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Althea Medical Journal
Published by Universitas Padjadjaran
ISSN : -     EISSN : 23374330     DOI : 10.15850/amj
Core Subject : Health,
Medicine & Pharmacology
Althea Medical Journal (AMJ) is a peer reviewed electronic scientific publication journal which is published every 3 months (March, June, September, and December). Althea Medical Journal publishes articles related to research in biomedical sciences, clinical medicine, family-community medicine, and public health.
Arjuna Subject : -
Articles 1,068 Documents
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Correlation between Levels of Serum Amylase, Lipase and Triglyceride in Acute Pancreatitis Patients Gunalan Govindarajan; Nina Tristina
Althea Medical Journal Vol 2, No 1 (2015)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Abstract

Background: Acute pancreatitis is an inflammation of pancreas associated with reversible pancreatic parenchymal injury. Studies in several countries indicate that the levels of amylase and lipase are usually elevated among patients with acute pancreatitis. Furthermore, hyperlipidemia, mainly high levels of triglycerides, may present in acute pancreatitis. The aim of this study was to determine the levels of serum amylase and lipase as well as their correlation with serum triglyceride level in acute pancreatitis patients.Methods: A retrospective study was conducted on medical records of 48 acute pancreatitis patients in Dr. Hasan Sadikin General Hospital Bandung, Indonesia from 2007to 2011. Data collected from the medical records were age, sex, levels of serum amylase, lipase and triglyceride. The distribution of data was determined using Shapiro-Wilk test. The correlation between serum pancreatic enzyme and triglyceride was analyzed using Spearman-rank test.Results: Most patients had increased levels of serum amylase and lipase in this study. However, no correlation between serum amylase and triglyceride (p-value = 0.312) was found. Furthermore, there was no correlation between serum lipase and triglyceride (p-value = 0.241).Conclusions: The levels of serum amylase and lipase increase in most patients with acute pancreatitis with no significant correlation between serum pancreatic enzymes (amylase and lipase) and triglyceride.Keywords: Acute pancreatitis, amylase, lipase, triglyceride DOI: 10.15850/amj.v2n1.420    
Comparison of Functional Capacity using Primary Percutaneous Coronary Intervention with Pharmacological Therapy on ST Elevation Acute Coronary Syndrome Patients Andini Nurkusuma Wardhani; Chaerul Achmad; Sunaryo B. Sastradimaja
Althea Medical Journal Vol 2, No 2 (2015)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Abstract

Background: Acute Coronary Syndrome (ACS) is a shift manifestations pattern of ischemic myocardium. Revascularization either with Primary Percutaneous Coronary Intervention (PCI) or pharmacological therapy is an optional treatment for ST Elevation Acute Coronary Syndrome (STEACS) patients. The aim of the study was to compare the functional capacity using six-minute walking test on STEACS patients who underwent Primary PCI or pharmacological therapy.Methods: A cross sectional study was conducted from September to October 2012 to 35 STEACS patients who were treated after two years. The samples were obtained from the list of patients at Dr. Hasan Sadikin General Hospital. Inclusion criteria consisted of patients diagnosed as STEACS, cooperative and not experiencing cognitive disturbance. The exclusion criteria were STEACS patients with unstable angina or myocardial infarct in the last month, stable exertional angina, and pregnant women. The patients underwent 6 minutes walking test,VO2max was measured using theCalahin and Cooper formula, then Metabolic Equation Task (METs) was calculated. Data were analyzed by unpaired T-test.Results: There were 19 Primary PCI and 16 pharmacological therapy patients. The average of age between the two groups was distributed evenly. Most of the STEACS patients were male, had a college/academic degree and were retired. Patients treated with pharmacological therapy had higher average of VO2 max and METs than patients with Primary PCI. There was no significantly differences of METs between those groups (p>0.05)Conclusions: There were no significantly differences of functional capacity in STEACS patients treated with Primary PCI or Pharmacological therapy. [AMJ.2015;2(1):162–6]
Pathogen Profile of Patients with Sepsis in Internal Medicine, Dr. Hasan Sadikin General Hospital, Bandung 2013 Afiq Syazwan Fauzi; Uun Sumardi; Nina Tristina
Althea Medical Journal Vol 3, No 2 (2016)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Abstract

