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Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)

JFST
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Published by Universitas Katolik Widya Mandala Surabaya

ISSN : 23388404 EISSN : 26572311 DOI : -

Core Subject : Health,

Medicine & Pharmacology

Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) is published twice a year, containing research articles, review, and short communication in pharmacy science field, including medicinal chemistry, analytical chemistry, biologjcal pharmacy, pharmaceutical sciences and clinical pharmacy research and practice of pharmacy in industry, clinic, and community practice, such as pharmacies, distributors, and pharmacy education.

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Articles 9 Documents

Search results for , issue "Vol 5, No 1 (2018)" : 9 Documents clear

Profil Penggunaan Insulin Pada Pasien Diabetes Melitus Tipe 2 Dengan Ulkus/ Gangren Di Rumah Sakit Umum Daerah (RSUD) Kabupaten Sidoarjo Hariyati, Fera; Hasmono, Didik; Kasih, Elisabeth
Jurnal Farmasi Sains dan Terapan Vol 5, No 1 (2018)
Publisher : Jurnal Farmasi Sains dan Terapan

Diabetis mellitus is still a health problem in the world. It is a condition of hyperglycemia which is at risk of causing macrovascular and microvaskular complications. The prevalence of diabetes mellitus continues to increase throughout the world, including in Indonesia. One of diabetes complications is diabetic ulcer or gangrene. Diabetic ulcer or gangrene is common complication of diabetes mellitus wich can be caused by uncontrolled blood glucose levels. The aim of this study was to find the profile of insulin use in patiens with type 2 diabetes mellitus with ulcer or gangren in RSUD Kabupaten Sidoarjo. It was an observational-descriptive study. Data were collected retrospective using purposive sampling method in the period of January 2017 to December 2017 at RSUD Kabupaten Sidoarjo. The results of observational study on 19 patients showed the insulin therapy used in this study, where 42% of patients used single insulin therapy and 58% of patiens used combination insulin therapy. In this study the commonly used single insulin was rapid acting insulin (NovorapidÂ®) 42%, whereas the combination insulin used was rapid acting insulin with long acting insulin (NovorapidÂ®-LantusÂ®) 58%. Based on glycemic target, patients with blood glucose levels reached the glycemic target were 10% of patients, the ones that not reached the glycemic target were 80% of patients and the ones that reached hypoglicemia were 10% of patients. In this study, the severity category of diabetes mellitus patients with ulcers/ gangrene was gangrene 58%, ulcers 26%, cellulitis 11% and sepsis 5%.

Studi Penggunaan Natrium Valproat Kurang Dari Tiga Bulan Terhadap Magnesium Serum Dan Jumlah Kejang Pasien Epilepsi Di RSUD Dr. Soetomo Latuasan, Ivana Rahayu; Sugianto, Paulus; Kasih, Elisabeth; Octavia, Evi
Jurnal Farmasi Sains dan Terapan Vol 5, No 1 (2018)
Publisher : Jurnal Farmasi Sains dan Terapan

Epilepsy is a brain disorder characterized by a tendency to cause continuous epilepsy attacks with neurobiological, cognitive, psychological and social consequences. The appearance of temporary signs or symptoms is caused by abnormal and excessive neuron activity in the brain. Sodium valproate can be used as epilepsy therapy because it is effective in inhibiting seizures, partial seizures, and tonic-clonic seizures. The mechanism of action of sodium valproate in the treatment of epilepsy is to increase the inactivation of Na + channels, thereby reducing the nerve's ability to transmit electric charges. Magnesium is a potential modulator of seizure activity because of its ability to inhibit excitation through N-methyl D-aspartate receptors. The aim of this study was to determine serum magnesium levels with sodium valproate treatment and the number of seizures as well as to identify drug-related problems in epilepsy patients who were less than three months old. The research was conducted in the Electroencephalography Room of the Regional Hospital Dr. Soetomo Surabaya by using observational methods in the form of prospective studies using data collection sheets and questionnaires. Samples were taken from July 1 to September 30, 2017. Based on laboratory results, the average magnesium content of patients with seizures was 2.22 mg / dL while non-seizure patients were 2.08 mg / dL. The conclusion of this study is that the use of sodium valproate does not affect magnesium levels in epilepsy patients and epilepsy patients who get sodium valproate therapy have a lower risk of seizures than those who do not get sodium valproate medication.

