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Jurnal Farmasi Klinik Indonesia

ijcp
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Published by Universitas Padjadjaran

ISSN : 23375701 EISSN : 2337 5701 DOI : -

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Indonesian Journal of Clinical Pharmacy (IJCP) is a scientific publication on all aspect of clinical pharmacy. It published 4 times a year by Clinical Pharmacy Master Program Universitas Padjadjaran to provide a forum for clinicians, pharmacists, and other healthcare professionals to share best practice, encouraging networking and a more collaborative approach in patient care. Indonesian Journal of Clinical Pharmacy is intended to feature quality research articles in clinical pharmacy to become scientific guide in fields related to clinical pharmacy. It is a peer-reviewed journal and publishes original research articles, review articles, case reports, commentaries, and brief research communications on all aspects of Clinical Pharmacy. It is also a media for publicizing meetings and news relating to advances in Clinical Pharmacy in the regions.

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Articles 540 Documents

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The Renal Toxicity of Welding Fumes in Heavy Equipment Manufacturer Workers Mulyana Mulyana; Nuri P. Adi; Meily Kurniawidjaja Kurniawidjaja; Vani N. Pratami; Andi Wijaya; Irawan Yusuf
Indonesian Journal of Clinical Pharmacy Vol 4, No 3 (2015)
Publisher : Universitas Padjadjaran

Exposure to welding fumes in the workplace has been associated with decreasing renal function. We studied renal function parameters in men workers from heavy equipment manufacturer exposed to welding fumes. This study aimed to evaluate renal function status among worker exposed to welding fumes. A case-control design, random study, was conducted among welder (35 subjects) and nonwelder (35 subjects) with more than 1 years experience in the same job task in a heavy equipment manufacturer. All subjects were completed physical examination, informed consent, questionnaire and laboratory tests. Renal function was easured as creatinine serum using enzimatic method. Urinary heavy metals level was analyzed using inductively coupled plasma mass spectrometry. Comparisson analysis between group was performed to determined median level for each variable. Linear regressionmodel was developed to predict renal function function parameter status urinary heavy metals level as variable. This study showed there were higher creatinine serum, chromium, iron, manganese and nickel in welder than non welder(p<0.05). After multivariate analysis, urinary nickel is a predictor for renal function status among welder. Exposure to welding fumes was significantly correlated with renal function status in welder. Nickel is the predictive variable for renal function. Although statistically significant but in clinical field needs carefully interpreting data.Keyword: Nickel, renal function, welder, welding fumesToksisitas Renal Uap Las pada Pekerja Industri Alat BeratPajanan uap las di tempat kerja telah dihubungkan dengan penurunan fungsi ginjal. Dalam penelitian ini, kami menguji status fungsi ginjal pada pekerja pria yang terpajan uap las di industri alat berat. Penelitian ini mengevaluasi status fungsi ginjal pada pekerja terpajan uap las, dengan desain kontrol kasus, acak, dilakukan pada 35 subjek pengelas dan 35 bukan pengelas yang telah bekerja paling tidak 1 tahun dengan jenis pekerjaan yang sama di industri alat berat. Seluruh subjek telah melakukan pemeriksaan fisik,pengisian form kesediaan setelah penjelasan, kuesioner, dan pemeriksaan laboratorium. Pemeriksaan kadar kreatinin dilakukan dengan metode enzimatik. Pemeriksaan kadar logam berat dalam urin dengan inductively copled plasma mass spectrometry. Dilakukan analisis perbandingan untuk membedakan nilai median antar kelompok. Dilakukan juga analisis multivariat untuk menentukan variabel prediksi. Hasil penelitian memperlihatkan bahwa status fungsi ginjal pada pekerja las lebih rendah dibandingkan dengan bukan pengelas. Nikel urin merupakan variabel prediksi yang bermakna terhadap penurunan fungsi ginjal. Walaupun secara statistik diketahui bermakna, namun dalam penggunaan klinis harus dilakukan interpretasi dengan hati-hati.Kata kunci: Fungsi ginjal, nikel, pengelas, uap las

Evaluasi Kualitas Hidup Responden Hipertensi Usia 40–75 Tahun Menggunakan Instrumen SF-36 di Kecamatan Kalasan, Sleman, DIY Fransisca Melani; Kresensia T. Hasrat; Bonifasia A. C. Widyasti; Rita Suhadi
Indonesian Journal of Clinical Pharmacy Vol 6, No 3 (2017)
Publisher : Universitas Padjadjaran