Background: Sepsis is a continuous disease which begins with systemic inflammatory response syndrome (SIRS), seen in association with a large number of clinical conditions. These include infectious insults that produce SIRS, such as pancreatitis, ischemia, multiple traumas and tissue injury, hemorrhagic shock, immunemediated organ injury, and the exogenous administration of such putative mediators of the inflammatory process as tumor necrosis factor and other cytokines. A frequent complication of SIRS is the development of organ system dysfunction, including such well-defined clinical conditions as acute lung injury, shock, renal failure, and multiple organ dysfunction syndrome (MODS). Hence, this study was conducted to identify the pathogen profile that often causes sepsis.Methods: A retrospective study was performed to 152 medical records of patients diagnosed as sepsis from Internal Medicine Department Dr. Hasan Sadikin General Hospital from January 2013 to December 2013. The variables observed from the medical records were age, sex, comorbidity, main infection, culture sample, type of gram bacteria, resistant bacteria, and antibiotic susceptibility test. After data collection was completed, the data were analyzed using computer. The data were presented in percentage.Results: Sepsis in male was higher than female. Highest comorbid was chronic kidney disease (CKD). The main infection was health care acquired pneumonia (HCAP). Highest pathogen that caused sepsis was Escherichia coli and highest multidrug-resistant organism (MDRO) was extended spectrum beta-lactamase(ESBL) Escherichia coli.Conclusions: The most common pathogen that causes sepsis is Escherichia coli. [AMJ.2016;3(2):200–5]DOI: 10.15850/amj.v3n2.785
Vitamin C Intakeand Risk Factors for Knee Osteoarthritis Nadia Ayu Destiani; Siti Nur Fatimah; Sumartini Dewi
Althea Medical Journal Vol 4, No 2 (2017)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (48.684 KB) | DOI: 10.15850/amj.v4n2.1067

Abstract

Background: Knee osteoarthritis (OA) is a degenerative disease of the knee joints characterized by progressive softening and disintegration of articular cartilage. In OA, which is influenced by several risk factors, free radicals are increased by local ischemia in the cartilage. As an exogenous antioxidant, vitamin C also plays an important role in collagen and glycosaminoglycan synthesis. This study was carried out to identify vitamin C intake as well as risk factors in knee OA. Methods: The study population was determined by non-probability sampling with convenient approach to knee OA patients at the Rheumatology Outpatient Clinic of Dr. Hasan Sadikin General Hospital in October–November 2013. Data were obtained through questionnaire interview about risk factors, severity index of OA and vitamin C intake profile. Data presentation was conducted by descriptive method.Results: There were 47 patients diagnosed with knee OA in the Rheumatology Outpatient Clinic. The result showed that 7 patients (14.9%) had low vitamin C intake for the last 3 months. There were 30 patients with family history of OA (63.8%). Thirty two patients (68.1%) were passive smokers, 44 patients (93.6%) had history of repeated use of knee joints and majority of respondents had obesity.  Conclusions: Most of the subjects have sufficient vitamin C intake and more than half have risk factors that may contribute to the incidence of knee OA. DOI: 10.15850/amj.v4n2.1067 
Nutritional Status and Infectious Disease of Undernourished Children under five in Desa Cipacing, Jatinangor Subdistrict, West Java, from April to December 2012 Palomina Caesarea Nurhasanah; Dewi Marhaeni Diah Herawati; Resnaldi Resnaldi
Althea Medical Journal Vol 2, No 3 (2015)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Abstract

