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Current Biochemistry
Published by Institut Pertanian Bogor
ISSN : 23557877     EISSN : 23557931     DOI : -
Core Subject : Science, Education,
Biochemistry, Genetics & Molecular Biology Education
Current Biochemistry (CB) publishes the results of original research that contribute significantly to the understanding of the chemical compound and reaction that occur within living organism. Preference will be accorded to manuscripts that develop new concepts or experimantal approaches, particularly in the advancing areas of biochemistry science. Manuscripts that are primarily theoretical in nature or in the field of bioinformatics must be directed toward explaining important results previously not understood, making important predictions that can be experimentally tested, or developing segnificant advances in theory of general interest to biochemists. Submission of manuscripts in emerging areas in biochemistry, chemical biology, biophysics, proteomics, model studies and structures, cellular and molecular biology, computational biochemistry, biotechnology, and new methods development is encouraged especially if they address basic biochemical mechanisms.
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Articles 4 Documents
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Search results for , issue "Vol. 8 No. 1 (2021)" : 4 Documents clear
Review: Gallotannins; Biosynthesis, Structure Activity Relationship, Anti-inflammatory and Antibacterial Activity Ilham Kurniawan; Hafizh Zahra
Current Biochemistry Vol. 8 No. 1 (2021)
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/cb.8.1.1

Abstract

Tannins are one of the main compounds in plants with potential health benefits. Gallotannin is one of the biologically active tannins groups produced by some medicinal plants. Gallotannins is a hydrolyzable tannin compound biosynthesized through gallic acid, shikimic acid, and pentagalloylglucose pathways. Gallotannins can be separated by cascade solvent extraction procedures, column chromatography, and preparative HPLC. This review focuses on the discussion of biosynthesis and structure-activity relationship of tannins as antibacterial and anti-inflammatory. The structure-activity relationship (SAR) and biological activity of gallotannins is caused by the molecular bonds between gallotannins and certain other compounds, especially proteins, which make complex compounds, change physiological and morphological processes in bacterial cells or tissues. The biological activities of gallotannin include anti-inflammatory, anticancer or antitumour, antiviral, antioxidant, antibacterial, and antidiabetic. This review used the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) method approach in a short, concise, and clear summary about tannins through various references. Keywords: Biological activities, Biosynthesis, Gallotannins
Minimum Concentration of Stingless Bee Propolis (Trigona sp.) in Inhibiting the Growth of Dandruff Bacteria Akhmad Endang Zainal Hasan; I Made Artika; Erlank Bagjavicenna
Current Biochemistry Vol. 8 No. 1 (2021)
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/cb.8.1.2

Abstract

Lack of confidence in men and women, one of which is when there is dandruff on the hair and scalp. Hair loss is a further symptom of the presence of white scales on the scalp that cause itching. The presence of excessive microorganisms can aggravate this dandruff. Ingredients such as ketocanozole, zinc pyrithione, selenium sulfide and sulfur are compounds commonly used in shampoo formulas. Propolis is an alternative natural ingredient to treat dandruff. The purpose of this study was to determine the minimum growth inhibitory concentration (MIC) of propolis against dandruff-causing bacteria. Dandruff-causing microbes were isolated from dandruff hair and with the well method in a petri dish, the minimum growth inhibitory concentration of propolis was determined. The microbial colonies produced were very diverse with a round shape like grapes, yellowish white in color. The concentration of 6.25% is the MIC value of propolis extract against dandruff microbes. The effectiveness values against ketoconazole and propolis X from the tested propolis extract were 223.52% and 99.59%, respectively. Keywords: hair loss, dandruff, propolis, bacteria , Trigona
Antioxidant Activity, Inhibition α-Glucosidase of Cymbopogon nardus (L.) Rendle and Identification of Active Compounds Najmah Najmah; Hasim Hasim; Didah Nur Faridah
Current Biochemistry Vol. 8 No. 1 (2021)
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/cb.8.1.3

Abstract

Diabetes mellitus (DM) has become a health problem in various countries, even in Indonesia, multiple of Covid-19 sufferers have DM as comorbid. Treatment of DM can be conducted by delaying glucose intake performed by the α-glucosidase enzyme in the intestine. Treatment using synthetic drugs often causes side effects. Instead to overcome these problems, herbal medicine is a choice. Cymbopogon nardus (L.) Rendle served as a potential candidate as seen from prior research but related to DM drugs, further exploration needs to be performed. This study aims to acquire a DM medicine by using Cymbopogon nardus (L.) Rendle . The leaves were macerated using 96% concentration of ethanol followed by multilevel fractionation with n-hexane, water and ethyl acetate as solvents. The test results showed that the n-hexane fraction was the best for antioxidant activity and α -glucosidase inhibition with IC50 values of 8,23 ppm and 311,87 ppm while the identification of the compound by using Liquid Chromatograph-Mass Spectrometry (LC-MS/MS) suspected compounds that have a role were ar-turmerone, beesioside N and notohamosin A. Based on the test, the n-hexane fraction was found as a source of antioxidants as well as α -glucosidase inhibitors. Keywords: Antioxidant, α -glucosidase, Cymbopogon nardus (L.) Rendle, LC-MS/MS.
Antioxidant Activities and α-glucosidase Inhibition of Gayo Arabica Coffee Skin (Coffea arabica L) Baharuddin Yusuf Habiby Harahap; Hasim Hasim; Didah Nur Faridah
Current Biochemistry Vol. 8 No. 1 (2021)
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/cb.8.1.4

Abstract

This research objectives to determine antioxidant activities and inhibition of α-glucosidase 96 % ethanol extract of gayo arabica coffee skin, n-hexane fraction, ethyl acetate fraction, and water fraction. Gayo arabica coffee skin was extracted by ethanol using maceration and fractionation using n-hexane, ethyl acetate, and water. Quercetin and Gallic acid were used as standard to found total flavonoids and phenolics. Test of antioxidant activity using the DPPH method. After being tested the inhibition of the α-glucosidase IC50 ethanol extract, the n-hexane fraction, ethyl acetate fraction, and water fractions. The total flavonoids of 96% ethanol extract, n-hexane fraction, ethyl acetate, and water fraction respectively are 76.74, 99.07, 73.55, 50.24 mg QE/g extract . Total phenolics of 96% ethanol extract, n-hexane fraction, ethyl acetate, and water fraction respectively are respectively 211.85, 136.67, 145.19, 127.41 mg GAE/ g extract. Antioxidants activity of ethanol extract, n-hexane fraction, ethyl acetate fraction, and water fraction are IC50 12.03 ppm, 36.08 ppm, 30.27 ppm, 11.62 ppm. Inhibition activity α-glucosidase enzyme respectively are 588.85 ppm, 341.81 ppm, 591.61 ppm, and 798.78 ppm. These showed that the ethanol extract and water fraction are the best in antioxidants and the ethanol extract and ethyl acetate fraction are the best in inhibiting the α-glucosidase enzyme. These results indicate that gayo arabica coffee skin extract has the potential to be developed as an antidiabetic compound. Keywords: Antidiabetic, Antioxidant, flavonoids, phenolics, α-glucosidase

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