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INDONESIA
Indonesian Journal of Cancer Chemoprevention
Published by Indonesian Society for Cancer Chemoprevention
ISSN : 23558989     EISSN : 20880197     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology
Indonesian Journal of Cancer Chemoprevention (IJCC) is an open access, peer-reviewed, triannual journal devoted to publishing articles on Cancer Chemoprevention including Experimental and Clinical Pharmacology, especially concerning Anti-Oxidants, Anti-Aging, Anti-Inflammation, Anti-Angiogenesis, and Anti-Carcinogenesis; Cancer Detection; Stem Cell Biology; Immunology; in vitro and in silico Exploration of Chemopreventive Mechanism; and Natural Products.
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Articles 20 Documents
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Search results for , issue "Vol 1, No 1 (2010)" : 20 Documents clear
The Influence of DMBA (7,12-dimethylbenz-[a]anthracene) Regimen In The Development of Mammae Carcinogénesis on Sprague Dawley Female Rat Agung Eru Wibowo; Sriningsih Sriningsih; Puspita Eka Wuyung; Raafqi Ranasasmita
Indonesian Journal of Cancer Chemoprevention Vol 1, No 1 (2010)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev1iss1pp60-66

Abstract

There are many methods for development of mammae cancer animal model, one of which is chemical induction using carcinogenic agent, DMBA. This research aimed to explore the influence of dose and time regimens of DMBA on development of mammae carcinogenesis on Sprague dawley female rats. The first study was 50 rats treated with 20 mg/kg bw of DMBA orally for eleven times at twice a week. Morphological evaluations were conducted with mammae palpation for 15 weeks and then all of rats were sacrificed for collecting mammae organs for histological analysis using hematoxylin-eosin staining. The results showed that the first and the latest nodules appeared at the fourth-week and the fourteenth-week after ending DMBA induction, respectively, in which the most often nodule appearances were at the seventh-week. The number of nodule incidence and multiplicity were by 74% and 2 noduls/rat, respectively. Histological analysis of mammae glands determined that they fell under in Ductal Carcinoma Invasive (DCIV) category. The second study was 25 rats gavaged orally with DMBA at dose 20 mg/kg bw for five times every three days. After palpating for 15 weeks, the results showed that no nodule was observed but the histological analysis demonstrated developing of mammae gland carcinogenesis reaching about 60% Ductal Carcinoma Insitu (DCIS) and 40% Ductal Carcinoma Invasive (DCIV) stages. Based on the results of this study can be concluded that the dose and frequency of DMBA will affect the successful development of mammary gland carcinogenesis. In DMBA induction with low frequency, no data showed the incidence and multiplicity of tumor, but histopathologic level carcinogenesis can be distinguished. In DMBA induction with high frequency, incidence and multiplicity of tumor data can be obtained but can not be distinguished histopathologically.Keywords: DMBA, doses, carcinogenesis, mammae, histopatology
Platinum Metal Complexes of Carbaboranylphophines: Potential Anti Cancer Agents Ilham Maulana Ilham Maulana; Peter Loennecke Peter Loennecke; Evamarie Hey-Hawkins Evamarie Hawkins
Indonesian Journal of Cancer Chemoprevention Vol 1, No 1 (2010)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev1iss1pp1-11