Background: Undernutrition frequently occurs in children under five. If not treated, it will cause acute health effects and affect on cognitive development, social, physical work capacity and productivity. Undernutrition  can be accompanied by the presence of infectious disease that can worsen the children’s nutritional status. This study aimed to describe the nutritional status and infectious disease of undernutrition children under five in Jatinangor Subdistrict.Methods: A qualitative study was carried out to 7 parents and undernourished children under five, in Desa Cipacing, Jatinangor. It was conducted from April to December 2012. The inclusion criterias were undernourished children under five with a history of infectious disease in the previous year, and the parents were willing to participate in this study. Exclusion criteria were parents and/or  the children who were not at home when the collection of the data was conducted.. Data collection was conducted using measurement of nutritional status, in depth interview and environmental observation. The data were presented in tables, figures and narration.Results: Three subjects with undernutrition (-3SD to -2SD) and four subjects with severe undernutrition (<-3SD). Factors affecting poor nutritional status were weight loss, no significant weight gain, diet and eating habit, and onset of disease. Commonly occurred infectious diseases were common cold, diarrhea, fever and cough. Some factors affecting infectious diseases were family member transmission, immunization, and treatment behavior.Conclusions: Poor nutritional status and infectious diseases contribute to undernutrition in children under five. DOI: 10.15850/amj.v2n3.553
Correlation between Cognitive Functions and Activity of Daily Living among Post-Stroke Patients Kurniawan Prakoso; Vitriana Vitriana; Anam Ong
Althea Medical Journal Vol 3, No 3 (2016)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Abstract

Background: Cognitive impairment is one of the most common post-stroke complications; however, neither patients nor health professionals are often aware of this complication. The impact of cognitive impairment on quality of life is reflected through basic activity daily living (bADL) and instrumental activity daily living (IADL). Prior studies concerning the correlation between cognitive impairment and activity daily living has shown contradictive results. This study was conducted in order to analyze the correlation between the cognitive functions and activity daily living in post stroke patients at Dr. Hasan Sadikin General Hospital.Methods: This cross-sectional study was carried out to 23 post-stroke patients from September–November 2015. Samples were collected through consecutive sampling at Dr. Hasan Sadikin General Hospital. Mini Mental State Examination (MMSE) was used to assess the cognitive functions and Lawton and Brody Scale to assess both bADL and IADL. Spearman correlation was selected to analyze the existing correlation between each cognitive domain and activity daily living.Results: Spearman statistical correlation showed an insignificant correlation between the cognitive functions and bADL (r2=0.181, p=0.408) and a significant correlation with IADL was obtained (r2=0.517, p=0.03). The only cognitive domain positively correlated with IADL was orientation to time and verbal recall.Conclusions: There is a correlation between cognitive functions and IADL among post-stroke patients at Dr. Hasan Sadikin General Hospital. [AMJ.2016;3(3):329–33] DOI: 10.15850/amj.v3n3.874
Treatment of Rheumatoid Arthritis with Methotrexate Alone or A Combination of Methotrexate and Hydroxychloroquine Natharubini Nadarajah; Riardi Pramudyo; Kuswinarti Kuswinarti
Althea Medical Journal Vol 3, No 3 (2016)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Abstract

Background: Rheumatoid arthritis (RA) is an autoimmune disease that causes significant morbidity in most patients and also premature mortality in some. To prevent this, therapeutic approaches call for the early treatment of RA by using disease-modifying antirheumatic drugs (DMARDSs), either as single therapy or combination therapy. Although in the previous decade DMARDs were rarely used as combination, however now they are used widely to treat RA. The objective of this study was to compare the effectiveness of methotrexate (MTX) alone and the combination of MTX & hydroxychloroquine (HCQ) in RA patients.Methods: An analytic retrospective cohort study was conducted from May 2014 until October 2014, on 46 patients with RA in the rheumatology clinic of Dr. Hasan Sadikin General Hospital Bandung from January 2009−October 2014 who were taking MTX or MTX & HCQ for at least 1 year. The secondary data obtained from these patients’ medical record were then analyzed using the independent t-test and Mann-Whitney test.Results: The study showed that 93.48% of the patients were females. The mean change in disease activity measures were not significant for any of the parameter (p-value for SJC = 0.337; TJC = 0.676; ESR = 0.780). Also the comparisons of the disease activity score (DAS 28) before and after therapy was not significant (p-value = 0.584).Conclusion: There is no difference in the effectiveness of DMARD monotherapy with MTX and combination therapy with MTX & HCQ in RA patients.DOI: 10.15850/amj.v3n3.474
Antipyretic Effect of Cinnamomum burmannii (Nees & T.Nees) Blume Infusion in Fever-induced Rat Models Qatrunnada Zaino; Eva M. Hidayat; Stanza Uga Peryoga
Althea Medical Journal Vol 1, No 2 (2014)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Abstract

