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Dinia R Dwijayanti,
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Biotropika
Published by Universitas Brawijaya
ISSN : 23027282     EISSN : 25498703     DOI : 10.21776/ub.biotropika.
Core Subject : Science, Agriculture,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology
Biotropika: Journal of Tropical Biology invites research articles, short communication, and reviews describing new findings/phenomena of biological sciences in tropical regions, specifically in the following subjects, but not limited to biotechnology, biodiversity, microbiology, botany, zoology, biosystematics, ecology, and environmental sciences.
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Articles 5 Documents
 1 
Search results for , issue "Vol. 11 No. 3 (2023)" : 5 Documents clear
A Comparative Profile of Free Radicals, Endogenous Antioxidants, and Cytokines in Mouse Model of Type 1 Diabetes Mellitus Fikriya Novita Sari; Rizky Senna Samoedra; Setyaki Kevin Pratama; Sri Rahayu; Aris Soewondo; Muhaimin Rifa'i
Biotropika: Journal of Tropical Biology Vol. 11 No. 3 (2023)
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.biotropika.2023.011.03.04

Abstract

Diabetes mellitus is a metabolic disorder characterized by high blood glucose (hyperglycemia). Hyperglycemia will cause the body to undergo physiological changes such as free radical, antioxidant and inflammation alteration. This research aims to compare the profile of free radicals, endogenous antioxidants, and cytokines in mouse models of type 1 diabetes mellitus (T1DM). Mice were separated into two different groups, normal and diabetic mice groups. The normal group was a group of mice that were not induced to have diabetic conditions, while the diabetic mice group was induced to be diabetic using streptozotocin injection. Blood glucose levels were checked every three days for 14 days, while the immune response was evaluated after 14 days using flow cytometry. Data analysis was done using SPSS software with t-test analysis. This research showed that the increasing ROS represented by MDA would trigger inflammation in T1DM represented by the increasing TNF-alpha along with IFN-gamma and reducing anti-inflammatory cytokines represented by IL-10. Interestingly, SOD expression, which is an endogenous antioxidant, is also increased in the diabetic mice group, and we conclude that it is some sort of adaptive response of the diabetic mice group against the increasing ROS.
Computational Design of a Truncated Javan Spitting Cobra (Naja sputatrix) Venom Cardiotoxin Analogue as a Promising Insulinotropic Agent Dinana, Ichda Arini; Widodo, Widodo; Kurniawan, Nia
Biotropika: Journal of Tropical Biology Vol. 11 No. 3 (2023)
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.biotropika.2023.011.03.03

Abstract

Treatment options for diabetes may vary widely, however, around 50% of all diabetic patients do not reach the minimum glycemic target. Therefore, drugs that are able to lower glucose levels through unconventional targets are still needed for the treatment of type 2 diabetes. This study aimed to investigate the activity of cardiotoxins from Naja sputatrix towards Kv channels as potential targets for glucose level reduction. Molecular docking analysis was conducted using the ClusPro web server, and the resulting protein-ligand interactions were visualized using BioVia Discovery Studio and LigPlus v.4.5.3. The stability of the docking structures was further examined through molecular dynamics simulations. The CTX-1, CTX-3, CTX-4, CTX-5, and CTX-KJC3 sequences from N. sputatrix were aligned and modeled, focusing on the 62-81 amino acid residues. The CTX-3, CTX-4, and CTX-5 models demonstrated interactions with the binding site of the KcsA receptor. Additionally, substituting the Val73 residue in the CTX62-81 fragment with Lys73 resulted in reduced binding energy and mitigated the cytotoxic effects of CTX while maintaining its insulinotropic activity.
Morphogenesis Response of Leaf and Petiole Explant of Rootstock Apple (Malus sylvestris Mill.) to Auxin and Cytokinin Nafika, Wirentyas; Munawarti, Aminatun
Biotropika: Journal of Tropical Biology Vol. 11 No. 3 (2023)
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.biotropika.2023.011.03.02