Abstract

Polyhedral heteroboranes in particular dicarba-closo-dodecaboranes(12) and their organic derivatives have been the subject of intense research for over 40 years due to their unique chemical and physical properties. The initial attraction to dicarba-closo-dodecaboranes(12) In the medicinal chemistry research, was a result of their high boron content and stability to catabolism, which are important criteria for cancer therapy, such as BNCT (boron neutron capture therapy) agents. The coordination compounds of the platinum group metals have also received large interest for their potential application as chemotherapeutic agents, since cis-diamminedichloroplatinum(II), cisplatin, has been reported to have  capability as tumor inhibitor. Hence, applications can be envisioned for related cis platinum complexes. Complex of cis-rac-[PtCl2{1,2-(PRCl)2C2B10H10}] (R=Ph, tBu, NEt2, NPh2) have been synthesized by employing known carbaborane based phosphine ligands of clorophoshino-closo-dodecaborane , with complex of cis-[PtCl2(COD)] (COD = 1,5-cyclooctadiene) in an N2-atmosphere. The obtained complexes possess expected structure configuration, namely cis-rac. The characterization of the complex has been carried out using 1H, 31P, 13C and 11B-NMR (Nuclear Magnetic Resonance), X-ray of single crystals, elemental analysis, IR (infra red) and mass spectroscopy (MS). The 31P{1H} NMR spectra of all the platinum complexes distinctly show the typical platinum satellites which are attributed to 31P-195Pt-coupling, in which the 31P{1H} NMR spectrum exhibits three lines with an intensity ratio of ca.1:4:1. The structure of the platinum complexes consists of a slightly distorted square-planar coordination sphere, in which the platinum atom is bonded to two chlorides and two phosphorus atoms of the chelating carbaboranylphosphine. Thus the platinum atoms exhibit the coordination number four, which is preferred in platinum(II) complexes.Keywords: Platinum complexes, phosphine ligand, carbaborane
Antioxidant Activity Test of 2,6-bis-(2’-furilidyn)-Cyclohexanone, ; 2,5-bis-(2’-furilidyn)-Cyclopentanone; 1,5-Difuryl-1,4-pentadien-3-one Ismi Rahmawati; Endang Sri Rejeki; Sardjiman Sardjiman
Indonesian Journal of Cancer Chemoprevention Vol 1, No 1 (2010)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev1iss1pp38-42

Abstract

Antioxidant is an essential compound to keep man’s health due to its function as radical scavenging. Curcumin analog compounds can function as antioxidant (Sardjiman, 2000). The aim of the experiment was to find out the antioxidant activity of 2,.6-bis-(2’-furilidin)-cyclohexanone, 2,.5-bis-(2’furilidin)-cyclopentanone, and 1,.5-difuril-1.4-pentadien-3-one compounds, and the antioxidant activity of each compound against DPPH  radical with IC50 parameter as well as the correlation of compounds structure’s activities against antioxidant. The antioxidant activity of curcumin analog compounds wereas tested against DPPH free radical. The test was conducted in 5 series of concentrations by adding 4.0 ml test solutions with 1.0 ml DPPH. The antioxidant activity against free radical was measured usingwith spectrophotometer at 517 nm wavelength and determined for the IC50 value. The experiment employed rutin as positive control. The result of the experiment showed that curcumin analog compounds have antioxidant activity with IC50 of rutin, 2,.6-bis-(2’-furilidin)-cyclohexanone, 2,.5-bis-(2’furilidin)-cyclopentanone, and 1,.5-difuril-1.4-pentadien-3-one as follows: 4.93 ppm, 22.73 ppm, 20.67 ppm, and 18.80 ppm  respectively. The highest antioxidant activity belonged to 1,.5-difuril-1.4-pentadien-3-one compound which is 18.80 ppm . Correlation of activity structure of the 3 compounds can be seen from the log p parameter and energy space of HOMO-LUMO.Key words: Antioxidant, DPPH, Analog Curcumin
Structure Modification of Ethyl p-methoxycinnamate Isolated from Kaempferia galanga Linn. and Citotoxicity Assay of The Products on WiDr Cells Juni Ekowati; Marcellino Rudyanto; Shigeru Sasaki; Tutuk Budiati; Sukardiman -; Adam Hermawan; Edy Meiyanto
Indonesian Journal of Cancer Chemoprevention Vol 1, No 1 (2010)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev1iss1pp12-18

