sign of kidney damage, including blood or urine composition abnormalities or radiology abnormalities. In addition, chronic renal failure is also defined as a condition of GFR value of less than 60 ml / minute / 1.73 m2, for more than 3 (three) months with or without kidney damage. One of the risk factor for chronic renal failure is hypertension. The purpose of antihypertensive administration is to prevent further damage to other organs, and also to reduce blood pressure in patients with chronic renal failure with a target of â‰¤ 140 mmHg. Angiotensin Receptor Blockers (ARB) is a first-line therapy used to reduce blood pressure so that it can delay kidney damage. The purpose of this study was to determine the pattern of antihypertensive drug use in the ARB class in patients with stage V chronic renal failure at Bhayangkara Hospital in Surabaya which was associated with clinical and laboratory data. The study was conducted observationally with a descriptive research design and retrospective data collection. The results showed that those who met the inclusion criteria were 30 patients using antihypertensive ARB therapy, where the highest number of sexes were 67% male and 33% female, the highest populations at the age of 31-70 years, the highest populations was 90% for ARB use and other antihypertensive drug and a single ARB use of 10 %, the most common combination ofantihypertensive group is ARB and Calsium Channel Blocker (CCB) 41%. The patientâ€™s blood pressure mostly meets the target of â‰¤ 140 mmHg.

Standarisasi Simplisia Kering Daun Beluntas (Pluchea indica L.) dari Tiga Daerah Berbeda Talia, Sela; Wijaya, Sumi; Setiawan, Henry Kurnia
Jurnal Farmasi Sains dan Terapan Vol 4, No 2 (2017)
Publisher : Jurnal Farmasi Sains dan Terapan

Indian Fleabane (Pluchea indica L.) are commonly used as hedgerows and traditionally the leaves are used as fresh salad or medicines to eliminate body odor, febrifuge, cough medicine, and antidiarrheal drugs. Along with the increasing technology of natural materials and the tendency of people to use products derived from natural materials, especially medicinal plants, a reference which contains the requirements for the quality of natural ingredients that are suitable for use as medicinal ingredients is needed. This research aims to determine the profile of specific and non specific standardization of dried powder of indian fleabane leaves. Standardization of indian fleabane leaves covers specific parameters and non specific parameters, characterization of microscopic characteristics of indian fleabane (Pluchea indica L.) leaves, characterization of the content of secondary metabolites using thin layer chromatography (TLC), determination of spectrum profiles using infrared spectrophotometer (IR), and determination of the levels of secondary metabolites by spectrofotometry. The data obtained is descriptive data that reflect the acquisition of data from 3 different locations. Based on microscopic observations indian fleabane leaf dried powder has vascular bundles with spiral thickening, anomocytic stomata, and multicellular trichomes. Ethanol solubility of dried powder indian fleabane is â‰¥5% while water solubility in water is â‰¥26%. The results of phytochemical screening showed positive results on the observations of alkaloids, flavonoids, phenols, steroids and terpenes. Total ash content is

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