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INDONESIA
Indonesian Journal of Pharmaceutical Science and Technology
Published by Universitas Padjadjaran
ISSN : 23561971     EISSN : 2406856X     DOI : -
Core Subject : Health, Science,
Computer Science & IT Medicine & Pharmacology
Jurnal Sains dan Teknologi Farmasi Indonesia (IJPST) adalah publikasi ilmiah pada seluruh aspek Sains dan Teknologi Farmasi. Jurnal ini diterbitkan 3 kali setahun untuk menyediakan forum bagi apoteker, dan profesional kesehatan lainnya untuk berbagi praktik terbaik, meningkatkan jaringan kerja dan pendekatan yang lebih kolaboratif dalam Sains dan Teknologi Farmasi.
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Articles 5 Documents
 1 
Search results for , issue "Vol 6, No 1 (2019)" : 5 Documents clear
Degradation Study of Ketorolactromethamine by a Validated UPLC Method Mohammad Nasir Uddin; Md. Al-Amin; Md. Nazmul Haque Mijan; Suman Das
Indonesian Journal of Pharmaceutical Science and Technology Vol 6, No 1 (2019)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (577.906 KB) | DOI: 10.24198/ijpst.v6i1.16508

Abstract

UPLC stability indicating method was developed for determining ketorolac tromethamine in its degradation study at different conditions. An isocratic mobile phase composition of 60:10:30 (v/v) containing CH3OH, CH3CN and 5mM NaH2PO4 and C18 column were used at a flow rate of 0.20 mL min-1. Satisfactory retention time was found 2.13±0.05 min at 320 nm when monitored by DAD detector. Forced degradation studies of ketorolac tromethamine was also performed at the following conditions: acid and basic hydrolysis, heat (50-70°C for 1 hr), photolytic (UV and sunlight for up to 3 hr), oxidation (3% hydrogen peroxide for 1 hr). Forced degradation study revealed that ketorolac degraded significantly under thermal conditions. In 1N acid and base hydrolysis, degradation was moderately significant and comparable. It was degraded marginally in 0.1N acid-base hydrolysis which was comparable to oxidative conditions. But in photolytic condition ketorolac shows insignificant degradation. Method was also applied to pharmaceutical formulation.Keywords: UPLC, Ketorolac tromethamine, pharmaceutical formulation, Forced degradation
Performance Evaluation of Molecularly Imprinted Polymer using Propanol as Porogen for Atenolol Recognition in Human Serum Meilia Suherman; Ike Susanti; Driyanti Rahayu; Rimadani Pratiwi; Aliya Nur Hasanah
Indonesian Journal of Pharmaceutical Science and Technology Vol 6, No 1 (2019)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (532.992 KB) | DOI: 10.24198/ijpst.v6i1.18671

Abstract

Atenolol is a cardiovascular drug that has a narrow therapeutic index with long-term use and it’s often used as doping. Atenolol has a small concentration in human boby and it’s in  biological matrix (serum) so in the testing need a selective extraction so  the analyte can be pra-concentration and removed from matrix. Two molecularly imprinted polymers (MIPs) on propanol as porogen  have been made with two different methods i.e. bulk polymerization and precipitation polymerization. The polymer was made using atenolol as a template, methacrylic acid as a functional monomer, and ethylene glycol dimethacrylate as a crosslinker. Prformance evaluations showed that polymers from bulk polymerization provide better performance than polymers from precipitation polymerization when tested against standard solution. However, this sorbent has low  recovery percentage after applied into serum sample and could not be used as alternative for atenolol extraction in human serum.Key words: Molecularly imprinted polymer, Atenolol, Solid Phase Extraction, Preparation  method, propanol.
Quantification of Formaldehyde Residue in Wet Noodles Marketed in Indonesia using RP-HPLC Derivatization Method Mutakin Mutakin; Renyiska Yula; Ida Musfiroh; Nuraeni Nuraeni; Nurdjanah Azinar; Jutti Levita
Indonesian Journal of Pharmaceutical Science and Technology Vol 6, No 1 (2019)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (347.264 KB) | DOI: 10.24198/ijpst.v6i1.18952

