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INDONESIA
Jurnal Sains dan Teknologi Farmasi
Published by Universitas Andalas
ISSN : -     EISSN : -     DOI : -
Core Subject : Science, Education,
Computer Science & IT Education
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Articles 11 Documents
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Search results for , issue " Vol 17 No 2 (2012)" : 11 Documents clear
Evaluasi Ketersediaan Pelayanan Informasi Obat Resep Glibenklamid sebagai Anti Diabetes Oral di Apotek-Apotek Wilayah Kabupaten Sleman DIY Djunarko, Ipang; Butar-Butar, Iryana
Jurnal Sains dan Teknologi Farmasi Vol 17 No 2 (2012)
Publisher : Fakultas Farmasi Universitas Andalas

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This study aimed at describing glibenclamide prescription service profile which includes the availability of glibenclamide prescription information services provided by pharmacist at the pharmacy as well as the availability and completeness of the prescription copies and the drug label. This study was non-experimental study or observational descriptive study design through Participatory observation Partial. The data obtained included type of drug information provided, copy of prescription, drug label, and the status of prescribing provider,which were analyzed by descriptive statistics. From 124 sample of pharmacies, 3 (2,43%) pharmacies refused to serve prescription. Profil of prescription service given : 30 (24,19%) pharmacies returned the prescription, 4 (3,23%) refused making copy of prescription, 1 (0,81%) pharmacy didn’t provide medicine appropriately with prescription, 21 (16,94%) didn’t attach drug label, 8 (6,45%) didn’t provide drug information service, and 53 (42,74%) pharmacies didn’t conduct the prescription service by competent pharmacist. From the amount of 113 which provide drug information service, there was no pharmacy give drug information service completely based on Kepmenkes RI No. 1027 tahun 2004. 
Uji Bioaktivitas Losartan Terhadap Jaringan Fibrosis Hati Tikus Yang di Induksi Karbon Tetraklorida (CCl4) Achmad, Anisyah
Jurnal Sains dan Teknologi Farmasi Vol 17 No 2 (2012)
Publisher : Fakultas Farmasi Universitas Andalas

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Hepatic fibrosis is an inflammation of  liver which involves series of cells and mediators. Hepatic fibrosis can lead to cirrhosis. Hepatic fibrosis increase the risk of clinical complication such as portal hypertension and hepatocyte disfunction. This study aimed at finding amarker for non invasive hepatic fibrosis or an antifibrotic by comparison of the degree of hepatic fibrosis  after administration of CCl4 and losartan. Thirty five rat’s were divided into 7 groups which were K-1, K-2, K-3, K-4, K-5, K-6, K-7 respectively. K-1 was olive oil control group, K-2, K-3 and K-4 were given CCl4 0,2 ml/100g interperitonially third a week, K-5, K-6 and K-7 were given CCl4 and losartan 5 mg/Kg BB per oral per day. CCl4 and losartan were given for 6 weeks and the change in rat’s hepatic histopathology was observed at week 1st, 4th, and 6th. Histopatology of rat’s liver changed from centrotubular necrosis to centrotubular degeneration but did not show hepatic fibrosis.
Uji Sitotoksik Ekstrak dan Fraksi Daun Jati (Tectona Grandis Linn. F.) dengan Metoda Brine Shrimp Lethality Bioassay Alen, Yohannes; Akhsanita, Mardha; mulyani, Isna; Susanti, Meri
Jurnal Sains dan Teknologi Farmasi Vol 17 No 2 (2012)
Publisher : Fakultas Farmasi Universitas Andalas

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he Study of cytotoxic effects of the methanolic extract and the fraction of Teak’s leave (Tectona grandis Linn. f.) by using Brine Shrimp Lethality Bioassay Method had been done. Results showed that the methanolic extract have cytotoxic level of (LC50) 16,58 ppm, n-hexane fraction 21,83 ppm, ethyl acetate fraction 21,31 ppm and residue fraction 21,27 ppm, respectively.
Tinjauan Penggunaan Metformin pada Pasien Diabetes Mellitus Tipe 2 Rawat Inap di SMF Ilmu Penyakit dalam RSUD Dr.Achmad Mochtar Bukittinggi, Indonesia Nasif, Hansen; Efrina, Yeni; Muchtar, Husni
Jurnal Sains dan Teknologi Farmasi Vol 17 No 2 (2012)
Publisher : Fakultas Farmasi Universitas Andalas