Pola Penggunaan Omeprazole pada Pasien HIV & AIDS di UPIPI RSUD DR. Soetomo Surabaya Ariana, Dona; Trijono, Erwin Astha; Surdijati, Sri; Nathalia, Aditya
Jurnal Farmasi Sains dan Terapan Vol 5, No 1 (2018)
Publisher : Jurnal Farmasi Sains dan Terapan

Human Immunodeficiency Virus (HIV) is a virus that spreads through body fluids and attacks the immune system, especially CD4 + lymphocyte-T cells (CD4). AIDS is a retroviral disease characterized by severe immune suppression that causes opportunistic diseases, secondary neoplasms, and neurological disorders. Patients suffering from chronic diseases, such as HIV & AIDS patients may experience severe shocks or trauma. This condition can trigger the release of excessive stomach acid to experience erosion or acute gastric ulcers with bleeding. This injury is classified as a gastric ulcer. Treatment of ulcers is needed, because a continuous ulcer can cause bleeding. Gastrointestinal bleeding can manifest in the direction of melena and hematemesis. The therapy that can be used is omeprazole which is a class of proton pump inhibitors. Omeprazole can prevent mucosal damage from gastric acid and can inhibit excess acid production from gastric parietal cells. This study aims to present omeprazole therapy data which includes dosage, route of drug administration, duration of use and qualitative analysis of interactions related to medical record data at UPIPI Hospital Dr. Soetomo Surabaya. The research method used was observational retrospective on the medical record of patients with HIV & AIDS. Sampling was carried out from January 1 to December 31, 2015. The results showed that omeprazole was the most widely used gastric ulcer drug in HIV & AIDS patients, as many as 56 patients (91.80%). The most frequent doses, frequencies, and routes were omeprazole 40 mg 2x1 IV in 55 patients (90.16%). Omeprazole therapy was given to patients with HIV & AIDS at UPIPI Hospital Dr. Surabaya Soetomo, regarding the dosage, frequency, route, and duration of administration are in accordance with existing guidelines.

Uji Potensi Ekstrak Daun Binahong (Anredera cordifolia (Ten.) Steenis) Terhadap Peningkatan Ketebalan Jaringan Granulasi dan Waktu Penyembuhan Luka Bakar Tikus Betriksia, Dea; Hamid, Iwan Syahrial; Hermanu, Liliek Suyatmiatun
Jurnal Farmasi Sains dan Terapan Vol 5, No 1 (2018)
Publisher : Jurnal Farmasi Sains dan Terapan

Burns are skin damage caused by high-temperature which contact to the skin. Second-degree burns are the most common accident at home. The process of wound healing can be accelerated using traditional medicines, one of which is Binahong (Anredera cordifolia (Ten.) Steenis). Binahong contains saponins, flavonoids, alkaloids, tannins, and steroids which have been shown to accelerate the wound healing process in previous experiments. The purpose of this study was to analyze the potential of binahong leaf extract to increase granulation tissue thickness and reduce healing time of burns. This study uses an experimental method. Wistar rats were used in this study, which were divided into 4 groups, namely K (-), K (+), and treatment groups namely the concentration of binahong leaf extract 20% (P1) and 40% (P2). Burns are made using an iron plate that has been heated to 95Â° C and pasted for 30 seconds on the lower back of the mouse to cause second-degree burns. The binahong leaf extract used in this study was made in the form of an ointment and given twice a day for 7 days. Increased granulation tissue thickness and wound healing time were observed on day 3 and day 7. The results showed an increase in granulation tissue thickness and shorter healing time in the experimental group given binahong leaf extract with a concentration of 40% (P2) compared to the experimental group that was given binahong leaf extract with a concentration of 20% (P1).