Hipertensi merupakan kondisi peningkatan tekanan darah sistolik lebih dari 140 mmHg dan tekanan darah diastolik lebih dari 90 mmHg. Status kesehatan yang buruk menunjukkan kualitas hidup yang buruk. Faktor-faktor yang dapat memengaruhi kualitas hidup adalah umur, pendidikan, penghasilan, BMI dan jenis kelamin. Tujuan dari penelitian ini adalah mengevaluasi perbedaan faktor risiko kesehatan dan faktor sosioekonomi dari kualitas hidup responden hipertensi di Kecamatan Kalasan, Sleman. Jenis penelitian ini adalah penelitian observasional dengan pendekatan cross-sectional. Responden dalam penelitian ini adalah penduduk usia 40–75 tahun. Pengambilan sampel dilakukan di 4 dukuh di Kecamatan Kalasan, yaitu Padukuhan Jetis, Padukuhan Pundung, Padukuhan Grumbulgede, dan Padukuhan Dhuri. Analisis data dilakukan dengan uji normalitas Kolmogorov-Smirnov, dilanjutkan dengan uji-t tidak berpasangan untuk masing-masing delapan domain kualitas hidup SF-36 dengan faktor risiko kesehatan dan sosioekonomi. Hasil penelitian menunjukkan pada faktor risiko kesehatan yaitu perbedaan kelompok usia memengaruhi kualitas hidup pada komponen kesehatan fisik (p<0,05), aspek fungsi fisik (p<0,05) dan peran fisik (p<0,05). Variabel sosioekonomi dari aspek sosioekonomi memengaruhi kualitas hidup pada komponen kesehatan mental (p<0,05) terkait aspek peran emosi (p<0,05) dan komponen kesehatan fisik (p<0,05) terkait aspek fungsi fisik (p<0,05) serta aspek peran fisik (p<0,05).Kata kunci: Hipertensi, kualitas hidup, risiko kesehatan dan sosioekonomiQuality of Life Evaluation of Respondents with Hypertension Aged 40–75 Years Using SF-36 Instruments in Kalasan District, Sleman, Yogyakarta ProvinceHypertension is a condition of an increase of systolic blood pressure over 140 mmHg and diastolic blood pressure over 90 mmHg. Poor health status indicates poor quality of life. There are many factors that may affect the quality of life, such as age, education, income, Body Mass Index (BMI) and sex. The purpose of this study was to evaluate the differences of health risk factors and socioeconomic factors on the quality of life of respondents with hypertension in Kalasan District, Sleman. This type of research is an observational study with cross-sectional approach. Respondents in this study were the people aged 40–75 years. Sampling was conducted in four hamlets in Kalasan District, named Padukuhan Jetis, Padukuhan Pundung, Padukuhan Grumbulgede, and Padukuhan Dhuri. The data analysis was performed with Kolmogorov-Smirnov normality test, followed by t-independent test for each of the eight domains of quality of life with the SF-36 health and socioeconomic risk factors. The results from health risk factors showed that the difference of age affected quality of life on physical health component (p<0.05), physical function aspect (p<0.05) and physical role (p<0.05). Socioeconomic aspects of socioeconomic variables affected the quality of life on the mental health component (p<0.05), related to the role of emotions aspect (p<0.05) and physical health component (p<0.05) related to physical function aspect (p<0.05) also the physical role aspect (p<0.05).Keywords: Health and socioeconomic risk factors, hypertension, quality of life

Uji Validitas dan Reliabilitas Kuesioner EORTC QLQ C-30 untuk Menilai Kualitas Hidup Pasien Kanker Ginekologi di RSUP Sanglah Denpasar Rini Noviyani; I Ketut Tunas; Ayu Indrayathi; Nyoman G. Budiana
Indonesian Journal of Clinical Pharmacy Vol 5, No 2 (2016)
Publisher : Universitas Padjadjaran

Dampak dari penyakit dan pengobatan kanker dapat diukur dengan indikator kualitas hidup menggunakan kuesioner EORTC QLQ C-30. Penelitian cross-sectional dilakukan menggunakan 30 pasien. Data dikumpulkan melalui metode purposive sampling pada pasien yang memenuhi kriteria inklusi, yaitu wanita berusia 30–70 tahun yang didiagnosis kanker ginekologi, pernah menjalani kemoterapi di RSUP Sanglah Denpasar, dan bersedia menandatangani formulir persetujuan pasca penjelasan. Pasien yang tidak dapat berkomunikasi secara rasional menjadi bagian kelompok eksklusi. Validitas dan reliabilitas instrumen diuji menggunakan analisis faktor konfirmatori dengan program STATA® versi 12. Hasil analisis faktor konfirmatori menunjukkan seluruh item pertanyaan memiliki loading factor ( ) > 0,70 sehingga seluruh butir pertanyaan adalah valid. Uji reliabilitas item memberikan nilai >0,50 untuk seluruh item pertanyaan yang menunjukkan seluruh item pertanyaan adalah reliabel. Hasil perhitungan validitas konstrak menghasilkan nilai VE= 0,90 dan reliabilitas konstrak (RF) adalah 1 yang berarti kuesioner EORTC QLQ C-30 memenuhi validitas dan reliabilitas konstrak. Kuesioner EORTC QLQ C-30 sebagai alat ukur kualitas hidup pasien kanker ginekologi di RSUP Sanglah Denpasar adalah valid dan reliabel.Kata kunci: Analisis faktor konfirmatori, kanker ginekologi, kuesioner EORTC QLQ C-30, RSUP Sanglah Denpasar, uji validitas dan reliabilitas Validity and Reliability of EORTC QLQ C-30 Questionnaire in Assessing Quality of Life of Gynecological Cancer Patients in Sanglah Hospital Denpasar The impacts of cancer and its treatment can be measured by indicators of quality of life using the EORTC QLQ C-30 questionnaire. A cross-sectional study was done on 30 patients in Sanglah Hospital Denpasar. Data were collected through purposive sampling of patients who fit the inclusion criteria: women who were 30–70 years old were diagnosed with gynecological cancer, had chemotherapy in Sanglah Hospital, and had agreed to be part of the research by signing the informed consent form. Patients who were unable to rationally communicate became part of the exclusion group in this research. Validity and reliability of the tools in this study were tested using confirmatory factor analysis with STATA ®version 12. Confirmatory factor analysis indicates that all items have a loading factor ( )> 0.70 so that it can be said that all the questions are valid. Reliability items have the value > 0.50 for all questions which shows all questions are reliable. Construct validity of the results of the calculation produce a value VE = 0.90 and the reliability construct (RF) of 1, which meet both validity and reliability constructs. Questionnaire EORTC QLQ C-30 as a measurement of the quality of life of gynecological cancer patients in Sanglah Hospital are valid and reliable.Key words: EORTC QLQ C-30 questionnaire, confirmatory factor analysis, gynecological cancer,Sanglah Hospital Denpasar, the validity and reliability

