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Tsania Faza
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INDONESIA
Medical Journal of Indonesia
Published by Universitas Indonesia
ISSN : 08531773     EISSN : 22528083     DOI : 10.13181
Core Subject : Health,
This quarterly medical journal is an official scientific journal of the Faculty of Medicine Universitas Indonesia in collaboration with German-Indonesian Medical Association (DIGM) Indexed in: IMSEAR; CAB Abstracts; Global Health; HINARI; DOAJ; DRJI; Google Scholar; JournalTOCs; Ulrichsweb Global Serial Directory; WorldCat; New Jour; Electronic Journals Library; ISJD Accredited (2013-2018) by DIKTI Kemendikbud Republik Indonesia (No:58/DIKTI/Kep/2013)
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Articles 1,648 Documents
Incidence of epilepsy among patients with cerebral palsy (CP) in Yayasan Pemeliharaan Anak Cacat (YPAC) – Medan
Medical Journal of Indonesia Vol. 11 No. 3 (2002): July-September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v11i3.69

Abstract

Epilepsy is a chronic condition due to cerebral function disorders. Epilepsy occurs as a common complication of many neurological disorders such as cerebral palsy (CP) that can cause further brain damage if especially they are accompanied with prolonged seizure. The incidence of epilepsy among patients with CP varies, 25-35%. The high incidence of epilepsy among patients with CP suggests that these disorders has common or related origins. We carried out a retrospective study to determine the incidence of epilepsy among patients with CP registered July 1988 to June 1998 in YPAC Medan and to determine whether the incidence of epilepsy was different according to type of CP. Data was compiled from medical records, including name, sex, parity, mothers age, prenatal, perinatal, and postnatal history, and EEG resuts. Data were analysed using statistical computer program and its significance was evaluated by chi square test at p < 0.05. There were 67 cases with CP, 53 cases spastic CP, 13 cases mixed CP and one case dyskinetic CP. Of the 67 cases CP, 47.8% were male, 52.2% female with the mean age of 50.3 (SD 36.9) months. There were 25 (37.3%) patients CP associated with epilepsy, 72% general seizures, 20% partial seizures, and 8% infantile spasm. The incidence of epilepsy was significantly different among patients with CP associated with the type of CP and gestational age, p < 0.05. We concluded that the incidence of epilepsy among patient with CP in YPAC Medan was 37.3% and showed significant difference in CP according to type and gestational age. (Med J Indones 2002; 11: 158-63) Keywords: epilepsy, cerebral palsy, obstetric history, gestational age
Nasopharyngeal bacterial carriage and antimicrobial resistance in underfive children with community acquired pneumonia
Medical Journal of Indonesia Vol. 11 No. 3 (2002): July-September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v11i3.70

Abstract

Pathogens in nasopharynx is a significant risk factor of pneumonia. According to WHO, isolates to be tested for antimicrobial resistance in the community should be obtained from nasopharyngeal (NP) swabs. The aim of this study is to know the bacterial patterns of the nasopharynx and cotrimoxazole resistance in under five-year old children with community acquired pneumonia. The study was carried out in 4 primary health clinic (Puskesmas) in Majalaya sub-district, Bandung, West Java, Indonesia. All underfive children with cough and/or difficult breathing and classified as having non-severe pneumonia (WHO guidelines) were placed in Amies transport medium and stored in a sterile jar, before taken to the laboratory for further examination, in the same day. During this nine month study, 698 children with clinical signs of non-severe pneumonia were enrolled. About 25.4% (177/698) of the nasopharyngeal specimens yielded bacterial isolates; i.e. 120 (67.8%) were positive for S pneumoniae, 21 for S epidermidis and alpha streptococcus, 6 for Hafnia alvei, 5 for S aureus, 2 for B catarrhalis, and 1(0.6%) for H influenza and Klebsiella, respectively. The antimicrobial resistance test to cotrimoxazole showed that 48.2% of S pneumoniae strain had full resistance and 32.7% showed intermediate resistance to cotrimoxazole. This result is almost similar to the other studies from Asian countries. It seems that H influenza is not a problem in the study area, however, a further study is needed. (Med J Indones 2002; 11: 164-8) Keywords: nasopharyngeal swab, S pneumoniae, cotrimoxazole
Diseases of the small bowel in chronic diarrhea: diagnosis and treatment
Medical Journal of Indonesia Vol. 11 No. 3 (2002): July-September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v11i3.71

