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Contact Name
Tsania Faza
Contact Email
-
Phone
08111400115
Journal Mail Official
mji@ui.ac.id
Editorial Address
Education Tower 6th floor, IMERI building, Faculty of Medicine Universitas Indonesia, Jalan Salemba Raya 6, Jakarta, 10430, Indonesia
Location
Kota depok,
Jawa barat
INDONESIA
Medical Journal of Indonesia
Published by Universitas Indonesia
ISSN : 08531773     EISSN : 22528083     DOI : 10.13181
Core Subject : Health,
This quarterly medical journal is an official scientific journal of the Faculty of Medicine Universitas Indonesia in collaboration with German-Indonesian Medical Association (DIGM) Indexed in: IMSEAR; CAB Abstracts; Global Health; HINARI; DOAJ; DRJI; Google Scholar; JournalTOCs; Ulrichsweb Global Serial Directory; WorldCat; New Jour; Electronic Journals Library; ISJD Accredited (2013-2018) by DIKTI Kemendikbud Republik Indonesia (No:58/DIKTI/Kep/2013)
Arjuna Subject : -
Articles 1,648 Documents
The patterns of breast-feeding and their effect on the time of resumption of menses
Medical Journal of Indonesia Vol. 11 No. 2 (2002): April-June
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v11i2.59

Abstract

The percentage of mother who had full/exclusive breast-feeding for four months after birth are 50%, and only less than 15% continued full/exclusive breast-feeding for up to the first six months afier birth. The mean duration of full/exclusive breast-feeding is 3.3 months. The median time of the resumption of menses in this study is 186 days (CI: 177-195 days). The median time of resumption of menses significantly associated with both the mean duration of full/exclusive breast-feeding and the average suckling frequency. The longer the mean duration of full/exclusive breast-feeding and the more the average of suckling frequency, the longer the median time of resumption of menses. The median time of resumption of menses in respondent who practiced full/exclusive breast-feeding up to three and more than three months are 149 (CI: 121-177) and 199 (CI: 186-212) days, respectively. And in the mothers who breast fed their infant for up to six times and more than 6 times per day the median time of resumption of menses are 125 (CI: 90-160) and 191 (CI: 181-201) days, respectively. (Med J Indones 2002; 11: 106-19)Keywords : breastfeeding, lactational amenorrhoea, resumption of menses
Phytoestrogens' beneficial effects on cardiovascular system
Medical Journal of Indonesia Vol. 11 No. 2 (2002): April-June
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v11i2.60

Abstract

Several lines of evidence, including epidemiological, clinical trial and basic science, suggest the plausability of a causal, inverse relationship between phytoestrogens and cardiovascular disease. Phytoestrogens are naturally occurring plant compounds that have 2-phenylnaphthalene-type chemical structures similar to those of estrogens. they are simply divided into three main classes, isoflavones, lignans, and coumestans. The majority of phytoestrogens found in typical human diets are the isoflavones and lignans. This review provides an overview of the potential sources and bio-availability of the phytoestrogens particularly isoflavones, and discusses their beneficial effects on cardiovascular system, i.e. on atherosclerosis, hypercholestrolemia, arterial compliance, and blood pressure. (Med J Indones 2002; 11: 120-3)Keywords: atherosclerosis, hypercholestrolemia, arterial compliance, blood pressure
Sick building syndrome
Medical Journal of Indonesia Vol. 11 No. 2 (2002): April-June
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v11i2.61

Abstract

Sick building syndrome describes a number of mostly unspesific complaints of some occupants of the building. The exact pathophysiological mechanism remains elusive. It is a multi factorial event which may include physical, chemical, biological as well as psycological factors. In many cases it is due to insufficient maintenance of the HVAC (heating, ventilation, air conditioning) system in the building. Sign and symptoms can be uncomfortable and even disabling, which may include mucus membrane irritation, neurotoxic symptoms, asthma like symptoms, skin complaints, gastrointestinal symptoms and other related symptoms. There are various investigation methods to diagnose sick building syndrome, and on site assessment of the building is extremely useful. Prevention through a proactive air quality monitoring program is far more desirable than dealing with an actual sick building. Indoor air and the sick building symdrome serves as a paradigm of modern occupational and environmental medicine. (Med J Indones 2002; 11:124-31)Keywords: indoor air pollution, sick building syndrome, building related illness
Distribution of genetic polymorphism of aldehyde dehydrogenase-2 (ALDH2) in Indonesian subjects
Medical Journal of Indonesia Vol. 11 No. 3 (2002): July-September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v11i3.62