Imunoekspresi Poly (ADP-Ribose) Polymerase sebagai Petanda Kemoresisten pada Karsinoma Ovarium Retno Westiningrum; Hermin A. Usman; Herry Yulianti; Bethy S. Hernowo
Indonesian Journal of Clinical Pharmacy Vol 7, No 2 (2018)
Publisher : Universitas Padjadjaran

Karsinoma ovarium merupakan keganasan kelima terbanyak dan penyebab kematian ginekologi pertama di dunia. Kemoterapi merupakan modalitas terapi utama karsinoma ovarium dengan stadium lanjut setelah dilakukan pembedahan. Poly (ADP-Ribose) Polymerase (PARP) dan B cell Lymphoma-2 (Bcl-2) merupakan petanda imunohistokimia yang berfungsi dalam proses DNA repair dan anti-apoptosis yang merupakan bagian dari lingkaran mekanisme kerja regimen kemoterapi pada sel tumor. Oleh karena itu dua mekanisme tersebut dianggap memegang peranan penting terhadap terjadinya resisten kemoterapi bahkan rekurensi. Tujuan penelitian ini adalah melihat hubungan imunoekspresi PARP dan Bcl-2 dengan respons kemoterapi pada karsinoma ovarium. Penelitian ini menggunakan desain analisis observasi secara potong lintang dengan menggunakan blok parafin pasien yang didiagnosis sebagai karsinoma ovarium selama periode tahun 2012−2015 di Departemen Patologi Anatomi RSUP Dr Hasan Sadikin Bandung. Jumlah sampel sebanyak 58 kasus yang terdiri atas 30 kasus kemoterapi sensitif dan 28 kasus kemoterapi resisten, keseluruhan sampel dilakukan pulasan imunohistokimia PARP dan Bcl-2. Analisis data menggunakan uji Chi-Square dengan taraf signifikansi 5%. Hasil dari penelitian ini adalah 60% sampel terekspresi PARP kuat dengan proporsi terbesar pada kelompok resisten (p=0,001) dan 74% sampel terekspresi Bcl-2 lemah dengan proporsi sama pada tiap kelompok respon kemoterapi (p=0,45). Respons kemoterapi sangat dipengaruhi oleh proses DNA repair yang dapat dinilai dengan pemeriksaan imunoekspresi PARP. Semakin tinggi imunoekspresi PARP maka semakin tinggi kemampuan DNA repair sehingga semakin tinggi kemungkinan kemoterapi resisten.Kata kunci: Bcl-2, karsinoma ovarium, kemoterapi, PARP Poly (ADP-Ribose) Polymerase Immunoexpression as Chemoresistance Marker in Ovarian CarcinomaAbstractEpithelial ovarian cancer (EOC) is the fifth most common cancer and the main cause of gynecological cancer death worldwide. Chemotherapy is the main therapy in advanced stage of EOC. Poly (ADP-Ribose) Polymerase (PARP) dan B cell Lymphoma-2 (Bcl-2) are immunohistochemistry markers that represent influential factors in chemotherapy response which have roles in DNA repair and anti-apoptosis. The aim of this study was to review the correlation between PARP and Bcl-2 expression with chemotherapy response in EOC. This research was performed as analytic-observational with cross-sectional design using paraffin block of patients diagnosed as EOC in 2012–2015 at Anatomical Pathology Department, Hasan Sadikin Hospital Bandung. Total sample was 58 cases which were divided into chemotherapy sensitive and resistant. All samples were stained by immunohistochemistry PARP and Bcl-2 and analysed using Chi-Square test with significant level of 5%. The results of this study showed that 60% of all samples have strong PARP expression whereas the largest proportion is in chemotherapy resistant group (p=0.001) and 74% of all samples have weak Bcl-2 expression in each group (p=0.45). The conclusion of this study in chemotherapy response was influenced by PARP. Higher PARP immunoexpression showed higher tumour cell ability to repair DNA and higher chemotherapy resistance.Keywords: Bcl-2, chemotherapy, EOC, PARP