Abstract

Ethyl p-methoxycinnamate, major ingredient of Kaempferia galanga rhizome, have been reported not only has analgesic – anti inflammatory activities like NSAIDs which inhibited cyclooxygenase, but also inhibit tumor cell proliferation in specimen of mouse epidermis. Therefore, it will be interesting to carry out synthetic studies on the derivates of ethyl p-methoxycinnamate and searching their citotoxic activity on WiDr cell. We wish to report of structure modification on carboxyl moiety of ethyl p-methoxycinnamate  and  evaluation on their citotoxic activity  on WiDr cell. Isolation of ethyl p-methoxycinnamate from Kaempferia galanga rhizome was carried out by percolation with ethanol 96% as solvent. Hydrolysis of ethyl p-methoxycinnamate in basic condition was performed to obtain p-methoxycinnamic acid. Preparation of some thiourea derivates of ethyl p-methoxycinnamate was carried out  by microwave irradiation. Citotoxicity assay was carried out by MTT method for 48 h.Modification of carboxyl group of ethyl p-methoxycinnamate to its thiourea form could be carried out by microwave irradiation gave; (E)-3-(4-methoxyphenyl)-N-(phenylcarba- mothioyl)acrylamide (50%); (E)-3-(4-methoxyphenyl)-N-(4-methoxyphenylcarbamothi- oyl)acrylamide (26%) and (E)-3-(4-methoxyphenyl)-N-(4-methylphenylcarbamothioyl) acrylamide (54%), yield calculated for 2 step from the acid chloride. All compounds showed no citotoxic effect on WiDr cell at 48 h incubation.Keywords :  ethyl p-methoxycinnamate, microwave irradiation, Kaempferia galanga, citotoxicity, WiDr cell
Curcumin and Extract of Plantago major, L Increased SPF Value of Cold Cream Base Nining Sugihartini
Indonesian Journal of Cancer Chemoprevention Vol 1, No 1 (2010)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev1iss1pp43-47

Abstract

Octyl methoxycinnamate as the active material of the sunscreen would be degradated after being exposed to the sunlight. Curcumin, rice flour and the  extract of Plantago  major, L was the material that could function as the sunscreen. The aim of this research was to know the SPF value and the physical characteristics of cream of the sunscreen with the active material octyl methoxycinnamate after the addition of the optimum composition of curcumin and the extract of Plantago major, L and the optimum composition of rice flour and the extract of Plantago major, L.In this research three formulas was examined, i.e. the  formula I with the active material octyl methoxycinnamate, the formula II with the active material octyl methoxycinnamate  and the optimum composition curcumin and the extract of Plantago  major, L, Formula III with the active material octyl methoxycinnamate and the optimum composition rice flour and the extract of Plantago major, L. SPF value of each formula was determined by using the Petro method (1981) using UV spectrofotometric method at a l 290 nm-320 nm. The physical characteristics i.e. the power spread, the adhesiveness and the viscosity were also examined analysed with Anova one way at a confidence level  95%. Result of the research show that SPF value increased after the addition of the optimum composition of curcumin and the extract of Plantago major, L. The physical characteristics of cream of the sunscreen do not change after the addition of the optimum composition curcumin and the extract of Plantago major, L and the optimum composition rice flour and the extract of Plantago major, L.Key words: Octyl methoxycinnamate,curcumin,flour rice,extract of Plantago major, L,sunscreen
Kaempferia galanga L. Rhizome As a Potential Dental Plaque Preventive Agent Triana Hertiani; Sylvia Utami Tunjung Pratiwi; Iramie Duma Kencana Irianto; Aini Febriana
Indonesian Journal of Cancer Chemoprevention Vol 1, No 1 (2010)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev1iss1pp19-25