Background: Fever is a frequent clinical sign encountered in human especially in children. Unfortunately, access to health care and medications (antipyretics) are hampered by shortage of services and affordability, which are accentuated by local resources mainly for those living in remote areas. Therefore, using herbal medicineas an alternative in treating fever should be developed as substituent reliance on synthetic antipyretic. This study is conducted to observe antipyretic effect of Cinnamomum burmannii (Nees & T.Nees) Blume infusion using Diphtheria Tetanus Pertussis (DTP) vaccine-induced fever in rats.Methods: Twenty-eight male Wistar rats (150200 g) were randomly allocated into control and treatment groups. Fever was induced with DTP vaccine intramuscularly injected (0.7 mL/200 g body weight) and 4 hours later, distilled water (5 mL) was administered orally to the control group while the treatment group received 5 mL of 3%, 6%, and 12% of cinnamon infusion. Rectal temperature was measured before the pretreatment, 4 hours afterDTP vaccine-induced fever injection and at a 30-minute interval during 180 minutes after the infusion administration. All procedures and protocols were performed in October 2012 at the Pharmacology Laboratory, Faculty of Medicine, Universitas Padjadjaran, Bandung.Results: Data analysis using the one way analysis of variance (ANOVA) showed significant reduction (p<0.001) of rectal temperature after 30 minutes and Duncan Post-Hoc test showed significant effect for  6% and 12% of cinnamon infusion groups.Conclusion The antipyretic effect of 6% and 12% of Cinnamomum burmannii (Nees & T.Nees) Blume infusion in fever-induced rat models is found in the first 30 minutes.Key words: Antipyretic, Cinnamomum burmannii (Nees & T.Nees) Blume, fever, herbal medicine Efek Antipiretik Infusa Cinnamomum burmannii (Nees & T.Nees) Blume pada Tikus yang Diinduksi Demam AbstrakLatar belakang: Demam merupakan suatu gejala yang sering muncul terutama pada anak-anak. Antipiretik merupakan obat yang sering digunakan untuk meringankan demam, namun akses kepada pelayanan kesehatan dan pengobatan masih belum terjangkau bagi penduduk yang tinggal di daerah terpencil. Menggunakan herbal sebagai alternatif pengobatan demam harus dikembangkan sebagai substituen terhadap ketergantungan pada obat sintetik. Penelitian ini dilakukan dengan tujuan untuk mengetahui efek antipiretik infusa Cinnamomum burmannii (Nees & T.Nees) Blume pada tikus yang diinduksi demam menggunakan vaksin Diphtheria Tetanus Pertussis (DTP).Metode: Penelitian yang dilakukan menggunakan 28 ekor tikus putih jantan galur Wistar yang dikelompokkan secara acak dan diinjeksi dengan vaksin DTP (0.7 mL/200 g BB) secara intramuskular untuk menimbulkan demam. Setelah 4 jam, kelompok kontrol diberikan 5mL air suling per oral dan kelompok uji diberikan infusa Cinnamomum burmannii (Nees & T.Nees) Blume per oral dengan dosis masing-masing 3%/5 mL, 6%/5 mL dan 12%/5 mL. Pengukuran suhu tubuh dilakukan melalui rektal sebelum pemberian vaksin DTP, 4 jam setelah pemberian vaksin DTP dan 30 menit interval setelah perlakuan sampai menit 180. Semua prosedur dan protokol dilaksanakan pada Oktober 2012 di Laboratorium Farmakologi, Fakultas Kedokteran, Universitas Padjadjaran, Bandung.Hasil: Hasil analisis data menggunakan uji ANOVA menunjukkan penurunan yang signifikan (p<0.001) dari suhu rektal pada menit 30 dan dengan uji Duncan Post-Hoc menunjukkan efek yang signifikan pada kelompok yang diberikan 6%/5 ml dan 12%/5 mL infusa Cinnamomum burmannii (Nees & T.Nees) Blume. Pada menit 60–180 tidak ada penurunan yang signifikan (p>0.05) dari suhu rektal, dimungkinkan karena durasi kerja yang singkat dari Cinnamomum burmannii (Nees & T.Nees) Blume.Simpulan: Efek antipiretik pada pemberian dosis 6% dan 12% infusa Cinnamomum burmannii (Nees & T.Nees) Blume pada tikus yang diinduksi demam ditemukan pada 30 menit pertama.Kata kunci: Antipiretik, Cinnamomum burmannii (Nees & T.Nees) Blume, demam, pengobatan herbal DOI: 10.15850/amj.v1n2.352
Characteristics of Thyroiditis Patients in Dr. Hasan Sadikin General Hospital in 2009–2013 Sri Maryanti; Hasrayati Agustina; Mifatuhrachman Mifatuhrachman
Althea Medical Journal Vol 3, No 1 (2016)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Abstract

