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INDONESIA
Indonesian Journal of Cancer Chemoprevention
Published by Indonesian Society for Cancer Chemoprevention
ISSN : 23558989     EISSN : 20880197     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology
Indonesian Journal of Cancer Chemoprevention (IJCC) is an open access, peer-reviewed, triannual journal devoted to publishing articles on Cancer Chemoprevention including Experimental and Clinical Pharmacology, especially concerning Anti-Oxidants, Anti-Aging, Anti-Inflammation, Anti-Angiogenesis, and Anti-Carcinogenesis; Cancer Detection; Stem Cell Biology; Immunology; in vitro and in silico Exploration of Chemopreventive Mechanism; and Natural Products.
Arjuna Subject : -
Articles 6 Documents
 1 
Search results for , issue "vol 16, no 2 (2025)" : 6 Documents clear
Chemotherapeutic and Supportive Treatment Approaches for Cervical Cancer Patients in Indonesia: A Cross-Sectional Study Sonlimar Mangunsong; Azzahra Nisrina; Sarmalina Simamora; Gunardi Pome; Rosnani Rosnani; Heni Sumastri
Indonesian Journal of Cancer Chemoprevention Vol 16, No 2 (2025)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev16iss2pp137-144

Abstract

Cervical cancer is one of the most common cancers in women and ranks as the second leading cause of cancer-related mortality in Indonesia. Its management largely depends on the stage of disease and often requires multimodal approaches. A retrospective cross-sectional descriptive study was conducted using medical records of 185 hospitalized cervical cancer patients from January to December 2024. Data collected included age, disease stage, type of therapy, drug utilization, routes of administration, and histopathological findings. Descriptive analysis was performed and presented as frequency distributions and percentages. Most patients were aged 45–64 years (58.9%) and diagnosed at stage III (49.73%). The most common therapy was surgery (49.73%), followed by brachytherapy (20.54%) and chemotherapy (11.8%). Tranexamic acid was the most frequently prescribed drug (22.01%), while cisplatin paclitacxel and carboplatin were the primary chemotherapeutic agents. The intravenous route dominated drug administration (72.03%). Histopathology most frequently revealed medium-sized tissue lesions (3–5 cm; 21.08%). The majority of cervical cancer patients were diagnosed at advanced stages and underwent surgery as the primary treatment. Cisplatin remains the gold standard chemotherapy agent, administered primarily via the intravenous route. These findings highlight the urgent need for early detection, expanded screening, and HPV vaccination programs to reduce advanced-stage cases.Keywords: malignant carcinoma of cervix, hospitalize patient, drug utilization, histopathology.
Anti-Cancer Activity of Rhizome of Emprit Ginger (Zingiber officinale Rosc.) and Tiwai Onion (Eleutherine palmifolia) through Apoptosis Induction and Cell Cycle Arrest: A Review Aisyah Nur Salsabilan; Annisa Khumaira; Ika Afifah Nugraheni
Indonesian Journal of Cancer Chemoprevention Vol 16, No 2 (2025)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev16iss2pp145-162