Standarisasi Simplisia Kering Daun Kelor (Moringa oleifera) Dari Tiga Daerah Berbeda Bata, Maria H C; Wijaya, Sumi; Setiawan, Henry K
Jurnal Farmasi Sains dan Terapan Vol 5, No 1 (2018)
Publisher : Jurnal Farmasi Sains dan Terapan

Miracle tree (Moringa oleifera) is known for its many benefits, and has been used in traditional medicine. This study aims to determine macroscopic and microscopic characteristics of Miracle tree leaves and to determine specific and non specific parameter os standardization of Miracle tree dried powder. Miracle tree dried powder was obtained from three different locations (Batu, Bogor and Pacet). Determination of specific parameter of Miracle tree dried powder include macroscopic, microscopic, determination of soluble extract, chromatogram pattern determination by TLC, determination of infrared spectrum profile (IR), determination of UV spectrum profile and determination of quantitative secondary metabolite compounds. Non specific parameters including determination of total ash content, ash content water soluble, acid soluble ash content, drying shrinkage and pH. Determinations of quantitative secondary metabolite compounds were done using colorimetric method. Based on the results, Miracle tree dried powder contain alkaloid, flavonoids, polyphenols, saponins, tannins, steroids and triterpenoids. Ethyl acetate: n-hexan (7: 3 v / v) can be used as eluent on thin layer chromatography. Miracle tree dried powder gave wave number of 3277 â€“ 3281, 2917 â€“ 2918, 2849 â€“ 2850, 1603 â€“ 1607, 1408, 1235 â€“ 1236, 1048 â€“ 1051, 889, 534 â€“ 536 and 452 - 455. Miracle tree dried powder gave standardization value of dried shrink rate 5.5% w/ w and total alkaloid content> 1.0% w/w.

Studi Penggunaan Asam Traneksamat pada Penderita Tuberkulosis dengan Hemoptisis di Instalasi Rawat Jalan Rumah Sakit Umum Haji Surabaya Yuni, Santi Eka; Hasmono, Didik; Kasih, Elisabeth; Ayumuyas, Nur Palestin
Jurnal Farmasi Sains dan Terapan Vol 5, No 1 (2018)
Publisher : Jurnal Farmasi Sains dan Terapan

Tuberculosis is one of the world's health problems, especially in developing countries with coughing in the form of blood (hemoptysis) as a sign of this disease. Tranexamic acid can be used as one of the treatments for hemoptysis. Tranexamic acid is a synthesis derivative of aminolenic acid which provides antifibrinolytic effects through reversible blocking of lysine binding sites on plasminogen molecules and inhibits plasmin. This study aims to analyze the pattern of use of tranexamic acid in tuberculosis patients with hemoptysis including dosage, frequency and duration of use in the Outpatient Installation of Surabaya Haji General Hospital. The study was conducted observationally with a retrospective method on medical records of patients diagnosed with tuberculosis with hemoptysis and received treatment for tranexamic acid, then analyzed descriptively. Sampling was done by purposive sampling, from January 1, 2016 to December 31, 2017. From the results of the study, the use of tranexamic acid single dose (3x500mg) as many as 2 patients (67%), 500 mg intravenously as many as 1 patient (33%) and combination with Vitamin K as many as 3 patients. The highest duration of use was 3 days in 11 patients (56%). The use of tranexamic acid in hemoptysis patients related to dose, frequency and duration of use is in accordance with the existing literature.