Abstract

Aldehyde dehydrogenase (ALDH) plays a pivotal role in the alcohol metabolism. Decreased activity of ALDH enzyme has more influence on the hypersensitivity to alcohol than of alcohol dehydrogenase. ALDH enzyme exists in several isozymes. Among these isozymes, ALDH2 is a major isozyme that has a very high affinity for acetaldehyde. Recent studies suggested that the deficiency of ALDH2 may be inherited. Functional polymorphism of ALDH2 gene has been observed in a nucleotide of the 487th codon. In the atypical gene, this codon consists of AAA nucleotides for lysine, instead of GAA for glutamic acid in the wild type gene. In this study, we have analyzed the genetic polymorphism of ALDH2 gene among 100 Indonesian students using genomic DNA extracted from hair roots. Polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) methods were performed for this purpose. Three oligonucleotide primers were designed for two steps PCR. The reverse primer R was intentionally constructed not to be 100% complementary to the template strand, to generate a restriction site for Eco RI within the variable nucleotide in the PCR product of ALDH2 gene. This study indicates that 70 subjects (70%) have wild type, 29 (29%) atypical heterozygote and only 1 (1%) atypical homozygote ALDH2 alleles. Conclusively, the atypical ALDH2 allele frequency in Indonesians (31/200) is higher than in Caucasoids (only about 5-10%), but less than in Mongoloids (40-50%). This may be due to the diverse ethnics of Indonesian population. (Med J Indones 2002; 11: 135-42) Keywords: alcohol hypersensitivity, genetic polymorphism, aldehyde dehydrogenase-2 (ALDH2) gene
Effect of beta blocker therapy on survival in severe heart failure
Medical Journal of Indonesia Vol. 11 No. 3 (2002): July-September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v11i3.63

Abstract

Beta-blocking agents have been shown to reduce the risk of hospitalization and death in patients with mild to moderate heart failure, but little is known about the efficacy or safety of these agents in severe heart failure. A case of beta blocker administration in severe heart failure with ejection fraction less than 25% is reported. The reported benefits of beta blockers with regard to morbidity and mortality in patients with mild to moderate heart failure were also found in the patient with severe heart failure as reported in this case. (Med J Indones 2002; 11: 174-5) Keywords: beta-blocking agents, heart failure, ejection fraction
Idiosyncratic chloroquine retinopathy − a case report
Medical Journal of Indonesia Vol. 11 No. 3 (2002): July-September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v11i3.64

Abstract

Chloroquine still remains the most widely used antimalarial of present time. Cumulative dose retinopathy has been reported with the use of chloroquine therapy, especially seen in patients on its chronic therapy in rheumatological disorders. A rare case report on chloroquine induced idiosyncratic retinopathy while being used in treatment of Falciparum malaria is being presented. (Med J Indones 2002; 11: 176-8)Keywords: cloroquine, adverse effects, idiosyncratic, malaria, retinopathy
Multiple cysticercus nodules in skin and brain in a Balinese woman: A case report
Medical Journal of Indonesia Vol. 11 No. 3 (2002): July-September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v11i3.65

Abstract

A case of multiple subcutaneous and cerebral cysticercosis in a 33-year-old Balinese female, is reported. The patient suffered from seizures since adolescence, which was not treated. Since three years before admission she started developing multiple nodules in the skin, starting from her forehead and since a year ago also in other parts of the head and body such as shoulders, chest and back. Serum sample tested against cysticercus antigen by immunoblot assay against antigen of Taenia solium was positive. The copro-antigen test was also positive, indicating the presence of the adult worm in the intestines. The patient was treated with praziquantel for the adult T. solium infection and thereafter with albendazole for the larval stages, which resulted in obvious reduction of the cerebral cysts and most of the subcutaneous nodules disappeared. However the adult worm was not recovered in the 24 hours stool specimen and after one year the immunoblot test was still positive. (Med J Indones 2002; 11: 169-73) Keywords: cysticercosis, Taenia solium, praziquantel, albendazole
Comparative study of azathioprine and cyclosporin in rheumatoid arthritis – a sixteen weeks follow-up study
Medical Journal of Indonesia Vol. 11 No. 3 (2002): July-September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v11i3.66

