Garuda - Garba Rujukan Digital

Article Per Year (5 Year)

All

Berkala Ilmu Kesehatan Kulit dan Kelamin

BIKK
Website

Published by Universitas Airlangga

ISSN : 19784279 EISSN : 25494082 DOI : 10.20473

Core Subject : Health, Science,

Immunology & microbiology Public Health

Arjuna Subject : -

Articles 481 Documents

1 2 3 4 5

Reverse Transcription Polymerase Chain Reaction (RT-PCR) untuk Mendeteksi Viabilitas Mycobacterium leprae pada Pasien Kusta Tipe Multibasiler Pascapengobatan MDT-WHO Gayatri, Lunni; Listiawan, M. Yulianto; Agusni, Indropo
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 26, No 2 (2014): BIKKK AGUSTUS 2014
Publisher : Faculty Of Medicine Airlangga University

Latar belakang: Kusta masih menjadi masalah besar di Indonesia. Penatalaksanaan dengan MDT-WHO telah menjadi regimen standar untuk pasien kusta sejak lama. Pada pasien kusta tipe multibasiler (MB), indeks bakteriologis (IB) belum mencapai nilai nol, meskipun telah menyelesaikan terapi 12 regimen. Metode Reverse Transcription-Polymerase Chain Reaction (RT-PCR) memiliki sensitivitas tinggi untuk mendeteksi viabilitas M. leprae. Tujuan: Mengevaluasi viabilitas M. leprae dengan metode RT-PCR pada pasien kusta tipe MB yang telah menyelesaikan regimen MDT 12 di RSUD Dr. Soetomo Surabaya. Metode: 15 pasien kusta tipe MB yang telah menyelesaikan pengobatan MDT-WHO 12 regimen dengan IB positif dilakukan biopsi kulit untuk pemeriksaan RT-PCR. Hasil: Terdapat 13 pasien (86,7%) dengan viabilitas M. leprae positif sementara seluruh pasien tersebut (100%) memiliki Indeks Morfologis (IM) 0%. Dua belas pasien (80%) memiliki Indeks Bakteriologis 2+ dan 10 pasien diantaranya adalah pasien kusta tipe Lepromatous Leprosy (LL) polar. Delapan pasien yang memiliki viabilitas positif tidak mendapatkan kortikosteroid oral selama siklus MDT. Simpulan: Pasien kusta yang telah menyelesaikan terapi MDT dengan MI 0%, didapatkan viabilitas M. Leprae positif dengan metode RT-PCR. Spektrum klinis pasien yang ditentukan dari imunitas seluler nampaknya menjadi faktor terpenting dalam viabilitas M. leprae.Katakunci: viabilitas, M. leprae, kusta tipe multibasiler, RT-PCR.

Increasing of Skin pH level in Childhood Atopic Dermatitis Primadiarti, Pedia; Rahmadewi, Rahmadewi; Zulkarnain, Iskandar
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 26, No 3 (2014): BIKKK DESEMBER 2014
Publisher : Faculty Of Medicine Airlangga University

Background: Atopic dermatitis (AD) has multifactorial etiologies such as genetic, environment, and imbalance of immunology basis.Â AD is marked with skin barrier dysfunction, whichcharacterized by fillagrin mutation. Fillagrin itself has an important role in skin hydration and pH adjustment, so that its functional nor amount defect will lead to hydration and pH adjustment impair, as well as shown in AD phenotype. Purpose: To evaluatethe difference of skin pH in AD (lesional and non lesional area) and normal children. Methods:Â Phase 1 study was descriptive observational study, to determinenormal skin pH in 98 children. The following phase 2 was observational analitic study in 38 AD patients todeterminepH level of atopic group (lesional and non lesional skin).Results: pH level of normal children skin was 4.86Â±0.461, lesional skin in AD was 5.86Â±0.564, and in nonlesional skin was 5.20Â±0.460. One way ANOVA test revealed value p=0.000, post hoc analysis value was p=0.000. Conclusions: Higher pH level was observed on AD patients. Skin pH is an important factor in the pathogenesis of AD, main concern in the treatment of AD is maintaining skin pH, which is important to reduce AD exacerbation.Key words: fillagrin, pH of atopic dermatitis,pH of normal children.

