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All Journal International Journal of Public Health Science (IJPHS) Indonesian Journal of Pharmaceutical Science and Technology Majalah Obat Tradisional Jurnal Kimia Riset Science and Technology Indonesia Majalah Farmaseutik
Sulaiman, Teuku Nanda Saifullah
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Environmental Science Health Professions Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health

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Potensi Cengkeh (Syzygium aromaticum (L.) Merr. & Perry) di Indonesia Sebagai Sumber Daya Alam dan Bahan Baku Obat Antibakteri dan Antijamur Pradana, Andi; Santosa, Djoko; Sulaiman, Teuku Nanda Saifullah
Majalah Farmaseutik Vol 20, No 1 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v20i1.86004

Abstract

Popularitas tanaman sebagai penanganan infeksi mikroba kian meningkat. Cengkeh adalah tanaman dengan kandungan senyawa kimia utama eugenol yang dapat digunakan sebagai antibakteri. Review ini dibuat menggunakan data sekunder dari database literatur ilmiah PubMed, Scopus, Google Scholar, SINTA, dan Science-Direct yang bertujuan untuk melihat potensi dari ektrak etanol bunga, daun dan batang cengkeh sebagai agen antimikroba. Aktivitas antibakteri E. coli dari daun dan bunga secara berturut-turut 20% (14,6mm); 31,25% (14mm). Daya hambat terhadap bakteri S. aureus dari batang, daun, bunga secara berturut-turut 40% (21,5mm); 50% (14,66mm); 62,50% (5mm). Aktivitas antibakteri terhadap S. mutans dari bunga dan daun secara berturut-turut 40% (18,83mm); 40% (12mm). Aktivitas bunga cengkeh terhadap jamur C. albicans konsentrasi 12,5% (20mm) dan memiliki KHM 1 μL/mL (44mm).
Penggunaan Surfaktan pada Sistem Dispersi Padat Terner: Manfaat dan Risiko Seftian, Muhammad; Laksitorini, Marlyn Dian; Sulaiman, Teuku Nanda Saifullah
Majalah Farmaseutik Vol 19, No 4 (2023)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v19i4.86720

Abstract

Beberapa decade terakhir, kelarutan menjadi tantangan besar dalam pengembangan obat. Diperkirakan lebih dari 90% kandidat obat baru memiliki kelarutan dalam air yang kurang baik. Berbagai inovasi teknologi telah diaplikasikan guna meningkatkan kelarutan obat dalam air, salah satunya dispersi padat. Seiring berkembangnya teknologi, dispersi padat generasi baru menambahkan surfaktan sebagai sistem terner. Penelitian sebelumnya mengungkapkan peningkatan kecepatan disolusi pada sistem terner obat-polimer-surfaktan terjadi lebih tinggi dibandingkan dengan dispersi padat tanpa surfaktan. Akan tetapi penelitian lain juga mengungkapan efek negatif dari surfaktan terhadap stabilitas sistem dispersi padat. Review ini mendiskusikan penggunaan surfaktan sebagai sistem terner dispersi padat. Salah satu tantangan pengembangan sistem dispersi padat adalah drug loading yang terbatas dan adanya rekristalisasi selama proses disolusi. Surfaktan mencegah kristalisasi obat selama proses disolusi melalui efek solubilisasi dengan cara mendispersikan molekul obat dalam bentuk nanodroplet. Di sisi lain, beberapa penelitian lain mengungkapkan hasil yang kontradiktif yang menyatakan surfaktan justru mempercepat nukleasi dan memberikan efek negatif terhadap stabilitas sistem dispersi padat. Efek surfaktan pada sistem dispersi padat akan tergantung pada struktur, afinitas interaksi, dan konsentrasi yang digunakan. Seleksi surfaktan yang kompatibel dengan sistem yang dikembangkan perlu dilakukan karena pada titik tertentu surfaktan dapat menjadi kompetitor yang menekan interaksi obat-polimer dan memicu kristalisasi
Thermosensitive hydrogels as drug carriers for breast cancer treatment: a systematic review Ikhsanudin, Azis; Sulaiman, Teuku Nanda Saifullah; Zai, Khadijah; Sudarmanto, Bambang Sulistyo Ari
International Journal of Public Health Science (IJPHS) Vol 12, No 3: September 2023
Publisher : Intelektual Pustaka Media Utama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijphs.v12i3.22773

