Althea Medical Journal
Althea Medical Journal (AMJ) is a peer reviewed electronic scientific publication journal which is published every 3 months (March, June, September, and December). Althea Medical Journal publishes articles related to research in biomedical sciences, clinical medicine, family-community medicine, and public health.
Articles
1,068 Documents
<![CDATA[Spinach Effects (Amaranthus hybridus) on Spatial Memory ]]>
<![CDATA[Intan Leonita]]>;
<![CDATA[Novi Vicahyani Utami]]>;
<![CDATA[Yusuf Wibisono]]>
<![CDATA[ Althea Medical Journal Vol 2, No 1 (2015) ]]>
Publisher : <![CDATA[Faculty of Medicine Universitas Padjadjaran ]]>
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<![CDATA[ Background: Spatial memory reduction in elderly is predicted to increase up to twice every 20 years. Spinach (Amaranthus hybridus) is widely consumed by Indonesian people and is believed to prevent declined spatial memory function. The aim of this study was to determine the effects of spinach on spatial memory in wistar rat induced by diazepam Methods: An experimental study was conducted during the period of October to November 2012 in Pharmacology and Therapy Laboratory, Faculty of Medicine, Universitas Padjadjaran. Twenty five wistar rats were divided into 5 groups; two groups as controls, and 3 groups were given 100, 200, and 400mg/kg BW ethanolic extract of spinach (EESL), respectively. On day 7, group 3, 4, and 5 were given 1 mg/kg BW diazepam injection. Morris water maze tests and calculations of escape latency time (ELT) were performed on day 7 and 8. Data were analyzed using analysis of variance (ANOVA) and least significance difference (LSD) test. Results: On day 7, group 2 experienced acceleration in ELT compared to group 4 and group 5. On day 8, group 2 experienced acceleration in ELT compared to group 3 and group 4. There was no significant increase in spatial memory in group 5 (EESL 400mg/kg BW) that due to the use of higher dosage does not always show better results. Conclusions: EESL can prevent impairment of spatial memory with an effective dose of 200 mg/kg BW.Keywords: Amaranthus hybridus, diazepam, spatial memory, spinach DOI: 10.15850/amj.v2n1.439 ]]>
<![CDATA[Anesthesia Technique Selection Pattern in Patients Undergoing Lower Extremities Surgery at Dr. Hasan Sadikin General Hospital from January–June 2013 ]]>
<![CDATA[Keshina Amalia Mivina Mudia]]>;
<![CDATA[Ezra Oktaliansah]]>;
<![CDATA[Ihrul Prianza Prajitno]]>
<![CDATA[ Althea Medical Journal Vol 3, No 1 (2016) ]]>
Publisher : <![CDATA[Faculty of Medicine Universitas Padjadjaran ]]>
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<![CDATA[Background: Musculoskeletal problems of the lower extremities are becoming more frequent lately. This problem usually requires surgery to be dealt quickly . The role of the anesthesiologist is needed to determine which anesthesia technique that has to be performed. Selection of proper anesthesia technique can reduce the incidence of complications . Objective of this study was to determine anesthesia technique selection pattern in patients undergoing orthopedic surgery at Dr. Hasan Sadikin General Hospital from January–June 2013.Methods: A quantitative study with retrospective descriptive method was conducted. This study was carried out from September–October 2013 at Dr. Hasan Sadikin General Hospital Bandung. Medical records were used as a research instrument. Data collection was conducted using total sampling method. There were 228 data of all cases, but only 151 patients who met the inclusion and exclusion criteria.Results: One hundred fifty one patients were identified. Sixty five subjects (43%) were performed under general anesthesia, 83 subjects (55%) under regional anesthesia and 3 subjects (2%) under combination of general-regional anesthesia. Regional anesthesia techniques consisted of spinal anesthesia (29%), epidural anesthesia (64%), combination of spinal-epidural anesthesia (5%), and peripheral nerve block (2%). Conclusions: Regional anesthesia is the most frequently technique used in lower extremities orthopedic surgery, with epidural anesthesia as the most common regional technique used because of all the benefits. [AMJ.2016;3(1):141–6] DOI: 10.15850/amj.v3n1.717]]>