Korelasi Antropometri terhadap Profil Lipid pada Masyarakat Pedesaan Cangkringan, Kabupaten Sleman, Daerah Istimewa Yogyakarta Phebe Hendra; Dita M. Virginia; Fenty Fenty; Aris Widayati
Indonesian Journal of Clinical Pharmacy Vol 6, No 2 (2017)
Publisher : Universitas Padjadjaran

Prevalensi abnormalitas profil lipid cukup besar pada masyarakat pedesaan. Pengukuran profil lipid (kolesterol total (KT), low density lipoprotein (LDL), high density lipoprotein (HDL), dan trigliserida (TG)) di laboratorium membutuhkan implementasi teknologi kesehatan sedangkan di daerah pedesaan kurang tenaga medis dan permasalahan ekonomi. Pengukuran antropometri yang mudah, tidak invasif, ekonomis, dan dapat dilakukan oleh tiap individu diharapkan dapat memprediksi abnormalitas profil lipid bagi masyarakat pedesaan. Penelitian ini bertujuan untuk mengobservasi korelasi pengukuran antropometri dengan abnormalitas profil lipid di daerah pedesaan. Penelitian ini merupakan penelitian observasional dengan desain potong lintang. Pengukuran antropometri meliputi Body Mass Index (BMI), lingkar pinggang (LP), dan rasio lingkar pinggang panggul (RLPP). Kriteria inklusi adalah penduduk Kecamatan Cangkringan, Sleman, DI Yogyakarta berumur 40–60 tahun, tidak ada riwayat penyakit kardiometabolik, tidak edema, dan konsumsi obat‑obatan terkait kardiometabolik. Lokasi penelitian dipilih menggunakan klaster random sampling. Sampel penelitian dipilih secara purposive sampling dan diperoleh besar sampel 100 responden. Analisis data menggunakan Kolmogorov-Smirnov, Mann‑Whitney, dan Spearman. Hasil penelitian ini menunjukkan korelasi antara BMI (r= –0,286; p=0,044), LP (r= –0,410; p=0,003), dan RLPP (r= –0,365; p=0,009) terhadap HDL pada kelompok wanita. Terdapat juga korelasi antara BMI (r=0,325; p=0,021), LP (r=0,394; p=0,005), dan RLPP (r=0,368; p=0,009) terhadap trigliserida pada kelompok wanita. Terdapat korelasi antara BMI terhadap KT (r=0,285;p=0,045), LDL (r=0,344;p=0,014), dan TG (r=0,446; p=0,001). Parameter LP pria memiliki korelasi terhadap HDL (r= –0,355; p=0,011) dan TG (r=0,488; p=0,000). Parameter RLPP pria memiliki korelasi terhadap seluruh profil lipid; terhadap KT (r=0,287; p=0,043), LDL (r=0,338; p=0,016), HDL (r=0,316; p=0,025), dan TG (r=0,359; p=0,011). Simpulan, pada kelompok wanita pengukuran anthropometri memiliki korelasi terhadap HDL dan TG, sedangkan parameter RLPP lebih sensitif pada kelompok pria.Kata kunci: Antropometri, masyarakat pedesaan, profil lipid Correlation between Anthropometric Measurement and Lipid Profile among Rural Community at Cangkringan Village, District Sleman, Yogyakarta ProvinceAbstractAbnormality lipid prevalence was higher in rural area communities. Measurement of lipid profile (total cholesterol (TC), low density lipoprotein (LDL), high density lipoprotein (HDL), and triglyceride (TG)) needs implementation of health technology whereas in rural areas lack of medical professional and economic problems. Anthropometric measurement is easy, non-invasive, economical, and every individual could do this independently, which is expected to predict abnormality of lipid profile in rural communities. Anthropometric measurements are easy and non-invasive. This study aimed to observe correlation between anthropometric measurements with abnormality of lipid profile in rural areas. This study was an observational study with cross-sectional design. Anthropometric measurements in this study were body mass index (BMI), waist circumference (WC), and waist to hip ratio (WHR). The inclusion criteria were person whose residence in Cangkringan village, Sleman, Yogyakarta Province, aged 40–60 years old, no history of cardio-metabolic disease, not edema, and no consumption of drugs associated cardio-metabolic. Locations were selected using random cluster sampling technique. Samples were selected by purposive sampling and obtained 100 respondents. Data analyzed using Kolmogorov‑Smirnov, Mann-Whitney, and Spearman. This study showed correlation between BMI (r= –0,286; p=0,044), WC (r= –0,410; p=0,003), WHR (r= –0,365; p=0,009) with HDL on women group. There was correlation between BMI (r=0,325; p=0,021), WC (r=0,394; p=0,005), WHR (r=0,368; p=0,009) with triglyceride on women. On men, there was correlation between BMI to TC (r=0,285;p=0,045), LDL (r=0,344;p=0,014), TG (r=0,446; p=0,001); WC have correlation to HDL (r= –0,355; p=0,011) TG (r=0,488; p=0,000); WHR have correlation with TC (r=0,287; p=0,043), LDL (r=0,338; p=0,016), HDL (r=0,316; p=0,025), TG (r=0,359; p=0,011). In conclusion, all anthropometric measurements (BMI, WC, and WHR) have correlation with HDL and TG on women group, whereas WHR has more sensitive correlation on men group.Keywords: Anthropometric, lipid profiles, rural areas communities