Abstract

Thermo-sensitive hydrogel is a drug delivery system in breast cancer therapy, where the influence of environmental temperature changes will affect the characteristics of the polymer base. This study aimed to determine the effectiveness of polymers in thermo-sensitive hydrogel bases as drug carriers in breast cancer therapy and compared them with traditional intravenous drug release. This study used a systematic literature review (SLR) using selected reporting items for systematic review and meta-analysis guidelines (PRISMA) (P), based on predetermined inclusion criteria, namely English article, thermos-sensitive hydrogel, breast cancer, and original article. An initial database search yielded 618 articles, PubMed (241), Scopus (364), and the Directory of Open Access Journals (DOAJ) (36). To maintain the quality of the data studied in this article, researchers used inclusion and exclusion criteria, where the exclusion criteria used were non-English languages, review articles, proceedings, communications, video articles, and not open access. After the article screening process, 11 articles were obtained which would then be summarized in data extraction. The conclusion of this study shows that the thermos-sensitive hydrogel drug delivery system has advantages in drug release, where the drug will be released continuously, but also has the disadvantage of uncontrolled drug release.
Drug Solubility Enhancement Strategies Using Amorphous Solid Dispersion: Examination on Type and The Amount of the Polymer Seftian, Muhammad; Laksitorini, Marlyn Dian; Sulaiman, Teuku Nanda Saifullah
Indonesian Journal of Pharmaceutical Science and Technology Vol 11, No 2 (2024)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v11i2.46908

Abstract

Solubility is one of the critical factors affecting the biopharmaceutical process of drugs. Low solubility limits the dissolution rate and the oral bioavailability. As a result, a higher drug load is required to compensate for the low bioavailability. Amorphous solid dispersion (ASD) is a recent approach to increase drug solubility by dispersing the drug in a carrier-commonly a hydrophilic polymer. It improves the solubility and dissolution rate by affecting the thermodynamic equilibrium of the drug in solution. The amorphous system has a random molecular arrangement leading to higher thermodynamic activity. The amorphous system in ASD has a higher free energy which facilitates a higher solubility and dissolution rate. Polymer is the main component after the active substance in the ASD system. Therefore, the success of ASD formulation will be determined by the selection of polymers and additives as well as their proportions in the system. In addition to the polymer, surfactants are used as a ternary system to give a synergistic effect on the dissolution rate. The system maintains drug supersaturation in the solution state through two main mechanisms: reducing molecular mobility and plasticizing effect.
OPTIMIZATION OF CURCUMIN ENCAPSULATION FORMULA WITH CHITOSAN AND ALGINATE USING SIMPLEX LATTICE DESIGN AND ITS EFFECT ON ANTIOXIDANT ACTIVITY Wiratantri, Fitra Indah; Peranginangin, Jason Merari; Sulaiman, Teuku Nanda Saifullah
Jurnal Kimia Riset Vol. 9 No. 2 (2024): December
Publisher : Universitas Airlangga, Campus C Mulyorejo, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jkr.v9i2.61384

Abstract

Curcumin is known to enhance the performance of antioxidant serums, such as superoxide dismutase (SOD). However, curcumin is prone to degradation when exposed to sunlight, necessitating the use of encapsulation technology to protect it from chemical degradation and improve its dispersibility. Biopolymers like chitosan and alginate are commonly used as encapsulation materials. This study aimed to determine the ideal concentrations of chitosan and alginate for curcumin encapsulation and evaluate its antioxidant activity. The optimal formulation was identified using Design Expert software version 13 with a Simplex Lattice Design. Encapsulation was carried out through the ionic gelation method, and the curcumin encapsulates were evaluated for encapsulation efficiency, particle size, zeta potential, and antioxidant activity. The optimal formulation was found to be 1.35% chitosan and 2.145% alginate, achieving an encapsulation efficiency of 71.85%, a particle size of 551.1 nm, a zeta potential of -46 mV, and strong antioxidant activity with an IC50 value of 36.32 ppm. In conclusion, the Simplex Lattice Design method successfully optimized the formulation. Chitosan increased particle size, while alginate enhanced encapsulation efficiency. The antioxidant activity was minimally affected by encapsulation, as most curcumin was retained in the droplets. The zeta potential value confirmed the stability of the encapsulate.
Development and Validation of the RP-HPLC Method for Dexamethasone Sodium Phosphate Determination in Nasal Chitosan Microsphere Preparations Desnita, Rise; Noviana, Eka; Zai, Khadijah; Sulaiman, Teuku Nanda Saifullah
Science and Technology Indonesia Vol. 10 No. 1 (2025): January
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2025.10.1.165-172