<![CDATA[Factors Related to Malnutrition in Children Under Five Years with Congenital Heart Disease ]]>
<![CDATA[Amani Sakinah Augiani]]>;
<![CDATA[Sri Endah Rahayuningsih]]>;
<![CDATA[Dewi Marhaeni Diah Herawati]]>
<![CDATA[ Althea Medical Journal Vol 4, No 1 (2017) ]]>
Publisher : <![CDATA[Faculty of Medicine Universitas Padjadjaran ]]>
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<![CDATA[Background: Congenital heart disease (CHD) is the most frequent type of heart disease that occurs in children. Children with CHD are more vulnerable to suffer impaired nutritional status related to morbidity and mortality. The nutritional status, however, may not be influenced only by CHD, but also by other factors.. The study was conducted to identify factors related to malnutrition in children with CHDMethods: This cross-sectional study involved 86 children with CHD recruited from Dr. Hasan Sadikin General Hospital Bandung from October to November 2015. Data collected in this study were obtained by conducting anthropometric measurements, interviewed the parents (obstetric history, patient’s medical history and socioeonomic status) and from medical records (the type and time of CHD diagnosis, other diseases that accompanied the CHD). The collected data were presented by frequency distribution. Results: There were 46.5% patients who had nutritional disturbance. Malnutrition in males and patients with Tetralogy of Fallot were higher than other groups. Almost half patients with maternal history of passive smoking during pregnancy had nutritional disturbance. The most common disease found was diarrhea followed by lower respiratory infection. Percentage of normal children in low-income parents group was lower than the high-income group. Conclusions: Nearly half of patients have nutritional disturbance. Percentage of nutritional disturbance in male was higher compared to female. Active and passive smokers, Tetralogi Fallot, diarrhea, lower respiratory infection and lower income were factors contributed to malnutrition. [AMJ.2017;4(1):111–7]DOI: 10.15850/amj.v4n1.1031]]>
<![CDATA[Generalized Seizure Due To Acute Hyperosmolar Hyponatremıa Followıng Coronary Angıography: A Lesson Learned From A Case Report ]]>
<![CDATA[Mehmet Coᶊgun]]>;
<![CDATA[Yilmaz Gunes]]>;
<![CDATA[Isa Sincer]]>;
<![CDATA[Aslı Mansiroglu]]>;
<![CDATA[Oğuz Kayabaᶊi]]>
<![CDATA[ Althea Medical Journal Vol 6, No 1 (2019) ]]>
Publisher : <![CDATA[Faculty of Medicine Universitas Padjadjaran ]]>
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DOI: 10.15850/amj.v6n1.1356
<![CDATA[Hyponatremia is a common electrolyte disorder, but symptomatic hyponatremia following coronary angiography is rare. Although patients with hyponatremia are generally asymptomatic, neurological manifestations may result in lethal complications.Here we presented a 69-year-old female, admitted for elective coronary angiography due to exertional chest pain. Seven hours later after coronary angiography, however, the patient had a headache, temporary mental confusion and her speech was slurring. A brain magnetic resonance imaging (MRI) test, arterial blood gas analysis, and the neurological examination were carried out. The neurological examination showed no focality and brain diffusion MRI was normal. Arterial blood gas analysis revealed sodium of 110 mmol/L and potassium of2.8 mmol/L. The patient was treated with hypertonic saline (3% NaCl) and vasopressin antagonist tolvaptan 15 mg at first and isotonic saline (0,09 NaCl) with a gradual normalization of electrolytes. Diagnosis of acute hyperosmolar hyponatremia should be considered in patients with developing mental or behavioral abnormalities following coronary angiography.]]>
<![CDATA[The Teratogenic Effect of The Mindi (Melia azedarach L) Leaves Ethanol Extract on Mice (Mus musculus) Fetus ]]>
<![CDATA[Adisti Erlina Sutomo]]>;
<![CDATA[Trully D. Sitorus]]>;
<![CDATA[Adhi Pribadi]]>
<![CDATA[ Althea Medical Journal Vol 2, No 2 (2015) ]]>
Publisher : <![CDATA[Faculty of Medicine Universitas Padjadjaran ]]>