Immunomodulators for a Variety of Viral infections of the Skin Wulan, I G A Kencana; Agusni, Indropo
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 27, No 1 (2015): BIKKK APRIL 2015
Publisher : Faculty Of Medicine Airlangga University

Background: In the last decade there has been inceasing prevalence of viral infections in the world, this led to increased efforts to find a variety of new drugs and vaccines against the virus that causes. Purpose: To disccuss the provision relating to the use of immunomodulators in viral infections. Review: Some diseases caused by viruses such as varicella, herpes zoster, herpes simplex, condyloma acuminata, molluscum contagiosum and Human immunodeficiency syndrome (HIV). Immunomodulator also known as biological response modifier, a wide variety of materials imunoaugmentor is either recombinant, synthetic, or natural medicines that returns an imbalance of the immune system that is used in immunotherapy. Immunotherapy is a treatment approach by restoring, enhancing, or suppresing the immune response. Immunomodulator administration on viral infections gave varying results. Conclusion: Immunomodulatory regimens on viral infections is an attractive therapeutic approach, because the side effects are often lighter than the side effects of drugs that have been there, in addition to the more rarely cause resistance to treatment of diseases caused by viral infection.Key word: viral infection, immunomodulator, immune response.

Characteristic of Subcutan Mycosis: A Retrospective study Sukmawati, Netty; Ervianty, Evy
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 27, No 3 (2015): BIKKK DESEMBER 2015
Publisher : Faculty Of Medicine Airlangga University

Background: Subcutaneous mycosis is a rare cases. Incidence of subcutaneous mycosis in Indonesia is unknown. Limited experiences, problems in diagnosis and management may cause difficulties in treating subcutaneous mycosis. Objective: To know the characteristic of subcutaneous mycosis cases in Indonesia and to improve the quality of medical service. Methods: Retrospective study of cases were treated in Departement of Dermatology and Venereology Dr. Soetomo General Hospital within 2010â2014 (5 years). The data include number of cases, age, sex, domicile, complained, risk factors, duration of illness, location of skin lesion, symptoms, laboratory examination, and treatment. Results: a number of cases ranged between 1-8 patients per year. There was 1 case in 2010, 2 cases in 2011, 2 cases in 2012, 2 cases in 2013, and 8 cases in 2014. The diagnosis included eumycetoma, actinomycetoma, chromoblastomycosis, basidiobolomycosis, and phaeohyphomycosis. No cases of sporotrichosis, lobomycosis, and rhinosporodiosis. Majority of patients showed specific characteristic history, clinical manifestation, and histopathology examination, but most culture results were negative. Treatment was given based on diagnosis. Conclusions: Number of subcutaneous mycosis cases per year is 1-8 patients. Diagnosis based on characteristic history, clinical manifestations and histopathology examination.Key words: mycosis subcutan, characteristic, retrospective study.

Insufisiensi Adrenal Sekunder pada Eritema Nodosum Leprosum: Studi Profil TNF-Î± dan Kortisol Serum Citrashanty, Irmadita; Suyoso, Sunarso; Rahmadewi, Rahmadewi
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 26, No 2 (2014): BIKKK AGUSTUS 2014
Publisher : Faculty Of Medicine Airlangga University