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Metformin, adalah suatu obat yang direkomendasikan sebagai obat pilihan utama dan digunakan luas untuk pengobatan diabetes mellitus tipe 2. Tujuan dari penelitian ini adalah untuk mempelajari penggunaan metformin pada pasien rawat inap di SMF Ilmu Penyakit Dalam RSUD Dr. Achmad Mochtar Bukittinggi, khususnya pada penggunaan yg dikategorikan kontraindikasi. Penelitian ini merupakan suatu studi prospektif  follow up pasien dengan teknik pengambilan sampel menggunakan metode purposive sampling. Data diambil dari bulan April sampai Juni 2010 di  SMF Ilmu Penyakit Dalam RSUD Dr. Achmad Mochtar Bukittinggi, dengan dasar perubahan kondisi pasien selama dirawat. Hasil penelitian, didapatkan 28 pasien yang memenuhi kriteria dalam penelitian ini, dengan 11 pasien teridentifikasi menggunakan metformin pada keadaan kontraindikasi. Ditemukan penggunaannya pada 3 pasien dengan gagal jantung kongesti dan gagal ginjal, 3 pasien dengan gagal jantung, 2 pasien dengan gagal ginjal, 2 pasien dengan sirosis hepatik, dan 1 pasien dengan dehidrasi akut disertai hipoperfusi. Terdapat 2 dari 11 pasien tersebut meninggal dalam masa pengamatan, namun masih belum bisa dipastikan bahwa penyebab kematian tersebut adalah karena penggunaan metformin. Farmasis harus selalu memperhatikan perubahan kondisi pasien untuk meyakinkan bahwa penggunaan obat masih aman bagi seorang pasien.
Pembuatan Mikrokristalin Selulosa dari Ampas Tebu (Saccharum officinarum L.) Zulharmita, Zulharmita; Dewi, Siska Nola; Mahyuddin, Mahyuddin
Jurnal Sains dan Teknologi Farmasi Vol 17 No 2 (2012)
Publisher : Fakultas Farmasi Universitas Andalas

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A study on the preparation of microcrystalline cellulose from sugar cane bagasse (Saccharum officinarum L.) has been carried out. A total of 250 grams of dry sugar cane bagasse was made into alpha-cellulose by the method of multistage pulping and hydrolyzed with hydrochloric acid to produce microcrystalline cellulose which was further characterized. Microcrystalline cellulose were obtained as much as 71.5 grams with a yield of 28.6%. Characterization of microcrystalline cellulose from dry sugar cane bagasse, was done, including loss on drying, organoleptic, blue-violet coloured with of iodinated zinc chloride solution, soluble in the ammoniacal copper tetrammine solution, water-disoluble substances, not giving blue coloured with iodine 0.05 M, pH ± 6 and absorbance spectrum using FT-IR spectrophotometer as same as the standard. It was concluded that microcrystalline cellulose from sugar cane bagasse and Vivacel PH 102® has fulfilled the requirements of British Parmacopoeia 2002.
Uji Efek Sitotoksik Ekstrak Etanol Akar Asam Kandis (Garcinia Cowa Roxb.) pada Mencit Putih Betina dengan Metode Micronucleus Assay Wahyuni, Fatma Sri; Siregar, Fitriyani; Dharma, Surya
Jurnal Sains dan Teknologi Farmasi Vol 17 No 2 (2012)
Publisher : Fakultas Farmasi Universitas Andalas

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The cytotoxic effect of ethanolic extract of Garcinia cowa Roxb. roots had been investigated on female mice using Micronucleus Assay method. Sixty mice were grouped into five: negative control, positive control, dosage I (extract 30 mg/kgBW), dosage II (extract 100 mg/kgBW), and dosage III (300 mg/kgBW) and then each group were grouped into three groups based on the duration of treatment. The group of mice were induced by cyclophosphamide 50 mg/kgBW intraperitoneally. After 30 hours, the treatment groups were administered the extract orally during 3, 7, and 15 days. After that, mice were sacrificed and the femur bone marrow was taken. Some of cytotoxic parameters were observed i.e micronuclei cells and hematocrit level. The percentage of micronuclei (MN) cells was calculated from the quantity of micronuclei cells of the slides of femur bone marrow by using microscope. Results confirmed that ethanolic extract of Garcinia cowa Roxb. roots decreased percentage of micronuclei cells not significantly (P > 0.05). The most lowering of micronuclei cells was showed by the extract in the dosage of 100 mg/KgBW for 15 days. 
Penggunaan Kombinasi Pati Bengkuang Avicel Ph101 sebagai Bahan Pengisi Co-Process Tablet Isoniazid Cetak Langsung Syofyan, Syofyan; Yelni, Ezi Afri; Azhar, Rieke
Jurnal Sains dan Teknologi Farmasi Vol 17 No 2 (2012)
Publisher : Fakultas Farmasi Universitas Andalas