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<![CDATA[Background: Mindi leaves (Melia azeradach L.) were used by Indonesians as a traditional medicine for pregnant women because it was considered to be safe. Mindi leaves contain several active compounds and one of them is suspected as a teratogen and can disrupt fetus growth in gestation. This research aims to know about the teratogenic effect of ethanol extract of Mindi leaves by using mice.Methods: This was a laboratory experimental study using 27 pregnant female mice (Mus musculus) of Swiss Webster strain which were randomly assigned to 3 groups (n=9) controlled (Carboxymethyl cellulose 1% for day 1–18 of pregnancy), group I (mindi leaves ethanol extract 3.22 mg+Carboxymethyl cellulose 1% day 1–5 of pregnancy), and group II (mindi leaves ethanol extract 3.22 mg+Carboxymethyl cellulose 1% day 6–18 of pregnancy). Observation was done to see total amount of fetus, live normal fetus count, length and weight of fetus, abnormal fetus count consisting of dead fetus count with normal and abnormal external morphology, and resorbed fetus count. This research was done from October to November 2012 in Pharmacological laboratory of Faculty of Medicine Universitas Padjajdjaran. Data analysis utilized unpaired t-test.Results: The result showed a significant difference (p<0.05), seen from live normal fetus count and abnormal fetus count consisting of dead fetus count with normal and abnormal external morphology, and resorpted fetus count. Conclusions: Administration of Mindi leaves extract during pregnancy of mices can cause teratogenic effect.[AMJ.2015;2(1):221–25]]]>
<![CDATA[Dermatophytosis among Elementary School Students in Jatinangor West Java ]]>
<![CDATA[Dwi Bandang Saskia]]>;
<![CDATA[Lies Marlysa Ramali]]>;
<![CDATA[Ramlan Sadeli]]>
<![CDATA[ Althea Medical Journal Vol 3, No 2 (2016) ]]>
Publisher : <![CDATA[Faculty of Medicine Universitas Padjadjaran ]]>
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<![CDATA[Background: Dermatophytosis is a common skin disease in tropical countries. In Indonesia, the incidence of dermatophytosis is quite high. Epidemiological studies showed that prevalence of dermatophytosis in children were higher than in adults. The aim of this study was to identify dermatophytosis cases among elementary school students in Jatinangor West Java.Methods: A descriptive study was carried out, involving 391 students aged 6–16 years from four elementary schools in Jatinangor West Java, who were selected by multi-stage sampling method. Six classes were chosen from each school. In every class, students were chosen to obtain the minimum number of samples. The inclusion criteria was elementary school students who were willing to participate in this study. The exclusion criteria were students who did not attend school at the time when the study wasperformed. The study’s procedure consisted of six steps i.e. preparation, interview, screening, physical examination, specimen collection and microscopic examination. The collected data was processed by calculating the frequency and percentage.Results: The study discovered that out of 391 students, 197 suffered from non specific skin lesions. After confirmed by a dermatologist, three students were suspected to have dematophytosis lesion. From microscopical examinations by a microbiologist, two students had positive dermatophyte hyphae. The number of dermatophytosis cases in elementary school students, in Jatinangor was 0.5% (2/391).Conclusions: The incidence of dermatophytosis cases in this study is relatively low compared with other studies. Clinical features are tinea corporis. Both patients with positive dermatophyte hyphae are ten -year -old females. [AMJ.2016;3(2):165–9]DOI: 10.15850/amj.v3n2.808]]>
<![CDATA[Knowledge, Attitude and Behavior Related to Antibiotic Use in Community Dwellings ]]>
<![CDATA[Rocci Jack Parse]]>;
<![CDATA[Eva Mardiana Hidayat]]>;
<![CDATA[Bachti Alisjahbana]]>
<![CDATA[ Althea Medical Journal Vol 4, No 2 (2017) ]]>
Publisher : <![CDATA[Faculty of Medicine Universitas Padjadjaran ]]>
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DOI: 10.15850/amj.v4n2.1082