Abstract

The incidence of chronic diarrhea in Asia is between 0.8-1.0%. The diseases and abnormalities according to the location, which can cause chronic diarrhea, are divided into three locations: the small bowel, the large bowel and extraintestinal. The small bowel diseases include infectious and non-infectious diseases. The infectious diseases are bacterial infections, parasitic infections etc. The non-infectious diseases include of Crohn’s disease, Celiac sprue, NSAID enteropathy, lactose intolerance, benign tumor, carcinoid tumor, carcinoma, post surgery complications, laxative etc. The approaches to diagnosis include good anamnesis, careful physical examination, supporting laboratory tests, more specialized supporting examinations including X-ray of the colon, esophagogastroduodenum follow-through, enteroclysis, ileo-colonoscopy and endoscopy on the upper portion of the digestive tract including the small intestine with biopsy for histopathology examinations. The treatment for chronic diarrhea is divided into supportive and causal therapy. (Med J Indones 2002; 11: 179-89) Keywords: small bowel, chronic diarrhea, approaches to diagnosis, treatment
Tuberculosis of the future
Medical Journal of Indonesia Vol. 11 No. 3 (2002): July-September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v11i3.72

Abstract

Beginning and during the 20th century there were several milestones in TB control, including the development of vaccine and chemotherapy. But, as we enter the 21th century, TB continue be a global public health problem and if there is no improvement in TB control, the number of new TB cases is projected to rise to 11 million by 2020. Problems faced include inability to deliver / assure chemotherapy, deficient case finding, inadequate vaccine, rising level of drug resistance, failure to employ preventive chemotherapy and migration, HIV epidemics and nosocomial transmission. As far as recent advances in TB diagnostics, there is a need to find a tool for identification of latent infection, detection of diseases in migrant and other high risk populations, replace or facilitate AFB microscopy, improve the diagnosis of AFB smear-negative cases, and simple tools for determining drugs susceptibility. New diagnostic technologies includes nucleic acid probes, amplification tests, high performances liquid chromatography (HPLC), gas / liquid chromatography (GLC), and automated system for radiometric and non radiometric detection and molecular fingerprinting approach. In the coming years new drugs are needed, especially to shorten the duration of TB treatment or otherwise simplify its completion, improve the treatment of latent TB infection and to be eliminate. MDR-TB. There are some problems in pursue tuberculosis research because of the high investment required to bring a product to market and lack of likely commercial returns. Some new drugs and molecules with promising antimycobacterial activity include Fluoroquinolone, Oxazolidinones, Nitroimidazole, Thiolactomycine, Nitroimidazopyran and Isocitrate lyase inhibitor. To deliver good case finding and treatment, effective TB control program should be implemented in the country, as well as globally. The integration of TB control program with tobacco control program and chronic respiratory diseases control program could be one of the alternative. (Med J Indones 2002; 11: 190-4) Keywords: tuberculosis, future and recent advances
Lowering blood pressure effect of Apium graviolens (seledri) and Orthosipleon stamineus benth (kumis kucing) in mild and moderate hypertension
Medical Journal of Indonesia Vol. 11 No. 4 (2002): October-December
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v11i4.73

Abstract

In Indonesia Apium graviolens and Orthosiphon stamineus benth have been used to as traditional medicines to lower blood pressure. Since at present time is avaiLable as a combination of those phytopharmaca in the market, therefore, it is necessary to conduct a study to evaLtnte the ffictivity and side effects of those phytopharmaca toward hypertensive subjects. A randomized double blind conftolled trial was conducted at area of Monica - Jakarta in South of Jalarta from July-untiL 29 October 2001 toward mild and moderate hypertensive subjects. The first group (72 subjects) received phytophanmaca (Tensigard® which contains Apium graviolens and Orthosiphon stamineus benth) 3 x 250 mg, whiLe the second grottp (70 subjects) had Amlodipine I x 5 mg. Obseruation were conducted for 12 weelcs, and the parameter observed wère systolic and diastolic blood pressure (SBP and DBP), plasma lipid, blood glucose before and after treatment, and electrolyte with nvo week intervals. The Resuhs revealed that the phytopharmaca treatment for 12 weel<s lowered SBP and DBP equivalent to Amlodipine (SBP 24.72 t 1.63 mm4g vs 26.27 + 2.18 mmHg; P > 0,05; DBP 10.00 t0.96 mmHg vs 9.49 t 1.37 ntmHg; P> 0.05). Phytopharmaca treatment for 12 weel<s did not influence plasma eLectolyte, as well blood glucose Levels. There was not asignificant side effects noted for both phytopharmaca and Amlodipine during the study period. [n conclusion, the trial reveals that the phytophnrmaca lowered systolic and diastolic blood pressure equivalent with Amlodipine among mild and moderate hypertensive subjects. During the study period there was not a significant side effect noted. (Med J Indones 2002; 11: 195-201)Keywords: blood pressure, phytopharmaca, side effect, plasma electrolytes
Comparative study between aspirin to acenocoumarol in regressing spontaneous echo contrast in mitral stenosis
Medical Journal of Indonesia Vol. 11 No. 4 (2002): October-December
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v11i4.74