Hubungan Kepatuhan Menggunakan Obat Inhaler β2-Agonis dan Kontrol Asma pada Pasien Asma Sri Haryanti; Zullies Ikawati; Tri M. Andayani; Mustofa Mustofa
Indonesian Journal of Clinical Pharmacy Vol 5, No 4 (2016)
Publisher : Universitas Padjadjaran

Asma tetap menjadi masalah kesehatan yang dialami banyak anak-anak dan orang dewasa di dunia. Sebagai penyakit kronis, tata laksana asma memerlukan pengobatan yang berkelanjutan. Salah satu masalah penting dalam tata laksana asma adalah kepatuhan dalam pengobatan. Kepatuhan yang rendah terhadap anti-asma yang diberikan menyebabkan meningkatnya morbiditas dan mortalitas. Penelitian ini dilakukan untuk mengkaji hubungan kepatuhan terhadap anti-asma yang diberikan dengan kontrol asma. Penelitian ini merupakan penelitian observasional menggunakan rancangan potong lintang yang dilakukan di empat rumah sakit di Daerah Istimewa Yogyakarta selama enam bulan, yaitu antara bulan Juni sampai Desember 2015. Subjek penelitian adalah pasien dengan gangguan fungsi pernafasan yang menjalani pengobatan di poliklinik penyakit dalam di rumah sakit tersebut dan memenuhi kriteria inklusi dan eksklusi serta bersedia ikut dalam penelitian dengan menandatangani surat pernyataan persetujuan. Kepatuhan diukur dengan Morisky Medication Adherence Scale (MMAS) dan kontrol asma diukur dengan Asthma Control Test (ACT). Uji korelasi Pearson digunakan untuk mengkaji hubungan antara kepatuhan dan kontrol asma. Total sebanyak 67 pasien diseleksi dan 57 diantara memenuhi kriteria inklusi dan eksklusi. Berdasarkan kepatuhannya, pasien dikelompokkan ke dalam kepatuhan sedang (31 pasien atau 54%) dan kepatuhan rendah (26 pasien atau 46%). Berdasarkan kontrol asma, pasien dikelompokkan ke dalam kontrol asma sebagian (11 pasien atau 19%) dan tidak terkontrol asma (47 pasien atau 81%). Terdapat hubungan signifikan antara kepatuhan dengan kontrol asma (r=0,303, p<0,05). Kesimpulan, kepatuhan terapi dapat meningkatkan kontrol asma.Kata kunci: Anti-asma, kepatuhan, kontrol asma, tata kelola asmaRelationship Between Compliance of Using β2-Agonist Inhaler Drugand Asthma Control on Asthma Patient Asthma remains a health problem affecting a large number of children and adult in the world. Being a chronic disease, asthma management requires continous medications. One of the most important issues in asthma management is adherence to treatment. Poor compliance with prescribed anti-asthma leads to increase in morbidity and mortality. This study was conducted to evaluate the relationship between ompliance prescribed anti-asthma and asthma control. This was an observasional study using cross-sectional design conducted in four hospitals around Province of DI Yogyakarta during six months om June until December 2015. Subjects were patients with respiratory disorders who underwent treatment in internal medicine polyclinic in the hospitals, met the inclusion and exclusion criteria and willing to participate in the study by signing the informed consent. Compliance was assesseed by Morisky Medication Adherence Scale (MMAS) and asthma control was assessed by Asthma Control Test (ACT). Pearson’s correlation test was used to evaluate the relationship between compliance and asthma control. A total of 67 patients were selected and 57 of them met the inclusion and exclusion criteria. Based on the patient’s compliance, the patients were grouped into moderate compliance (31 patients or 54%) and low compliance (26 patients or 46%). Whereas based on the asthma control, the patients were grouped into partly controlled asthma (11 patient or 19%) and uncontrolled asthma (47 patients or 81%). There is a significant relationship between compliance with asthma control (r=0303, p<0.05). Conclusion, compliance can increase asthma control.Keywords: Anti-asthma, asthma control, asthma management, compliance

Evaluasi Nilai Antigen Squamous Cell Carcinoma Pasien Kanker Serviks Sel Skuamosa Stadium II B–III B yang Menerima Kemoterapi Bleomisin, Oncovin®, Mitomisin, dan Cisplatin Rini Noviyani; Ketut Suwiyoga; Intan Puspa; Nyoman Budiana; Ketut Tunas
Indonesian Journal of Clinical Pharmacy Vol 4, No 2 (2015)
Publisher : Universitas Padjadjaran