<![CDATA[Background: Irrational antibiotic use is the major reason for insidence of antibiotic resistance. Antibiotic misuse in community is influenced by environmental and behavioral factors. Environment included community preference for purchasing antibiotics, lack of health care infrastructure, lack of general practitioner and policy in regulating antibiotic use. Behavior is influenced by lack of information in antibiotic use and unawareness of antibiotic resistancy. The aim of the study was to assess the level of knowledge, attitude and behavior regarding antibiotic use in community dwellings.Methods: A cross sectional descriptive study was carried out to 96 respondents who were selected by a rapid survey sampling method in Cileles village Jatinangor, Sumedang, West Java, Indonesia in August 2013. Data were collected using questionnaires. The data was analyzed in the form of frequency and percentage.Results: Out of 96 respondents, only 40.6% had good knowledge regarding antibiotic use, 12.5% of respondents were prescribed antibiotics, but in the last course did not purchased all the antibiotics prescribed by the clinician and 55.2% of respondents did not complete their treatment course.Conclusions: Most of the community still have poor knowledge regarding antibiotic use and its consequences such as allergy, and resistancy based on the knowledge questions has a total score ≤6. Their attitude and behavior regarding antibiotic use are still poor which is also based on incompletion of the antibiotic treatment and irregular use.DOI: 10.15850/amj.v4n2.1082]]>
<![CDATA[The Protective Effect of Field Mint Leaves in Reducing Stomach Ulcer in Rats Induced by Aspirin ]]>
<![CDATA[Vanitha Ratha Krisnan]]>;
<![CDATA[Januarsih A. Rachman]]>;
<![CDATA[Abdul Hadi Hassan]]>
<![CDATA[ Althea Medical Journal Vol 2, No 3 (2015) ]]>
Publisher : <![CDATA[Faculty of Medicine Universitas Padjadjaran ]]>
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<![CDATA[Background: Stomach mucosal wall erosion is caused by the imbalance of the aggressive factors and mucosal defensive factors due to the common causes such as the side effect of consuming non-steroidal anti-inflammatory drugs. Field mint (Menthaarvensis) leaves have been used as an alternative option to cure and prevent the gastric problems. The aim of this study was to analyze the protective effect of Field mint leaves infusion in reducing stomach ulcer in rats induced by Aspirin.Methods: The experimental study was conducted at Histology Laboratory of Faculty of Medicine, Universitas Padjadjaran, Bandung. Sixteen rats were divided into 4 groups randomly: group I (control negative group), group II (control positive group, given 90mg/day Aspirin, group III (the treatment group, given 5cc of Field mint leaves infusion and 90 mg Aspirin) and group IV (the treatment group, given 5.6µg of Misoprostol and 90 mg Aspirin). Mucosal wall erosions were determined by using microscope. Data were analyzed using non-parametric Kruskal-Wallis test and Mann-Whitney U-test (CI 95% and p-value<0.05)Results: Group II had high score of mucosal wall erosions after given only aspirin. In group III and IV, the score of mucosal wall erosions were low. However there was no difference in score of mucosal wall erosions between group III-IV (p<0.05)Conclusions: Field mint (Menthaarvensis) leaves infusion is able to prevent stomach mucosal wall erosions induced by Aspirin as misoprostol does. DOI: 10.15850/amj.v2n3.496]]>
<![CDATA[Gastroprotective Effect of Carrot (Daucus carota L.) Juice in Rat Models ]]>
<![CDATA[Wong Hui Jiin]]>;
<![CDATA[Eva M. Hidayat]]>;
<![CDATA[Kiki A. Lukman]]>
<![CDATA[ Althea Medical Journal Vol 1, No 1 (2014) ]]>
Publisher : <![CDATA[Faculty of Medicine Universitas Padjadjaran ]]>