Abstract

Cancer is a disease caused by the abnormal growth of cells and tissues. One of the main therapeutic approaches for cancer is chemotherapy. The use of plants as an alternative treatment is considered quite relatively effective and efficient. Emprit ginger (Zingiber officinale Rosc.) and tiwai onion (Eleutherine palmifolia) are plants that have potential anticancer properties due to their active compounds. The purpose of this literature review is to examine the various uses of these active compounds and their mechanisms of action as anticancer agents, both in vitro and in vivo, from emprit ginger and tiwai onion. The results of this literature review indicate that emprit ginger contains active compounds, namely gingerol (6-gingerol and 10-gingerol), shogaol (4-shogaol, 6-shogaol, and 10-shogaol), and paradol, which have anticancer activity. Similarly, tiwai onion contains active compounds, namely flavonoids (isoliquiritigenin), polyphenols (oxyresveratrol), and naphtoquinones (elecanacin, eleutherin, eleutherol, eleutherinol, eleutherinon, eleuthoside B, eleutherinoside A), which have anticancer activity. Pre-clinical in vitro and in vivo studies show that emprit ginger and tiwai onion have anticancer activity, including the inhibition of cancer growth through modulation of cell signaling pathways, induction of apoptosis, and cell cycle arrest.Keywords: anticancer activity, apoptosis, cell cycle arrest, emprit ginger (Zingiber officinale Rosc.), tiwai onion (Eleutherine palmifolia).
Chemopreventive Potential of Calotropis gigantea Root Fraction on MCF-7 Cells: In Vitro and In Silico Study Rifki Febriansah; Vidia Noviyanti
Indonesian Journal of Cancer Chemoprevention Vol 16, No 2 (2025)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev16iss2pp93-106

Abstract

Cancer remains a major global health issue due to its high mortality rate. Chemotherapy, though commonly used, often causes severe side effects by damaging both cancerous and healthy cells. Therefore, safer and more selective chemopreventive agents from natural sources are needed. This study aims to evaluate the chemopreventive potential of the ethanol fraction of biduri root (EFBR, Calotropis gigantea L.) through in vitro and in silico approaches. Phytochemical screening was used to identify bioactive compounds. Molecular docking using AutoDock Vina assessed calotropin’s interaction with Bcl-2 and HER-2 proteins. Antioxidant activity was measured by the DPPH method, and cytotoxic activity was tested on MCF-7 breast cancer cells and normal Vero cells using the MTT assay. EFBR was found to contain cardiac glycosides, flavonoids, terpenoids, saponins, and tannins. Docking results showed strong binding of calotropin to Bcl-2 (-9.3 kcal/mol) and HER-2 (-8.1 kcal/mol). EFBR showed weak antioxidant activity (IC₅₀: 518.93 μg/mL) but moderate cytotoxicity against MCF-7 (IC₅₀: 159.80 μg/mL), with low toxicity on Vero cells (IC₅₀: 2703.61 μg/mL) and a high selectivity index (SI: 16.91). These results indicate that EFBR has potential as a selective chemopreventive agent against breast cancer.Keywords: Calotropis gigantea L., molecular docking, MTT assay, DPPH, MCF-7.
In Silico Study of Potential Active Compounds in Guava Leaves (Psidium guajava L.) Targeting Beta Estrogen for Breast Cancer Therapy Nazma Mumtaz Sidik; Nabillah Fauziyyah; Nissa Andjani Kusmawidiyanti; Difla 'Afina Ghifari Suhendar; Nawadhir Fauzan; Shela Salsabila; Muchtaridi Muchtaridi
Indonesian Journal of Cancer Chemoprevention Vol 16, No 2 (2025)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev16iss2pp79-92

Abstract

Breast cancer is a disease that is the main cause of death, especially in women, where malignant cells form in breast tissue. Some breast cancers are sensitive to hormone estrogen. Overexpression that occurs from an estrogen receptor will increase excessive proliferation. ER-β was chosen as a therapeutic target protein because it can inhibit the proliferation and invasion of breast cancer cells and trigger apoptosis. In this in silico study, a test was carried out on the activity of the active compound content of potential secondary metabolites in Guava plants (Psidium guajava L.) in the leaves aimed at the Estrogen Beta receptor (ER-β) for breast cancer therapy. The goal is to obtain new compound candidates to help pharmacological therapy of breast cancer. This can be seen from the results of re-docking of natural ligands (Genistein) and docking of fifty test ligands which are potential secondary metabolite compounds contained in Guava plants (Psidium guajava L.) in the leaves. The compound that has the greatest potential to activate ER-β as an antiproliferation of breast cancer cells is Clionasterol.Keywords: Breast cancer, Psidium guajava L., ER-β Agonist, molecular docking, clionasterol.
Molegro Virtual Docker-Based Prediction of Rhodomyrtus tomentosa Metabolites Targeting Ribonucleotide Reductase as Potential Anticancer Agents Imam Nurjaman; Dini Kesuma; Tegar Achsendo Yuniarta; Nina Dewi Oktaviyanti
Indonesian Journal of Cancer Chemoprevention Vol 16, No 2 (2025)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev16iss2pp107-122