Abstract

Mitral stenosis is one of the most often valvular disease in Division of Cardiology, M. Hoesin hospital, Palembang, and there was strong evidence of thromboembolic phenomenon in mitral stenosis (MS) patients. Many studies evaluated the spontaneous echo contrast (SEC) that was regarded as a precursor of thrombo embolic phenomenon. So far there were controversies regarding how to regress spontaneous echo contrast. A randomized double blind controlled study was done on 22 MS patients with positive SEC, receiving either aspirin 100 mg or acenocoumarol 1 mg and followed up after 4 weeks. There was 100 % regression of SEC in acenocoumarol group that consisted of 40% regression from severe SEC to mild, and 60% complete resolution. In aspirin group there was no resolution of SEC. In acenocoumarol group, 2 of 4 thrombus totally disappeared while the rest was reduced in size. On the other hand, in aspirin group, after 4 weeks, the patients with thrombus was increased from 3 to 4 patients. In conclusion, four week therapy with acenocoumarol 1 mg is effective and save in regressing spontaneous echo contrast and thrombus in mitral stenosis patients without any significant change in hemodynamics. (Med J Indones 2002; 11: 202-7)Keywords: thrombus, thromboembolic phenomenon, transthoracal, esophageal, echocardiography
Double blind, placebo-controlled trial of Tranexamic acid on recent internal hemorrhoid bleeding
Medical Journal of Indonesia Vol. 11 No. 4 (2002): October-December
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v11i4.75

Abstract

Double blind randomized placebo controlled trial was conducted to evaluate the efficacy of Tranexamic acid in 54 patients with recent hemorrhoid bleeding. Age, gender, body weight, height, grade of hemorrhoid, time of onset of recent bleeding were comparable between two groups. Analysis of haemostatic effect or stop bleeding as an immediate outcome of this study revealed that in the grade 2 patients, 23/23 (100%) of tranexamic group and 18/23(78.26%) of placebo group the bleeding stop. After 3 days of observation, there was statistically significant different for the rate of stop bleeding as well as at the end of observation. Bleeding stop earlier in the Tranexamic group with median 4 days (3-5 days), compare to placebo, median 11(9.55-12.45). Analysis of recurrent bleeding as an outcome of this study revealed that in the placebo group 9/18(50%) of grade 2 patients and all grade 3 (100%)patients suffered from recurrent bleeding. Since the days 4, both group have significant different time for recurrent bleeding and at the end of observation, cumulative probability of free of bleeding between two groups significantly different. Median still stop bleeding in the placebo group was 36 days, and the tranexamic group never reaches the median until the end of observation. Conclusion: tranexamic acid was an effective drug to stop recent hemorrhoid bleeding and prevent further recurrent bleeding, significantly better than placebo. (Med J Indones 2002;11: 215-21)Keywords: Tranexamic acid, hemorrhoid bleeding, haemostatic effect, recurrent bleeding.
Effect of smoking on Pulse Wave Velocity in different arterial segments
Medical Journal of Indonesia Vol. 11 No. 4 (2002): October-December
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v11i4.76