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<![CDATA[Background: Gastritis has become one of the very common gastrointestinal tract disorders in clinical practice. One of the factors causing gastritis is the prolonged intake of nonsteroidal anti-inflammatory drugs (NSAIDs) which is commonly adopted by people suffering pain. The NSAIDs such as aspirin cause loss of mucosal integrity resulting in gastric mucosa inflamation. Carrot (Daucus carota L.) has long been used as a traditional medicine for various ailments. The presence of flavonoids and carotenoids in carrot is associated with gastroprotective effect.Methods: The present study was undertaken to determine the gastroprotective effect of 4.08 g carrot juice administered by feeding tube on the hydrochloric acid (HCL) concentration in the stomach in aspirin-induced Wistar-strain rats. This was a laboratory experimental study performed at the Pharmacology Laboratory Faculty of Medicine Universitas Padjadjaran, Bandung Indonesia in October 2012. The parameter used HCL Concentration determined by titration method.Results: The result of carrot juice consumption together with aspirin shows a statistically significant reduction in HCL concentration in the stomach (p<0.05). The result was also significant when compared with another medication, Misoprostol.Conclusion: Carrot juice extract possesses gastroprotective effect when consumed with aspirin and thus support the use of carrot as an alternative treatment. [AMJ.2014;1(1):35–9]Keywords: Aspirin, Carrot juice extract, gastroprotective, HCL concentrationEfek Perlindungan Lambung dengan Jus Wortel (Daucus carota L.) pada TikusLatar belakang: Gastritis merupakan salah satu kelainan pada saluran pencernaan yang sering ditemui. Salah satu penyebab dari gastritis adalah pemakaian nonsteroidal anti-inflammatory drugs (NSAIDs) dalam waktu lama dan biasanya digunakan oleh orang yang menderita sakit. Obat-obatan NSAID seperti aspirin dapat menyebabkan integritas mukosa menghilang dan terjadinya inflamasi pada mukosa lambung. Wortel (Daucus carota L.) merupakan tanaman tradisional yang sudah banyak digunakan untuk berbagai macam penyakit. Flavonoid dan carotenoid yang ada pada wortel memiliki efek perlindungan terhadap lambung. Metode: Penelitian dilakukan untuk menentukan efek perlindungan lambung dengan jus wortel pada konsentrasi HCL dalam lambung tikus yang diinduksi dengan aspirin. Penelitian ini merupakan suatu studi eksperimental yang dilakukan di Laboratorium Farmakologi Fakultas Kedokteran Universitas Padjadjaran, Bandung, Indonesia pada bulan Oktober 2012. Parameter yang digunakan adalah konsentrasi HCL yang ditentukan dengan metode titrasi.Hasil: Hasil dari penggunaan jus wortel bersama dengan aspirin menunjukkan penurunan konsentrasi HCL yang signifikan pada lambung (p<0.05). Hasil ini juga signifikan bila dibandingkan dengan medikasi lain yaitu, Misoprostol.Simpulan: Ekstrak jus wortel memiliki efek perlindungan lambung ketika digunakan dengan aspirin dan hal ini mendukung wortel sebagai pengobatan alternatif.Kata kunci: Aspirin, jus wortel, efek perlindungan lambung, konsentrasi HCL DOI: 10.15850/amj.v1n1.295]]>
<![CDATA[Demographic Profile of Knee Osteoarthritis Patients in a Teaching Hospital West Java, 2013 ]]>
<![CDATA[Tranggana Nugrahaputra]]>;
<![CDATA[Tertianto Prabowo]]>;
<![CDATA[Henny Anggraini Sadeli]]>
<![CDATA[ Althea Medical Journal Vol 2, No 4 (2015) ]]>
Publisher : <![CDATA[Faculty of Medicine Universitas Padjadjaran ]]>
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<![CDATA[Background: Osteoarthritis is the most common degenerative musculoskeletal diseases occur worldwide. It usually affects the weight-bearing joint such as knee and vertebra. Osteoarthritis is influenced by various risk factors. The aim of the study was to identify the demographic profile of knee osteoarthritis patients.Methods: A retrospective descriptive study was performed to 247 medical records of knee osteoarthritis patients who attended to Physical Medicine and Rehabilitation of Dr. Hasan Sadikin General Hospital Bandung in 2013. The inclusion criteria were medical records that consisted of age, sex and occupation of the patients, and payment methods. Exclusion criteria were incomplete of the necessary data mentioned in the inclusion criteria. The study was conducted from August until November 2014. The collected data were analyzed and presented using frequency distribution.Results: From all the patients, 40.9% was 60-69 years old, 77.7% were women and 82.6% were retired patients. Most of the patients had a social health insurance.Conclusions: Majority of patients is 60–69 years old women, retired and has the financial protection. [AMJ.2015;2(4):597–600] DOI: 10.15850/amj.v2n4.468]]>
