Indonesian Journal of Tropical and Infectious Disease
This journal is a peer-reviewed journal established to promote the recognition of emerging and reemerging diseases specifically in Indonesia, South East Asia, other tropical countries and around the world, and to improve the understanding of factors involved in disease emergence, prevention, and elimination.
The journal is intended for scientists, clinicians, and professionals in infectious diseases and related sciences. We welcome contributions from infectious disease specialists in academia, industry, clinical practice, public health, and pharmacy, as well as from specialists in economics, social sciences and other disciplines.
Articles
382 Documents
<![CDATA[AWARENESS OF USING RINGER LACTAT SOLUTION IN DENGUE VIRUS INFECTION CASES COULD INDUCE SEVERITY ]]>
<![CDATA[Soegijanto, Soegeng]]>;
<![CDATA[Sari, Desiana W.]]>;
<![CDATA[Yamanaka, Atsushi]]>;
<![CDATA[Kotaki, Tomohiro]]>;
<![CDATA[Kameoka, Masanori]]>;
<![CDATA[Konishi, Eiji]]>
<![CDATA[ Indonesian Journal of Tropical and Infectious Disease Vol 4, No 4 (2013) ]]>
Publisher : <![CDATA[Institute of Topical Disease ]]>
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<![CDATA[Background: In 2012, serotype of Dengue Virus had changed from Den-2 and Den-3 to Den-1. In 5â10 years ago, serotype of Den-1 case showed a mild clinical manifestation; but now as a primary case it can also show severe clinical manifestation. One of indicator is an increasing liver enzyme, AST and ALT, with level more than 100â200 U/L. Aim: To getting a better solutions for this problem. Method: Obsevasional Study had been done in medical faculty of Airlangga University (Dr. Soetomo and Soerya hospital) Surabaya on MeiâAugust 2012. There were 10 cases of dengue virus infection were studied, 5 cases got Ringer Acetate solution (Group A) and 5 cases got Ringer Lactate solution (Group B). The diagnosis was based on criteria WHO 2009. Result: Five cases of Dengue Virus Infection had showed a liver damage soon after using Ringer Lactate solution; AST and ALT were increasing more than 100â200 U/L; but the other 5 cases showed better condition. It might be due to use Ringer Acetate that did not have effect for inducing liver damage. By managing carefully, all of the cases had shown full recovery and healthy condition when being discharged. Conclusion: Using Ringer Acetate as fluid therapy in Dengue Virus Infection is better to prevent liver damage than using Ringer Lactate.]]>
<![CDATA[Relationship Between Clinical Manifestations and Antibody Serum in Outbreaks Anthrax ]]>
<![CDATA[Redhono, Dhani]]>
<![CDATA[ Indonesian Journal of Tropical and Infectious Disease Vol 5, No 5 (2015) ]]>
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<![CDATA[Introduction: Anthrax is a zoonotic disease that often affects the grass-eating animals, which occurs due to the entry of spores into the bodies of animals and can be transmitted to humans. This disease often appear in certain seasons and occurs in endemic areas, including Indonesia. Cutaneous anthrax is the clinical manifestations that often arise on outstanding events in the area. This study aims to determine how the relationship between the clinical manifestations of the serum antibodies in people who are exposed to anthrax. Material and methods: This study is an observational cross sectional analytic approach, in people exposed to anthrax to assess the clinical manifestations and antibody serum Anthrax. Results: Obtained in this study respondents were 101 people with a history of contact with animals suffering from anthrax. The number of respondents with the highest age distribution was 31 to 40 years by 42%, and most were female gender, which is 57.7%, the highest level of education is 74% finished elementary school. Forty-four percent of working as a housewife. Risk factors are the most direct contact with and consume the flesh of animals as much as 34.6%. Results of Ig G antibody serum showed 50% negative, 15.4 borderline and 34.6% positive. Clinical manifestations that occur in the skin as much as 13.5%, that is the eschar on all respondents and 92.8% showed positive Ig G. While 86.5% did not show any clinical signs of anthrax, of that number 25.5% with Ig G positive, 16.6% and 57.7% showed borderline negative with p 0.02. Conclusion: There was a significant association between the clinical manifestation with antibody serum anthrax. But also found apositive Ig G without the appearance of clinical signs in the skin.]]>