Latar belakang: Beberapa studi mengemukakan bahwa peningkatan tumor necrosis factorâalpha (TNF-Î±) sebanding dengan derajat keparahan Eritema Nodosum Leprosum (ENL), sehingga sitokin ini dianggap sebagai seromarker. Sekresi adrenocorticotropin hormone (ACTH) meningkat akibat pelepasan sitokin proinflamasi, kemudian ACTH akan merangsang pelepasan glukokortikoid adrenal sebagai umpan balik. Apabila rangsangan sitokin ini berlangsung kronis, korteks adrenal akan mengalami kelelahan yang berakibat menurunnya serum kortisol. Pemberian kortikosteroid eksogen jangka panjang diduga menyebabkan terjadinya penurunan kortisol. Tujuan: Mengevaluasi profil TNF-Î± dan kortisol serum pada pasien ENL yang diterapi kortikosteroid berdasarkan riwayat lamanya ENL. Metode: Dua puluh satu subjek dilakukan pemeriksaan fisik, anamnesis riwayat ENL, dan pengambilan sampel darah jam 08.00-09.00 untuk melihat kadar TNF-Î± dan kortisol serum. Hasil: Dari 21 sampel didapatkan rerata TNF-Î± serum sebesar 4,51 Â± 1,7 Ïg/mL. Rerata kortisol serum pada pasien dengan riwayat ENL 1-12 bulan sebesar 15,23 Â± 2,3 Î¼g/dL, riwayat ENL > 12-24 bulan sebesar 8,75 Â± 4,8 Î¼g/dL, dan riwayat ENL > 24-36 bulan sebesar 1,17 Â± 0,7 Î¼g/dL. Simpulan: Rerata penurunan kortisol serum tampak seiring dengan semakin lamanya pasien menderita ENL dan mendapatkan terapi kortikosteroid. Insufisiensi adrenal sekunder pada penelitian ini dapat disebabkan oleh pemberian kortikosteroid jangka panjang maupun adanya paparan sitokin proinflamasi kronis. Kata kunci: eritema nodosum leprosum, insufisiensi adrenal sekunder, kortikosteroid, TNF-Î±, kortisol.

Non Bullous Congenital Ichthyosiform Erythroderma Setyowatie, Lita; Zulkarnain, Iskandar
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 26, No 2 (2014): BIKKK AGUSTUS 2014
Publisher : Faculty Of Medicine Airlangga University

Background: Non bullous congenital ichthyosiform erythroderma (NBCIE) is an inherited genodermatosis, very rare autosomal recessive inflammatory ichthyosis, chronic, characterized by dryness and scaling. Purpose: To describe the clinical manifestations of NBCIE since it is a rare case, occurs in 1 in 300.000 people. Case: Baby MR 5 month old, Javanese boy, with main complaint white scale and redness patches on almost all of his body since 1.5 month old. Born as collodion baby, then the membrane was slowly thinning and became generalized erythroderma on almost all of his body accompanied with fine white scale, large, thick, plate-like scale only on lower leg. No ectropion and eclabium. No relatives in the pedigree suffer from the same disease. Histopathology examination showed non-bullous congenital ichthyosiform erythroderma. Case management: Emollient after bath and pH balance soap. Conclusions: Diagnosis of NBCIE is established from history taking, clinical features, and histopathology examination. Emollient therapy and pH balance soap will eventually lead to improvement.Key words: non bullous congenital ichthyosiform erythroderma, genodermatosis, collodion baby.

Viral infection proï¬le in Pediatric Dermatology Division clinic of Dermatology and Venereology Outpatient Dr. Soetomo General Hospital Surabaya Prabawaningrum, Kinanti; Zulkarnain, Iskandar
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 27, No 1 (2015): BIKKK APRIL 2015
Publisher : Faculty Of Medicine Airlangga University