Abstract

Pulse wave velocity (PWV) was recorded in different arterial segments in 25 male nonsmokers and compared with age and sex matched smokers before and after smoking. Blood pressure (BP), Heart rate (HR) and PWV were comparable between nonsmokers and smokers before smoking. Just after cigarette smoking there was rise in HR, BP and PWV in Aorta to Radial (Ao-Rad), and femoral to Dorsalis Pedis (Fem-Dp) arterial segments, but the PWV was reduced in Aorta to Femoral (Ao-Fem) arterial segment, indicating that both peripheral and central arterial segments show different response to smoking. (Med J Indones 2002; 11: 207-10)Keywords: smoking, pulse wave velocity
Survival of borderline tumors of the ovary and its prognostic factors at Dr. Cipto Mangunkusumo hospital from 1990 to 1999
Medical Journal of Indonesia Vol. 11 No. 4 (2002): October-December
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v11i4.77

Abstract

Sixty-two patients with borderline tumors of ovary were historical cohort analyzed for survival characteristics. There were 9 patients with FIGO stage IA, 9 with stage IC, 3 with stage IIIA, 2 with stage IIIB, 4 with stage IIIC, 1 with stage IV and 34 with inadequate stage tumors. Twenty one patients had surgical staging with radical surgery, 10 patient had at least a total abdominal hysterectomy and bilateral salpingo-oophorectomy, 6 patient had surgical staging with conservative surgery, 24 patient had at least a unilateral salphingo-oophorectomy or ovarian cystectomy and 1 patient had biopsy. Sixteen patients received cisplatin-based combination chemotherapy, that were 8 with inadequate stage tumors, 7 with stage III tumors and 1 with stage IV tumor. Follow-up range from 0.02 to 10.48 years, with a median of 3.5 years. Fifty nine patient were alive. Three patients died, all of disease. Recurrence were found in 4 patients. The overall 2-years survival rate was 96% and 10-years survival rate was 94%. In log rank test, residual disease and histology type were significant predictor of survival. (Med J Indones 2002; 11:222-9)Keywords: borderline tumors of ovary, survival
The influence of smoking cessation, regular physical exercise and/or physical activity on survival: a 13 years cohort study of the Indonesian population in Jakarta
Medical Journal of Indonesia Vol. 11 No. 4 (2002): October-December
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v11i4.78

Abstract

Preventing atherosclerosis with smoking cessation, regular physical exercise and/or physical activity known as SOK (S-top/ no S-moking, sp-O-rt/ physical exercise, wor-K/ physical activity) is a simple preventive measure, which can be applied in the community. To determine the role of SOK on survival, to create cardiovascular risk score for Indonesian patients and to have a special formula to predict survival. A historical cohort study over thirteen years recruited from the subpopulation MONICA patients who resided at three districts of South Jakarta. Patients were divided into two groups, those with SOK and those without (non-SOK group). Assessment included complete history including cardiovascular risk factors (hypertension, diabetic, hyperlipidemia, obesity), physical examination, laboratory examination, twelve-lead ECG recording and level of physical activity/exercise. Outcomes included survival rate and all-cause of mortality. Statistical analysis included kappa statistic and various survival analyses. 479 participants were included in the SOK study. Mean age 46 years (range 25-64), 56% female. Cardiovascular mortality rate (including stroke) was 1.2% per year and 42.9% of mortality caused by heart disease. Survival rate was higher in SOK group compared with non-SOK (95.7% vs 81.1%) with Hazard Ratio (HR) 0.2 for SOK group (95% CI 0.08-0.57, p=0.002) In relation to the cardiovascular mortality rate: 1) any physical activity/exercise (OK) vs no-OK will lower the risk; low-OK (HR 0.4, p=0.003), medium-OK (HR 0.32, p=0.004), high-OK (HR 0.000, p=0.000) 2) Smoking will increase the risk vs non-smoking (HR 4.99, p=0,000). For predicting the cardiovascular events in ten-year time (CV10), we formulated the Jakarta Cardiovascular Score. The score was divided into low-risk (-7-1) with CV10 <10%, average-risk (2-4) with CV10 = 10-20%, high-risk (score > 5) with CV10 >20%. Smoking cessation, regular physical exercise and/or physical activity is an effective method to reduce cardiovascular death, thus enhances the survival. We formulated a simple method to predict cardiovascular events in our community known as the Jakarta Cardiovascular Score. (Med J Indones 2002; 11: 230-41)Keywords: smoking, physical activity, survival, Jakarta cardiovascular score.

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