Abstract

The increasing number of cancer cases has prompted the search for new drug candidates from natural ingredients, particularly plant-derived compounds considered safer and more effective. Rhodomyrtus tomentosa (Aiton) Hassk. contains various metabolites responsible for various biological activities. This study aimed to predict the anticancer potential of R. tomentosa metabolites against the Ribonucleotide Reductase (RNR) enzyme using an in silico approach. The RNR protein structure (PDB ID: 2WGH) was obtained from the RCSB Protein Data Bank. Molecular docking was performed on 25 compounds previously reported in the literature as metabolites of R. tomentosa using Molegro Virtual Docker (MVD) version 7.0 to evaluate ligand-receptor binding affinity based on MolDock Score values using a validated docking protocol (RMSD≤2.0 Å), followed by interaction analysis and pharmacokinetic evaluation using ADMET parameters. The results indicated that most compounds exhibited favorable binding affinities toward RNR, as reflected by negative MolDock Score values. Rhodomyrtosone B (−137.144 kcal/ mol) showed the best binding affinity, followed by Malvidin-3-glucoside (−135.173 kcal/ mol), Delphinidin-3-galactoside (-132.359 kcal/mol), Rhodomyrtosone I (−130.004 kcal/ mol), and Cyanidin-3-galactoside (-127.741 kcal/mol). Interaction analysis revealed stable interactions with key amino acid residues (Arg256, Asp226, and Ser269) through hydrogen bonding, hydrophobic, and electrostatic interactions. ADMET analysis indicated variability in pharmacokinetic properties, including absorption, distribution, metabolism, and toxicity. In conclusion, Rhodomyrtosone B has potential as a natural product-based anticancer agent targeting RNR, providing a basis for further in vitro and in vivo studies.Keywords: anticancer, Rhodomyrtus tomentosa, molecular docking, Ribonucleotide Reductase; in silico.
In Silico Identification of Heterotrigona itama Propolis Compounds as GC-C Agonists and LGR5 Inhibitors for Colorectal Cancer Chemoprevention Clara Vinny Amalia; Paula Mariana Kustiawan
Indonesian Journal of Cancer Chemoprevention Vol 16, No 2 (2025)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev16iss2pp123-136

Abstract

Abnormal regulation of LGR5 receptors in the Wnt pathway and loss of Guanylyl Cyclase C (GCC) expression have been implicated in the pathogenesis of colorectal cancer, rendering them promising therapeutic targets for further exploration. With the growing focus on natural product-based drug development, Heterotrigona itama propolis emerges as a potential source of bioactive compounds. This in silico study aims to analyze the potential of active compounds from stingless bee propolis as GCC receptor agonists and LGR5 receptor inhibitors and to identify the compounds with the most favorable binding affinity. The results revealed that eleven propolis compounds, including CAPE, Quercetin, Chrysin, 9-octadecenoic acid, Cardol, Cardanol, and Anacardic acid, could bind to both GC-C and LGR5 target receptors. Among these, cardanol had the highest binding affinity for GCC (-7.3 kcal/mol), while Anacardic acid showed the best binding affinity for LGR5 (-6.5 kcal/mol). Overall, the Heterotrigona itama propolis compounds exhibited a stronger binding affinity for LGR5 than for GCC. The substance has good action in binding to the receptor, suggesting that it may be used as treatment to prevent the progression of colorectal cancer. These findings provide a foundational basis for further studies to validate the pharmacological potential of propolis for colorectal cancer treatment.Keywords: cancer, colorectal, LGR5, GCC, propolis.

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