Abstract

Apple rootstock is a plant type used in grafting propagation. Research related to the response of morphogenesis in this plant has not been widely carried out. This study aims to examine the influence of auxin and cytokinin ratios on morphogenesis in leaf and petiole explants of rootstock apples, seeking optimal response modifications. A 2-factorial, completely randomized design (CRD) was utilized in the investigation, with variations in the types of explants and combinations of plant growth regulators (PGR) in the culture medium. There were 12 treatments with five repetitions. Explants of young apple leaf (third leaf) and petiole rootstock that had been sterilized and cut with a size of 5x5 mm for the leaf and 5 mm long for the petiole were inoculated into MS medium with cytokinin, BAP (1 ppm) combined with auxin, IBA (0, 0.1, 0.2, 0.3, 0.4, 0.5 ppm). Each culture bottle contains five explants. The results showed that the average leaf explant was capable of producing 34% callus. Meanwhile, petiole explants produced 4% callus. Callus began to form on leaf and petiole explants on the 26th and 42nd days after inoculation, respectively. Most calluses have a compact texture with green, yellowish-white, and brownish-green variations. The PGR combination with the highest percentage of callus production in leaf explants was BAP 1 ppm + IBA 0.4 ppm treatment, whereas the petiole was BAP 1 ppm + IBA 0.3 ppm treatment. Therefore, the combination of PGR with the best callus response in this study can be used as a reference in the development of apple tissue culture.
Antioxidant Activity in Melon (Cucumis melo L. 'Gama Melon Parfum') as Antiaging Cream Formulation Wahyuni, Satria; Wibowo, Wiko Arif; Sulaiman, Teuku Nanda Saifullah; Daryono, Budi Setiadi
Biotropika: Journal of Tropical Biology Vol. 11 No. 3 (2023)
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.biotropika.2023.011.03.05

Abstract

Antiaging cosmetics are becoming increasingly popular among the general public. Melon (Cucumis melo L.) Gama Melon Parfum cultivars ('GMP') are one of the plants that can be utilized as a basic ingredient in the production of antiaging cosmetics. 'GMP' melon has cucurbitacin compounds that can be utilized as antiaging and contains flavonoid, saponin, and terpenoid compounds that have antioxidant properties. This research aims to analyze the difference in antioxidant activity of 'GMP' melon extract and 'GMP' melon cosmetic cream preparation cultivated in Yogyakarta with 'GMP' melon cultivated in Bandung, analyze extract standardization parameters, and determine the phenolic and flavonoid contents of each melon extract contains. The activity of antioxidants was determined by the DPPH method, the Folin-Ciocelteu method to measure phenolics, and the AlCl3 solution-based colorimetric approach to measuring flavonoid content. It was revealed that the highest % RSA of antioxidant activity is in ‘GMP’ melon extract cultivated in Bandung. The results of the standardization of 'GMP' melon extract met the requirements of standard parameters. The greatest total phenolic content is derived from the extract of ‘GMP’ melon in Bandung, while the highest total flavonoid content in 'GMP' melon extracts is cultivated in Yogyakarta. The highest to lowest antioxidant activity of ‘GMP’ melon cream was formula IV (‘GMP’ melon extract 30% cultivated in Bandung), formula III (‘GMP’ melon extract 20% grown in Bandung), formula II (‘GMP’ melon extract 30% cultivated in Yogyakarta), formula I (‘GMP’ melon extract 20% cultivated in Yogyakarta), and the lowest is in K- with formula without ‘GMP’ melon extract.
Mangrove Density Mapping for Sustainable Utilization and Management in Klawalu Mangrove Tourism Park, Sorong City Pattiasina, Thomas Frans; Tjolli , Ihwan; Bless, Aplena Ellen; Lekitoo, Krisma
Biotropika: Journal of Tropical Biology Vol. 11 No. 3 (2023)
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.biotropika.2023.011.03.01

Abstract

Data and information on resource utilization supported by vegetation mapping are the basis for developing a sustainable mangrove management strategy. This study aims to map the vegetation density and identify the use of mangroves by the community in the Klawalu Mangrove Tourism Park (Taman Wisata Mangrove Klawalu-TWMK) Sorong City. The satellite imagery used is Sentinel 2A level 1C. Image pre-processing includes atmospheric correction, geometric correction and image cropping. Determination of the extent and distribution of mangrove vegetation is carried out by applying the color composite method and mangrove boundary delineation. Mangrove vegetation density mapping was carried out by applying the Normalized Difference Vegetation Index (NDVI) method. Identification of the species and intensity of mangrove utilization was carried out through observation and interviews with respondents who were determined purposively. Based on the results of the analysis, the total area of mangrove vegetation in TWMK and its mapped surroundings is 144.64 ha. Of this area, 69.01 ha (47.71%) is classified as very dense, 34.96 ha (24.17%) is classified as dense, and 24.23 ha (16.75%) is classified as moderate, 12. 94 ha (8.95%) is classified as sparse, and 3.5 ha (2.42%) is classified as very sparse. The intensity of resource utilization from the mangrove ecosystem is quite high, especially the utilization of mangrove wood and coral mining. Awareness/education efforts need to be continued, as well as alternative livelihood solutions to reduce the heavy dependence on mangrove resources.

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