Abstract

Rheumatoid Arthritis (RA) is a chronic progressive deforming polyarthritic disease involving multisystems and associated with considerable morbidity. Immunosuppressive drugs have been used to reduce/arrest the progression of the disease. The present study was undertaken to compare the efficacy of Azathioprine and cyclosporin in Rheumatoid Arthritis patients. Study consisted of 100 patients of Rheumatoid Arthritis (as per criteria of American Rheumatism Association, 1987) divided into two groups : group I received Azathioprine 1 mg/kg/d and group II received cyclosporin 2.5-3.0 mg/kg/d for 16 weeks. Assessment of efficacy was based on clinical, biochemical and radiological parameters. All patients showed marked improvemen (p value < 0.001) in all clinical parameters i.e. relief in pain, reduction in morning stiffness, painful/swollen joint along with walking time for 50 feet and increase in grip strength. All patients showed reduction (p < 0.001) in ESR without any change in rheumatoid factor titres. Both drugs showed equal efficacy (p value = NS) in improvement of clinical and biochemical parameters. But cyclosporin showed more reduction in bony erosions and juxtaarticular osteoporosis. Ten patients showed nephrotoxicity with cyclosporin. Cyclosporin has an edge over azathioprine in reducing the rate of progression of joint change in Rheumatoid Arthritis but is associated with increased incidence of side effects that are generally manageable. (Med J Indones 2002; 11: 153-7) Keywords: azathioprine, cyclosporin, rheumatoid arthritis
Utility of bone marrow aspiration in extrapulmonary tuberculosis
Medical Journal of Indonesia Vol. 11 No. 3 (2002): July-September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v11i3.67

Abstract

This study was undertaken to look for evidence of acid fast bacilli (AFB) in bone marrow (BM) in patients of extrapulmonary tuberculosis. Fifty cases suspected of extrapulmonary tuberculosis underwent bone marrow aspiration from sternum/illiac crest and were put on a therapeutic trial of antituberculosis therapy. All cases taken in the study responded to the therapy. The pattern of involvement were – abdominal (20), CNS (19), pericardial involvement (5), cervical lymphadenopathy (2), PUO (2), spinal (1) and miliary (1). 52% cases showed evidence of AFB in BM (on Ziehl Neelsen’s (ZN) staining) whereas only 4% of cases showed evidence of AFB in any other body fluid (CSF/pericardium/peritonium). Besides this, cytomorphological changes of BM showed evidence of lymphocytosis (22%), increased plasma cells (80%) and prominence of macrophages (88%), thus signifying infective pathology with macrophage overactivity. So we conclude that bone marrow aspiration has a definite diagnostic value and may prove useful when other investigations are unrewarding. (Med J Indones 2002; 11: 148-52) Keywords: bone marrow aspiration, acid fast bacilli, extrapulmonary tuberculosis
Viral load profiles in drug users with asymptomatic HIV infection and normal CD4 cell counts
Medical Journal of Indonesia Vol. 11 No. 3 (2002): July-September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v11i3.68

Abstract

Since the year 2000 there has been a steep increased in the number of HIV/AIDS patients in Indonesia, coming mostly from intravenous drug users. Antiretroviral treatment has been proved to decrease mortality and increase quality of life of HIV/AIDS patients. The treatment is given according to clinical condition of the patients, number of CD4 and viral load. In this study, CD4 and viral load were examined in 71 asymptomatic HIV patients originated from injecting-drug users. CD4 counting was performed by indirect immunoflouresence method using monoclonal antibody, and viral load was tested using PCR technique. Among 56 patients who has the number of CD4 more than 200/mm3, 30 patients (55.4 %) has viral load more than 55,000 copies/ml and 35.7% has viral load 5,000-55,000 copies/ml. Correlation between the number of CD4 and viral load gave the r value of 0.194. It is concluded that there is no association between the number of CD4 and viral load in drug user HIV/AIDS patients. The treatment of HIV/AIDS for these patients should be given according to the viral load. (Med J Indones 2002; 11: 143-7)Keywords: viral load, CD4, injecting-drug user

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