Abstract

Dental plaque prevention can be achieved by inhibition of mouth cavity microbes to built biofilm. Kaempferia galanga rhizome has been known as a potential antibacterial agent. This research aimed to reveal the potency of Kaempferia galanga extract and essential oil as anti plaque active agents, based on their in vitro inhibitory activity against the planktonic growth and biofilm of Streptococcus mutans ATCC 21752. Kaempferia galanga extract was obtained by defatting dried-pulverized samples in petroleum ether prior to immersion in 70% ethanol. The fresh rhizome was steam-hydro distilled for 6 h to yield the essential oil. Antibacterial and anti biofilm assays were measured by micro dilution technique on polystyrene 96-wells micro titer plates at 37°C. The percentage of inhibition was calculated by comparing the absorbance of samples to the vehicle (control) measured by micro plate reader at 595 nm. Biofilms formed were first stained by 1% crystal violet. The above assays were performed in triplicates. This study revealed that both K. galanga rhizome essential oil and ethanolic extract showed antibacterial and antibiofilm activity towards S. mutans. The ethanol extract showed MIC90 value at 0.091% w/v and MBC at 2.724% w/v for antibacterial activity; IC50 at 0.048 % w/v for anti biofilm formation activity; and EC50 at 0.052%w/v for biofilm degradation activity. Until the highest concentration tested (0.6%w/v), the MIC90 and MBC values of the essential oil were not revealed, but higher biofilm inhibitory activity i.e. IC50 at 0.025 % w/v; and EC50 at 0.034 %w/v were observed. Key words: biofilm inhibitor, antibacterial, Kaempferia galanga
The Effect of Addition of Antioxidant to The Stability of Green Tea Water Extract As Anti Acne Nadya Fadila Saib
Indonesian Journal of Cancer Chemoprevention Vol 1, No 1 (2010)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev1iss1pp48-53

Abstract

There are so many potential effects that green tea, such as antibacterial activity against Propionibacterium acnes, that caused acne. In the previous study, green tea had been made in gel. In this study, formula of green tea water extract gel is developed with addition of antioxidant so that stability of the gel would increase. Gel of green tea water extract were made using Carbopol 940 with glycerin as the solvent. The chosen antioxidant was sodium sulfite. It is also combined with chelating agent, EDTA (Edetic Acid). The activity of green tea water extract gel was determined and tetracycline HCl gel was used as the reference. The addition of sodium sulfite 1% w/w into gel with Carbopol 940 1% w/w as the base prevent the change of color in more than eight weeks. Minimum Inhibitory Concentration (MIC) of green tea water extract without either sodium sulfite or EDTA was 1.20 ± 0.11 cm against Propionibacterium acne. MIC of green tea water extract with addition of sodium sulfite 1% w/w was 1.19 ± 0.28 cm. MIC of green tea water extract with addition of sodium sulfite 1% w/w and EDTA 0.1% w/w was 1.25 ± 0.22 cm. The addition of sodium sulfite 1% w/w caused viscosity of gel decrease 42.1%. The addition of sodium sulfite 1% w/w increased the color stability of green tea water extract. The addition of sodium sulfite 1% w/w didn’t decrease its antibacterial activity against Propionibacterium acnes.Keywords: green tea, anti acne, Propionibacterium acnes, gel, antioxidant
Synergistic Combination of Ciplukan (Physalis angulata) Herbs Ethanolic Extract and Doxorubicin on T47D Breast Cancer Cells Inna Armandari; Kartika Dyah Palupi; Sofa Farida; Adam Hermawan; Ratna Asmah Susidarti; Edy Meiyanto
Indonesian Journal of Cancer Chemoprevention Vol 1, No 1 (2010)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev1iss1pp26-31