Abstract

Illegal practices of formaldehyde as preservatives in wet noodles have been proven. These formaldehyde-preserved wet noodles are sold in West Java, Indonesia. This compound may be harmful to the body due to a decreasing of blood pressure, coma, acidosis, and acute renal failure. In this study we proposed a quantification method using high performance liquid chromatography (HPLC). A simulation was carried out as comparison. This simulation comprised of formaldehyde-spiked fish then the process was continued by washing, frying, and distilling the fish in a closed-system distillation. Similar condition was applied onto wet noodles purchased from traditional markets in Bandung. Method used was RP-HPLC derivatization method based on the reaction of formaldehyde carbonyl with two different reagents of DNPH (2,4-dinitrophenylhydrazine) and Nash (acetyl acetone, ammonium acetate and acetic acid) reagents. Result showed that formaldehyde residue was detected and quantified in all wet noodle samples with a range of 21-59 ppm. In conclusion, this method can be used for routine analysis to control illegal practices of formaldehyde in wet noodles. Moreover, washing and frying the formaldehyde-preserved food were proven could significantly help reducing formaldehyde level in food.Keywords: 2,4-dinitrophenylhidrazine, formaldehyde, RP-HPLC, wet noodles
Antibacterial Activity of Extract and Fraction From Shitake Mushroom (Lentinula edodes) Against Acne Bacteria Ika Kurnia Sukmawati; Ari Yuniarto; Widhya Alighita; Ade Zam-zam J
Indonesian Journal of Pharmaceutical Science and Technology Vol 6, No 1 (2019)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (522.261 KB) | DOI: 10.24198/ijpst.v6i1.14732

Abstract

Acne is an inflammatory disease that occurs in the skin triggered by the bacteria acne treatment can be done by using natural materials that shiitake mushrooms (Lentinus edodes). This aims of this study were to determining the antibacterial activity of extracts and fractions shiitake mushrooms with broth microdilution method, determining the value of equality shiitake mushrooms with antibacterial comparison and determining the morphological changes of bacteria after exposure to the test sample with a Scanning Electron Microscope (SEM). Tests conducted antibacterial activity against Propionibacterium acnes, Staphylococcus epidermidis and Staphylococcus aureus at concentrations used is 1 ppm, 2 ppm, 4 ppm, 8 ppm, 16 ppm, 32 ppm, 64 ppm, 128 ppm, 256 ppm, 512 ppm. Best MIC value obtained in fraction of ethyl acetate and n-hexane fraction of the bacterium Propionibacterium acnes, Staphylococcus epidermidis and Staphylococcus aureus at a concentration of 256 ppm. KBM value of the n-hexane fraction against Staphylococus aureus bacteria at concentrations of 512 ppm and ethyl acetate fraction against bacteria Staphylococus aureus and epidermidis at a concentration of 512 ppm. Value equality is obtained 1 mg of ethyl acetate fraction of shiitake mushrooms equivalent to 5.346 x 10-2 mg of tetracycline. SEM test results showed the presence of antibacterial activity which is indicated by a change in cell morphology, their lumps and their cell wall frown on Propionibacterium acnes were exposed to ethyl acetate fraction.Key words: Acne, Lentinus edodes, antibacterials, microdilution, SEM
Isolation and Activity Assay of Secondary Metabolites of Aspergillus niger in-Habiting in Termite’s Queen Nest Macrotermes gilvus Hagen., on Enriched Media Yohannes Alen; Evi Guslianti; Netty Suharti
Indonesian Journal of Pharmaceutical Science and Technology Vol 6, No 1 (2019)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (514.342 KB) | DOI: 10.24198/ijpst.v6i1.15735

Abstract

The Fungus is a group of the microorganisms that produce secondary metabolites. Secondary metabolites of fungus may be changed in different media. Secondary metabolites from Aspergillus niger in habiting in termite’s queen nest Macrotermes gilvus Hagen are disappeared gradually in artificial media. It was the reason to enrich the media with termite’s queen nest. The purpose of this research was to obtain the similar secondary metabolites of Aspergillus niger as it grows in their habitat. Enrichment was done with the experimental method. It used three concentrations of nest 0.25; 0.75 and 1 g/mL Sabouraud Dextrose Agar (SDA) media. Isolation was done use chromatography method. The antibiotic activities against Pseudomonas aeruginosa ATCC 27853 and Enterococcus faecalis ATCC 10541 were performed by the diffusion method. Results showed that enrichment of nest 1 g/mL media gave the best growth of fungus and it obtain the similar secondary metabolites as it grows in their habitat. Three pure compounds, EG-13-31-2, EG-13-34-9, and EG-13-44-2 were obtained. Based on physicochemical data, all compounds were terpenoid class and one of them (EG-13-34-9) contain the phenolic group. All compounds have activity against Pseudomonas aeruginosa ATCC 27853 and Enterococcus faecalis ATCC 10541 the bacteriostatic category.Key words: Aspergillus niger; Macrotermes gilvus Hagen; Sabouraud Dextrose Agar (SDA); Isolation; Enrich Media; Diffusion Method

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