Background: Viral infections are common in children and distributed widely in the world. There are not many studies that discuss the proï¬le of viral infection in children in East Java. Purpose: To evaluate viral infections patients proï¬les in the Pediatric Dermatology Division Dermatovenereology Outpatient Clinic of Dr. Soetomo General Hospital in 2008-2010 including prevalence, demographic data, type of infection, patient complaints, skin lesions and management. Methods: A retrospective study using medical records for the period January 2008-December 2010. Basic data (age , gender), history (chief complaint, began to arise, disease history), examination (morphology) and treatment (therapy, repeat visits) were recorded. Results: Viral infection patients as much as 285 patients (6.5 % of all pediatric patients at URJ). Most found diagnosis is molluscum contagiosum (40.4%), in the age group 5-14 years (68.4 %), highest complaints pimples (42.8 %) , most duration of diseases >10 days (40 %). Most management actions in the cosmetics division (61.1 %). Conclusion: Viral infection patients in Pediatric Dermatology Division clinic of Dermatology and Venereology Outpatient Dr. Soetomo General Hospital Surabaya in 2008-2010 is likely to increase each year and require a more comprehensive management.Key words : viral infection, child, RSUD Dr. Soetomo.

Laboratory Examination in Genital Chlamydia trachomatis Infection Reza, Novianti Risky; SHW, Tantari
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 27, No 2 (2015): BIKKK AGUSTUS 2015
Publisher : Faculty Of Medicine Airlangga University

Background: Chlamydia trachomatis (CT) is one of the most common agents caused nonspesific genital infections in both men and women worldwide and also in Indonesia. Chlamydial infection can be asymptomatic, became source of infection for the partner, and serious complication may be occurred. Early diagnosis and prompt treatment were needed to prevent the complication. Purpose: To review the advantages and disadvantages of numerous laboratory diagnostic methods of genital CT infections. Review: The gold standart in CT infection diagnosis was culture but it was difficult to do in clinical setting. Diagnosis by direct antigen methods for diagnosing CT infections, such as direct fluoresence assay (DFA),enzim immuno assay (EIA), nucleic acid detection, citology ,and serology can be done. Conclusion: Combining two or more different methods of laboratory examinationÂ will give better results in diagnosis with better sensitivity and specificity.Key words: Chlamydia trachomatis, genital infection, laboratory.

Studi Retrospektif: Psoriasis Pustulosa Generalisata Gayatri, Lunni; Ervianti, Evy
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 26, No 1 (2014): BIKKK APRIL 2014
Publisher : Faculty Of Medicine Airlangga University

Latar belakang: Angka kejadian kasus psoriasis pustulosa di Indonesia belum diketahui. Selama ini belum pernah dilakukan penelitian retrospektif terhadap penyakit psoriasis pustulosa generalisata. Tujuan: Mengevaluasi gambaran kasus psoriasis pustulosa generalisata untuk meningkatkan mutu pelayanan terhadap pasien di masa mendatang. Metode: Studi retrospektif pasien psoriasis pustulosa generalisata yang dirawat inap di Instalasi Rawat Inap Kulit dan Kelamin RSUD Dr. Soetomo Surabaya selama periode 1 Januari 2001 sampai 31 Desember 2011. Dilakukan penelitian mengenai jumlah kasus, umur, jenis kelamin, anamnesis, pemeriksaan fisik, diagnosis, pemeriksaan penunjang, dan terapi yang diberikan. Hasil: Didapatkan 21 pasien psoriasis pustulosa generalisata dari pengamatan selama 11 tahun. Kasus terbanyak terjadi pada usia antara 2140 tahun (57,1%), pasien perempuan lebih banyak daripada lakilaki (16:5). Pemeriksaan histopatologi dilakukan pada 15 pasien dengan hasil 80% sesuai dengan gambaran psoriasis pustulosa. Terapi methotrexate diberikan pada seluruh pasien, dengan hasil 52,3% pasien dinyatakan mulai sembuh saat pasien keluar rumah sakit. Simpulan: Kasus psoriasis pustulosa generalisata setiap tahun berjumlah 13 pasien. Diagnosis ditegakkan berdasarkan anamnesis, gejala klinis, kemudian dicocokkan dengan hasil patologi anatomi. Kata kunci: pustula, psoriasis pustulosa generalisata, methotrexate.