Background: It is reported that thyroid diseases affect around 200 milion people in the world. One of them is thyroiditis that may cause the risk of cancer. Moreover, thyroiditis can also cause hormonal disorders, such as hypothyroid and hyperthyroid. It is assumed that thyroiditis has distinctive clinical characteristics. The aim of this study was to evaluate the characteristics of thyroiditis based on age, gender, location, and clinical features of the patient.Methods: The study was conducted using descriptive-retrospective method. The data were collected from patients’ medical records through total sampling from January 2009 to Desember 2013 in Dr. Hasan Sadikin General Hospital, Bandung.Results: It was found 35 cases of thyroiditis. Based on the histopathological type, the most frequently found thyroiditis was Hashimoto’s thyroiditis. Based on age, thyroiditis mostly affected people at age 41–60 years old. Based on the gender, thyroiditis mostly affected female and the location of lesions were bilateral. The majority clinical features of patients were hypothyroid in Hashimoto’s thyroiditis, hyperthyroid in acute thyroiditis, and normothyroid in sub-acute granulomatous thyroiditis.Conclusions: Based on age, gender, and the location, the majority type of thyroiditis did not show specific characteristics. However, thyroiditis showed specific characteristics based on the clinical features of patient. [AMJ.2016;3(1):49–53]DOI: 10.15850/amj.v3n1.701
Motoric Clinical Symptoms in Late Onset Parkinson’s Disease at Dr. Hasan Sadikin General Hospital Bandung Jasvinee Sivakurunathan; Thamrin Syamsudin; Haryono Tansah
Althea Medical Journal Vol 4, No 1 (2017)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Abstract

Background: Parkinson’s disease (PD) is a progressive neurological that disorder is characterized by a number of motoric symptoms which are resting tremor, bradykinesia, rigidity and postural disturbance. The main aim in carrying out this study was to observe the motoric clinical pattern in patients with late onset Parkinson’s disease based on age, gender, and staging of the disease.Methods: This was a descriptive retrospective study to 89 medical record of patients with late onset Parkinson’s disease from Neurology outpatient clinic of Dr. Hasan Sadikin General Hospital Bandung in the period January 2010 to January 2013. Total sampling was used to determine the population sample size The motoric clinical symptoms in patients with late onset Parkinson’s disease were classified based on age at diagnosis, gender, and staging of the disease conducted using descriptive retrospective method. Besides, staging was made based on Hoehn and Yarl scale.Results: Overall, 92% of the patients with late onset Parkinson’s disease had resting tremor, and postural instability was less frequently found in 21% of patients. Sixty one men suffered from this disease, 43% were from the age group 60–69, and 32% were in stage III.Conclusions: A majority of patients with the late onset Parkinson’s disease show resting tremor that has the common motoric clinical pattern, followed by bradykinesia, rigidity, and some show postural instability. [AMJ.2017;4(1):11–5]DOI: 10.15850/amj.v4n1.1013

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