Kemoterapi Bleomisin, Oncovin®, Mitomisin, dan Cisplatin (BOMP) merupakan salah satu tatalaksana terapi untuk kanker serviks. Penelitian ini bertujuan mengevaluasi respons kemoterapi regimen BOMP pada pasien kanker serviks sel skuamosa stadium IIB–IIIB dengan antigen SCC. Pada penelitian potong lintang prospective ini diperoleh 12 pasien kanker serviks yang memenuhi kriteria inklusi yang diambil dengan metode consecutive sampling. Pemeriksaan kadar antigen SCC dilakukan dengan cara mengambil darah pasien sebelum kemoterapi BOMP seri pertama dan sesudah kemoterapi BOMP seri ketiga kemudian diperiksa dengan alat ARCHITECT SCC assay. Data dianalisis menggunakan paired test dengan interval kepercayaan 95%. Terdapat penurunan rerata nilai antigen SCC pada penderita kanker serviks tipe sel skuamosa setelah tiga seri kemoterapi BOMP meskipun penurunan tersebut tidak bermakna secara statistik (p>0,05). Perbedaan yang tidak bermakna secara statistik ini mungkin disebabkan kurangnya jumlah pasien yang digunakan. Hasil penelitian ini dapat digunakan oleh dokter sebagai pertimbangan untuk melanjutkan kemoterapi BOMP hingga seri keenam sesuai dengan prosedur yang diberlakukan dengan pemantauan rutin terhadap kondisi pasien khususnya nilai antigen SCC untuk untuk memprediksi prognosis dan respons kemoterapi.Kata kunci: Antigen SCC, BOMP, kanker serviks sel skuamosa, kemoterapi, stadium IIB–IIIBEvaluation of Squamous Cell Carcinoma Antigen Value in Stadium IIB–IIIB Squamous Cell Cervical Cancer Patients which Receiving Bleomycin, Oncovin®, Mitomycin, and Cisplatin ChemotherapyBleomycin, Oncovin®, mitomycin, and cisplatin (BOMP) chemotherapy is one of the management of cervical cancer therapy. The aim of this study was to evaluate the response to BOMP chemotherapy regimens in patients squamous cell cervical cancer stage IIB-IIIB using SCC antigen. In this prospective cross sectional study was obtained 12 cervical cancer patients who met the inclusion criteria, which is taken by using consecutive sampling method. Examination of SCC antigen levels was conducted by taking a patient’s blood before the first series and after the third series of BOMP chemotherapy, then further examined by ARCHITECT SCC assay. Data were analyzed using paired test with 95% confidence intervals. Statistical analysis showed that there were a decrease in the average value of SCC antigen in patients with squamous cell cervical cancer types after 3 series of BOMP chemotherapy although this reduction was not statistically significant (p>0.05). The differences are not statistically significant is probably due to insufficient number of patients used in this study. The doctor may consider to continue chemotherapy until the sixth series in accordance with the procedures by routine monitoring of the patient’s condition, especially SCC antigen values for predicting the prognosis and response of chemotherapy.Key words: BOMP, chemotherapy, SCC antigen, squamous cell of cervical cancer, stadium IIB–IIIB

Perbandingan Profil Farmakokinetika Bupivakain 0,5% pada Pasien Hamil Normotensi dan Preeklampsia yang Menjalani Sectio Caesarea di RSUP dr. Sardjito Yogyakarta Helmina Wati; Dita A. D. Sandi
Indonesian Journal of Clinical Pharmacy Vol 6, No 1 (2017)
Publisher : Universitas Padjadjaran