Ki-67 Immunohistochemistry Examination in Pityriasis Rubra Pilaris Sari, Diana Kartika; Prakoeswa, Cita Rosita Sigit; Soemarno, Troef
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 26, No 3 (2014): BIKKK DESEMBER 2014
Publisher : Faculty Of Medicine Airlangga University

Background: Pityriasis rubra pilaris (PRP) is a papulosquamous disorder of unknown etiology. PRP is often difficult to be distinguished with psoriasis in early phase of the disease. Purpose: To deliver information about Ki-67 immunohistochemistry examination in PRP. Reviews: The diagnosis of PRP can be established by histological examinations or even immunohistochemistry. The best treatment options are retinoids, photochemotherapy (PUVA), and antimetabolites (methotrexate). Conclusion: Immunohistochemistry examination can provide complete feature to distinguish between PRP and psoriasis because of its high specifity.Key words: Ki-67 immunohistochemistry, pityriasis rubra pilaris, diagnosis.

Page 3 of 49 | Total Record : 481

1 2 3 4 5

Filter by Year

2014 2025

Filter By Issues

All Issue Vol. 37 No. 2 (2025): AUGUST Vol. 37 No. 1 (2025): APRIL Vol. 36 No. 3 (2024): DECEMBER Vol. 36 No. 2 (2024): AUGUST Vol. 36 No. 1 (2024): APRIL Vol. 35 No. 3 (2023): DECEMBER Vol. 35 No. 2 (2023): AUGUST Vol. 35 No. 1 (2023): APRIL Vol. 34 No. 3 (2022): DECEMBER Vol. 34 No. 2 (2022): AUGUST Vol. 34 No. 1 (2022): APRIL Vol. 33 No. 3 (2021): DECEMBER Vol. 33 No. 2 (2021): AUGUST Vol. 33 No. 1 (2021): APRIL Vol. 32 No. 3 (2020): DECEMBER Vol. 32 No. 2 (2020): AUGUST Vol. 32 No. 1 (2020): APRIL Vol. 31 No. 3 (2019): DESEMBER Vol. 31 No. 2 (2019): AGUSTUS Vol. 31 No. 1 (2019): APRIL Vol. 30 No. 3 (2018): DESEMBER Vol. 30 No. 2 (2018): AGUSTUS Vol. 30 No. 1 (2018): APRIL Vol. 29 No. 3 (2017): DESEMBER Vol. 29 No. 2 (2017): AGUSTUS Vol. 29 No. 1 (2017): APRIL Vol. 28 No. 3 (2016): DESEMBER Vol. 28 No. 2 (2016): AGUSTUS Vol. 28 No. 1 (2016): APRIL Vol 27, No 3 (2015): BIKKK DESEMBER 2015 Vol. 27 No. 3 (2015): BIKKK DESEMBER 2015 Vol 27, No 2 (2015): BIKKK AGUSTUS 2015 Vol. 27 No. 2 (2015): BIKKK AGUSTUS 2015 Vol. 27 No. 1 (2015): BIKKK APRIL 2015 Vol 27, No 1 (2015): BIKKK APRIL 2015 Vol. 26 No. 3 (2014): BIKKK DESEMBER 2014 Vol 26, No 3 (2014): BIKKK DESEMBER 2014 Vol. 26 No. 2 (2014): BIKKK AGUSTUS 2014 Vol 26, No 2 (2014): BIKKK AGUSTUS 2014 Vol 26, No 1 (2014): BIKKK APRIL 2014 Vol. 26 No. 1 (2014): BIKKK APRIL 2014 More Issue

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name
-

Contact Email
-

Phone
-

Journal Mail Official
-

Editorial Address
-

Location
Kota surabaya,

Jawa timur

INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name -

Contact Email -

Phone -

Journal Mail Official -

Editorial Address -

Location Kota surabaya, Jawa timur INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
-

Contact Email
-

Phone
-

Journal Mail Official
-

Editorial Address
-

Location
Kota surabaya,

Jawa timur

INDONESIA