Abstract

The purpose of this work was to provide a robust, sensitive, accurate, and straightforward analytical method for measuring dexamethasone sodium phosphate (DSP) in chitosan microspheres preparedn using the spray drying method. DSP was quantitatively analyzed using RP-HPLC with an ultraviolet detector at 254 nm, a mobile phase that contained a mixture of acetonitrile and 0.1% sodium dihydrogen phosphate monohydrate (50:50) operating isocratically at a flow rate of 1.0 mL/min, and a stationary phase that was a C18 PrincetonSPHER-100 C18-QB 100A HPLC Column (250 × 4.6 mm, 5 um). The ICH recommendations were followed in the validation of the analytical method. DSP had a retention duration of 2.899 minutes and a tailing factor of 0.827. The RP-HPLC method was linear (R = 0.9992) in the 15-60 ug/mL concentration range. The limits of quantitation (LOQ) and detection (LOD) were 4.425 ug/mL and 1.327 ug/mL, respectively. The relative standard deviations for the intra-day and inter-day precisions were 0.057-0.876% and 0.780-0.949%, respectively. The recovery percentages at 50, 100, and 200% concentration levels were within the 99.269-100.980% range. The validated method has been successfully applied to determine DSP entrapment efficiency in chitosan microspheres. A linear, sensitive, accurate, precise, and robust technique of determining DSP in chitosan microsphere preparations is offered by the established RP-HPLC method.
Cucumis melo L. ‘Gama Melon Parfum’ Extract: Volatile Compound Profile, Optimization, Preparation and Perfume Radar Gunawan, Indra; Daryono, Budi Setiadi; Noviana, Eka; Sulaiman, Teuku Nanda Saifullah
Majalah Obat Tradisional Vol 30, No 1 (2025)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.95553

Abstract

Perfume notes are a sophisticated blend of essential or fragrance oils that give perfumes a distinct scent. Melon notes are highly favored aromatic elements in perfumes. Melon (Cucumis melo L. ‘Gama Melon Parfum’), known by the local name Gama Melon Parfum (GMP), is a melon breed that has unique phenotypic characteristics: bitter taste, batik-like pattern, and fragrant aroma. GMP has a fresh and fruity melon character, typically used as a top note in the perfume pyramid concept. Our study aimed to develop a perfume derived from GMP volatile extract as a fragrance ingredient. The process included collection, identification, extraction, physicochemical characterization, volatile compound analysis, perfume optimization, preparation, and perfumery radar. GMP can serve as the top note in a perfume formulation. From the D-optimal mixture design, an ideal perfume formula could be created from a mixture of 0.95 mL GMP, 0.55 mL rose, and 0.50 mL vanilla. The composition was found to produce a perfume that met sensory standards: a transparent and uniform liquid without impurities. It also had a unique aromatic scent with a relative density of 0.8102 g/cm3 which fell within the specified range of 0.7000-1.200 g/cm3, viscosity of 0.7931 cps within the required range of 0.7830-1.4030 cps, and a hedonic level of 9.72 cm out of a maximum of 15.00 cm. The perfume radar showed fruity-floral-musk characteristics. Results from this research indicate that enhancing GMP as a fragrance ingredient enables the creation of an optimal perfume that meets the required standards, is well-received, and demonstrates an inclination toward femininity.
Co-Authors Azis Ikhsanudin BUDI SETIADI DARYONO Djoko Santosa Eka Noviana Jason Merari Peranginangin Marlyn Dian Laksitorini, Marlyn Dian Mochammad Imron Awalludin Pradana, Andi Rise Desnita, Rise Seftian, Muhammad Sudarmanto, B.S. Ari Wiratantri, Fitra Indah zai, Khadijah