Pada kehamilan preeklampsia terjadi penurunan filtrasi glomerulus dan penurunan protein plasma dibandingkan terhadap hamil normotensi. Penelitian ini bertujuan melihat perbedaan profil farmakokinetika dengan model nonkompartemen bupivakain 0,5% antara pasien hamil normotensi dengan pasien hamil preeklampsia yang menjalani Sectio Caesarea (SC). Penelitian dilakukan terhadap 5 pasien hamil normotensi vs hamil preeklampsia yang menjalani SC dengan teknik epidural menggunakan bupivakain 0,5% dosis 75 mg di Gedung Bedah Sentral Terpadu (GBST) RSUP Dr. Sardjito Yogyakarta. Darah diambil sebanyak 3 cc pada menit ke-0;15’;20’;25’;30’;45’;60’;90’ melalui vena dan ditetapkan kadar bupivakain dengan menggunakan metode High Performance Liquid Chromatography (HPLC). Harga profil farmakokinetika bupivakain (AUC (Area Under Curve), AUMC (Area Under Moment Concentration), MRT (Mean Resident Time)) dihitung berdasarkan data kadar bupivakain dalam darah versus waktu dengan model nonkompartemen. Profil farmakokinetika pasien hamil normotensi dan hamil preeklampsia kemudian dianalisis dengan uji statistik untuk melihat ada tidaknya perbedaan. Hasil penelitian menunjukkan AUC(0–~) rata-rata pada pasien hamil normotensi dan pasien hamil preeklampsia secara berturut-turut adalah 109,56± 9,22 μg.mL–1.menit dan 133,780±25,47 μg.mL–1.menit. Nilai AUMC(0–~) rata-rata pada pasien hamil normotensi dan pasien hamil preeklampsia secara berturut-turut sebesar 6.956,41±2.559,99 µg/mL.menit2 dan 11.085,74±5733,94 µg/mL.menit2. Rata‑rata nilai MRT pasien hamil normotensi dan pasien hamil preeklampsia secara berturut-turut sebesar 64,06±25,70 menit dan 110,45±78,30 menit. Hasil uji statistik menunjukkan bahwa nilai AUC(0–~), AUMC(0–~), dan MRT pada obat bupivakain 0,5% antara pasien hamil normal dengan pasien preeklampsia tidak memiliki perbedaan yang signifikan (p>0,05). Kesimpulannya, profil farmakokinetik bupivakain pada pasien hamil normotensi dan preeklampsia tidak memiliki perbedaan yang signifikan.Kata kunci: Bupivakain, hamil normotensi, preeklampsia, profil farmakokinetik Comparison of Pharmacokinetics Profiles 0.5% Bupivacaine of Normal Pregnant Patients and Preeclampsia Patients Undergoing Sectio Caesarea at dr. Sardjito Hospital YogyakartaAbstractIn preeclampsia pregnancy, there is a decrease in glomerular filtration and plasma protein. This study was conducted on 5 patients with normotensive pregnancy and sectio caesarea with preeclampsia pregnancy used of bupivakain 0,5% dose of 75 mg. Blood was collected as much as 3 cc at minute 0; 15’;20’;25’;30’;45’;60’;90’, through a vein and set the levels of bupivacaine by using High Performance Liquid Chromatography (HPLC). The value of bupivacaine pharmacokinetic profile (AUC (Area Under the Curve), AUMC (Area Under Concentration Moment), MRT (Mean Time Resident)) were calculated based on the levels of bupivacaine in the blood versus the time with noncompartement models, and then were analyzed with statistical test. The result showed that the value of AUC(0–~); value of AUMC(0–~); value of MRT on average for patients with normal pregnancy and preeclampsia pregnant patients respectively were 109.56±9.22 μg.mL-1.minute and 133.78 ± 25.47 μg.mL-1.minute; 6,956.41 ± 2,559.99 µg/mL.minute2 and 11,085.74±5733,94 µg/mL.minute2; 64.06±25.70 minutes and 110.45± 78.30 minutes. Statistical analysis results showed that the value of AUC(0–~), AUMC(0–~), and MRT at bupivacaine had no significant difference (p>0.05).Keywords: Bupivacaine, normotensive pregnant, pharmacokinetics profiles, preeclampsia

Influence of Antidiabetic Herbal Medicine to a Decrease Blood Glucose Levels of Diabetes Mellitus Patients at The ‘Hortus Medicus’ Scientification of Jamu Clinic Tawangmangu, Karanganyar Emalia O. Rahayu; Titik Lestari; Nutrisia A. Sayuti
Indonesian Journal of Clinical Pharmacy Vol 5, No 1 (2016)
Publisher : Universitas Padjadjaran

Diabetes mellitus (DM) was an annual disease characterized by parennials of blood glucose levels exceeding normal and impaired metabolism of carbohydrates, fat and protein caused by defficiency of insulin hormone relative as well as absolute. Management of patients with DM can be done by some effort, among others was consume an antidiabetic drug or antidiabetics herbal medicine. Antidiabetic herbal medicine were consisting of bitter, brotowali, salam leaf, and AAI (analegtic, antiinflamation, and immunomodulator). The resesarch aimed to know the influence of antidiabetic herbal medicine to decrese blood glucose levels in patient with DM at The ‘Hortus Medicus’ Scientification of Jamu Clinic, Tawangmangu, Karanganyar. The method was quasi experimental with one group pre-post test. The samples were 37 people of the patients with DM diagnose with purposive sampling technique methode. The research report that among 37 respondents, 32 (86.5%) of respondent got a decreased blood glucose levels. The mean value of blood glucose level before consuming antidiabetic herbal medicine was 290.30 mg/dl and the mean value after consuming the herbal medicine was 241.78 mg/dl with difference of the mean value before and after consuming the herbal medicine was 48.52 mg/dl. There were influence of antidiabetic herbal medicine to decrease blood glucose levels of diabetes mellitus patients at the clinic with p-value=0.00 (p<0.05).Key words: Blood glucose, brotowali, diabetes mellitus, herbal medicine, salam leaf, sambilotoPengaruh Obat Herbal Antidiabetes untuk Menurunkan Kadar Glukosa Darah pada Pasien Klinik Jamu Scientific “Hortus Medicus” Tawangmangu, KaranganyarDiabetes melitus (DM) adalah penyakit menahun yang ditandai dengan peningkatan kadar glukosa darah melebihi normal dan gangguan metabolisme karbohidrat, lemak, dan protein yang disebabkan oleh kekurangan hormon insulin secara relatif maupun mutlak. Manajemen pasien dengan DM dapat dilakukan dengan beberapa upaya, antara lain adalah mengonsumsi obat atau obat herbal antidiabetes (jamu). Jamu antidiabetes yang digunakan terdiri dari sambiloto, brotowali, daun salam, dan AAI (analgesik, antiinflamasi, dan imunomodulator). Penelitian ini bertujuan untuk mengetahui pengaruh jamu antidiabetes untuk menurunkan kadar glukosa darah pada pasien DM di klinik Saintifikasi Jamu ‘Hortus Medicus’, Tawangmangu, Karanganyar. Metode penelitian ini adalah kuasi eksperimental dengan one group pre-post test. Sampel yang digunakan adalah 37 orang pasien terdiagnosis DM dengan teknik pengambilan sampel purposive method sampling. Data penelitian menunjukkan bahwa di antara 37 responden, 32 (86,5%) dari responden mengalami penurunan kadar glukosa darah. Kadar glukosa darah sebelum mengonsumsi jamu antidiabetes adalah 290,30 mg/dl dan nilai rata-rata setelah mengkonsumsi jamu antidiabetes adalah 241,78 mg/dl dengan perbedaan nilai rata-rata sebelum dan setelah mengkonsumsi jamu adalah 48,52 mg/dl. Terdapat pengaruh jamu antidiabetes terhadap penurunan kadar glukosa darah pada pasien DM di klinik dengan p-value= 0.00 (p <0,05)Kata kunci: Brotowali, daun salam, diabetes mellitus, jamu, kadar glukosa, sambilot