<![CDATA[COMPARATIVE STUDY ON THE INTENSITY OF Mycobacterium leprae EXPOSURE BETWEEN HOUSEHOLD AND NONHOUSEHOLD CONTACT OF LEPROSY ]]>
<![CDATA[Arsyad, Yuniarti]]>;
<![CDATA[Jifanti, Friska]]>;
<![CDATA[Amiruddin, Muhammad Dali]]>;
<![CDATA[Anwar, Anis Irawan]]>;
<![CDATA[Adriaty, Dinar]]>;
<![CDATA[Wahyuni, Ratna]]>;
<![CDATA[Iswahyudi, Iswahyudi]]>;
<![CDATA[Agusni, Indropo]]>
<![CDATA[ Indonesian Journal of Tropical and Infectious Disease Vol 3, No 1 (2012) ]]>
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<![CDATA[Leprosy stills a public health problem in West Sulawesi which has a Case Detection Rate (CDR) around 43.69/100.000 population. Household contacts of leprosy are a high risk group to be infected, due to droplet infection mode of transmission of the disease. A nose swab examination and serological study was conducted to detect exposure of M. leprae of people who live in leprosy endemic area. Detection of M. leprae in the nasal cavity will represent the exposure rate from outside and the measurement of specific antibody is represented the result of exposure to the immune system. Two group of inhabitants (30 household contacts of leprosy and 30 nonhousehold contacts) were involved in the study. They live in Banggae district, a leprosy endemic area of Majene Regency, West Sulawesi. Sixty nose swab samples and sixty capillary blood samples from the same invidividuals of the two groups were collected and sent to Leprosy laboratory of the Institute of Tropical Disease, Airlangga University Surabaya. A Polymerase Chain Reaction (PCR) was performed to the nose swab samples for detection of M. leprae. The blood samples were examined serologically to measure the level of anti PGL-1 antibody. PCR examination of nose swab samples showed 1/30 positive result in the household contact group and also 1/30 positive result in non-household contact of leprosy (statistically no significant difference, p > 0.05). Serological study showed higher sero-positive result in the household contact group (15/30 or 50%) compared to non-household contact (11/30 or 36%), but statistical calculation revealed no significant difference between the two groups (p > 0.05) on sero-positive results of leprosy. It is concluded that household and non-household contact in leprosy have the same risk to be affected by the disease. The term of household and non-household contact need to be redefined. The possible role of exposure from the environment was also discussed, especially from non-human resource of M. leprae.]]>
<![CDATA[The Photodynamic Effect of LED-Magnetic Exposure to Photoinactivation of Aerobic Photosyntetic Bacteria ]]>
<![CDATA[Astuti, Suryani Dyah]]>
<![CDATA[ Indonesian Journal of Tropical and Infectious Disease Vol 5, No 1 (2014) ]]>
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<![CDATA[All photosynthetic bacteria have a major pigment of bacteriochlorophyl and accessor pigment e.g. the carotenoids, which both have an important role in photosynthesis process. This study aim to explore the exogenous organic photosensitizer from photosyntetic bacteria for photodynamic therapy application. This study is an experimental research aiming to test the potential illumination of LED with wavelength 409, 430, 528 and 629 nm, and power optimization and time exposure LED-magnetic for optimum photo activation Rhodococcus growth. The reseach design use a factorial completely randomized design with factor of power and exposure time. The number of bacterial colonies grown measure using of Total Plate Count (TPC) methods. The result of anova test shows that irradiation treatment with LED 409 nm, 430 nm, 528 nm and 629 nm significantly affects on bacterial colony growth. LED 409 nm exposure has the greatest potential to boost the growth of bacterial colonies by 77%. LED exposure and the addition of 1.8 mT magnetic fieldincreases bacterial colony growth by 98%. Results of optimization of LED and magnetic fields show power 46 mW and a 40 minute (energy dose 110 J/cm2) optimum growth of bacterial colonies increase by 184%. So LED and magnetic illumination has potentially increased the viability of an aerob photosyntetic bacteria colonies.]]>