Uji Antipiretik Patch Ekstrak Etanol Bawang Merah (Allium ascalonicum L.) dengan Matriks Chitosan dan Enhancer Tween-80 Jennifer Rachel Willyanto; Iwan Sahrial Hamid; Teguh Widodo
Jurnal Farmasi Sains dan Terapan Vol 5, No 1 (2018)
Publisher : Jurnal Farmasi Sains dan Terapan

Onion is a traditional medicine that has a lot of pharmacological potential. Flavanoid compounds found in onions have an antipyretic effect that acts as an inhibitor of cyclooxygenase (COX) enzymes that play a role in the formation of prostaglandins. In this study red onion is formulated into a patch because of its practical use and can avoid the first metabolic pathway. This study aims to analyze the effect of onion ethanol extract patch (Allium ascalonicum L.) on the decrease of body temperature and the number of monocytes in white rats induced by DPT vaccine. This study used 4 treatment groups: positive controls administered paracetamol syrup, negative controls given placebo patch, treatment group 1 treated with red onion ethanol extract without enhancers and treatment group 2 treated with an red onion ethanol extract with enhancers. Rats adapted for 7 days before temperature being measured and the blood being collected from the rat tail in order to calculate the number of monocytes. The animal temperature was measured after injected with vaccine DPT at 15, 30, 45, 60, 75, 90, 105, 120, 150, 180 minutes meanwhile number of monocyte were calculated every 15 minutes for 120 minutes. The results showed that there was no significant difference in monocyte count of treatment group with positive control but there were significant differences in temperature. The use of onion ethanol extract patch may decrease the temperature and number of monocytes in white mice induced by DPT vaccine.

Uji Aktivitas Antimikroba Ekstrak Etanol Daun Cayratia trifolia terhadap Staphylococcus aureus dan Candida albicans Sari, Rizki Sari Endah; Soegianto, Lisa; Hermanu, Liliek S,
Jurnal Farmasi Sains dan Terapan Vol 5, No 1 (2018)
Publisher : Jurnal Farmasi Sains dan Terapan

Cayratia trifolia is a wild plant that is easily found in the lowlands, tropical and subtropical regions. Cayratia trifolia is known to be efficacious as an antibacterial, antifungal, antiprotozoa, hypoglycemia, anticancer and diuretic. This study aims to determine whether the ethanol extract of Cayratia trifolia leaves has antimicrobial activity against Candida albicans and Staphylococcus aureus using well diffusion method; to determine the value of the Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) using microdilution method; and to determine the secondary metabolite groups which have antimicrobial activity against Staphylococcus aureus and Candida albicans. In this study bioautography method was carried out to determine the secondary metabolite group that can inhibit microbial growth. Ethanol extract of Cayratia trifolia (Galing-galing) leaves has no antimicrobial activity against Candida albicans. The MIC value of the ethanol extract of Cayratia trifolia (Galing-galing) leaves against Staphylococcus aureus is at a concentration of 125 ppm, while the MBCvalue is at a concentration of 250 ppm. The group of compounds that have antibacterial activity against Staphylococcus aureus is polyphenol, meanwhile flavonoid suspected has activity against Candida albicans.

Formulasi Sediaan Eyeshadow Ekstrak Air Buah Syzygium cumini dalam Bentuk Compact Powder Dwiwulandari, Fransisca Yunita; Darsono, Farida Lanawati; Wijaya, Sumi
Jurnal Farmasi Sains dan Terapan Vol 5, No 1 (2018)
Publisher : Jurnal Farmasi Sains dan Terapan

Coloring substance are needed in eyeshadow. It is used to give colors, shadows, and glittery effect on eyes. The trend in beauty world nowadays is using a natural dye because of safety issues. Antocyanine, which is contained in â€œjuwetâ€ fruit (Syzygium cumini), is one of the potential natural dyes. The aim of this research is to know the effect of Syzygium cumini in different concentration (20%, 25% dan 30%) on the physical quality and ffectiveness of the eyeshadow. The extract of Syzygium cumini fruit was formulated into compact powder eyeshadow. This type of preparation is the dominant dosage form used because it has good adhesiveness to the skin. The extract was obtained by extracting the juice and evaporated it using thermostatic water bath in the temperature of 40-60Â°C. The result showed that the increase in extract concentration significantly affected the physical quality test results (organoleptic, pH, particle size, friability and hardness), but did not affect the color dispersion and effectiveness. Based on the evaluation, formula II (extract of Syzyium cumini 25 %) was chosen as the best formula.

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