Abstract

Doxorubicin is one of chemotherapeutic agent widely used in breast cancer treatment, but in high dose doxorubicin gives negative side effect, including vomit, nausea, immune suppression, and cardiac toxicity. This toxicity hopefully could be reduced by combination chemotherapy using natural herbs such as ciplukan herb. This research was conducted to explore cytotoxic activity of single ciplukan herbs ethanolic extract and its combination with doxorubicin on T47D breast cancer cells. Cytotoxic activity of ciplukan herbs ethanolic extract only and its combination with doxorubicin were tested on T47D cells using MTT assay to obtain IC50 value and combination index (CI), respectively. Single extract showed cytotoxic activity on T47D cells with IC50 value of was 160 µg/ml. Thus, combination treatment from ciplukan herbs ethanolic extract and doxorubicin showed synergistic effect (CI<1,0). This effect was reached at concentration of ciplukan herbs ethanolic extract-doxorubicin 80 μg/ml- 2 nM, 80 μg/ml-4 nM, and 80 μg/ml-8 nM. This research indicated that ciplukan herbs ethanolic extract is potential to be applied as co-chemotherapeutic agent in breast cancer therapy.Key word : ciplukan herbs, doxorubicin, co-chemotherapy, T47D cells
Potency of Industrial Tea Waste: Comparison Between Green And Black Tea Industrial Wastes as UV Filter for Sunscreen Yohanes Martono
Indonesian Journal of Cancer Chemoprevention Vol 1, No 1 (2010)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev1iss1pp54-59

Abstract

Indonesia is one of ten biggest countries that produce tea for world. It makes Indonesia produce various tea products. Every tea production process produces the large quantity of industrial tea wastes every day. Our previous research showed that industrial tea wastes still have antioxidant activity. It means that industrial tea wastes contained of phenolic compounds which can be used as UV filter for sunscreen. This research compared antioxidant activity, total phenolic contents and UV filter effectiveness between green and black industrial tea wastes. Antioxidant activity were analyzed by reducing power and DPPH method, total phenolic contents of tea wastes extract were analyzed using Folin-Ciocalteu assay, while UV filter effectiveness were assessed by UV spectra and absorbance of each tea wastes extract related to its concentration in order to yield maximum protection. The results showed that although green tea waste extract had higher antioxidant activity but adversely, black tea had higher total phenolic contents. UV filter effectiveness is affected by polyphenols content in substances, so it suggested that black tea waste extract is more potential than green tea waste extract as photoprotection substance.Keywords: tea waste, UV filter, sunscreen
Leunca (Solanum nigrum L.) Herbs Ethanolic Extract Increase Cytotoxic Activity of Cisplatin on Hela Cervical Cancer Cells Raditya Prima Istiaji; Maya Fitria; Larasati Larasati; Fortunella Tjondro; Astrid Ayu Maruti; Erna Prawita Setyowati; Edy Meiyanto
Indonesian Journal of Cancer Chemoprevention Vol 1, No 1 (2010)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev1iss1pp32-37

Abstract

Cervical cancer is one of leading causes of cancer death in women in the developing countries. The use of cisplatin as chemotherapy agent in cervical cancer is known to cause side effects and also resistance for long-term uses. One of the strategies to prevent cervical cancer based on combination agents is being developed. Leunca (Solanum nigrum L.) has been revealed to inhibit growth of human cancer cells. Therefore, it can be used in combination with cisplatin to reduce those side effects and prevent the occurrence of cell resistance. Ethanolic extract of Leunca Herb (ELH) and cisplatin were tested their cytotoxic effect on HeLa cervical cancer cell by using MTT assay to determine IC50 value. The combinationss of cisplatin-ELH were tested to determine the combination index (CI value). The IC50 of ELH and cisplatin on HeLa cells were 227 µg/mL and 17 µM. rRespectively. Tthe study of combination resulted that almost all the index combinations were <0,9 showed the effect of synergism combination. The Ooptimum concentration of combination was 1/8 IC50 cisplatin–1/8 IC50 ELH. The results indicated that ELH had a potency to be combination agent to enhance the activity of cisplatin on HeLa cervical cancer cells. Therefore, further study on its molecular mechanism needs to be explored. Key words: Leunca (Solanum nigrum L.), cisplatin, cytotoxic, combination agent, HeLa cells

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