<![CDATA[MANAGEMENT OF HIV/AIDS INFECTION IN PREGNANCY ]]>
<![CDATA[Dewati, Endah]]>;
<![CDATA[Nasronudin, Nasronudin]]>
<![CDATA[ Indonesian Journal of Tropical and Infectious Disease Vol 5, No 2 (2014) ]]>
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<![CDATA[Twenty years since identified for the first time, the disease of HIV/AIDS spread and cause greater damage than the previous prediction. According to the Director General of P2M and Environmental Sanitation Department of Health by the end of 1999, there were 1066 people in Indonesia who are infected with HIV even though this must be realized that the rate is still far lower than the actual numbers, because there are many cases of HIV infection reported in addition to energy awareness health of the possibility of HIV infection has not been evenly distributed. Management of HIV infection/AIDS in pregnancy is done in time of antepartum, intrapartum and post partum, for mother and the baby, in general and specific. The important matters include the use of ART, nutrition and psychological support. Prevention and management of opportunistic infections to PWHA are not different with that of non pregnant woman. However, it is not routinely advised because of drug toxicity.]]>
<![CDATA[RI SK FACTOR OF BACTEREMI A I N CHI LDREN WI TH PNEUMONIA ]]>
<![CDATA[Asih, Retno]]>
<![CDATA[ Indonesian Journal of Tropical and Infectious Disease Vol 2, No 1 (2011) ]]>
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<![CDATA[Background: Pneumonia is known as a frequent cause of morbidity and mortality among children in developing countries. In children,it caused predominantly by bacteria. Bacteremia has been associated with severity and mortalitas of pneumonia. Identify factors caused bacteremia important to prevent severity and mortalitas of pneumonia. Objective: The objective of this study was to identify risk factors of bacteremia in children with pneumonia. Methods: A retrospective study was conducted in children with pneumonia in Dr. Soetomo Surabaya Hospital from January 2007 to December 2008. Blood cultures be performed on all of this patients. Factors associated with bacteremia were identified following review of medical records include clinical features, laboratory , radiology and blood culture results. Results: Frequency of bacteremia was 8,2% (36 patients) of 438 children with pneumonia. Interval from onset of symptoms to hospital admission more than 5 days (22.69 CI 95%), severe malnourished (OR 9.05 CI 95%), anemia (OR 2.44 CI 95%), leucocyt counts less than 5000/mm3 and more than 20.000/mm3 (OR 2.41 CI 95%) and paO2 less than 80 mmHg (OR 4.25 CI 95%) were at increased risk of bacteremia in children with pneumonia. Conclusion: Risk factors bacteremia in children with pneumonia included age under 1 year, symptoms more than 5 days, severe malnourished ,anemia, leucosyt counts less than 5000/mmand more than 20.000/mm3 and paO2 less than 80 mmHg.]]>
<![CDATA[ETHNIC AND ATOPIC DERMATITIS: WHAT HAVE WE LEARNED IN ASIAN POPULATION? ]]>
<![CDATA[Prakoeswa, Cita]]>
<![CDATA[ Indonesian Journal of Tropical and Infectious Disease Vol 3, No 2 (2012) ]]>
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<![CDATA[Atopic Dermatitis (AD) is a chronic inflammatory skin disease, with relapsing remitting course. Management of AD is challenging due to the complexities of this disease. Two hypotheses concerning the mechanism of AD have been proposed. One holds that the primary defect resides in an immunologic disturbance that causes Ig E-mediated sensitization, with epithelial barrier dysfunction regarded as a consequence of the local inflammation. The others propose that an intrinsic defect in the epithelial cells leads to the barrierdysfunction; the immunologic aspects is considered to be an epiphenomenon. Many studies support that AD is a complex trait which has interactions between genes and environmental factors contributing to disease manifestation, but the result of replicate association between genetic markers and AD is inconsistence. An important factor contributing to this inconsistency is related to population diversity. It is possible that certain genetic markers might contribute to increase the risk in certain ethnic population but not in others, either because of the differences in frequencies of the risk alleles and the specific