A Prospective Study of Adverse Drug Reactions in 1 Month–12 Years Old Pediatric Patients Asawari Raut; Vijay Kalrao; Roja Rani; Ravi Kumar
Indonesian Journal of Clinical Pharmacy Vol 4, No 1 (2015)
Publisher : Universitas Padjadjaran

Adequate controlled clinical trials in pediatric population, especially in oncology and vaccinations are still insufficient due to ethical considerations. Certain conditions in children in general and in Indian children in particular, suggested the need for Adverse Drug Reaction (ADR) monitoring. Thus this study was aimed to investigate the incidence of ADRs in pediatric populations. A prospective spontaneous reporting study was conducted over a period of six months from October 2012 to March 2013 in pediatric inpatients ward of Bharati Hospital in Pune. Reported ADRs were assessed for its causality by using WHO causality assessment scale, and its severity by using Hart wig Severity Scale. A total of 107 suspected ADRs were reported and evaluated from 54 patients, showing an overall incidence of 4.75%. Incidence rate of ADRs during hospitalization was 4.13%, while ADRs induced hospitalization was 0.62%. The gastrointestinal system (48.59%) was the most affected, and antibiotics was the most common the drug class associated to ADRs. In term of causality, 55.14% of the reactions were classified as possible, while in term of severity, 64.49% were classified as moderate. Most patients (60.75%) recovered from the incidence. Although the prevalence and severity of ADRs in pediatrics populations is reported to be higher than those of in adults, the incidence of ADRs in our study was only 4.75% which is lower than those of reported in adults, this may due to the spontaneous reporting system that used in this study.Keywords: Adverse drug reaction, causality, prospective spontaneous reporting system, severity Studi Prospektif Reaksi Obat yang Merugikan pada Pasien Anak 1 Bulan–12 TahunUji klinik pada anak khususnya onkologi dan vaksinasi masih kurang memadai karena pertimbangan aspek etik. Kondisi tertentu pada anak secara umum dan khususnya di India memerlukan pemantauan Rekasi Obat yang Merugikan (ROM). Penelitian ini bertujuan untuk mengetahui insidensi ROM pada pasien anak. Studi pelaporan spontan prospektif dilakukan selama enam bulan pada Oktober 2012–Maret 2013 di bangsal anak Rumah Sakit Bharati di Pune. ROM yang dilaporkan dinilai kausalitasnya dengan WHO causality assessment dan keparahan dengan skala Wig Hart Severity. Sebanyak 107 suspek ROM dilaporkan dan dievaluasi dari 54 pasien menunjukkan insidensi sebesar 4,75%. Tingkat kejadian ROM selama rawat inap sebesar 4,13% sementara ROM yang menyebabkan pasien dirawat inap sebesar 0,61%. Sistem pencernaan (48,5%) paling sering dilaporkan dan antibiotik sebagai obat yang berasosiasi dengan ROM. Berdasarkan kausalitas, 55,14% reaksi obat diklasifikasikan possible (55,14%) sementara dalam aspek kepaharahan, 64,49% diklasifikasikan moderat. Mayoritas pasien sembuh dari ROM (60,75%). Prevalensi dan keparahan ROM pada anak dilaporkan lebih tinggi dibandingkan dewasa, akan tetapi insiden ROM pada penelitian ini hanya 4,75% yang lebih rendah daripada yang dilaporkan pada orang dewasa, dimungkinkan karena penelitian ini merupakan sistem pelaporan spontan.Kata kunci: Causality, keparahan, reaksi obat yang merugikan, sistem pelaporan spontan prospektif

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Contact Name
Rizky Abdulah

Contact Email
r.abdulah@unpad.ac.id

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Location
Kota bandung,

Jawa barat

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