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Starch yam bean (Pachyrrhizus erosus Urban) is tablet excipient with poor of both flowability and compressibility which can not be used as diluents of direct tablet compression. The purpose of this research is to know the influence of the combination avicel PH101 – starch as a filler material co-process. Tablet made with direct compression method with isoniazid as a model drug. Results of the study show that the formula 4 (Avicel PH101 concentration with 4%) can produce co-process with mechanical and physical properties of compresibilitas-the most good, as for the evaluation of isoniazid tablets do not meet the requirements of violence and friabilytas on all formula. In summary, use of Co-Process yam bean starch – Avicel PH101 with 0-4% Avicel PH101 concentration was not produced a tablet that meet the requirements.
Pengaruh Pemberian Jus Buah Naga Hylocereus Undatus (Haw.) Britt&Rose Terhadap Jumlah Hemoglobin, Eritrosit dan Hematokrit pada Mencit Putih Betina Arifin, Helmi; Nofiza, Welli; Elisma, Elisma
Jurnal Sains dan Teknologi Farmasi Vol 17 No 2 (2012)
Publisher : Fakultas Farmasi Universitas Andalas

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Sub-acute toxicity test of dragon fruit juice has been research Hylocereus undatus (Haw.) Britt. & Rose of with  hematological  parameters to female white mice. Juice given orally by 0,5 mL/20 g of  weight dose with variation are 100%, 50% and 25%, once a day along 7, 14 and 21 days. A female white mice were only given food and water used as comparison. Calculated and measured parameters are levels of hemoglobin, erythrocytes and hematocrit, using tools haemometer Sahli, haemositometer and centrifuge. Results  that given dose of dragon fruit juice Hylocereus undatus (Haw.) Britt. & Rose has been provided the effect to increased hemoglobin and erythrocytes level (p < 0,05), but did not raised the hematocrit level (p > 0,05).
Pengembangan Kulit Buah Kering Asam Kandis sebagai Herbal Medicine: Optimasi Formulasi Tablet Effervesen dan Uji Efeknya Terhadap Kenaikan Berat Badan dan Pola Makan Tikus Lucida, Henny; Ben, Elfi Sahlan; Delita, Elfi
Jurnal Sains dan Teknologi Farmasi Vol 17 No 2 (2012)
Publisher : Fakultas Farmasi Universitas Andalas

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This paper reports an optimization technique of effervescent tablet formulation from the ethanolic extract of “asam kandis” dried rinds (Garcinia cowa Roxb) and an assay of its reconstituted solution effect on rat’s body weight and feeding behavior. Formulation optimization was done by factorial design of 2 factors (extract concentration; composition of tablet disintegrant) and 3 levels. Nine formulas (FI – FIX) were prepared and subjected to evaluations including granule’s physicochemical and tablet’s pharmaceutical properties. The best formula was then chosen and given orally to 4 groups of rats: that was given standard food, high fat diet, high fat diet with reconstituted tablet 250 mg and high fat diet with reconstituted tablet 500 mg respectively. All groups were given 10 g of standard food every day for 10 days followed by high fat diet for the next 22 days. Two treatment groups were given reconstituted tablet at day 11th. The amount of food consumed by each group was weighed and rat’s body weight was measured. The optimization technique showed that both factors influenced the physicochemical properties of granules and the pharmaceutical properties of tablets significantly (p < 0.05). FV (extract concentration 500 mg, disintegrant: sodium bicarbonat 500 mg + citric acid 200 mg + tartaric acid 200mg) was chosen as the best.  Results showed that administration of reconstituted tablet FV to rats increased the bodyweight of the treated groups for the first week which then decreased during the next 3 week observation, while the body weight of control group kept increasing. Reconstituted tablet at dose 500 mg significantly influenced rat’s bodyweight and the feeding behavior (p<0.05). The group given reconstituted tablet 500 mg had the lightest body weight and consumed the least food during 3 weeks observation.
Penggunaan Metode Rasio Absorban dalam Penetapan Kadar Parasetamol dan Salisilamida Berbentuk Sediaan Campuran Dantes, Ehrlich Von; Armin, Fithriani; Rusdi, Rusdi
Jurnal Sains dan Teknologi Farmasi Vol 17 No 2 (2012)
Publisher : Fakultas Farmasi Universitas Andalas

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A study on the determination of paracetamol and salicylamide in a mixture by absorbance ratio method has been done. The absorption spectrum of both compounds crossing one each other at isoabsorption point. The maximum wavelength of paracetamol, salicylamide, and wavelength of isoabsorpsi line which show the relation of paracetamol fractions in a mixture containing paracetamol and salicylamide in various proportions and absorbances at isoabsorption wavelength was constructed. The measurement of absorbance was done at 247,2 nm and 300,3 nm. The experiment showed that the absorbancy ratio method can be used to determine paracetamol and salicilamyde. The percent recovery of paracetamol was 101,31 % with 0,642 % of standard deviation and coefficient of variation 0,616 %. The salicylamide content was then calculated and found to be 99,66 % with 0,863 % of standard deviation and 0,861 % of coefficient variation.

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