genes interaction. There is limited information about the role of ethnicity in Asian population. The overall purpose of this review is to present an update on ethnicity approach of AD in Asian population. Research on prevalence, risk factor, innate and adaptive immune response genes, skin barrier dysfunction genes and geneenvironmentinteraction such as epigenetic, is discussed. It is generally approved that the ethnicity of study subject is a key factor in interpreting genetic polymorphism studies. Therefore, discussion of some current areas of research about polymorphism are presented, including filaggrin (FLG) gene and CD14 C-159TSNP. Addressing the issues described above may improve our understanding of AD pathogenesis that has implications for the clinical management of AD.]]>
<![CDATA[COLOSTRUM-COLLAGEN-HYDROXYAPATITE COMPOSITE, AN EXCELLENT CANDIDATE BIOMATERIAL FOR BONE REPAIR AND BONE INFECTION MANAGEMENT ]]>
<![CDATA[Setiawan, Dio Nurdin]]>;
<![CDATA[Anwar, Mirzaq Hussein]]>;
<![CDATA[Putri, Kholifatul Wanda]]>;
<![CDATA[Fiddarain, Nilna Faizah]]>;
<![CDATA[Widiyanti, Prihartini]]>;
<![CDATA[Purnobasuki, Heri]]>
<![CDATA[ Indonesian Journal of Tropical and Infectious Disease Vol 5, No 2 (2014) ]]>
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<![CDATA[In the case of bone fracture or defect after surgery, which is common in patients with bone cancer (osteosarcoma), it takes a long time for closure and it may cause an infection problem. The use of collagen-hydroxyapatite composite with a blend of colostrum as a scaffold is aimed to accelerate the process of osteoblast growth, inhibite the emergence of infections, and act as bone tissue repair material. The method used was the hydrogel formation process and freeze dry process to remove the solvent and to form pores. The composition of scaffold composite manufactured was 15% collagen, 75% hydroxyapatite and 10% colostrum. Combination of scaffold collagen-hydroxyapatite-colostrum has quite reliable properties because SEM test showed that scaffold could bind to both and could bind to both and could form sufficient pores to provide enough place for bone cells (osteoblats) to grow. The results of MTT assay revealed percentage of above 60%, which indicates that the material is not toxic. In conclusion, collagen-hydroxyapatite-colostrum combination is an excellent biomaterial candidate for bone repair and bone infection management.]]>
<![CDATA[MANIFESTATION OF AIDS WITH DIARRHEA ]]>
<![CDATA[Zainuddin, Rahmat]]>;
<![CDATA[Nasronudin, Nasronudin]]>
<![CDATA[ Indonesian Journal of Tropical and Infectious Disease Vol 5, No 3 (2014) ]]>
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<![CDATA[Infectious diseases HIV/AIDS is a global health problem. According to WHO (2000) reported that 58 million people in the world are infected with HIV, within the 22 million people died from AIDS or 7000 people die every day. HIV Infection caused decrease and disorder of humoral and cellular immunity. Intestinal mucosal normally shows a physiologic inflamation that account for intestinal mucosal integrity. Diarhhea in HIV infection due to immune deficiency can caused by pathogen and non pathogen. Acute and chronic diarrhea usually found in HIV infection patient, the latter is more frequent. HIV enteropathy cause chronic diarrhea without pathogen infection because intestinal mucous damage by HIV direct infection. Treatment is characterized as causative supportive and symptomatic treatment causal, supportive and Symptomatic. Immunonutrient is very important within management patient HIV/AIDS.]]>
<![CDATA[USING LEARNING VECTOR QUANTIZATION METHOD FOR AUTOMATED IDENTIFICATION OF MYCOBACTERIUM TUBERCULOSIS ]]>
<![CDATA[Purwanti, Endah]]>;
<![CDATA[Widiyanti, Prihartini]]>
<![CDATA[ Indonesian Journal of Tropical and Infectious Disease Vol 3, No 1 (2012) ]]>
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<![CDATA[In this paper, we are developing an automated method for the detection of tubercle bacilli in clinical specimens, principally the sputum. This investigation is the first attempt to automatically identify TB bacilli in sputum using image processing and learning vector quantization (LVQ) techniques. The evaluation of the learning vector quantization (LVQ) was carried out on Tuberculosis dataset show that average of accuracy is 91,33%.]]>
